Epilepsy breakthrough: naloxone may stop fatal breathing failure after seizures

NCT ID NCT02332447

First seen Oct 31, 2025 · Last updated May 13, 2026 · Updated 27 times

Summary

This study tested whether naloxone, a drug that reverses opioid overdoses, could help people with epilepsy breathe better after a severe seizure. About 485 adults with drug-resistant epilepsy were monitored in the hospital. Those who had a generalized tonic-clonic seizure received either naloxone or a placebo right after the seizure ended. The goal was to see if naloxone could speed up the return of normal oxygen levels, potentially reducing the risk of sudden unexpected death in epilepsy (SUDEP).

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for EPILEPSY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Locations

  • Service de Neurologie Fonctionnelle et d'Epileptologie et Institut des Epilepsies Hôpital Neurologique

    Lyon, France

Conditions

Explore the condition pages connected to this study.