Botox for swallowing trouble: a small study shows promise

NCT ID NCT01955174

First seen Jan 05, 2026 · Last updated May 15, 2026 · Updated 25 times

Summary

This study tested whether injecting botulinum toxin (Botox) into the lower esophagus can help people with nutcracker esophagus, a condition that causes chest pain and trouble swallowing. Twenty-four adults received either Botox or a placebo in a double-blind setup. The main goal was to see if symptoms improved enough to lower their Eckardt score below 3.

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Contacts and locations

Locations

  • Service d'Exploration Fonctionnelle Digestive - Hôpital Edouard Herriot Pavillon H 5 - Hospices Civils de Lyon

    Lyon, 69437, France

  • Service d'Hépato-Gastro-Entérologie et Oncologie Digestive- Hôpital Haut Lévêque - CHU de Bordeaux

    Bordeaux, 33075, France

Conditions

Explore the condition pages connected to this study.