New drug cocktail shows promise for Tough-to-Treat uterine cancer

NCT ID NCT02755844

First seen Nov 01, 2025 · Last updated May 13, 2026 · Updated 26 times

Summary

This study tested a combination of three drugs (cyclophosphamide, metformin, and olaparib) in 35 women with advanced or metastatic endometrial cancer that had come back after standard chemotherapy. The goal was to find the safest dose and see if the combination could stop the cancer from growing. The approach aims to control the disease, not cure it, and patients may need ongoing treatment.

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Contacts and locations

Locations

  • Centre Hospitalier Lyon Sud

    Pierre-Bénite, 69495, France

  • Comité Gynécologique, Institut Gustave Roussy

    Villejuif, 94800, France

  • Département d'Oncologie Médicale, Centre Antoine Lacassagne

    Nice, 06189, France

  • Département de Cancérologie Cervico-Faciale et Thoracique, Centre Oscar Lambret

    Lille, 59000, France

  • Service d'Oncologie Médicale, Centre François Baclesse

    Caen, 14076, France

  • Service d'Oncologie Médicale, Institut Curie

    Paris, 75248, France

Conditions

Explore the condition pages connected to this study.