Hospices Civils De Lyon

This study tests if a hormone pill (clomiphene citrate) can help men who produce no sperm and had a failed testicular surgery. Men will take the drug or a placebo for 9 months before a second surgery to try to find sperm for IVF. The goal is to see if the treatment increases the …

This study is testing whether adding two immunotherapy drugs (zimberelimab and domvanalimab) to a standard chemotherapy (FOLFIRI) works better than the chemotherapy alone for patients with a rare, fast-growing neuroendocrine cancer that has returned after first treatment. It will…

This study tests whether a simple, non-invasive arm cuff procedure can improve survival for adults with septic shock in intensive care. The procedure, called remote ischemic postconditioning, temporarily restricts and then restores blood flow in the arm. Researchers will measure …

This study aims to see if a new system of text message reminders and advice helps people with type 2 diabetes stick to their gum care plan better than standard check-ups alone. It will involve over 500 adults in France who have both diabetes and a treated gum disease called perio…

This study aims to see if giving a seizure-prevention drug (levetiracetam) right after a brain bleed stroke helps people recover better. It will involve 580 adults who recently had this type of stroke. Researchers will compare recovery, measured by independence in daily activitie…

This study aims to find the best way for doctors to access a patient's vein when implanting a first-time pacemaker or defibrillator. It will compare three different techniques to see which one is most successful, fastest, and has the fewest complications like bruising or lung inj…

This study aims to see if a special diet designed to increase the variety of gut bacteria helps people maintain weight loss after bariatric surgery better than standard dietary advice. It will involve 60 adults who have had weight loss surgery, comparing the two diet approaches o…

This study is testing a new, more convenient way to manage care for adults who get a cochlear implant. It combines remote monitoring from home with a streamlined initial setup process. The goal is to see if this new approach works as well as the standard in-person visits for main…

This study tests whether gentle electrical brain stimulation can help patients with severe brain injuries regain consciousness. Five patients who have been in minimally conscious or vegetative states for 3-12 months will receive personalized stimulation targeting specific brain w…

This study aims to test a new, standardized screening program to find advanced liver fibrosis in people with type 2 diabetes. It will enroll over 1,700 patients seen by private-practice diabetes doctors. The goal is to see if this two-step screening process, which uses a blood te…

This study aims to see if a machine can detect respiratory infections like COVID-19 and influenza by analyzing chemicals in a person's exhaled breath. Researchers will enroll about 1,665 adults, including people with symptoms and healthy volunteers, to test the device. The goal i…

This study aims to improve how doctors check a fetus's bowel on ultrasound scans. Currently, a 'bright bowel' finding can be a false alarm, causing unnecessary worry and extra tests for parents. Researchers will test a new computer program that measures shades of gray on the scan…

This study is testing whether a special camera can help neurosurgeons see the brain more clearly during surgery. The camera is designed to measure color and light changes that might indicate healthy versus diseased tissue or areas important for brain function. The goal is to prov…

This study is testing a new type of medical scan to see if it can better detect when a specific form of breast cancer (called lobular carcinoma) has spread to other parts of the body. Researchers will compare this new scan to the standard scan currently used. The goal is to find …

This study is testing a new type of brain scanner designed to more accurately find the specific area of the brain causing seizures in people with epilepsy. The goal is to improve planning for surgery that could control or cure seizures. Researchers will compare the new, more comp…

This study aims to see if analyzing chemicals in a person's exhaled breath can quickly and accurately diagnose serious respiratory infections in hospitalized patients. Researchers will collect breath samples from 777 adults with infections like COVID-19, flu, or Legionnaires' dis…

This study aims to find the best length of time to give blood-thinning medication to new mothers who have a specific genetic trait that increases their risk of developing dangerous blood clots after giving birth. Researchers will look back at the medical records of 100 women with…

This study aims to see if giving babies a protective shot against RSV (a common virus) in their first year can prevent wheezing and lower the risk of developing asthma later in childhood. Researchers will compare health records of about 218,000 French children who received the sh…

This study aims to see if taking probiotic supplements can help reduce common stomach side effects like nausea, diarrhea, and abdominal pain in people starting new GLP-1 weight-loss medications (semaglutide or tirzepatide). Researchers will enroll 50 adults with obesity and rando…

This study is testing if starting a personalized exercise program right when hormone therapy begins can prevent or reduce the severe joint and muscle pain it often causes. It will involve 182 postmenopausal women with early-stage breast cancer. Half will start the exercise progra…

This study aims to see if a special education program helps adults with neuroendocrine tumors better manage the side effects of taking oral cancer drugs at home. It will follow 100 patients to check if the program reduces severe side effects and improves their quality of life. Th…

This study is testing whether injections of platelet-rich plasma (made from a person's own blood) can improve smell function in adults who have persistent smell loss not caused by tumors. Participants will receive three injections over four weeks and have their smell function mea…

This study aims to see if different types of psychological support can improve the quality of life and mental health for women living with endometriosis. It will compare individual therapy, group therapy, and a combination of both against no treatment. The goal is to find the bes…

This study aims to understand how the body's automatic nervous system is involved in liver cancer (HCC). Researchers will enroll 100 adults with liver cirrhosis, some with and some without early signs of cancer. They will use questionnaires, heart rate tests, and analysis of live…

This study aims to understand how people with intellectual disabilities, specifically Down syndrome and Fragile X syndrome, decide who to trust. Researchers will use computer tasks, eye-tracking, and brain scans (MRI) to compare how 112 participants from these groups and typical …

This study aims to understand what a normal immune response looks like in healthy adults aged 80 and older. Researchers will measure specific immune markers in the nose and blood of 62 participants who show no signs of infection. The goal is to create reference data that can help…

This study aims to understand how cancer and its treatments affect patients' enjoyment of food and eating. Researchers will survey 180 adults with various cancers to identify which factors most harm food-related quality of life. The goal is to create a model to predict which pati…

This study aims to understand how gut bacteria might contribute to fatty liver disease (MASLD) by producing specific substances. Researchers will analyze stool and blood samples from 24 participants—some with MASLD and some healthy—to measure these bacterial products and identify…

This research study aims to learn more about rare autoinflammatory diseases, which cause unexplained episodes of fever, rash, and joint pain. Researchers will collect blood samples from 60 patients (adults and children) who have these conditions. The goal is to analyze how inflam…

This study aims to understand how having one leg slightly longer than the other affects the joints in children's hips and lower backs. Researchers will use special low-radiation imaging and force-measuring platforms to create detailed models of 100 children aged 10-15. The goal i…

This study aims to understand how viruses in the throat and gut of very premature babies might be linked to a serious lung disease called bronchopulmonary dysplasia (BPD). Researchers will observe 40 babies born before 30 weeks, collecting samples in their first three weeks of li…

This study aims to understand how the COVID-19 pandemic and its social restrictions affected suicidal thoughts and behaviors in children and teenagers. Researchers will examine the medical records and interview a sample of about 6,500 young people aged 8 to 18 in France who were …

This study aims to understand how social skills develop over time in people with 7q11.23 microduplication syndrome, a rare genetic condition linked to autism and developmental challenges. Researchers will track 15 participants aged 5-50 years through assessments of their communic…

This study aims to understand why pregnancies from frozen embryo transfers sometimes have more complications, like high blood pressure, than fresh transfers or natural pregnancies. Researchers will measure levels of a pregnancy hormone called relaxin in the blood of 60 women who …

This study aims to understand if people who carry a specific gene change (CYP24A1) are at higher risk for developing kidney stones. Researchers will compare the health of people with different versions of this gene to see how it relates to stone formation. The goal is to gather k…

This study aims to understand how the brain creates and controls our inner voice, which we use for thinking and problem-solving. Researchers will use MRI brain scans on 60 healthy volunteers, including some who don't experience an inner voice, to see which brain areas are involve…

This study aims to understand why people with cystinosis, a rare genetic disease, experience premature aging and bone problems. Researchers will compare the energy production in blood cells from 25 patients with cystinosis to see if their cellular 'power plants' (mitochondria) wo…

This study aims to understand the link between how infants with Down syndrome suck on a pacifier and the severity of their sleep apnea. Researchers will measure sucking patterns and sleep breathing in 30 six-month-old infants to see if a simple sucking test could become an easier…

This study aims to understand the link between gut bacteria and malnutrition in people with digestive cancers who are starting chemotherapy. Researchers will collect stool and saliva samples from 150 patients to see if the types of bacteria present are connected to their nutritio…

This study aims to understand if children with suspected obstructive sleep apnea have weaker tongue muscles or less tongue movement compared to healthy children. Researchers will measure tongue strength and mobility in 78 children who are already scheduled for an overnight sleep …

This study aims to understand brain changes in adults with Dravet syndrome, a severe form of epilepsy with a high risk of sudden death. Researchers will use PET and MRI brain scans to compare 30 participants: 10 with Dravet syndrome, 10 with other drug-resistant epilepsy, and 10 …

This study aims to see if a special PET scan can detect a protein called PSMA in recurrent meningiomas, which are brain tumors that have come back after standard treatments. Researchers will scan 40 adult patients whose tumors have returned after surgery or radiation. If enough t…

This study aims to understand why people with polycythemia vera (a rare blood disorder) often have trouble with physical activity. Researchers will test 54 patients during exercise to see if their blood becomes too thick, which might limit oxygen delivery to muscles. The goal is …

This study aims to see if giving an educational brochure to older adults helps change their attitudes and beliefs about reducing or stopping their long-term use of benzodiazepine medications (like certain sleep or anxiety pills). Researchers will give the brochure to 96 hospitali…

This research study aims to understand how a specific type of immune cell, called MAIT cells, is involved in hidradenitis suppurativa (HS), a chronic and painful skin condition. Researchers will compare blood and skin samples from 45 adults with moderate-to-severe HS to samples f…

This study is testing whether a new computer tool called 'Lianeli' can help primary care doctors and their patients better manage recommended health screenings. The tool is designed to quickly identify which screenings a patient might need based on their health profile and suppor…

This study aims to understand how drug-resistant epilepsy might change specific pathways in the brain that control breathing and sleep-wake cycles. Researchers will use advanced MRI and PET scans to compare brain activity and chemistry in 50 adults (some with epilepsy, some healt…