Hospices Civils De Lyon

This study investigates cryoablation, a procedure that freezes and destroys tumor tissue, for treating the primary breast tumor in women with metastatic breast cancer. The goal is to see if this minimally invasive approach can control the local tumor for 12 months while patients …

This study tests whether a fluorescent dye called 5-ALA can help surgeons see and remove abnormal brain tissue in people with drug-resistant epilepsy caused by focal cortical dysplasia (FCD). FCD lesions are often hard to distinguish from healthy brain during surgery, making comp…

This study tests whether adding flexible bands (tethers) at the top of a spinal fusion can prevent a common complication called proximal junctional kyphosis (PJK), where the spine curves forward above the surgical site. About 128 adults undergoing spinal fusion for deformity will…

This study tests whether a sedative called dexmedetomidine can improve survival in people with refractory septic shock, a life-threatening condition where blood pressure stays dangerously low despite standard treatments. The drug aims to calm an overactive stress response that ma…

This study compares three methods for inserting the wires (leads) of pacemakers or defibrillators during first-time implantation. The three techniques are: cutting down to a vein in the shoulder, using ultrasound to guide a needle through the skin, or using a special ultrasound p…

This study tests whether a non-invasive arm cuff procedure, called remote ischemic postconditioning, can reduce deaths in adults with septic shock. The cuff is inflated and deflated in cycles to briefly restrict blood flow, which may trigger protective effects. 720 ICU patients w…

This study tests whether giving the seizure medicine levetiracetam right after a brain bleed (intracerebral hemorrhage) can prevent seizures and improve long-term recovery. About 580 adults will receive either the drug or a placebo for up to 7 days, and their level of disability …

This study tests whether adding two immunotherapy drugs (zimberelimab and domvanalimab) to standard chemotherapy (FOLFIRI) helps people with a rare, fast-growing neuroendocrine cancer live longer. About 122 adults whose cancer has worsened after first treatment will take part. Th…

This study tests whether a gentle, non-invasive brain stimulation technique called alpha tACS can improve consciousness in people who have been in a vegetative or minimally conscious state for 3–12 months after a traumatic brain injury. Five adults will each receive alternating t…

This study tests whether sending SMS reminders and advice to people with type 2 diabetes and gum disease can improve their blood sugar control over two years. 516 adults who recently completed gum disease treatment will be split into two groups: one gets standard follow-up, the o…

This study is testing a new cognitive assessment called the ExéSem battery, designed to help doctors tell the difference between language problems caused by memory loss versus those caused by thinking difficulties. Researchers will enroll 140 people, including those with Alzheime…

This study tests a new, more comfortable brain scanner (OPM MEG) that fits directly on the head to locate where seizures start in people with epilepsy. Researchers will compare its accuracy to standard methods in 70 patients aged 6 to 65 who are already scheduled for epilepsy sur…

This study tests whether analyzing chemicals in a person's breath can quickly identify serious respiratory infections like COVID-19, flu, and Legionella in hospitalized patients. Researchers will collect breath samples from 777 adults using a simple bag, then analyze them in a la…

This study aims to see if analyzing chemicals in a person's breath can rapidly detect respiratory infections like COVID-19 or the flu. Researchers will collect breath samples from 1,665 adults with symptoms and healthy volunteers. If successful, this non-invasive test could offer…

This study tests a new type of PET scan using a tracer called 68Ga-FAPI-46 to find cancer that has spread in patients with lobular breast cancer. Standard scans often miss these metastases. The trial will enroll 45 adults whose standard PET scan was negative or unclear, and see i…

This study tests whether a special ultrasound setting can more accurately measure the brightness of a fetus's bowel. Currently, doctors rely on a subjective impression, which often leads to false alarms and unnecessary worry. The study will compare gray levels in the bowel and bo…

This study tests whether a special pacifier, called CURAPROX, can reduce the severity of obstructive sleep apnea (OSA) in infants with Down syndrome. Fifty infants will be enrolled at one month old, with half using the pacifier and half not. At six months, sleep tests will measur…

This study will follow over 200,000 infants in France to see if early immunization with nirsevimab, an antibody against RSV, reduces wheezing episodes in preschool years. Researchers will compare hospitalization rates for wheezing between immunized and non-immunized children. The…

This study looks at whether interventional radiology—a minimally invasive technique using needles or probes—can reduce pain and improve daily life for people with advanced or metastatic cancer. About 125 adults whose cancer has spread and who are expected to live at least 3 month…

This study tests whether injecting a person's own platelet-rich plasma (PRP) into the nose can help restore smell in adults who have had smell loss for more than 6 months due to aging or head injury. Thirty participants will receive three PRP injections over four weeks and be fol…

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This study tests whether taking probiotics can reduce digestive side effects like nausea and diarrhea in people starting weight-loss drugs such as semaglutide or tirzepatide. Fifty adults with obesity will take either a probiotic capsule or a placebo daily for 26 weeks. The goal …

This study tests a new care pathway for adults getting a cochlear implant. Instead of the usual nine clinic visits in the first year, the new plan uses early activation of the implant and remote monitoring visits. The goal is to see if this approach is at least as good for hearin…

This study compares four surgical techniques for removing bladder stones in patients who have a continent catheterizable urinary reservoir, a surgically created pouch that stores urine. The techniques include using a mini-percussion device through the stoma, a flexible scope thro…

This study follows adults waiting for a liver transplant to see how their sleep quality changes from before surgery to six months after. Researchers use questionnaires to measure sleep, anxiety, and other factors. The goal is to understand what influences sleep problems in these …

This study follows 100 adults with advanced heart failure for 2 years to understand how kidney function changes over time and how it relates to serious heart events like death or need for a transplant. Researchers will collect blood, urine, and stool samples, along with quality-o…

This study will collect blood and nasal swab samples from 100 healthy adults aged 18 to 65 to establish normal reference values for immune markers called interferons. These markers can help doctors tell if a person has an active viral infection. By defining what is 'normal,' the …

This study aims to create a score that predicts the risk of infection within 30 days after a liver transplant. Researchers will collect blood samples from 279 liver transplant patients before and after surgery to measure immune markers. The goal is to combine these markers with o…

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study will test whether smelling a pleasant food odor (madeleine scent) before drinking a sugary solution changes how the body handles blood sugar. Twenty adults, some with obesity and mild insulin resistance and some without, will each undergo two sessions: one with the sce…

This study looks at brain activity in people with aphantasia, a condition where someone cannot form mental images. Researchers will use MEG scans to compare brain patterns during tasks like imagining movements or preparing to move. The goal is to understand how the brain handles …

This study checks if a French version of the New Mobility Score (NMS) works well for older adults hospitalized after a hip fracture. The NMS is a simple test that measures how well a person can move indoors, outdoors, and while shopping. Researchers will test it with 100 patients…

This study will test whether a special brain scan called magnetoencephalography (MEG) can detect electrical differences within gliomas, the most common malignant brain tumors in adults. Researchers will scan 60 newly diagnosed patients before surgery to see if MEG can identify mo…

This observational study will use brain scans (fMRI) and facial expression recordings to understand how emotions influence decision-making in everyday situations. 120 healthy adults aged 18-45 will perform tasks that mimic real-life choices while their brain activity and facial e…

This study checks on children who had a moderate to severe head injury years ago to see if they have any lasting hormone or growth problems. Researchers will call participants for a 15-minute interview to measure their height and ask about symptoms. The goal is to learn how commo…

This study will survey about 950 men who stored sperm at a French fertility center before cancer treatment between 2010 and 2024. Researchers want to know how many later became fathers, whether naturally or with medical help, and if they used their frozen sperm. The goal is to be…

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study uses advanced PET/MRI scanning to examine the noradrenaline system in the brains of 165 healthy adults and people with Parkinson's disease. Participants receive a radioactive tracer that binds to specific receptors, allowing researchers to see how this system changes w…

This study looks at why many people with obstructive sleep apnea still feel very sleepy during the day even after successful treatment with CPAP or other devices. Researchers will test 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this lef…

This study will test a two-step screening program for advanced liver fibrosis in people with type 2 diabetes. About 1,714 patients will first get a blood test (FIB-4), and if that suggests risk, they will receive a liver stiffness measurement (transient elastography). The goal is…

This study looks at 40 premature babies (born before 30 weeks) to see if viruses in their lungs and gut during the first three weeks of life are linked to a serious lung condition called bronchopulmonary dysplasia (BPD). Researchers will collect throat and stool samples to track …

This study looks at a hormone called relaxin in women who get pregnant through IVF. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, and if low levels are linked to pregnancy complications. 60 first-time mothers will give an extra blood …

This study tests whether giving older hospital patients an educational leaflet about benzodiazepines (medications for sleep and anxiety) changes their attitudes toward reducing or stopping these drugs. Researchers will survey 96 geriatric patients at two time points to see if the…

This study looks at the brain activity behind your inner voice—the little voice in your head. Researchers will use MRI scans to compare people who have an inner voice with those who don't (aphantasics). The goal is to understand which brain areas control inner speech, which could…

This study will follow 15 people aged 5 to 50 with 7q11.23 microduplication syndrome, a rare genetic condition linked to autism and social difficulties. Researchers will track developmental milestones, social skills, and behavior using interviews and questionnaires. The goal is t…

This study looks at how cancer and its treatments change the way people experience food, including taste, mouth health, and overall eating pleasure. Researchers will ask 180 adults with different cancers to fill out a detailed questionnaire about their eating habits and feelings.…

This study looks at how people with Down syndrome and Fragile X syndrome decide who to trust. Researchers will use eye-tracking and behavioral tasks to measure how participants read faces, behaviors, and detect deception. The goal is to understand the brain mechanisms behind trus…

This study tests whether a special PET scan (PSMA PET) can detect a protein on recurrent meningiomas, a common brain tumor. If the protein is present, it might allow a new type of targeted radiation therapy. The study involves 40 adults whose meningioma has come back after standa…

This study looks at how certain immune cells, called MAIT cells, behave in people with hidradenitis suppurativa (HS), a painful skin condition. Researchers will take skin and blood samples from 45 adults with HS and compare them to samples from people with other skin diseases. Th…

This study looks at why people with polycythemia vera (PV), a rare blood disorder that makes too many red blood cells, often struggle with exercise. Researchers will measure blood thickness and oxygen levels in 54 patients during a treadmill stress test. The goal is to see if a b…

This study looks at how energy production inside cells (mitochondria) works in people with cystinosis, a rare disease that causes cystine buildup and early aging. Researchers will measure cell energy activity in 25 patients and compare it to healthy people. The goal is to underst…

This study tests whether a camera can record useful video of the brain during neurosurgery to help surgeons tell healthy tissue from diseased tissue. Researchers will record 50 adult patients undergoing brain surgery for tumors, epilepsy, or other conditions. The goal is to see i…

This study will enroll 100 adults with neuroendocrine tumors who are starting oral anti-cancer drugs like everolimus or sunitinib. Researchers want to see if a therapeutic education program—including questionnaires and nurse consultations—helps patients handle side effects and ma…

This study looks at whether having one or two faulty copies of the CYP24A1 gene makes kidney stones more likely. Researchers will compare people with different gene variants to see how often stones occur. The goal is to better understand the genetic factors behind this common and…

This study looks at how the bacteria in the gut and mouth relate to nutrition in 150 adults with digestive cancer starting chemotherapy. Researchers will collect stool and saliva samples, along with questionnaires and tests, before and after the first chemo cycle. The goal is to …

This study uses brain scans to see how epilepsy changes a brain chemical called adenosine in areas that control breathing and wakefulness. Researchers will compare 50 people with drug-resistant epilepsy to healthy volunteers. The goal is to better understand why some epilepsy pat…

This study aims to better understand rare autoinflammatory diseases by developing blood tests that measure inflammation markers. Researchers will analyze blood samples from 60 adults and children with these conditions. The goal is to identify specific inflammation pathways, which…