Hospices Civils De Lyon

This phase 3 trial tests whether giving the seizure medicine levetiracetam early after a brain bleed (intracerebral hemorrhage) can improve recovery and reduce disability. About 580 adults will receive either the drug or a placebo for up to 7 days, and their functional status wil…

This study looks at whether a special dental follow-up program (with text message reminders and tips) can help people with type 2 diabetes and gum disease better control their blood sugar. About 516 adults who have already had gum treatment will be split into two groups: one gets…

This study tests whether a non-invasive treatment called remote ischemic postconditioning (RIPOST) can improve survival in adults with septic shock. The treatment involves briefly inflating a blood pressure cuff on the arm to trigger protective effects in the body. The trial will…

This study tests whether adding two immunotherapy drugs (zimberelimab and domvanalimab) to standard chemotherapy (FOLFIRI) helps people with a rare, fast-growing neuroendocrine carcinoma of the digestive tract or unknown origin live longer. About 122 adults whose cancer worsened …

This study tests whether taking clomiphene citrate (a fertility drug) for 9 months can help men with non-obstructive azoospermia (no sperm in semen due to testicular failure) produce sperm for IVF. About 128 men who had a failed first sperm retrieval surgery will receive either t…

This study aims to see if a machine that analyzes chemicals in your breath can quickly tell if you have a respiratory infection, like COVID-19 or the flu. About 1,665 adults with symptoms and healthy volunteers will breathe into a special device. If successful, this could offer a…

This study tests a new type of PET scan (68Ga-FAPI) to see if it can find cancer spread in people with lobular breast cancer when the standard scan is negative or unclear. About 45 adults whose standard scan didn't show clear spread will get the new scan. If it finds hidden tumor…

This study tests a new, more comfortable brain scanner (OPM MEG) to locate where seizures start in people with epilepsy who are planning surgery. About 70 children and adults will get both the new scanner and standard tests. The goal is to see if the new device can pinpoint seizu…

This study tests a new way to measure bowel brightness on fetal ultrasound using computer analysis of gray shades, instead of relying on the doctor's eye. The goal is to reduce false alarms that cause worry for parents and overload specialist clinics. About 50 pregnant women in t…

This study explores whether analyzing the chemicals in a person's breath can quickly and painlessly diagnose serious respiratory infections like COVID-19, flu, and Legionella in hospitalized adults. Researchers will collect breath samples from 777 participants using a simple beds…

This study looks at whether giving babies a medicine called nirsevimab early in life can prevent wheezing and asthma-like symptoms as they grow up. Researchers will compare 218,000 children in France who received the shot with those who did not, using health records to track hosp…

This study tests a new care pathway for adults with severe hearing loss who get a cochlear implant. Instead of many in-person visits, patients will use remote monitoring and have their device activated earlier using data from surgery. The goal is to see if this approach improves …

This study looks at whether interventional radiology—a minimally invasive technique using needles or catheters—can reduce pain and improve quality of life in people with advanced or metastatic cancer. About 125 adults whose cancer has spread and who are expected to live at least …

This study tests whether taking probiotics can reduce common stomach issues like nausea, diarrhea, and abdominal pain caused by GLP-1 weight-loss drugs (semaglutide or tirzepatide). About 50 adults with obesity starting these medications will receive either probiotics or a placeb…

This study looks at whether a special education program helps people with neuroendocrine tumors better manage side effects from oral cancer drugs like everolimus or sunitinib. About 100 adults will be followed for 3 months to track side effects, hospital visits, and quality of li…

This study tests a non-invasive brain stimulation technique called alpha tACS in 5 adults with disorders of consciousness after traumatic brain injury. The goal is to see if repeated sessions can improve their level of consciousness. Each person will be their own control, compari…

This study tests if starting a personalized exercise program early can prevent or reduce the joint and muscle pain that many breast cancer patients get from hormone therapy (aromatase inhibitors). About 182 postmenopausal women will be assigned to either the exercise program or u…

This study tests whether psychological support—individual therapy, group sessions, or a mix—can improve quality of life and mental health in women with endometriosis. Forty participants will be randomly assigned to one of four groups, including a no-intervention control. The goal…

This pilot study tests if injections of platelet-rich plasma (PRP) made from a person's own blood can improve smell in adults who have had smell loss for over 6 months due to aging or injury. Thirty participants will receive three PRP injections over four weeks and be followed fo…

This study looks at how epilepsy changes certain brain areas that control breathing and waking up. Researchers will use brain scans to compare 50 people with drug-resistant epilepsy and healthy volunteers. The goal is to understand why some people with epilepsy may stop breathing…

This study compares three ways to reach a vein when putting in a pacemaker or defibrillator for the first time. About 900 adults will be randomly assigned to one of three techniques: ultrasound-guided puncture from inside the incision, ultrasound-guided puncture through the skin,…

This study checks if a new set of thinking tasks (the ExéSem battery) can tell the difference between problems with word meaning and problems with the thinking skills needed to use that meaning. Researchers will test 140 adults aged 50-90, including people with Alzheimer's, other…

This study looks at why over a third of people treated for obstructive sleep apnea still feel very sleepy during the day, raising their risk of accidents. Researchers will study 100 adults to see if the amount of oxygen drops during sleep before treatment predicts this problem. T…

This study looks at whether special immune cells, called MAIT cells, play a role in hidradenitis suppurativa (HS), a chronic skin condition causing painful boils. Researchers will compare blood and skin samples from 45 adults with HS to those with other skin diseases. The goal is…

This study looks at why people with polycythemia vera, a rare blood disorder, have trouble exercising. Researchers will measure blood thickness and oxygen levels during exercise tests in 54 patients. The goal is to understand the causes of exercise intolerance to help tailor phys…

This study looks at whether gut bacteria in people with fatty liver disease (MASLD) produce certain chemicals that may harm the liver. Researchers will collect stool samples from 24 adults (patients and healthy volunteers) and grow the bacteria in the lab to measure these chemica…

This study will use a special PET scan to look for a protein called PSMA in people whose meningioma brain tumors have come back after standard treatments. The goal is to see how many of these tumors have enough PSMA to possibly be treated with a new type of targeted radiation the…

This study looks at how the bacteria in the gut and mouth are linked to nutrition in people with digestive cancer starting chemotherapy. Many cancer patients struggle with malnutrition, which can make treatment harder. By collecting stool and saliva samples, along with questionna…

This study looks at how energy production inside cells (mitochondria) works in people with cystinosis, a rare genetic disease that causes cystine buildup and early aging. Researchers will compare blood cells from 25 cystinosis patients with healthy cells to find clues about bone …

This study looks at whether giving older hospital patients an educational leaflet about benzodiazepines (medicines for sleep or anxiety) can change their attitudes toward reducing or stopping these drugs. Researchers will survey 96 geriatric patients before and after they receive…

This study tests a new imaging technique called electrical impedance tomography (EIT) to measure how air and blood flow in the lungs of children with acute breathing failure. The study will include 20 children under 12 years old who are on a breathing machine. The goal is to see …

This study looks at how the COVID-19 pandemic and related social restrictions may have influenced suicidal thoughts and actions in children and adolescents aged 8 to 17 in the Auvergne-Rhône-Alpes region of France. Researchers will gather data from up to 6,500 young people who ha…

This study tests whether a special camera can measure color changes in the brain during surgery to tell healthy tissue from diseased tissue. About 50 adults having brain surgery will be recorded. The goal is to see if the camera can provide useful information that might help surg…

This study aims to see if a two-step screening process—a blood test followed by a liver scan—can help find advanced liver scarring in people with type 2 diabetes. About 1,714 adults with type 2 diabetes will be screened by their regular diabetes doctor. The goal is to catch serio…

This study looks at whether having just one faulty copy of the CYP24A1 gene (instead of two) makes people more likely to develop kidney stones. Researchers will compare 45 people with one or two faulty gene copies to understand their health history and lab results. The goal is to…

This study uses advanced PET/MRI brain scans to see how the noradrenaline system changes as people age and in Parkinson's disease. Researchers will compare healthy volunteers aged 20-80 with people who have Parkinson's. The goal is to understand how these brain changes relate to …

This study aims to better understand rare autoinflammatory diseases, where the body's immune system causes inflammation without a clear reason. Researchers will collect blood samples from 60 adults and children with these conditions to study how inflammation signals work. The goa…

This study looks at how the brain manages inner speech—the voice inside your head. Researchers will use brain scans (fMRI) to see which areas are active when people talk to themselves silently. They aim to understand why some people have no inner voice and how this relates to men…

This study looks at a hormone called relaxin in women who become pregnant after embryo transfer. Researchers want to see if relaxin levels differ between fresh and frozen embryo transfers, which may help explain why frozen transfers have higher risks of problems like preeclampsia…

This study follows 15 people with 7q11.23 microduplication syndrome (7DUP) from age 5 to 50 to track how social skills develop over time. Researchers will use interviews, questionnaires, and tests to measure social, communication, and motor milestones. The goal is to better under…

This study looks at how cancer and its treatments change the way patients experience food, including taste, appetite, and enjoyment of eating. Researchers will survey 180 adults with breast, head and neck, gynecologic, gastrointestinal, or lung cancer to understand which factors …

This study checks if children who had a moderate to severe head injury develop long-term hormone problems that affect growth. Researchers will call about 90 past participants for a 15-minute phone interview to measure their current height and ask about symptoms. The goal is to un…

This study looks at whether the types of viruses found in the lungs and gut of very preterm babies (born before 30 weeks) influence their risk of developing bronchopulmonary dysplasia (BPD), a serious chronic lung disease. Researchers will collect throat and stool samples from 40…

This study looks at how people with Down syndrome or Fragile X syndrome decide who to trust. Researchers will use computer tasks and eye-tracking to measure how participants judge faces, behaviors, and whether someone is lying. The goal is to understand why these groups are more …