Double immunotherapy attack shows promise against rare gut cancer
NCT ID NCT07337447
First seen Jan 16, 2026 · Last updated May 13, 2026 · Updated 12 times
Summary
This study tests whether adding two immunotherapy drugs (zimberelimab and domvanalimab) to standard chemotherapy (FOLFIRI) helps people with a rare, fast-growing neuroendocrine carcinoma of the digestive tract or unknown origin live longer. About 122 adults whose cancer worsened after first treatment will be randomly assigned to the new combo or chemotherapy alone. The goal is to see if more patients are alive after 12 months with the combination.
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Locations
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CHU Amiens Picardie
Amiens, France
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CHU Avicenne APHP
Bobigny, France
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CHU Caen Normandie
Caen, France
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CHU Dijon
Dijon, France
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CHU Montpellier - Hôpital Saint Eloi
Montpellier, France
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CHU Rouen
Rouen, France
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CHU Timone
Marseille, France
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CHU de Bordeaux - Hôpital Haut-Leveque
Pessac, France
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CHU de Grenoble
Grenoble, France
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CHU de Poitiers
Poitiers, France
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Centre Oscar Lambret
Lille, France
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Centre Paul Strauss
Strasbourg, France
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HEGP
Paris, France
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Hôpital Beaujon
Clichy, France
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Hôpital Henri MONDOR
Créteil, France
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Hôpital Robert Debré, CHU de Reims
Reims, France
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Hôpital Saint Antoine APHP
Paris, France
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Hôpital Saint Louis APHP
Paris, France
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Institut Gustave Roussy
Villejuif, France
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Institut Paoli Calmettes
Marseille, France
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Service d'Oncologie Médicale - Hôpital Edouard Herriot - Hospices Civils de Lyon
Lyon, France
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Conditions
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