Could a blood pressure cuff help fight septic shock?

NCT ID NCT07273942

Not yet recruiting Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive arm cuff procedure, called remote ischemic postconditioning, can reduce deaths in adults with septic shock. The cuff is inflated and deflated in cycles to briefly restrict blood flow, which may trigger protective effects. 720 ICU patients will be randomly assigned to receive the procedure or standard care, and survival at 90 days will be compared.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: remote ischemic conditioning (arm cuff inflation/deflation cycles)
What this could lead to: If it works, this could offer a simple, cheap, non-invasive way to reduce deaths from septic shock.
What could go wrong: This is a large trial but still early for this specific condition. Previous benefits seen in other diseases may not apply to septic shock, and the intervention may have no effect on survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

toxic shock syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADULT PATIENTS WITH SEPTIC SHOCK ADMITTED IN INTENSIVE CARE UNIT

Contacts and locations

Locations

Service Réanimation Polyvalente, Centre Hospitalier de Fleyriat

Bourg-en-Bresse, 01012, France
Service Réanimation Polyvalente, Centre Hospitalier de Roanne

Roanne, 42328, France
Service Réanimation Polyvalente, Hôpital Saint-Joseph Saint-Luc

Lyon, 69007, France
Service d'Anesthésie - Réanimation - Médecine Intensive, Hôpital Lyon Sud, Hospices Civils de Lyon

Pierre-Bénite, 69495, France
Service de Médecine Intensive - Réanimation, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris

Paris, 75014, France
Service de Médecine Intensive et Réanimation Polyvalente, Hôpital Robert Debré, CHU Reims

Reims, 51090, France
Service de Médecine Intensive- Réanimation, Hôpital Gabriel Montpied, CHU de Clermont-Ferrand

Clermont-Ferrand, 63003, France
Service de Médecine Intensive-Réanimation, Hôpital Bicêtre, Assistance Publique des Hôpitaux de Paris

Le Kremlin-Bicêtre, 94270, France
Service de Médecine Intensive-Réanimation, Hôpital Bretonneau, CHRU de Tours

Tours, 37000, France
Service de Médecine Intensive-Réanimation, Hôpital Central, CHRU de Nancy

Nancy, 54035, France
Service de Médecine Intensive-Réanimation, Hôpital Edouard Herriot, Hospices Civils de Lyon

Lyon, 69003, France
Service de Médecine Intensive-Réanimation, Hôpital Henri Mondor, Assistance Publique des Hôpitaux de Paris

Créteil, 94000, France
Service de Médecine Intensive-Réanimation, Hôpital Nord, Assistance Publique des Hôpitaux de Marseille

Marseille, 13015, France
Service de Médecine Intensive-Réanimation, Hôpital Salengro, CHU de Lille

Lille, 59037, France
Service de Médecine Intensive-Réanimation, Hôtel Dieu, CHU de Nantes

Nantes, 44093, France
Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, CHU de Strasbourg

Strasbourg, 67091, France
Service de Médecine intensive-Réanimation, Hôpital Lapeyronie, CHU de Montpellier

Montpellier, 34295, France
Service de Médecine intensive-Réanimation, Hôpital Nord, CHU de St Etienne

Saint-Priest-en-Jarez, 42270, France
Service de Médecine intensive-Réanimation,Hôpital Albert Michallon, CHU de Grenoble

La Tronche, 38700, France
Service de Médecine intensive-Réanimation,Hôpital F Mitterrand, CHU de Dijon

Dijon, 21079, France
Service de Réanimation Médicale, Hôpital Jean-Minjoz, CHU de Besançon

Besançon, 25030, France
Service de Réanimation des Urgences, Hôpital de la Timone, CHU de Marseille

Marseille, 13385, France
Service des maladies infectieuses et réanimation médicale, Hôpital Pontchaillou, CHU de Rennes

Rennes, 35000, France