Kidney stone mystery: why some gene carriers get sick and others stay healthy
NCT ID NCT06283082
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at people who carry one copy of a mutated AGXT gene, which is linked to a rare kidney stone disease. Some carriers develop kidney stones, while others do not. Researchers will compare their urine oxalate levels and lifestyle factors to find out what triggers symptoms. The goal is to better understand why the disease appears in some carriers and not others.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- What this could lead to
- If successful, this study could help identify why some carriers of an AGXT mutation develop kidney stones, potentially leading to better prevention advice.
- What could go wrong
- This is a small, observational study with only 25 participants. It does not test a treatment, so it cannot directly lead to a new therapy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CLIMA, pavillon R, Hôpital Edouard Herriot
Lyon, 69003, France