Can a simple blood test predict which flu patients will need a breathing machine?
NCT ID NCT02392858
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to study gene activity in severely ill patients. The goal is to find early warning signs so doctors can act faster.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help doctors identify which flu patients are at highest risk of severe breathing failure, allowing earlier and more targeted care.
What could go wrong
This is an observational study, not a treatment trial. The biomarker may not prove reliable enough for routine use, and results may not apply to all flu patients.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CHU Service de Réanimation Adulte
Saint-Etienne, France
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CHU Service de Réanimation Pédiatrique
Saint-Etienne, France
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CHU service réanimation adulte
Clermont-Ferrand, France
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CHU service réanimation adulte
Dijon, France
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CHU service réanimation adulte
Grenoble, France
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CHU service réanimation pédiatrique
Clermont-Ferrand, France
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CHU service réanimation pédiatrique
Dijon, France
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CHU service réanimation pédiatrique
Grenoble, France
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Centre Hospitalier Lyon Sud
Pierre-Bénite, France
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Centre de Biologie et Pathologie Est
Lyon, France
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Centre de Biologie et de Pathologie Nord
Lyon, Auvergne-Rhône-Alpes, 69500, France
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Hôpital Edouard Herriot
Lyon, France
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Hôpital Femme Mère Enfant
Bron, France
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Hôpital de la Croix Rousse-service réanimation adulte chirurgicale
Lyon, France
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Hôpital de la Croix Rousse-service réanimation adulte médicale
Lyon, France