Can a simple blood test predict which flu patients will need a breathing machine?

NCT ID NCT02392858

Completed Knowledge-focused Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 227 adults and children in the intensive care unit with severe flu. Researchers wanted to see if a specific blood marker (soluble HLA-G5) could predict which patients would develop severe breathing failure. They also collected respiratory samples to study gene activity in severely ill patients. The goal is to find early warning signs so doctors can act faster.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this could help doctors identify which flu patients are at highest risk of severe breathing failure, allowing earlier and more targeted care.
What could go wrong: This is an observational study, not a treatment trial. The biomarker may not prove reliable enough for routine use, and results may not apply to all flu patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

influenza respiratory tract infectious disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA SEVERE RESPIRATORY INFECTION

Contacts and locations

Locations

CHU Service de Réanimation Adulte

Saint-Etienne, France
CHU Service de Réanimation Pédiatrique

Saint-Etienne, France
CHU service réanimation adulte

Clermont-Ferrand, France
CHU service réanimation adulte

Dijon, France
CHU service réanimation adulte

Grenoble, France
CHU service réanimation pédiatrique

Clermont-Ferrand, France
CHU service réanimation pédiatrique

Dijon, France
CHU service réanimation pédiatrique

Grenoble, France
Centre Hospitalier Lyon Sud

Pierre-Bénite, France
Centre de Biologie et Pathologie Est

Lyon, France
Centre de Biologie et de Pathologie Nord

Lyon, Auvergne-Rhône-Alpes, 69500, France
Hôpital Edouard Herriot

Lyon, France
Hôpital Femme Mère Enfant

Bron, France
Hôpital de la Croix Rousse-service réanimation adulte chirurgicale

Lyon, France
Hôpital de la Croix Rousse-service réanimation adulte médicale

Lyon, France

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