Tiny skin tests reveal psoriasis nerve clues
NCT ID NCT02652065
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how skin blood flow and nerve sensitivity differ in psoriasis plaques compared to healthy skin. Twenty adults with psoriasis on their back received mild electrical currents to deliver vasodilators (acetylcholine, sodium nitroprussiate, or plain water) into both plaque and healthy skin. Blood flow was tracked with laser Doppler, and nerve sensitivity was tested with fine filaments. The goal was to understand the link between nerve function and skin inflammation in psoriasis.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
acetylcholine, sodium nitroprussiate, and purified water delivered via iontophoresis
What this could lead to
If successful, this could help explain why psoriasis causes pain or discomfort, potentially guiding future treatments that target nerve-related inflammation.
What could go wrong
This is a very small, early-stage observational study (20 people) that measures only temporary skin responses, not a treatment. Results may not lead to any new therapy.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PSORIASIS are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Hôpital Edouard Herriot - Service de Dermatologie et Vénéréologie
Lyon, 69437, France