New dialysis strategy aims to prevent fluid overload in critical care

NCT ID NCT04801784

Completed Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a method to carefully remove extra fluid from critically ill patients with kidney failure who are on continuous dialysis. The goal was to keep their fluid levels balanced without causing dangerous drops in blood pressure. Researchers used advanced heart monitoring to guide the fluid removal rate. The trial involved 65 adults in the ICU who needed blood pressure support and had severe kidney injury.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Increased net ultrafiltration with advanced hemodynamic monitoring
What this could lead to: If successful, this approach could help doctors safely manage fluid levels in critically ill patients, potentially reducing complications from fluid overload.
What could go wrong: This is a small, early-stage study (65 participants) focused on safety and feasibility, so results may not apply broadly. The intervention carries risks of hemodynamic instability.

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Conditions

The condition(s) this trial relates to.

acute kidney injury Edema Shock

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FLUID OVERLOAD

Contacts and locations

Locations

Hospices Civils de Lyon - Hôpital de la Croix Rousse

Lyon, 69004, France

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