Could an extra year of Low-Dose steroids keep vasculitis at bay?
NCT ID NCT03290456
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at whether continuing a low dose of prednisone (5 mg/day) for an extra 12 months can help people with a type of blood vessel inflammation called ANCA-associated vasculitis stay in remission. About 146 adults who are already in remission and receiving rituximab will be randomly assigned to either extended prednisone or a placebo. The goal is to see if the extended treatment reduces the chance of a relapse over 30 months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Prednisone (a corticosteroid drug)
What this could lead to
If it works, this could show that longer low-dose prednisone use reduces relapse risk in people with vasculitis who are already on rituximab maintenance therapy.
What could go wrong
This is a Phase NA trial with only 146 participants, so results may not apply to everyone. Prednisone has known side effects like weight gain, high blood sugar, and infection risk.
Disclaimer
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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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CH Bretagne Atlantique
RECRUITINGVannes, 56017, France
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CH Lyon Sud
RECRUITINGPierre-Bénite, 69495, France
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CH Lyon Sud
RECRUITINGPierre-Bénite, 69495, France
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CH Valenciennes
RECRUITINGValenciennes, 59322, France
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CH de Troyes
RECRUITINGTroyes, 10003, France
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CH de Verdun
NOT_YET_RECRUITINGVerdun, 55100, France
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CHIC Créteil
NOT_YET_RECRUITINGCréteil, 94010, France
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CHRU Bretonneau
NOT_YET_RECRUITINGTours, 37044, France
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CHRU François Mitterrand
NOT_YET_RECRUITINGDijon, 21000, France
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CHRU François Mitterrand
NOT_YET_RECRUITINGDijon, 21000, France
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CHRU Hautepierre
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CHRU Lille - Hôpital Claude Huriez
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RECRUITINGRennes, 35200, France
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CHU Amiens-Hôpital Nord
RECRUITINGAmiens, 80054, France
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RECRUITINGAngers, 49933, France
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CHU Estaing
RECRUITINGClermont-Ferrand, 63003, France
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CHU Gabriel Montpied
RECRUITINGClermont-Ferrand, 63003, France
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CHU Nantes - Hôtel Dieu
RECRUITINGNantes, 44093, France
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NOT_YET_RECRUITINGStrasbourg, 67000, France
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CHU de Caen - Cote de Nacre
RECRUITINGCaen, 14033, France
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CHU de Nice - Hôpital Pasteur 2
RECRUITINGNice, 06001, France
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CHU de Poitiers
NOT_YET_RECRUITINGPoitiers, 86021, France
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Centre Hospitalier Croix Rousse
RECRUITINGLyon, 69004, France
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Centre Hospitalier Lyon Sud
RECRUITINGPierre-Bénite, 69310, France
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Clinique Rhône-Durance
NOT_YET_RECRUITINGAvignon, 84000, France
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HP Site Belle Isle
NOT_YET_RECRUITINGMetz, 57045, France
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Hopitaux Universaitaire de Strasbourg Hopitaux
RECRUITINGStrasbourg, France
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Hôpital Avicenne
NOT_YET_RECRUITINGBobigny, 93009, France
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Hôpital Charles Nicolle
RECRUITINGRouen, 76031, France
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Hôpital Cochin
RECRUITINGParis, 75014, France
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Hôpital Edouard Herriot
RECRUITINGLyon, 69137, France
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NOT_YET_RECRUITINGLyon, 69137, France
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Hôpital Européen G. Pompidou
NOT_YET_RECRUITINGParis, 75015, France
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Hôpital Foch
NOT_YET_RECRUITINGSuresnes, 92150, France
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NOT_YET_RECRUITINGPessac, 33600, France
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RECRUITINGBrest, 29200, France
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Hôpital La Timone
NOT_YET_RECRUITINGMarseille, 13385, France
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Hôpital Louis Pasteur
NOT_YET_RECRUITINGChartres, 28018, France
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Hôpital Louis Pradel
RECRUITINGBron, 69500, France
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Hôpital Saint Louis
NOT_YET_RECRUITINGParis, 75475, France
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Hôpital de la Conception
NOT_YET_RECRUITINGMarseille, 13005, France
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Hôpital de la Conception
NOT_YET_RECRUITINGMarseille, 13005, France
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Hôpital la Pitié Salpêtrière
RECRUITINGParis, 75013, France
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Hôpitaux de Brabois
NOT_YET_RECRUITINGVandœuvre-lès-Nancy, 54511, France
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