New PET scan could spot tiny brain tumors missed by MRI

NCT ID NCT07463625

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a special PET scan using [18F]FET can better locate small pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in up to 30% of cases. Researchers will compare PET results with MRI and surgical findings in 20 adults to see if the new scan improves tumor detection and surgical planning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

[18F]fluoroethyl-L-tyrosine (FET) PET imaging

What this could lead to

If successful, this imaging method could help doctors locate hard-to-find pituitary tumors more accurately, guiding surgery and reducing the need for invasive diagnostic procedures.

What could go wrong

This is a small, early-stage observational study with only 20 participants. The PET scan may not prove more accurate than current MRI, and results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ACTH-dependent Cushing syndrome ACTH-producing pituitary gland neoplasm Cushing disease due to pituitary adenoma pituitary gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Hôpital Louis Pradel - Service de Médecine Nucléaire

    RECRUITING

    Bron, 69500, France