New PET scan could spot tiny brain tumors missed by MRI

NCT ID NCT07463625

Recruiting now Diagnosis Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a special PET scan using [18F]FET can better locate small pituitary tumors that cause Cushing's disease. Standard MRI misses these tumors in up to 30% of cases. Researchers will compare PET results with MRI and surgical findings in 20 adults to see if the new scan improves tumor detection and surgical planning.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F]fluoroethyl-L-tyrosine (FET) PET imaging
What this could lead to: If successful, this imaging method could help doctors locate hard-to-find pituitary tumors more accurately, guiding surgery and reducing the need for invasive diagnostic procedures.
What could go wrong: This is a small, early-stage observational study with only 20 participants. The PET scan may not prove more accurate than current MRI, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

ACTH-dependent Cushing syndrome ACTH-producing pituitary gland neoplasm Cushing disease due to pituitary adenoma pituitary gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACTH-PRODUCING PITUITARY TUMOUR CUSHING DISEASE

Contacts and locations

Locations

Hôpital Louis Pradel - Service de Médecine Nucléaire
RECRUITING

Bron, 69500, France

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