Gene study aims to decode rare nerve disorder variations
NCT ID NCT07038239
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how different mutations in the MORC2 gene lead to different symptoms, from Charcot-Marie-Tooth disease to a more complex condition called DIFGAN. Researchers will collect skin and blood samples from 45 participants to measure epigenetic and genetic markers. The goal is to improve diagnosis by linking specific gene changes to patient outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this could help doctors better predict which symptoms a patient with a MORC2 mutation will develop, leading to earlier and more accurate diagnoses.
What could go wrong
This is a small, early-stage observational study (45 participants) focused on understanding the disease, not testing a treatment. It may not lead to immediate changes in patient care.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CH Pitié Salpêtrière
RECRUITINGParis, 75013, France
Contact Email: •••••@•••••
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CH de Versailles
RECRUITINGLe Chesnay, 78150, France
Contact Email: •••••@•••••
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CHRU Brest
RECRUITINGBrest, 29200, France
Contact
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CHU Grenoble
RECRUITINGGrenoble, 38700, France
Contact Email: •••••@•••••
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CHU Marseille
RECRUITINGMarseille, 13005, France
Contact
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CHU Strasbourg
RECRUITINGStrasbourg, 67000, France
Contact
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CHU de Besançon
RECRUITINGBesançon, 25030, France
Contact Email: •••••@•••••
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CHU de Nantes
RECRUITINGNantes, 44000, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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CHU de Saint-Etienne
RECRUITINGSaint-Etienne, 42270, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hospices Civils de Lyon
RECRUITINGLyon, 69317, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hôpital Necker
RECRUITINGParis, 75015, France
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Service de Génétique moléculaire, pharmacogénétique, hormologie Hôpital Bicêtre
RECRUITINGLe Kremlin-Bicêtre, 94270, France
Contact Phone: •••-•••-••••