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Kidney shield: a simple care bundle may prevent organ failure after severe injury

NCT ID NCT06834633

Recruiting now Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial tests whether a set of five kidney-protecting measures — given early to severe trauma patients identified as high-risk by a urine test — can reduce the chance of acute kidney injury. About 500 adults with severe injuries will be randomly assigned to receive either the bundle or standard care. The goal is to see if early, targeted action can prevent kidney damage within the first three days in the ICU.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a bundle of five kidney-protecting measures (avoiding nephrotoxic drugs, optimizing blood flow, controlling blood sugar, detecting muscle breakdown, monitoring kidney function)
What this could lead to
If it works, this could give hospitals a simple, targeted way to prevent kidney failure in severely injured patients, potentially saving lives and reducing long-term complications.
What could go wrong
The bundle requires significant resources to implement fully, and earlier trials in other settings may not translate to trauma patients. The test used to identify high-risk patients is not perfect, so some may be misclassified.

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Conditions

The condition(s) this trial relates to.

injury acute kidney injury prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMA; COMPLICATIONS

Contacts and locations

Locations

  • Centre Hospitalier universitaire Estaing, Service anesthésie-réanimation

    RECRUITING

    Clermont-Ferrand, 63100, France

  • Centre hospitaler Annecy Genevois, Service de réanimation

    RECRUITING

    Épagny, 74370, France

  • Centre hospitalier universitaire de Grenoble Alpes, Pôle anesthésie-réanimation

    RECRUITING

    La Tronche, 38700, France

  • Centre hospitalier universitaire de Saint Etienne, Hôpital Bellevue, Service anesthésie-réanimation

    RECRUITING

    Saint-Etienne, 42000, France

  • Hospices Civils de Lyon, Hôpital Edouard Herriot, Service d'anesthésie-réanimation

    RECRUITING

    Lyon, 69003, France

  • Hospices Civils de Lyon, Hôpital Lyon-Sud, Service d'anesthésie-réanimation

    RECRUITING

    Pierre-Bénite, 69310, France

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