World-First larynx transplant trial offers new hope for silent patients
NCT ID NCT02821299
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This pilot study will test laryngeal transplantation in 3 adults who have permanently lost the ability to speak, breathe, or swallow normally due to severe larynx damage. The goal is to restore these functions using a donor larynx, with a new nerve reconnection technique to improve outcomes. Patients will need lifelong immunosuppressive drugs to prevent rejection, so the procedure is reserved for those with no other treatment options.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for LARYNGEAL TRANSPLANTATION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Centre de soins de suite et de réadaptation fonctionnelle - SSR Val Rosay
RECRUITINGSaint-Didier-au-Mont-d'Or, 69370, France
-
Service ORL & Chirurgie Cervicofaciale - Hôpital Charles Nicolle - CHU Rouen
RECRUITINGRouen, 76000, France
-
Service d'Urologie et Chirurgie de la Transplantation - Hôpital Edouard Herriot - Hospices Civils de Lyon
RECRUITINGLyon, 69003, France