Can a malaria drug help sarcoidosis patients ditch steroids?
NCT ID NCT05841758
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tests if hydroxychloroquine, a drug used for malaria and autoimmune diseases, can help people with sarcoidosis reduce or stop taking steroids. Sarcoidosis causes inflammation, often in the lungs, but this trial focuses on cases affecting the skin, eyes, or bones. 140 adults will receive either hydroxychloroquine or a placebo for 12 months, and doctors will track whether they can safely lower their steroid dose without the disease flaring up.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hydroxychloroquine
What this could lead to
If successful, this could offer a safer, long-term treatment option for sarcoidosis patients, reducing their reliance on steroids and their side effects.
What could go wrong
This is a Phase 4 trial with a moderate size of 140 participants. Hydroxychloroquine is already used for other conditions, but its effectiveness for sarcoidosis is not yet proven, and it carries risks like retinal damage.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Locations
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CHU Tours - Médecine interne
NOT_YET_RECRUITINGTours, France
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Hôpital Cochin - Médecine interne
NOT_YET_RECRUITINGParis, France
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Hôpitaux Saint Joseph et Marie LANNELONGUE
NOT_YET_RECRUITINGParis, France
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Service de Médecine Interne Infectiologie Aïgue Polyvalente- Hôpital Henri Duffaud
RECRUITINGAvignon, 84 000, France
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Service de Médecine Interne et Immunologie Clinique - CHU Dijon Bourgogne
NOT_YET_RECRUITINGDijon, 21 079, France
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Service de Médecine Interne et Immunologie Clinique - Hôpital Sud
RECRUITINGRennes, 35 2000, France
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Service de Médecine Interne et maladies infectieuses - Hôpital Haut Lévêque
NOT_YET_RECRUITINGPessac, 33 604, France
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Service de Pneumologie - Hôpital Avicenne
NOT_YET_RECRUITINGBobigny, 93000, France
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Service de medecine interne - Hôpital Claude Huriez
NOT_YET_RECRUITINGLille, 59 000, France
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Service de medecine interne - Hôpital Duputryen
NOT_YET_RECRUITINGLimoges, 87 042, France
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Service de medecine interne - Hôpital Henri Mondor
NOT_YET_RECRUITINGCréteil, 94000, France
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Service de medecine interne - Hôpital Hôtel Dieu
NOT_YET_RECRUITINGNantes, 44000, France
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Service de medecine interne - Hôpital Nord
NOT_YET_RECRUITINGSaint-Etienne, 42 055, France
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Service de medecine interne - Hôpital Saint Eloi
NOT_YET_RECRUITINGMontpellier, 34 295, France
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Service de medecine interne 2- Hôpital de la Pitié-Salpétrière
NOT_YET_RECRUITINGParis, 75013, France
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Service de médecine interne - Centre Hospitalier Saint Joseph Saint Luc
NOT_YET_RECRUITINGLyon, 69007, France
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Service de médecine interne - Clinique Saint exupéry
RECRUITINGToulouse, 31077, France
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Service de médecine interne - Hôpital Edouard Herriot
NOT_YET_RECRUITINGLyon, 69004, France
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Service de médecine interne - Hôpital Lariboisière
NOT_YET_RECRUITINGParis, 75010, France
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Service de médecine interne - Hôpital Lyon Sud
NOT_YET_RECRUITINGLyon, 69004, France
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Service de médecine interne - Hôpital de la Croix Rousse
RECRUITINGLyon, 69004, France
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