Can a malaria drug help sarcoidosis patients ditch steroids?

NCT ID NCT05841758

Recruiting now Disease control Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tests if hydroxychloroquine, a drug used for malaria and autoimmune diseases, can help people with sarcoidosis reduce or stop taking steroids. Sarcoidosis causes inflammation, often in the lungs, but this trial focuses on cases affecting the skin, eyes, or bones. 140 adults will receive either hydroxychloroquine or a placebo for 12 months, and doctors will track whether they can safely lower their steroid dose without the disease flaring up.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hydroxychloroquine
What this could lead to: If successful, this could offer a safer, long-term treatment option for sarcoidosis patients, reducing their reliance on steroids and their side effects.
What could go wrong: This is a Phase 4 trial with a moderate size of 140 participants. Hydroxychloroquine is already used for other conditions, but its effectiveness for sarcoidosis is not yet proven, and it carries risks like retinal damage.

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Conditions

The condition(s) this trial relates to.

pulmonary sarcoidosis sarcoidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SARCOIDOSIS, PULMONARY

Contacts and locations

Locations

CHU Tours - Médecine interne
NOT_YET_RECRUITING

Tours, France
Hôpital Cochin - Médecine interne
NOT_YET_RECRUITING

Paris, France
Hôpitaux Saint Joseph et Marie LANNELONGUE
NOT_YET_RECRUITING

Paris, France
Service de Médecine Interne Infectiologie Aïgue Polyvalente- Hôpital Henri Duffaud
RECRUITING

Avignon, 84 000, France
Service de Médecine Interne et Immunologie Clinique - CHU Dijon Bourgogne
NOT_YET_RECRUITING

Dijon, 21 079, France
Service de Médecine Interne et Immunologie Clinique - Hôpital Sud
RECRUITING

Rennes, 35 2000, France
Service de Médecine Interne et maladies infectieuses - Hôpital Haut Lévêque
NOT_YET_RECRUITING

Pessac, 33 604, France
Service de Pneumologie - Hôpital Avicenne
NOT_YET_RECRUITING

Bobigny, 93000, France
Service de medecine interne - Hôpital Claude Huriez
NOT_YET_RECRUITING

Lille, 59 000, France
Service de medecine interne - Hôpital Duputryen
NOT_YET_RECRUITING

Limoges, 87 042, France
Service de medecine interne - Hôpital Henri Mondor
NOT_YET_RECRUITING

Créteil, 94000, France
Service de medecine interne - Hôpital Hôtel Dieu
NOT_YET_RECRUITING

Nantes, 44000, France
Service de medecine interne - Hôpital Nord
NOT_YET_RECRUITING

Saint-Etienne, 42 055, France
Service de medecine interne - Hôpital Saint Eloi
NOT_YET_RECRUITING

Montpellier, 34 295, France
Service de medecine interne 2- Hôpital de la Pitié-Salpétrière
NOT_YET_RECRUITING

Paris, 75013, France
Service de médecine interne - Centre Hospitalier Saint Joseph Saint Luc
NOT_YET_RECRUITING

Lyon, 69007, France
Service de médecine interne - Clinique Saint exupéry
RECRUITING

Toulouse, 31077, France
Service de médecine interne - Hôpital Edouard Herriot
NOT_YET_RECRUITING

Lyon, 69004, France
Service de médecine interne - Hôpital Lariboisière
NOT_YET_RECRUITING

Paris, 75010, France
Service de médecine interne - Hôpital Lyon Sud
NOT_YET_RECRUITING

Lyon, 69004, France
Service de médecine interne - Hôpital de la Croix Rousse
RECRUITING

Lyon, 69004, France

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