Can Weight-Loss surgery change how medicines work?

NCT ID NCT03519893

Recruiting now Knowledge-focused Sponsor: Norwegian University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This study looks at whether weight-loss surgeries like gastric bypass or sleeve gastrectomy change how the body absorbs and processes the blood pressure medication losartan. Researchers will measure losartan levels in the blood of 12 people before and after surgery. The goal is to understand if surgery alters drug availability, which could help personalize dosing for patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: losartan
What this could lead to: If this trial succeeds, it could help doctors adjust medication doses for people who have had bariatric surgery, ensuring they get the right amount of drug.
What could go wrong: This is a small, early study with only 12 participants, so results may not apply to everyone. The findings may not lead to immediate changes in clinical practice.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

Locations

St. Olavs University Hospital
RECRUITING

Trondheim, Norway

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