No-Scalpel weight loss: new stomach burn procedure tested

NCT ID NCT05574777

Completed Disease control Sponsor: Erbe Elektromedizin GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new, non-surgical weight loss technique called Gastric Mucosal Ablation (GMA) in 13 people with class III obesity. The procedure uses a device to carefully burn the stomach lining, aiming to mimic the hormonal effects of weight-loss surgery. The main goal was to check if the procedure is safe and feasible, with participants followed for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hybrid argon plasma coagulation (HybridAPC) device
What this could lead to: If successful, this could offer a less invasive weight-loss option for people with severe obesity, avoiding the need for surgery.
What could go wrong: This was a very small, early feasibility study with only 13 participants. It focused on safety, not weight-loss effectiveness, so much more research is needed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADIPOSITY MORBID OBESITY

Contacts and locations

Locations

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

São Paulo, Brazil

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