Can a common drug be tailored to help teens lose weight?

NCT ID NCT04986631

Completed Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how the drug topiramate works in teenagers with severe obesity. Researchers wanted to understand why some teens lose weight while others don't, by measuring drug levels in the blood. The goal is to eventually personalize dosing for better results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

topiramate

What this could lead to

If successful, this could help doctors tailor topiramate doses for individual teens, making weight loss treatment more effective.

What could go wrong

This is an early-phase study with only 62 participants, so results may not apply to all teens. Topiramate can cause side effects like dizziness or tingling.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, CHILDHOOD

Contacts and locations

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Locations

University of Minnesota

Minneapolis, Minnesota, 55455, United States