Could a common ADHD drug help kids with severe obesity?

NCT ID NCT05416125

Completed Disease control Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 11, 2026 · Updated 5 times

Summary

This study tests whether the drug lisdexamfetamine (Vyvanse), usually used for ADHD, can help children aged 6 to 12 with severe obesity lose weight. About 44 children will receive either the drug or a placebo, plus lifestyle therapy, for 24 weeks. The main goal is to see if their body mass index (BMI) improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Lisdexamfetamine (Vyvanse)
What this could lead to: If it works, this could point toward a new treatment option for severe obesity in children who have not succeeded with lifestyle changes alone.
What could go wrong: This is a very early, small trial (44 kids) with no results yet. The drug may not work for weight loss in children, and side effects like decreased appetite or sleep problems are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity Obesity obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, CHILDHOOD

Contacts and locations

Locations

University of Minnesota

Minneapolis, Minnesota, 55414, United States

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