Opioid-Free anesthesia: a safer way to wake up after Weight-Loss surgery?

NCT ID NCT07337135

Completed Symptom relief Sponsor: Hospital dos Lusíadas Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether avoiding opioids during weight-loss surgery leads to less pain and fewer side effects like nausea. Sixty adults having laparoscopic bariatric surgery were randomly assigned to receive either opioid-free anesthesia (using other drugs) or standard opioid-based anesthesia. Researchers measured pain scores, need for extra painkillers, and nausea after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Opioid-free anesthesia (dexmedetomidine, ketamine, lidocaine) vs opioid-based anesthesia (remifentanil)
What this could lead to: If successful, this could show that avoiding opioids during weight-loss surgery reduces side effects like nausea and speeds recovery.
What could go wrong: This is a small, single-center trial with only 60 patients, so results may not apply broadly. The opioid-free approach may not control pain as well for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity Nausea Pain, Postoperative Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BARIATRIC SURGERY MORBID OBESITY OPIOID-FREE ANESTHESIA POSTOPERATIVE PAIN

Contacts and locations

Locations

Hospital Lusíadas Amadora - Lusíadas Saúde, S.A.

Amadora, 2724-002, Portugal

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