New weekly shot could help severely obese heart patients shed pounds

NCT ID NCT05882045

First seen May 27, 2026 · Last updated Jun 16, 2026 · Updated 3 times

Summary

This study tests a once-weekly injection called retatrutide in about 1,946 people with severe obesity (BMI 35 or higher) and heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over nearly two years. Participants are randomly assigned to receive the drug or a placebo, and neither they nor their doctors know which they get.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Ambulatorium Sp. z o.o.

    Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

  • Areteus s.r.o.

    Trebišov, Košice Region, 075 01, Slovakia

  • Austin Health - Repatriation Hospital

    Heidelberg West, Victoria, 3081, Australia

  • BC Diabetes Office

    Vancouver, British Columbia, V5Y 3W2, Canada

  • Barwon Health

    Geelong, Victoria, 3220, Australia

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Brengle Family Medicine

    Indianapolis, Indiana, 46260, United States

  • C.I.C. Mauricie inc.

    Trois-Rivières, Quebec, G8T 7A1, Canada

  • CDH Research Institute

    Maroochydore, Queensland, 4558, Australia

  • CEDIC

    CABA, Buenos Aires, C1060ABN, Argentina

  • CIPADI - Centro Integral de Prevencion y Atencion en Diabetes

    Godoy Cruz, Mendoza Province, 5501, Argentina

  • Camden Hospital

    Camden, New South Wales, 2570, Australia

  • Canberra Hospital

    Canberra, Australian Capital Territory, 2605, Australia

  • CardioVasc HR Inc

    Saint-Jean-sur-Richelieu, Quebec, J3A 1J2, Canada

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Central Illinois Diabetes and Clinical Research a Division of Prairie Education and Research Cooperative

    Springfield, Illinois, 62711, United States

  • Central Phoenix Medical Clinic

    Phoenix, Arizona, 85020, United States

  • Centre de Medecine Metabolique de Lanaudiere (CMML)

    Terrebonne, Quebec, J6X 4P7, Canada

  • Centricity Research Oshawa

    Oshawa, Ontario, L1J 2K9, Canada

  • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

    Mexico City, Mexico City, 11650, Mexico

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina

  • Centro Medico Privado CEMAIC

    Capital, Córdoba Province, X5008HHW, Argentina

  • Centro Medico Privado San Vicente Diabetes

    Córdoba, Córdoba Province, 5006, Argentina

  • Centro Multidisciplinario de Diabetes de Pachuca

    Pachuca, Hidalgo, 42084, Mexico

  • Centro Médico Viamonte

    Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina

  • Centro de Atención e Investigación Cardiovascular del Potosí

    San Luis Potosí City, 78200, Mexico

  • Centro de Investigacion Cardiovascular y Metabólica

    Tijuana, Estado de Baja California, 22500, Mexico

  • Centro de Investigacion Medica de Occidente, S.C.

    Zapopan, Jalisco, 44260, Mexico

  • Centro de Investigaciones Clinicas del Litoral

    Santa Fe, S3000FWO, Argentina

  • Centro de Investigaciones Clínicas Baigorria

    Granadero Baigorria, Santa Fe Province, 2152, Argentina

  • Centro de Investigaciones Metabólicas (CINME)

    Ciudad Autónoma de Buenos Aires, Buenos Aires, 1056, Argentina

  • Centro de Investigaciones Médicas Tucuman

    SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina

  • Centro de Salud e Investigaciones Médicas

    Santa Rosa, La Pampa Province, 6300, Argentina

  • Centrum Badan Klinicznych PI-House sp. z o.o.

    Gdansk, Pomeranian Voivodeship, 80-546, Poland

  • Centrum Medyczne Pratia Katowice

    Katowice, Silesian Voivodeship, 40-081, Poland

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, Łódź Voivodeship, 90338, Poland

  • Charter Research - Winter Park

    Orlando, Florida, 32803, United States

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • ClinDiab Kft.

    Budapest, 1089, Hungary

  • Clinical Neuroscience Solutions, Inc.

    Orlando, Florida, 32801, United States

  • Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

    Jacksonville, Florida, 32256, United States

  • Clinical Research Management Group Inc

    Ponce, 00717, Puerto Rico

  • Clinique de médecine Urbaine du Quartier Latin

    Montreal, Quebec, H2L 4E9, Canada

  • Clínica García Flores SC

    Monterrey, Nuevo León, 64610, Mexico

  • Collaborative Neuroscience Research, LLC

    Los Alamitos, California, 90720, United States

  • Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval

    Ferrol, A Coruña [La Coruña], 15405, Spain

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Consultorio de Investigación Clínica EMO SRL

    Buenos Aires, Buenos Aires F.D., 1405, Argentina

  • Core Research Group

    Brisbane, Queensland, 4064, Australia

  • Cotton O'Neil Diabetes & Endocrinology

    Topeka, Kansas, 66606, United States

  • DIM Clínica Privada

    Ramos Mejía, Buenos Aires, B1704ETD, Argentina

  • DRC Gyógyszervizsgáló Központ

    Balatonfüred, Veszprém megye, 8230, Hungary

  • Debreceni Egyetem Klinikai Központ

    Debrecen, 4031, Hungary

  • Diab - Int

    Bytča, Žilina Region, 014 01, Slovakia

  • Discovery Clinical Services

    Victoria, British Columbia, V8T 5G4, Canada

  • Dr. Steven V. Zizzo Research Professional Corporation

    Hamilton, Ontario, L8J 0B6, Canada

  • EME RED Hospitalaria

    Mérida, Yucatán, 97000, Mexico

  • Ecogene-21

    Chicoutimi, Quebec, G7H 7K9, Canada

  • Ecogene-21 - Cmas

    Chicoutimi, Quebec, G7H 0S7, Canada

  • Elite Clinical Trials

    Blackfoot, Idaho, 83221, United States

  • Emeritus Research

    Botany, New South Wales, 2019, Australia

  • Emeritus Research

    Camberwell, Victoria, 3124, Australia

  • Eukarya PharmaSite

    Monterrey, Nuevo León, 64718, Mexico

  • FAICIC S. de R.L. de C.V.

    Veracruz, 91900, Mexico

  • Fundación Respirar

    Buenos Aires, C1426ABP, Argentina

  • Fusion Clinical Research

    Adelaide, South Australia, 5000, Australia

  • Great Lakes Clinical Trials - Gurnee

    Gurnee, Illinois, 60031, United States

  • Hospital General Universitario Gregorio Marañon

    Madrid, 28009, Spain

  • Hospital Quiron Infanta Luisa

    Seville, Andalusia, 41010, Spain

  • Hospital Universitari Son Espases

    Palma, Balears [Baleares], 07120, Spain

  • Hospital Universitari Vall d'Hebron

    Barcelona, Barcelona [Barcelona], 08035, Spain

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez"

    Monterrey, Nuevo León, 66460, Mexico

  • Hospital Universitario Arnau de Vilanova de Lleida

    Lleida, Lleida [Lérida], 25198, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, 41013, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010, Spain

  • Hospital Universitario de La Ribera

    Alzira, Valenciana, Comunitat, 46600, Spain

  • Hospital Virgen de las Montañas

    Villamartín, Cádiz, 11650, Spain

  • Hospital Virgen del Camino

    Sanlúcar de Barrameda, Cádiz, 11540, Spain

  • Human Care s.r.o.

    Košice, Košice Region, 04001, Slovakia

  • Humphreys Diabetes Center

    Boise, Idaho, 83702, United States

  • IDIM - Instituto de Investigaciones Metabólicas

    Ciudad de Buenos Aires, Buenos Aires, C1012AAR, Argentina

  • IMA Clinical Research Warren

    Warren Township, New Jersey, 07059, United States

  • IMED Internal Medicine Clin Trials

    Monterrey, Nuevo León, 64060, Mexico

  • INECO Neurociencias Oroño

    Rosario, Santa Fe Province, 2000, Argentina

  • Indago Research & Health Center, Inc

    Hialeah, Florida, 33012, United States

  • Instituto Médico DAMIC

    Córdoba, 5003DCE, Argentina

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, Santa Fe Province, 2000, Argentina

  • Instituto de Investigaciones Clínicas Mar del Plata

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos

    Chihuahua City, 31110, Mexico

  • Investigaciones Medicas Imoba Srl

    Buenos Aires, Buenos Aires F.D., C1056ABH, Argentina

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50265, United States

  • Joanne F. Liutkus Medicine Professional Corporation

    Cambridge, Ontario, N3H 4L5, Canada

  • KLIMED Marek Klimkiewicz

    Bialystok, Podlaskie Voivodeship, 15-704, Poland

  • Kawartha Cardiology Clinical Trials

    Peterborough, Ontario, K9J 0B2, Canada

  • LMC Clinical Research Inc. (Thornhill)

    Concord, Ontario, L4K 4M2, Canada

  • Lahoja. Asociacion Para La Investigacion Y La Farmacovigilancia

    Durango, 34000, Mexico

  • Las Vegas Medical Research

    Las Vegas, Nevada, 89128, United States

  • Latin Clinical Trial Center

    San Juan, 00909, Puerto Rico

  • Logan Hospital

    Meadowbrook, Queensland, 4131, Australia

  • MEDI-DIA s.r.o.

    Sabinov, Presov, 083 01, Slovakia

  • MICA - Medicina e Investigación Cardiometabólica

    Del Viso, Buenos Aires, 1669, Argentina

  • Manna Research Toronto

    Toronto, Ontario, M9W 4L6, Canada

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451, United States

  • MediTask

    Bratislava, 831 03, Slovakia

  • MediVet s.r.o.

    Malacky, Bratislava Region, 901 01, Slovakia

  • Medical Care and Research SA de CV

    Mérida, Yucatán, 97070, Mexico

  • Medifarma 98 Kft

    Nyíregyháza, Nyíregyháza, 4400, Hungary

  • Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET

    Krakow, Lesser Poland Voivodeship, 31-261, Poland

  • Metabol KLINIK

    Bratislava, Bratislava Region, 811 08, Slovakia

  • Milestone Research Inc.

    London, Ontario, N5W 6A2, Canada

  • NBR Polska

    Warsaw, Masovian Voivodeship, 00-710, Poland

  • NZOZ Salvia CM

    Katowice, Silesian Voivodeship, 40-772, Poland

  • Nemocnica s poliklinikou Lucenec

    Lučenec, Banská Bystrica Region, 984 01, Slovakia

  • Neuro-Pain Medical Center

    Fresno, California, 93710, United States

  • Nightingale Research

    Adelaide, South Australia, 5000, Australia

  • North York Diagnostic and Cardiac Centre

    North York, Ontario, M6B 3H7, Canada

  • Northern Beaches Clinical Research

    Brookvale, New South Wales, 2100, Australia

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • One Clinical Research

    Nedlands, Western Australia, 6009, Australia

  • Pacific Diabetes & Endocrine Center

    Honolulu, Hawaii, 96817, United States

  • Palm Research Center Tenaya

    Las Vegas, Nevada, 89128, United States

  • Pinnacle Clinical Research

    Austin, Texas, 78757, United States

  • Ponce Medical School Foundation Inc.

    Ponce, 00716, Puerto Rico

  • Progressive Medical Research

    Port Orange, Florida, 32127, United States

  • RM Pharma Specialists

    Mexico City, Mexico City, 03100, Mexico

  • Rainier Clinical Research Center

    Renton, Washington, 98057, United States

  • Regia Med Kft

    Székesfehérvár, Fejér, 8000, Hungary

  • Rochester Clinical Research, LLC

    Rochester, New York, 14609, United States

  • Royal Brisbane and Women's Hospital

    Brisbane, Queensland, 4029, Australia

  • Samodzielny Publiczny Szpital Kliniczny nr 1 SUM

    Zabrze, Silesian Voivodeship, 41-800, Poland

  • Sanatorio Norte

    Santiago del Estero, 4200, Argentina

  • Sanatorio San Martin

    Venado Tuerto, Santa Fe Province, 2600, Argentina

  • Sleep Therapy Research Center

    San Antonio, Texas, 78229, United States

  • South Texas Clinical Research

    Corpus Christi, Texas, 78404, United States

  • Southern Adelaide Diabetes & Endocrine Services

    Mount Gambier, South Australia, 5290, Australia

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, South Australia, 5046, Australia

  • Southern Endocrinology Associates

    Mesquite, Texas, 75149, United States

  • Stat Research S.A.

    Buenos Aires, Buenos Aires F.D., C1023AAB, Argentina

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Syneos Health

    Québec, G1P0A2, Canada

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ

    Szeged, Csongrád megye, 6725, Hungary

  • Szent Lázár Megyei Kórház

    Salgótarján, Nógrád megye, 3100, Hungary

  • TRANTOR'99 Bt. Anyagcsere Centrum

    Budapest, 1213, Hungary

  • Tatratrial s.r.o.

    Rožňava, Košice Region, 04801, Slovakia

  • Texas Diabetes & Endocrinology, P.A.

    Austin, Texas, 78731, United States

  • Texas Diabetes & Endocrinology, P.A.

    Round Rock, Texas, 78681, United States

  • The AIM Centre / Hunter Diabetes Centre

    Merewether, New South Wales, 2291, Australia

  • Trial Management Associates

    Myrtle Beach, South Carolina, 29572, United States

  • Tribe Clinical Research - Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Tribe Clinical Research, LLC

    Greenville, South Carolina, 29607, United States

  • UPMC Montefiore University Hospital

    Pittsburgh, Pennsylvania, 15213, United States

  • Unidad de Investigación Clínica y Atención Médica HEPA

    Guadalajara, Jalisco, 44670, Mexico

  • University of Sydney - Charles Perkins Centre

    Sydney, New South Wales, 2006, Australia

  • Valley Clinical Trials, Inc.

    Covina, California, 91723, United States

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Valley Research

    Fresno, California, 93720, United States

  • Velocity Clinical Research, Panorama City

    Van Nuys, California, 91405, United States

  • Velocity Clinical Research, Westlake

    Los Angeles, California, 90057, United States

  • Vithas Hospital Sevilla

    Seville, Sevilla, 41950, Spain

  • Weill Cornell Medical College

    New York, New York, 10021, United States

  • Zala Megyei Szent Rafael Kórház

    Zalaegerszeg, Zala County, 8900, Hungary

  • Óbudai Egészségügyi Centrum

    Budapest, 1036, Hungary

  • Óbudai Egészségügyi Centrum - Kaposvár Site

    Kaposvár, Somogy County, 7400, Hungary

  • Óbudai Egészségügyi Centrum - Zalaegerszeg

    Zalaegerszeg, 8900, Hungary

Conditions

Explore the condition pages connected to this study.

Conditions inferred from the trial description

These were inferred from the trial's summary, not listed by the trial registrant.