Morbid obesity

This study tests three home-based programs—healthy eating, physical activity, and gardening—designed to prevent obesity in Hispanic children aged 3 to 4 living in rural West Texas. Over 24 months, researchers will measure changes in body mass index, waist-to-height ratio, and bod…

This study tests whether adding an AI chatbot to a 12-week smartphone weight loss program helps young adults with overweight or obesity lose more weight and stay engaged. Twenty participants will either get the standard program or the program plus a chatbot for extra support. Res…

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study looks at whether sewing shut a specific incision site (the epigastric trocar) during sleeve gastrectomy can prevent hernias from forming later. People having their first sleeve gastrectomy for obesity are included, while those with prior stomach banding or repeat sleev…

This study aimed to see if blocking blood vessels to part of the stomach (bariatric embolization) could help super obese patients lose weight before sleeve gastrectomy surgery, potentially lowering surgical risks. It planned to enroll patients with a BMI over 50 and at least thre…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests whether using a connected scale at home can help people who had bariatric surgery avoid regaining too much weight. About 182 adults who had surgery one year ago will either get standard follow-up or also weigh themselves weekly with a smart scale. If the scale sh…

This pilot trial tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. Thirty participants will either receive the drug or standard care. The study tracks weight changes and any stomach-r…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether the drug liraglutide, combined with healthy lifestyle changes, can help children aged 6 to 12 with severe obesity lose weight and improve heart function. Thirty children will receive either liraglutide injections plus lifestyle advice or lifestyle advice …

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This study follows 120 teenagers aged 13 to 18 with severe obesity to see if weight-loss surgery (gastric bypass) leads to better health than standard treatments like diet and exercise. Participants are tracked for up to 10 years, measuring weight loss, quality of life, and menta…

This study planned to test a procedure called bariatric embolization for people with morbid obesity who cannot have standard weight-loss surgery. The procedure involves injecting tiny particles into blood vessels near the stomach to reduce blood flow, which may lower hunger hormo…

This study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…

This study tests a new magnetic device that creates connections between parts of the gut during weight-loss surgery. The goal is to see if it is safe and works as intended in 28 adults with severe obesity. If successful, it may offer a simpler way to perform these surgeries.

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This study compares two weight loss surgeries for people with severe obesity: sleeve gastrectomy with transit bipartition (SG+TB) and Roux-en-Y gastric bypass (RYGB). About 320 participants will be followed for two years to see which surgery leads to greater weight loss and fewer…

This study tests a peer mentoring program to help rural Appalachian children with overweight or obesity become more active. Over 400 seventh graders will receive virtual mentoring sessions and family support to increase daily physical activity and reduce sugary drinks. The goal i…

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This pilot study is testing whether a procedure called endoscopic sleeve gastroplasty (ESG) is safe and helpful for weight loss in 10 obese adolescents aged 12-17. Instead of traditional weight-loss surgery, doctors use a device inserted through the mouth to stitch the stomach sm…

This study compares two types of weight-loss surgery for people who have already had a sleeve gastrectomy but still have obesity. One surgery is the standard duodenal switch, and the other is a simpler single-loop version. Researchers want to see if the simpler surgery causes few…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigne…

This study tests community-based programs in six countries to help children ages 6-13 eat healthier and be more active. The goal is to prevent obesity and improve quality of life in disadvantaged urban communities. Researchers will track changes in body mass index and health-rela…

This study tests an 8-week mindfulness program (MB-EAT) for people who had bariatric surgery at least six months ago and struggle with eating guidelines. About 85 participants will be split into two groups: one gets the mindfulness training, the other does not. Researchers will t…

This study tests a remote program called ReConnect for people who had bariatric surgery about 2 years ago and their romantic partners. The program uses weekly handouts and videos with positive psychology activities to improve mood, resilience, and relationship satisfaction. 82 co…

This study looks at how losing weight affects sexual function and sperm quality in men with severe obesity. About 59 men will either have weight-loss surgery or follow a standard diet plan. Researchers will measure changes in sexual health, hormone levels, and sperm quality to se…

This study looks at whether two types of exercise training can improve body composition, heart and lung function, and quality of life in people who have had bariatric surgery. Researchers will compare high-intensity interval training (HIIT) and moderate-intensity continuous train…

This study tests whether a mix of ketamine and dexmedetomidine (ketodex) can reduce the need for strong painkillers after laparoscopic sleeve gastrectomy in obese patients. Eight adults with a BMI over 35 are randomly assigned to receive either ketodex or standard opioid-based an…

This pilot study tests whether an 8-week program combining mindful eating and yoga is practical and well-liked by adults with overweight or obesity. Researchers will check if participants stick with the program and if it leads to better mindfulness, healthier eating, more physica…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study tests whether a safe green dye, injected during gastric bypass surgery, can help surgeons see blood flow to the new stomach connection. Poor blood flow can lead to ulcers, leaks, or narrowing. The trial involves 300 adults and will follow them for two years to see if u…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight and improve health. Researchers will track changes in weight and blood sugar over time. The goal is to find out which eating schedule works best and is easier to stic…

This study looks at how head and neck position (sniffing vs. ramped) and the type of blade used on a video laryngoscope affect how quickly a breathing tube can be placed in 140 severely obese patients (BMI 40 or higher) undergoing elective surgery. The goal is to find the best co…

This study looks at whether reducing exposure to everyday chemicals called endocrine disruptors (found in plastics, cosmetics, and food) can help people with overweight or obesity lose weight. About 226 participants will either follow a program to lower chemical exposure or use a…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at how changing the length of the small intestine re-routed during gastric bypass surgery affects metabolism and inflammation. Researchers will compare two surgical techniques in 50 people with severe obesity and also include 15 healthy lean individuals as a comp…

This pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…

This study planned to analyze data from a large U.S. health survey to see if eating a diet rich in antioxidants is linked to better metabolic health in overweight or obese adults. Researchers would have looked at body mass index and markers like blood sugar and cholesterol. Howev…

This study looks at whether a specific blood protein, apolipoprotein, can predict how much weight people lose after sleeve gastrectomy surgery for severe obesity. Researchers will measure protein levels before surgery and track weight loss for 8 months in 110 adults. The goal is …

This study looks at how weight-loss (bariatric) surgery might change memory and thinking skills in people with obesity who also have cognitive decline. Researchers will test memory and thinking before and after surgery in up to 9,500 participants. The goal is to understand if los…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study aimed to measure pressure inside the chest (pleural pressure) in people with morbid obesity using a low-dose CT scan and a thin balloon placed in the esophagus. Researchers planned to compare 6 people with a BMI over 40 to 6 people with a BMI under 30. The study was wi…

This study looks at whether the standard doses of the antibiotic cefazolin given before bariatric surgery are high enough for obese patients. Researchers will measure drug levels in the blood and tissues of 70 patients to see if they reach the needed concentration to prevent infe…

Researchers are analyzing data from 8,000 patients who had bariatric surgery for severe obesity. The goal is to learn which procedures lead to the best weight loss and health improvements, while also tracking risks like complications and death. This study does not test a new trea…

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or sal…

This study looks at how two types of weight-loss surgery affect bone health in teenagers and young adults aged 13-21. Researchers will measure changes in bone density and strength over two years in 240 participants, comparing those who had surgery with those who did not. The goal…

This study follows 75 people who had either sleeve gastrectomy or gastric bypass for severe obesity. Researchers track acid reflux symptoms, esophageal damage, and other measures for 8 years using tests like endoscopy and pH monitoring. No new treatments are given—it's purely obs…