Keto diet showdown: can a Very-Low-Calorie version beat the mediterranean diet for Long-Term weight loss?

NCT ID NCT05781269

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigned to one of the two diets. Researchers will track weight, blood sugar, cholesterol, blood pressure, and other health markers to see which diet works better long-term.

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Conditions

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As listed by the trial registrant

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Contacts and locations

Locations

  • Istituto Auxologico Italiano

    Milan, 20145, Italy

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