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New weekly shot aims to curb obesity in rare genetic disorders

NCT ID NCT06239116

Recruiting now Disease control Sponsor: Rhythm Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a weekly injection called RM-718 in healthy people with obesity and in patients with obesity caused by problems in the MC4R pathway, including hypothalamic obesity and Prader-Willi syndrome. The main goal is to check the drug's safety and how the body processes it. About 150 participants will be enrolled.

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Conditions

The condition(s) this trial relates to.

acquired hypothalamic obesity Obesity obesity disorder Prader-Willi syndrome Sexual Infantilism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOTHALAMIC OBESITY PRADER-WILLI SYNDROME PWS

Contacts and locations

Locations

  • Ann and Robert H. Lurie Children's Hospital of Chicago (Part C and Part D)

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Boston Children's Hospital (Part C only)

    RECRUITING

    Boston, Massachusetts, 021115, United States

  • Brigham and Women's Hospital (Part C and Part D)

    RECRUITING

    Boston, Massachusetts, 02115, United States

  • UAB Pediatric Endocrinology (Part C and Part D)

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Utah Pediatric Endocrine Clinic (Part C and Part D)

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • Vanderbilt University Medical Center (Part C only)

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Worldwide Clinical Trials (Part A and Part B)

    COMPLETED

    San Antonio, Texas, 78217, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.