PRADER-WILLI SYNDROME
Clinical trials for PRADER-WILLI SYNDROME explained in plain language.
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Gut bugs vs. genetic hunger: can probiotics tame a rare disorder?
Disease control Recruiting nowThis study is testing whether dietary supplements called prebiotics and probiotics can help control appetite and weight gain in children with Prader-Willi syndrome, a rare genetic disorder that causes constant hunger and severe obesity. Sixty children will be divided into groups …
Matched conditions: PRADER-WILLI SYNDROME
Phase: NA • Sponsor: Children's Hospital of Fudan University • Aim: Disease control
Last updated Mar 30, 2026 14:31 UTC
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New hope for rare obesity syndromes? weekly injection trial begins
Disease control Recruiting nowThis study is testing how well a weekly weight loss medication called tirzepatide works for one year in young adults (ages 18-26). It aims to compare its effects in people with rare, hard-to-treat obesity from genetic conditions like Prader-Willi Syndrome against those with gener…
Matched conditions: PRADER-WILLI SYNDROME
Phase: PHASE4 • Sponsor: Grace Kim • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Weekly shot aims to tame hunger and control weight in rare obesity disorders
Disease control Recruiting nowThis study is testing a new weekly injection called RM-718 to see if it is safe and can help control weight and hunger. It will involve about 150 people, including adults with general obesity and patients with obesity due to specific conditions like Prader-Willi Syndrome or brain…
Matched conditions: PRADER-WILLI SYNDROME
Phase: PHASE1, PHASE2 • Sponsor: Rhythm Pharmaceuticals, Inc. • Aim: Disease control
Last updated Mar 19, 2026 14:56 UTC
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New fitness program aims to empower adults with intellectual disabilities
Symptom relief Recruiting nowThis study is testing a 16-week physical activity program called PACE for adults with intellectual disabilities. The program includes weekly group fitness classes, coaching sessions, and online resources. Researchers want to see if it helps participants become more active, improv…
Matched conditions: PRADER-WILLI SYNDROME
Phase: NA • Sponsor: University of North Carolina, Chapel Hill • Aim: Symptom relief
Last updated Mar 24, 2026 12:01 UTC
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New hope for managing key symptoms in rare genetic disorder
Symptom relief Recruiting nowThis study is testing whether a medication called pitolisant can help reduce excessive daytime sleepiness and improve difficult behaviors in people aged 6 and older with Prader-Willi syndrome. About 134 participants will be randomly assigned to receive either the real medication …
Matched conditions: PRADER-WILLI SYNDROME
Phase: PHASE3 • Sponsor: Harmony Biosciences Management, Inc. • Aim: Symptom relief
Last updated Mar 23, 2026 15:18 UTC
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Wearable device trial offers hope for reducing severe temper outbursts in rare genetic disorder
Symptom relief Recruiting nowThis study is testing whether a wearable device that gently stimulates a nerve in the ear can safely reduce severe temper outbursts in people with Prader-Willi syndrome (PWS). About 102 participants, aged 10 to 40, will wear the device daily for several months to see if it helps …
Matched conditions: PRADER-WILLI SYNDROME
Phase: PHASE3 • Sponsor: Foundation for Prader-Willi Research • Aim: Symptom relief
Last updated Mar 20, 2026 14:47 UTC
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Scientists test magnetic brain zaps to understand extreme hunger disorder
Knowledge-focused Recruiting nowThis research study aims to understand how a noninvasive brain stimulation technique might affect the constant hunger experienced by people with Prader-Willi syndrome. Researchers will use magnetic pulses directed at the brain (transcranial magnetic stimulation) while measuring b…
Matched conditions: PRADER-WILLI SYNDROME
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Massive study launched to unlock secrets of rare genetic diseases
Knowledge-focused Recruiting nowThis French study aims to better understand a group of rare genetic conditions called imprinting disorders by tracking 2,000 patients over time. Researchers will observe patients' health patterns to identify common metabolic risks like diabetes or heart disease. The goal is to ga…
Matched conditions: PRADER-WILLI SYNDROME
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:11 UTC
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Hospital launches major effort to map the mysteries of rare diseases
Knowledge-focused Recruiting nowThis study aims to create a single, large registry to collect information on many different rare diseases. It will enroll about 380 patients already being treated at the Hospital Italiano de Buenos Aires who have one of the listed rare conditions. The goal is to gather data to be…
Matched conditions: PRADER-WILLI SYNDROME
Sponsor: Hospital Italiano de Buenos Aires • Aim: Knowledge-focused
Last updated Mar 10, 2026 12:53 UTC