Magnetic brain zap could curb uncontrollable hunger in rare disorder
NCT ID NCT05938543
First seen Dec 16, 2025 · Last updated Jun 23, 2026 · Updated 24 times
Summary
This study tests whether a noninvasive technique called transcranial magnetic stimulation (TMS) can change brain activity related to hunger and fullness in people with Prader-Willi syndrome. Researchers will stimulate a part of the brain called the cerebellum and measure changes in brain scans and appetite. The trial is very small (20 people) and is focused on whether the procedure is feasible and safe, not yet on proving it works as a treatment.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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McLean Hospital
RECRUITINGBelmont, Massachusetts, 02478, United States
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive transcranial magnetic stimulation (rTMS)
What this could lead to
If it works, this could point toward a noninvasive way to reduce extreme hunger in Prader-Willi syndrome.
What could go wrong
This is a very small, early feasibility study (20 people) with no control group. It is designed mainly to see if the procedure is practical, not to prove it works.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.