Magnetic brain zap could curb uncontrollable hunger in rare disorder

NCT ID NCT05938543

Recruiting now Symptom relief Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a noninvasive technique called transcranial magnetic stimulation (TMS) can change brain activity related to hunger and fullness in people with Prader-Willi syndrome. Researchers will stimulate a part of the brain called the cerebellum and measure changes in brain scans and appetite. The trial is very small (20 people) and is focused on whether the procedure is feasible and safe, not yet on proving it works as a treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: repetitive transcranial magnetic stimulation (rTMS)
What this could lead to: If it works, this could point toward a noninvasive way to reduce extreme hunger in Prader-Willi syndrome.
What could go wrong: This is a very small, early feasibility study (20 people) with no control group. It is designed mainly to see if the procedure is practical, not to prove it works.

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Conditions

The condition(s) this trial relates to.

Prader-Willi syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRADER-WILLI SYNDROME

Contacts and locations

Locations

McLean Hospital
RECRUITING

Belmont, Massachusetts, 02478, United States

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