Weight-loss surgery may alter how pain medication works in the body

NCT ID NCT03476538

Recruiting now Knowledge-focused Sponsor: Norwegian University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study investigates how gastric bypass and sleeve gastrectomy—two common weight-loss surgeries—affect the absorption of gabapentin, a drug used for nerve pain and seizures. Researchers measure gabapentin levels in the blood of 12 participants before and after surgery. The goal is to understand whether these surgeries change how the body processes medication, which could help doctors prescribe safer, more effective doses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: gabapentin
What this could lead to: If successful, this could help doctors adjust medication doses for people who have had bariatric surgery, ensuring they get the right amount of drug.
What could go wrong: This is a very small, early-stage study with only 12 participants, so results may not apply to everyone. It only looks at one drug, gabapentin.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

St. Olavs University Hospital
RECRUITING

Trondheim, Norway

Contact

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