Can new breathing methods keep obese patients off ventilators?
NCT ID NCT05918575
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
About 20% of severely obese patients need their breathing tube reinserted after it's removed, which raises risks of pneumonia and longer hospital stays. This study tests whether using noninvasive breathing support (alternating between two devices) for 24 hours after tube removal can lower that risk. Researchers will enroll 250 adults with a BMI of 40 or higher who are ready to come off the ventilator.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
noninvasive ventilation and high flow nasal cannula
What this could lead to
If successful, this could provide a standard approach to prevent breathing tube reinsertion in severely obese patients after surgery or critical illness.
What could go wrong
This is a single-center trial with 250 participants, so results may not apply broadly. The interventions are supportive and not a cure for obesity or underlying conditions.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Central DuPage Hospital
NOT_YET_RECRUITINGWinfield, Illinois, 60190, United States
Contact Email: •••••@•••••
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Hospital Civil Fray Antonio Alcalde
RECRUITINGGuadalajara, Jalisco, 44280, Mexico
Contact Email: •••••@•••••
Contact
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McGovern Medical School, The University of Texas Health Science Center
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
Contact
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Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Email: •••••@•••••
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Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
Contact Email: •••••@•••••
Contact
Contact Email: •••••@•••••
Contact