Can new breathing methods keep obese patients off ventilators?

NCT ID NCT05918575

Recruiting now Disease control Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

About 20% of severely obese patients need their breathing tube reinserted after it's removed, which raises risks of pneumonia and longer hospital stays. This study tests whether using noninvasive breathing support (alternating between two devices) for 24 hours after tube removal can lower that risk. Researchers will enroll 250 adults with a BMI of 40 or higher who are ready to come off the ventilator.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: noninvasive ventilation and high flow nasal cannula
What this could lead to: If successful, this could provide a standard approach to prevent breathing tube reinsertion in severely obese patients after surgery or critical illness.
What could go wrong: This is a single-center trial with 250 participants, so results may not apply broadly. The interventions are supportive and not a cure for obesity or underlying conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

morbid obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXTUBATION FAILURE OBESITY, MORBID

Contacts and locations

Locations

Central DuPage Hospital
NOT_YET_RECRUITING

Winfield, Illinois, 60190, United States
Hospital Civil Fray Antonio Alcalde
RECRUITING

Guadalajara, Jalisco, 44280, Mexico
McGovern Medical School, The University of Texas Health Science Center
RECRUITING

Houston, Texas, 77030, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States

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