Weight-loss surgery may alter how blood pressure medication works

NCT ID NCT03476551

Recruiting now Knowledge-focused Sponsor: Norwegian University of Science and Technology Source: ClinicalTrials.gov ↗

First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time

Summary

This study looks at how gastric bypass or sleeve gastrectomy affects the way the body handles hydrochlorothiazide, a common blood pressure medication. Researchers will measure drug levels in the blood of 12 people before and after surgery. The goal is to understand whether weight-loss surgery changes how well the drug is absorbed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hydrochlorothiazide
What this could lead to: If it works, this could help doctors adjust blood pressure medication doses for people who have had weight-loss surgery.
What could go wrong: This is a very small study (12 people) that only measures drug levels in the blood, not health outcomes. Results may not apply to everyone.

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Conditions

The condition(s) this trial relates to.

morbid obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY, MORBID

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

St. Olavs University Hospital
RECRUITING

Trondheim, Norway

Contact

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