One-Size-Fits-All diet fails? mayo clinic tests custom Weight-Loss plans

NCT ID NCT06770049

Recruiting now Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a lifestyle program tailored to a person's specific obesity type helps them lose more weight and keep it off. Researchers at Mayo Clinic will enroll 228 adults with obesity and give them either a standard or a personalized diet and exercise plan for 12 months. The goal is to see if matching the intervention to individual traits leads to better long-term results.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: behavioral intervention (personalized diet and exercise program)
What this could lead to: If successful, this could show that tailoring lifestyle advice to a person's specific obesity type leads to more effective and lasting weight loss.
What could go wrong: This is a relatively small, early-stage trial (228 participants) testing a behavioral approach, so results may not apply to everyone. Weight loss programs often have high dropout rates and variable success.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States

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