Thyroid pill plus diet may boost weight loss in obesity, new trial suggests

NCT ID NCT07332273

Recruiting now Disease control Sponsor: Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This phase 3 trial tests whether adding a low dose of levothyroxine (a thyroid hormone) to a Mediterranean diet and exercise program helps adults with obesity lose more weight and keep it off. The study enrolls 286 people aged 25-60 with grade I-II obesity and higher-than-normal thyroid hormone levels. Participants take either levothyroxine or a placebo daily for 9 months, while all follow the same lifestyle program. Researchers will measure weight, body fat, and metabolic health at 3 and 9 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: levothyroxine (thyroid hormone)
What this could lead to: If it works, this could point toward a new way to boost weight loss and prevent regain in people with obesity who have higher thyroid hormone levels.
What could go wrong: This is still an early-phase trial with 286 people, so results may not apply to everyone. Levothyroxine can cause heart palpitations or bone loss if overused.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Hospital Clínico Universitario de Valladolid
NOT_YET_RECRUITING

Valladolid, Spain
Hospital Puerta del Mar
NOT_YET_RECRUITING

Cadiz, Spain
Hospital Reina Sofía
NOT_YET_RECRUITING

Córdoba, Spain
Hospital Universitario Virgen de la Victoria
RECRUITING

Málaga, Spain
Hospital Universitario de Jaén
NOT_YET_RECRUITING

Jaén, Spain

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