OBESITY

This study tested whether a virtual coach delivered through a patient portal could help obese patients lose weight before ventral hernia surgery. Researchers compared the virtual coach approach to usual care for 32 patients over six months. The goal was to see if this digital too…

This study tested whether a weekly injection called semaglutide could help teenagers with overweight or obesity manage their weight. Over 200 teens received either the real medication or a placebo (dummy shot) for about 15 months, along with counseling on healthy eating and activ…

This study tested whether adding a new investigational medicine (NNC0165-1875) to an existing weight management drug (semaglutide) could help people with obesity lose more weight. About 120 adults received either the two-drug combination or semaglutide with a placebo for 26 weeks…

This early-stage study tested an experimental drug called AMG 133, given as injections under the skin, in 120 adults who are overweight or have obesity. The main goal was to understand how the drug moves through and stays in the body after multiple doses. Researchers also closely…

This study tested whether a new injectable medication called GZR18 could help people with obesity or overweight lose weight. It involved 340 Chinese adults who received either the real injection or a placebo (dummy shot) for 30 weeks. Researchers measured changes in body weight a…

This study tested whether eating strawberry powder daily could improve heart and metabolic health in overweight or obese adults with borderline high cholesterol. Participants tried different amounts of strawberry powder for four weeks at a time to see effects on cholesterol, bloo…

This study tested whether adding a psychological therapy program before weight loss surgery could help patients. 94 adults preparing for surgery were randomly assigned to receive either the therapy or standard care. The goal was to see if the therapy helped patients develop healt…

This study tested a new magnetic device designed to perform a type of weight-loss surgery. The device connects part of the small intestine to the stomach to help manage weight and improve blood sugar levels in adults with obesity and type 2 diabetes. The main goal was to see if t…

This study tested a weekly injection called LY3437943 (retatrutide) in people who are overweight or have obesity and also have painful knee osteoarthritis. The main goals were to see if the treatment safely reduced knee pain and helped participants lose weight over about 77 weeks…

This small, completed trial tested a new type of weight loss surgery for people with both obesity and type 2 diabetes. The procedure combined two surgical techniques to see if it could help patients lose weight and improve their diabetes control. Researchers monitored 18 particip…

This study tested whether losing weight before starting IVF treatment helps overweight women have a baby. Researchers split 158 women into two groups: one followed a 3-month diet and exercise plan before IVF, while the other received standard care. The goal was to see if the weig…

This study tested whether adding vitamin D supplements to standard diet and exercise advice improves blood vessel function in obese teenagers. Researchers compared 49 adolescents over three months to see if the vitamin D group showed better vascular health. The goal was to see if…

This Yale University study tested whether a medication called lisdexamfetamine (LDX) could help people with binge-eating disorder and obesity maintain their progress after initial treatment. The Phase 3 trial involved 61 adults who had already responded well to earlier therapy. R…

This study tested different settings for a deep brain stimulation device already implanted in three people with severe obesity. The goal was to see which electrical settings best increased the body's resting metabolic rate, which is how many calories you burn at rest. Researchers…

This study tested which of two diet coaching methods works better for weight loss. Over 200 overweight adults followed a program that either gave them a fixed daily calorie goal or a goal that changed from day to day. Researchers measured weight loss, body composition, and how pa…

This study compared two types of weight loss surgery for people with severe obesity. Researchers tested a newer, simpler procedure called SADI-S against the established BPD-DS surgery. They followed 62 patients to see which approach was safer, led to better weight loss and diabet…

This study investigated whether a new combination medicine called CagriSema affects how much people eat, their appetite, and how quickly their stomach empties. The 32-week trial involved 62 adults with overweight or obesity, who were randomly assigned to receive either the active…

This study tested whether walking down stairs is as good as or better than walking up stairs for improving health in obese, inactive women. Twenty-four participants were split into two groups, with one group walking down stairs and the other walking up, twice a week for eight wee…

This study tested whether patients could safely go home the same day after weight loss surgery, instead of staying overnight. Researchers compared 200 adults having gastric bypass surgery, with half going home the same day and half staying one night. They tracked whether patients…

This study tested whether teaching women about the Mediterranean diet and sustainable eating could help improve their body composition. Researchers worked with 62 women aged 20-49 who had overweight or obesity, providing them with nutrition education sessions. The goal was to see…

This study tested whether a new behavioral program called 'Fun First' could help people maintain weight loss better than a standard program like Weight Watchers. Over 300 adults with obesity and elevated blood pressure were randomly assigned to one of the two 12-month programs an…

This study tested whether a program using financial incentives and smartphone tools could help adults from economically disadvantaged backgrounds lose weight. It involved 195 adults with obesity who used their phones to track progress and could earn small monetary rewards. The go…

This study tested whether taking a low dose of aspirin twice a day is better than once a day at preventing future heart attacks, strokes, or other serious heart problems in people with diabetes or obesity who recently had a heart attack or chest pain. Researchers enrolled over 2,…

This study tested whether adding a weight-loss drug (loxenatide) to a standard hormonal IUD treatment improves outcomes for obese women with a precancerous uterine condition called atypical endometrial hyperplasia. The goal was to see if helping patients lose weight could lead to…

This study tested if a 12-week time-restricted eating plan was practical and acceptable for older adults with mild memory problems and obesity. Participants worked with a psychologist to fast for 16 hours on 2-3 days each week. Researchers measured changes in memory, thinking ski…

This study tested if a diet high in boron (found in foods like nuts and dried fruits) could improve weight and metabolic health in obese adults, compared to a well-known Mediterranean-style diet. Forty participants followed one of the two specific diets for four weeks. Researcher…

This large, late-stage study tested a once-daily oral medication called LY3502970 (orforglipron) to see if it could help people lose weight and better manage their type 2 diabetes. Over 1,600 adults with obesity or overweight and type 2 diabetes participated, comparing the drug t…

This early-stage study tested the safety and effects of a new drug called LY3841136, both by itself and combined with the existing weight-loss medication tirzepatide. It involved 128 Japanese adults who were living with obesity or overweight. The main goals were to check for side…

This study looked at how a weekly injection called semaglutide affects people's appetite, food cravings, and eating behavior over a long period. 120 adults with obesity received either the medication or a placebo (inactive shot) along with diet and exercise counseling for 72 week…

This study tested if sharing daily health data helps people maintain weight loss. Over 300 adults with overweight or obesity followed a 2-year lifestyle program. They tracked their weight, activity, and food, and researchers tested if sharing this data with a coach, a support gro…

This study tested whether a remote, video-based lifestyle program could help veterans with obesity and obstructive sleep apnea (OSA) lose weight and improve their sleep-related quality of life. Nearly 700 participants were randomly assigned to either receive the 12-month coaching…

This study tested a new remote health coaching system for adults with severe obesity and obstructive sleep apnea. The goal was to see if people could use the devices at home and if the program was helpful for making lifestyle changes. Researchers gathered feedback from 17 partici…

This study tested whether having a peer coach helps people lose more weight than trying to manage weight on their own. It involved 375 adults with obesity who were patients at primary care clinics in the Southeast. Researchers compared a structured program with regular support fr…

This study tested if customizing ventilator pressure during surgery is better than using a standard setting for obese patients having spinal surgery. It involved 80 patients to see if the personalized approach improved oxygen levels during the operation and reduced breathing prob…

This study looked at how a year-long diabetes prevention program affected weight, heart health, and stress levels in 15 adults from socioeconomically disadvantaged communities. Researchers measured changes in body weight, cardiovascular risk factors, and psychological stress to s…

This study tested whether a weekly injection called survodutide could help adults with obesity and a serious fatty liver disease called NASH. Over 200 participants were randomly assigned to receive either the real medicine or a placebo (dummy injection) for 48 weeks, alongside di…

This study tested whether having a live-in support person helps veterans lose more weight and keep it off. 300 veterans with obesity and their cohabitating partners were randomly assigned to do a virtual weight management program alone or as a team. The main goal was to see which…

This study tested whether taking a specific probiotic (Bifidobacterium breve) could help healthy, overweight adults lose body fat. For 12 weeks, 95 participants took either the probiotic or a placebo pill while also following an exercise program. Researchers measured changes in b…

This study tested whether an online family support program could work well alongside a standard weight loss program for Black adults. Researchers wanted to see if adding family skills training online would be practical and acceptable to participants. The program focused on improv…

This study tested whether a daily pill called oral semaglutide could help adults with overweight or obesity lose weight. Over 300 participants took either the real pill or a placebo (a dummy pill) for 64 weeks. Researchers measured how much weight people lost and whether it impro…

This early-stage study tested the safety and side effects of an experimental drug called AMG 133 (maridebart cafraglutide) in adults with obesity. The main goal was to see how the body processes the drug and what side effects occur when given as single or multiple doses. Research…

This early-stage study tested the safety and side effects of a single dose of eloralintide, an experimental weight management drug, in 30 Chinese adults with obesity or overweight. Researchers monitored participants for 10 weeks to see how their bodies handled the medication and …

This study tested whether using a mobile app for remote follow-up could help obese teenagers lose more weight than traditional in-person clinic visits. After an initial intensive program, 91 teens were randomly assigned to either continue with quarterly clinic visits or use a spe…

This study tested whether a weekly injection of semaglutide, a medication for weight loss, could improve daily life for people with a specific type of heart failure linked to obesity. Over 500 participants with obesity and heart failure were randomly assigned to receive either th…

This study looked at whether starting the medication liraglutide (a weight management drug) early could help people who were still obese six months after weight loss surgery. It involved 100 patients to see if this extra treatment led to better weight loss and improved health mar…

This early-stage study tested a new injection called PB-119 in Chinese adults with obesity. The main goal was to check if the injection was safe and how the body processed it. Researchers also looked to see if it helped people lose weight over a 20-week treatment period.

This early-stage study tested the safety of a new weekly injectable drug, BI 3006337, in adults who have both overweight/obesity and fatty liver disease. The main goal was to find the highest dose participants could tolerate without serious side effects. Researchers also checked …

This study tested whether pairing people with a community health worker for 10 months could help them better manage chronic health conditions like diabetes, high blood pressure, and obesity. The program provided navigation help to access health services, education, and support fo…

This study tested whether a capsule containing a heat-killed gut bacteria called Akkermansia could help with weight and metabolism in overweight adults. Sixty-one participants took either the probiotic or a placebo pill while following a specific diet. Researchers measured change…

This study tested a new weekly injection called CagriSema against an existing drug, tirzepatide, to see which helps people with obesity lose more weight. About 800 adults without diabetes received weekly injections for over a year. The main goal was to see if the new combination …

This study tested whether a weekly injectable medication called survodutide helps people with obesity lose weight. About 274 Japanese adults with obesity and related health problems like type 2 diabetes or high blood pressure participated. For 76 weeks, two-thirds received survod…

This study followed over 1,500 patients for up to 10 years after weight-loss surgery to see if it provides lasting control of metabolic syndrome. Researchers tracked blood pressure, weight, blood sugar, and cholesterol levels to understand both immediate and long-term effects. Th…

This study directly compared two types of gastric bypass surgery for people with severe obesity. Researchers wanted to see if a newer, simpler procedure called the Omega Loop Bypass was as effective and safe as the traditional Roux-en-Y surgery. They followed 256 patients for two…

This study tested a weight loss program designed specifically for adults with long-term spinal cord injuries. The program combined three approaches: portion-controlled meals, self-monitoring tools, and lifestyle coaching. Researchers aimed to find the best combination to help peo…

This small study tested a new magnetic device designed to help with weight-loss surgery. The device was used to connect parts of the small intestine in 10 adults with obesity, some of whom also had type 2 diabetes. The goal was to see if this magnetic method was safe and worked a…

This study tested two ways to help people maintain weight loss using phone support. After participants lost at least 5% of their weight in a program, they received follow-up calls either monthly or only when an algorithm predicted they were at high risk for regaining weight. The …

This small study tested whether group doctor visits could help people with obesity lose weight. Eleven patients attended 90-minute sessions where they created personalized health plans with a medical team. The goal was to see if this group approach was more effective than standar…

This study tested whether a new weight-loss medicine called survodutide (BI 456906) is safe for the heart. It involved 110 otherwise healthy adults with overweight or obesity who received weekly injections for about 30 weeks. Researchers closely monitored participants' heart rhyt…

This study tested whether a weekly injection called survodutide helps adults in China with overweight or obesity lose weight. Over 300 participants were randomly assigned to receive one of two doses of the drug or a placebo injection for about 19 months. Researchers measured chan…

This study tested a culturally tailored program designed to help African American women manage stress, improve their diet, and increase physical activity. The goal was to see if this approach could lower their risk for heart disease, stroke, and diabetes. 175 women who were overw…

This study tested if a wearable device on the ear could help people eat less. The device sends gentle electrical pulses to a nerve. Researchers compared the active device to a fake one in 60 healthy women to see if it reduced food intake and feelings of hunger during meals.

This study tested whether a weekly injection called semaglutide helps adults with overweight or obesity lose weight. About 240 participants were randomly assigned to receive either the real medication or a placebo (dummy injection) for one year. Researchers measured how much weig…

This Yale University study tested whether a combination of two existing medications (naltrexone and bupropion) could help people with binge-eating disorder and obesity, especially if other treatments hadn't worked. It was a controlled trial comparing the drug combo to a placebo. …

This study tested whether an experimental drug called AMG 133 could help people lose weight and keep it off for a year. Nearly 600 adults with obesity, some of whom also had type 2 diabetes, received either the drug or a placebo injection. Researchers measured how much weight par…

This study tested a new weekly injection called petrelintide to see if it helps people with obesity or overweight lose weight. Nearly 500 participants received either the drug or a placebo (dummy shot) along with a reduced-calorie diet and exercise for about 10 months. The main g…

This study tested if adding food support to a standard weight-loss program helps people who have obesity and struggle to afford healthy food. Researchers compared giving people food vouchers or delivering groceries to their home against the standard program alone. They measured w…

This study compared two diets for adults with type 1 diabetes and obesity. Researchers tested if eating all meals within a 6-8 hour window each day (time-restricted eating) works better for weight loss and blood sugar control than traditional daily calorie counting. The goal was …

This study tested whether providing free, healthy meals designed for medical conditions, with or without weekly group health sessions, could help people manage high blood pressure, diabetes, and obesity. It involved 75 Black adults from a Cleveland community with high rates of he…

This study tested whether a daily pill called orforglipron helps people maintain weight they had already lost in a previous trial. It involved 376 adults with obesity or overweight who had weight-related health issues. Participants were randomly assigned to receive either the act…

This early-stage study tested the safety of an experimental drug called AMG 786 in healthy adults and people with obesity. Researchers gave single and multiple doses to 65 participants to check for side effects and see how the body processes the drug. The main goal was to determi…

This small pilot study tested if a weight loss program before knee replacement surgery helps people recover better. Researchers enrolled 24 people with obesity and assigned some to a 3-month diet and counseling program before their operation. The main goal was to see if this appr…

This study tested whether taking spirulina supplements while reducing calories could help improve health in men with obesity. For 30 days, participants took spirulina capsules while following a calorie-restricted diet. Researchers measured changes in weight, body fat, cholesterol…

This study looked at over 1100 adults with severe obesity who were prescribed the weight-loss medication Wegovy. Its main goal was to see how much weight people lost after one year and to figure out which types of patients responded best. Researchers used detailed health data and…

This study tested whether a low daily dose of colchicine, an anti-inflammatory drug used for gout, could improve how the body processes sugar in people with obesity. Researchers enrolled 152 adults and adolescents who were overweight, had signs of body-wide inflammation, and high…

This study tested whether simply sleeping longer could improve the body's ability to use sugar (glucose) in people with obesity. Researchers asked half of the 31 participants to increase their time in bed to get more than 7 hours of sleep per night, while the other half kept thei…

This study tested a new, higher weekly dose (7.2 mg) of the injectable medication semaglutide to see if it helps people with obesity and type 2 diabetes lose more weight and better control their blood sugar than a lower dose or a placebo. Over 500 adults participated for about 1.…

This study tested whether a daily oral tablet called semaglutide could help Chinese adults with overweight or obesity lose weight. For about one year, 200 participants took either the real pill or a placebo, alongside counseling on healthy eating and physical activity. The main g…

This study tested a new digital care approach for families with children living with obesity in Sweden. It compared standard in-person clinic visits to a program that replaced half the visits with a smartphone app for tracking health goals and communicating with caregivers. The g…

This study tested whether high-intensity interval training (HIIT) and weight-loss surgery could prevent or reduce nerve damage (neuropathy) in obese patients. Researchers followed 140 people from bariatric surgery clinics for two years, comparing a special exercise program to sta…

This study tested an investigational drug called CT-868 to see if it could help lower blood sugar and reduce body weight in adults with type 2 diabetes who are also overweight or obese. Over 100 participants received either the drug or a placebo for 26 weeks. The main goal was to…

This small pilot study tested whether a common weight-loss surgery (laparoscopic sleeve gastrectomy) could be safely performed as a day-case procedure, meaning patients go home the same day instead of staying overnight. It involved 30 adults with obesity to see if this faster rec…

This early-stage study tested the safety of a new oral medication called ecnoglutide in 87 healthy adults. The medication is being developed to help manage type 2 diabetes and obesity. Researchers gave participants increasing doses to check for side effects and see how the body p…

This study tested the safety of combining two weight management drugs, tirzepatide and a new drug called LY3841136, in overweight and obese adults. It involved 96 participants and lasted about 42 weeks. The main goal was to see if the combination was safe and well-tolerated, whil…

This study tested whether a higher dose of a daily oral medication (semaglutide 50 mg) could help adults with overweight or obesity lose weight. Over 660 participants were randomly assigned to take either the active pill or a placebo (dummy pill) for 68 weeks, alongside lifestyle…

This study compared two versions of a common weight loss surgery (gastric bypass) that use a special 'wrap' technique on the stomach. Researchers wanted to see which version was better at preventing painful stomach inflammation and ulcers after surgery. They enrolled 200 people w…

This study tested whether a weight loss medication (phentermine/topiramate) could help control kidney stone formation in people who are obese and have diabetes or pre-diabetes. Over 18 months, researchers compared the medication against standard treatments in a small group of 19 …

This study tested whether a weekly injection called semaglutide could help adults who have both type 1 diabetes and obesity. The 115 participants were already using an automated insulin pump system but still had difficulty managing their blood sugar. For 26 weeks, half received t…

This study tested whether a new, higher dose of the medication semaglutide (7.2 mg) is more effective for weight loss than a placebo or a standard lower dose. Over 1,400 adults with obesity received weekly injections alongside lifestyle counseling for 72 weeks. The main goal was …

This study tested how well community organizations could run a healthy lifestyle program for Deaf adults who use American Sign Language. Researchers worked with 85 adults in New York to see if local groups could successfully lead the program, which focused on diet and exercise. T…

This study tested a new community-based approach to weight management. Researchers trained local residents to lead 'house chat' support groups in their own homes for neighbors in Petersburg, Virginia. The goal was to see if this grassroots coaching model was practical and accepta…

This Yale University study tested whether a GLP-1 drug (semaglutide) could help people with obesity by reducing cravings for tasty foods, lowering hunger, and decreasing stress. For 12 weeks, 96 participants received either the drug or a placebo (dummy treatment) to see its effec…

This early-stage study tested a single dose of an experimental weight management drug called AMG 133 (Maridebart Cafraglutide) in 20 Chinese adults with overweight or obesity. The main goal was to see how the drug moves through the body and to check for any immediate side effects…

This study tested the safety of a new weight control injection called NNC0487-0111 in Chinese men with overweight or obesity. For about 53 days, 36 participants received either the real injection or a placebo (dummy shot) to see how their bodies reacted. The main goal was to chec…

This study tested whether an 8-week personalized exercise program could improve heart and blood vessel function in men with type 2 diabetes or obesity. Researchers compared these men to healthy volunteers to understand how these conditions affect the body during rest and exercise…

This study tested whether a personalized online program could help pregnant women with obesity manage their weight gain and improve their birth experience. Over 850 women were randomly assigned to either use the web-based program, which offered diet, exercise, and lifestyle coach…

This study tested whether a phone-based therapy program could help people with severe obesity and food addiction. 154 participants were assigned to receive either 12 weeks of phone therapy sessions or their usual medical care. Researchers wanted to see if the therapy could reduce…

This study tested a new weekly injection called CagriSema to see if it helps people with obesity and type 2 diabetes lose weight and better control their blood sugar. About 1,200 participants were randomly assigned to receive either the real medicine or a placebo (dummy medicine)…

This study tested whether adding specific mindfulness and acceptance skills to standard remote weight loss counseling helps people lose more weight. Researchers worked with 276 adults who were overweight or obese to see if learning awareness, acceptance, and values-clarity techni…

This early-stage study tested two different versions of an experimental medicine called NNC0519-0130, intended for people with excess body weight. Researchers compared how much of each drug formula ended up in the blood of 46 adults with overweight or obesity to see if they were …

This small pilot study tested two different health coaching strategies for Black adults with obesity and related conditions like high blood pressure or prediabetes. One approach focused on weight loss, while the other focused on increasing physical activity without emphasizing we…

This small, early-stage study tested whether a daily antioxidant pill called MitoQ could improve lung function in adults with both obesity and poorly controlled asthma. Over 14 weeks, 40 participants took either MitoQ or a placebo pill. The main goal was to see if MitoQ reduced a…

This early-stage study tested how a new drug called orforglipron changes body fat, especially deep belly fat, in adults with obesity or overweight who do not have diabetes. It compared the drug's effects to a placebo (inactive substance) in 120 participants over about 8 months. T…

This study tested whether a new weekly injection called CagriSema could slow kidney damage in adults with type 2 diabetes, chronic kidney disease, and overweight or obesity. It compared CagriSema against its individual components (semaglutide and cagrilintide) and a placebo over …

This study tested whether adding a heat treatment (Hybrid Argon Plasma Coagulation) to a stomach-stitching procedure (Endoscopic Sleeve Gastroplasty) leads to better weight loss results. It involved 45 adults with obesity who had not succeeded with diet and exercise alone. Resear…

This study tested whether a virtual weight management program, combined with a continuous glucose monitor, could help adults with type 2 diabetes better control their blood sugar. 152 participants were assigned to either try this digital program or continue with their usual care …

This study looked at whether GLP-1 medicines like semaglutide and tirzepatide, used for weight loss, also improve mental health and quality of life. It followed 90 veterans with obesity for six months while they received this treatment. The key finding was that participants repor…

This large study followed 1,500 obese patients, some who had weight-loss surgery and some who did not. The goal was to understand what factors help people with Type 2 diabetes go into remission and recover from other obesity-related health problems after surgery. Researchers trac…

This study tested if rinsing the surgical area with warm saline (body temperature) instead of room-temperature saline reduces early bleeding after a common weight loss surgery. Involving 200 patients, it found this simple, low-cost change during surgery helped control bleeding be…

This early-stage study tested the safety and how the body processes two experimental drugs, eloralintide alone and combined with tirzepatide, for weight management. It involved 188 adults who were overweight or obese, giving weekly injections under the skin for up to 26 weeks. Re…

This study aimed to see if combining weight loss with exercise is better than exercise alone for improving fitness in obese older adults. Researchers tested 180 sedentary, obese seniors by having them follow a walking program along with different diet plans for five months. The g…

This study tested how a new weight-loss medicine called CagriSema affects people's appetite, food cravings, and brain activity. It involved 164 adults with overweight or obesity, comparing those who received the medicine to those who received a dummy treatment. Researchers used q…

This study tested a new weekly injection called CT-388 to see if it helps people with obesity or overweight lose weight and improve related health measures. Nearly 470 adults received either the drug or a placebo (dummy injection) for 48 weeks. The main goal was to measure the pe…

This study tested a flexible lifestyle program for people with conditions like insulin resistance, obesity, or prediabetes. It started with either nutrition or exercise counseling. If a person's insulin resistance didn't improve enough after 8 weeks, the program could switch them…

This study tested a 24-week virtual program that combined WeightWatchers behavioral coaching with prescription weight-loss medications (like Wegovy or Zepbound). It aimed to see if this combined approach helped people lose weight and improve related health factors. The study foll…

This study tested whether a weekly injection called semaglutide could help people with obesity and prediabetes lose weight and return their blood sugar to normal levels. Over 200 participants received either the real medicine or a placebo dummy injection for one year, alongside l…

This study tested a new smartphone app designed to help people with obesity better manage their weight, diet, and activity. For 16 weeks, some participants used the app alongside their usual care, while others received only standard care. The goal was to see if the app could impr…

This study tested a new weekly injection called NNC0519-0130 to help people with overweight or obesity lose weight. It involved 355 adults and compared up to six different doses over about 10 months. The main goal was to see how safe the medicine was and how much weight people lo…

This small, completed study tested a new magnetic device for creating a partial intestinal bypass. The goal was to see if this new surgical method was safe and could help adults with obesity and type 2 diabetes manage their weight and blood sugar. The procedure reroutes food thro…

This study tested whether a weight loss app and team competition could help hospital employees with obesity lose weight. Over 500 staff members with a high body mass index participated in the program, which encouraged healthy eating and exercise. The goal was to create a healthie…

This study tested whether quercetin, a natural substance found in foods like apples and onions, could help control blood sugar. Researchers gave 24 adults with obesity or type 2 diabetes either quercetin or a placebo during sugar tolerance tests to see if it slowed sugar absorpti…

This study tested if a weight loss drug (Semaglutide) combined with a very low-calorie diet could better treat a serious brain pressure condition called Idiopathic Intracranial Hypertension (IIH). It involved 38 women with new IIH and obesity, comparing the drug and diet plan to …

This study tested two different settings on non-invasive breathing machines for patients hospitalized with acute, severe breathing failure. It focused on patients with obesity (BMI ≥ 30) who are at risk for sleep apnea or poor breathing while asleep. Researchers compared a standa…

This study compared the effectiveness of the weight loss medication semaglutide (Wegovy) against four other approved drugs for obesity. It involved 500 employed adults with obesity from diverse job backgrounds across three US companies. The main goal was to see which medication h…

This study looked at whether weight-loss surgery (sleeve gastrectomy) could improve the health of the pancreas, kidneys, and heart in young people (ages 12-21) with type 2 diabetes. Researchers measured organ function in about 50 participants before and after surgery to understan…

This small, completed pilot study tested whether a 6-month smartphone app program was practical and acceptable for helping young adult cancer survivors manage their weight. The program used an app, a smart scale, and an activity tracker to help with diet and exercise. Researchers…

This study tested if a weight management program run by local community coaches, through informal 'house chats,' is a practical and acceptable approach for adults in an underserved area. It aimed to see if this grassroots model could be successfully set up and sustained in a real…

This study tested whether adding a weekly injection called semaglutide could allow people with type 2 diabetes to use less daily insulin while still controlling their blood sugar. Researchers compared two approaches over 11 months in 568 overweight adults: one group received the …

This early-stage study tested whether a new drug, LY3437943, could help people with obesity eat fewer calories and use energy differently while dieting. It compared the drug to a placebo in 85 participants over about six months. The main goal was to see if the drug changed how mu…

This study directly compared two injectable medications, tirzepatide and semaglutide, to see which one helps people lose more weight. It involved 751 adults who had obesity or were overweight with related health problems like high blood pressure, but who did not have diabetes. Th…

This study tested the safety of a new injectable medication called NNC0662-0419 for people with overweight or obesity. It was the first time this experimental drug was given to humans. Researchers monitored 100 participants for about 9 months to see how their bodies handled the m…

This study tested whether combining time-restricted eating (eating within a specific daily window) with supervised exercise is more effective at reducing harmful liver fat and improving heart health than doing either one alone. It involved 187 adults with obesity over 12 weeks. R…

This study tested whether sending specific, well-timed messages through a phone app could help young adults with overweight or obesity stick to daily weight loss behaviors. Over 200 participants used an app with lessons, tracking, and daily goals for weighing, activity, and food.…

This study monitored the safety and effectiveness of Saxenda, a prescription weight management medication, during routine use in Taiwan. Researchers followed 300 obese adults and adolescents for about 6 months to track side effects and weight loss results. The study aimed to unde…

This study tested if a drug called bromocriptine helps people with obesity lose weight, and if it works better for those with a specific gene linked to higher body weight. 120 participants with obesity were randomly given either the drug or a placebo for 18 weeks, and their progr…

This study tested whether intermittent fasting is an effective long-term weight loss strategy compared to traditional daily calorie counting. For one year, 165 adults with obesity followed either a fasting diet (severe restriction 3 days a week) or a daily reduced-calorie diet, w…

This study tested whether a drug called tesamorelin could help people with obesity and nonalcoholic fatty liver disease (NAFLD). It involved 51 adults and aimed to see if the treatment could reduce harmful fat and inflammation in the liver. The drug works by boosting a natural ho…

This study tested a 3-month remote support program for people who regained weight after gastric sleeve surgery. 100 participants were randomly assigned to either the program or standard care. The program included online meetings with diet, sleep, and activity experts, plus weekly…

This study tested whether text messages about diet and exercise, combined with monthly phone calls from community health workers, could help residents of Boston public housing lose weight. Researchers compared three groups: text messages alone, text messages plus phone support, a…

This study tested whether a new weekly injection called semaglutide could help people with overweight or obesity manage their weight. About 375 participants were randomly assigned to receive either the real injection or a placebo for about a year, alongside lifestyle counseling. …

This study tested whether a lifestyle program combining alternate-day fasting with exercise could be an effective, drug-free way to treat non-alcoholic fatty liver disease (NAFLD). It involved 80 adults with obesity and NAFLD, comparing changes in liver fat measured by MRI. The g…

This early-stage study tested the safety and side effects of an experimental drug called LY3532226 in 132 adults with obesity. Researchers gave participants either the drug or a placebo weekly or monthly and measured how much medication entered their bloodstream and how long it s…

This study tested if a new drug called VTX3232 is safe and well-tolerated when taken alone or combined with the established weight-loss medication semaglutide. About 176 adults with obesity received either the new drug, a placebo, or combinations of these for 12 weeks. The main g…

This study tested if a drug called enobosarm could help people aged 60 and older keep their muscle while using popular weight-loss medications (GLP-1 agonists). Researchers wanted to see if adding enobosarm to the weight-loss treatment could prevent the loss of lean body mass, wh…

This study tested whether intermittent fasting (eating only during specific time windows) could improve how the pancreas works in people with early type 2 diabetes. Researchers enrolled 51 adults recently diagnosed with diabetes to see if this eating pattern could help the pancre…

This study tested whether an 8-week exercise program could improve health markers in overweight young women. Twenty-two participants either followed a circuit workout plan or continued their usual activities. The results suggest the exercise program increased a beneficial hormone…

This study tested whether using a whole-body vibration machine could help overweight university students manage their weight and body composition. Researchers randomly assigned 32 students to either use the vibration platform or not, then measured changes in their body mass index…

This small pilot study tested whether delivering healthy meals to new mothers' homes is a practical way to help them manage their weight after having a baby. Eleven low-income women with obesity received 10 meals per week for 8 weeks. The main goal was to see if participants like…

This study tested a new injectable drug called NNC0487-0111 to see if it is safe and helps with weight loss in people with overweight or obesity. It involved 125 adults who received either the drug or a placebo (dummy) injection. The main goals were to check for side effects and …

This study tested whether the timing of meals affects weight, body fat, and metabolism in people with obesity. 38 obese adults ate all their provided meals either during daytime hours (8am-7pm) or delayed hours (12pm-11pm) for 8-week periods, with their health closely monitored. …

This study tested a lifestyle program designed to help pregnant women with obesity manage their weight and body fat. It involved 100 women and compared a special weight maintenance program to standard care. The goal was to see if the program could safely improve the mother's heal…

This small pilot study tested whether restricting daily eating to specific time windows helps people maintain weight they've already lost. Researchers recruited 29 adults who had recently lost at least 5% of their body weight through a program. Participants were randomly assigned…

This study tested if time-restricted eating (eating only during a specific daily window) works as well as traditional calorie counting for weight loss in obese adults. Researchers followed 115 participants for 12 weeks to see which approach led to better weight loss, fat reductio…

This study tested whether a weekly injectable medication called survodutide helps adults with overweight or obesity lose weight. Over 700 participants, who had previously struggled to lose weight through diet alone, received either the drug or a placebo for about a year and a hal…

This small pilot study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and acceptable for cancer survivors. It involved 20 survivors who were overweight and had finished active cancer treatment. The main goal was to s…

This large, completed study looked back at health records of over 285,000 overweight or obese adults to see if taking the weekly medication semaglutide was linked to fewer serious heart problems. It focused on three groups: people with existing heart failure, people with heart ar…

This study tested a new, non-surgical procedure for weight loss called Gastric Mucosal Ablation (GMA). Doctors used a special tool to carefully remove the inner lining of the stomach in 15 people with obesity, thinking it might affect hunger hormones. The main goal was to check i…

This study tested whether a weekly injection of semaglutide could help Asian adults with obesity lose weight. For about a year, 150 participants either received the active drug or a placebo (dummy) injection, combined with lifestyle counseling. The main goal was to see how much b…

This completed study tested whether daily capsules containing a heat-treated form of a specific gut bacteria (Akkermansia muciniphila) could help with weight management and improve metabolic health markers like cholesterol. The trial involved 61 overweight or obese adults who fol…

This study tested a new weight management program designed specifically for college students. The program used a 'small changes' approach, asking students to make a few simple adjustments to their eating habits rather than following a strict diet. Researchers wanted to see if off…

This study tested if taking pea protein helps people with obesity keep their muscle mass while they lose weight. Researchers compared pea protein to whey protein and a placebo over 12 weeks. They measured changes in muscle, strength, and overall health in 60 participants.

This study tested whether a 6-week mindfulness training program could help overweight teenagers who are at risk for developing type 2 diabetes. Researchers compared mindfulness training against two other approaches—cognitive behavioral therapy and health education—to see which wa…

This study tested whether daily text messages could help people with obesity manage their weight. It compared 120 participants who received standard group weight management care against those who also got daily supportive text messages for three months. The goal was to see if the…

This early-stage study tested how a common anti-nausea medicine (ondansetron) affects the way the body processes a new weight management drug called AMG 133. It involved 59 adults who were overweight or had obesity. The main goal was to check if taking the two drugs together chan…

This study tested a new 5-week hospital program designed to help adults with Prader-Willi syndrome, a rare genetic disorder that causes constant hunger and leads to severe obesity. The program combined tailored physical activity, nutrition guidance, and education workshops. Resea…

This study tested a new weight-loss medicine called PF-07976016 to see if it's safe and effective for adults with obesity. Researchers compared people taking the medicine to those taking a placebo (inactive pill) to measure changes in body weight and side effects. The trial invol…

This early-stage study tested a new weekly injection called NNC0519-0130 for people with obesity, with or without type 2 diabetes. Researchers wanted to see if the medicine was safe, how it moved through the body, and if it could help with weight loss and blood sugar control. The…

This study tested if taking a sodium butyrate supplement for 12 weeks, along with a reduced-calorie diet, helps people lose more weight than a diet alone. It involved 46 overweight or obese adults, some with type 2 diabetes, to see if the supplement also improved blood sugar, cho…

This study tested a new, non-invasive blood test called the LLIFT to see if it could accurately diagnose fatty liver disease (NAFLD) and its more severe form (NASH). It involved 158 people at high risk for metabolic problems like obesity and diabetes. The goal was to find a simpl…

This study tested a program to help prevent excessive weight gain during pregnancy for women who are overweight or have obesity. The program was delivered through local WIC clinics and used text message reminders, personalized feedback, and nutrition counseling. Researchers wante…

This study tested whether a home-based education program could help prevent obesity in Hispanic mothers and their infants. Researchers worked with 211 mother-baby pairs, providing education about reducing sugary drinks and, for some families, delivering bottled water to their hom…

This study tested whether providing education about healthy eating and modest exercise to overweight or obese pregnant women could help prevent rapid weight gain in their children during the first two years of life. Researchers compared women who received this special education p…

This small study tested whether taking a daily supplement called bovine lactoferrin (a protein found in milk) is a practical and acceptable way to help prevent iron deficiency anemia in pregnant women with obesity. Researchers enrolled 23 women to see if they could stick with the…

This study tested if a stretching program is better than standard exercise advice for lowering heart and blood pressure risks in pregnant women with obesity. It involved 224 women from 27 to 37 weeks of pregnancy. The goal was to see if stretching could help prevent serious pregn…

This study aimed to prevent breathing failure in obese patients after they had a breathing tube removed in the intensive care unit (ICU). It compared two types of non-invasive breathing support to standard oxygen therapy to see which was better at keeping patients from needing th…

This study tested health education and lifestyle programs aimed at preventing obesity in children. It involved 500 healthy Egyptian children aged 6 to 12 years old in the Gharbia region. Researchers measured changes in the children's weight, height, body mass index (BMI), and blo…

This was a small, early-stage study to see if paying people makes it easier for them to adopt healthy habits. Researchers worked with 8 adults from a low-income community who were at risk for obesity and diabetes. They tested if offering money for walking and to buy healthy food …

This study tested a new mobile app designed to make it easier for small corner stores in low-income Baltimore neighborhoods to order and receive healthy, affordable foods from local suppliers. Researchers worked with 38 stores to see if using the app increased the amount of healt…

This study tested whether a healthy lifestyle program could prevent weight gain in young mothers when delivered through an existing home visiting organization. The program was offered to 620 overweight or obese women aged 18-45 who were participating in Parents as Teachers servic…

This study tested whether a family-centered program led by community health workers could help prevent obesity in young children. The program involved home visits, text messaging, and coaching on healthy eating and activity for 300 families with children aged 2-6 who were overwei…

This study tested whether mindfulness training could help adults who had recently lost weight keep it off. Researchers worked with 48 people, including some who had bariatric surgery, to see if learning mindful awareness of eating behaviors would prevent weight regain over 6 mont…

This study tested whether a one-year online program could help inactive adults at risk for heart disease get more exercise. The program included weekly coaching sessions, remote support, and a wearable activity tracker. Researchers compared this intensive program to a simpler app…

This study tested if adding a special introductory session helps people stick with a proven diabetes prevention program. Researchers randomly assigned nearly 500 at-risk adults to either get this 'pre-session' or start the program as usual. The goal was to see if the extra step l…

This study tested whether a diet and exercise program started before pregnancy could lead to healthier babies for women with obesity. Researchers wanted to see if improving a mother's health before conception, rather than during pregnancy, could reduce the baby's body fat at birt…

This study tested whether a fully automated smartphone app could be as effective as a traditional human coach program at helping people with prediabetes lower their risk of developing type 2 diabetes. 368 adults were randomly assigned to use either the app with a smart scale or a…

This study tested whether a weekly lifestyle program could help overweight or obese pregnant women manage their weight gain and reduce diabetes risks. It involved 123 women who received either the intensive program with group classes or standard care with extra health information…

This study tested whether a special probiotic supplement, called a psychobiotic, could improve mental health and aid weight loss in obese women. Forty participants followed a weight-loss diet and took either the probiotic or a placebo pill daily for four weeks. Researchers measur…

This study tested a new type of workout for people with obesity that combines regular exercise with special breathing muscle training. Researchers wanted to see if this combined approach could improve body composition, fitness levels, breathing strength, and certain health marker…

This small pilot study tested whether a 12-week, doctor-prescribed exercise program delivered through a smartphone app is practical and acceptable for adults who have both obesity and poorly controlled asthma. Twenty participants used the app to follow a personalized exercise pla…

This study tested whether a weekly weight loss injection (semaglutide) could also reduce pain and improve daily life for people with obesity and knee osteoarthritis. Over 400 adults received either the real injection or a placebo (dummy medicine) for about 1.5 years, alongside ad…

This study tested whether a special education program based on talk therapy could help people with obesity. The program aimed to reduce emotional eating and improve mental resilience. 81 participants were randomly assigned to either receive the 8-week program or be in a compariso…

This study tested whether a single 4-hour therapy workshop could help women with obesity start and maintain healthier eating and exercise habits. Researchers compared 52 women who attended the workshop to a waitlist group, measuring changes in their mindset, body image, and behav…

This study checked if giving the pain medication lidocaine through an IV is safe for very obese patients having weight-loss surgery. Researchers measured the drug levels in patients' blood to see if a standard, weight-based dose was safe and didn't cause harmful side effects. The…

This study tested if a drug called tradipitant could reduce the common side effects of nausea and vomiting caused by GLP-1 agonist medications, which are used for weight loss. It involved 124 healthy, overweight volunteers who took either tradipitant or a placebo (a dummy pill) a…

This study tested whether a breathing muscle training program could improve heart health and mood in postmenopausal women. Researchers worked with 28 women aged 50-75 to see if using a handheld breathing device for several weeks made a difference. The goal was to gather informati…

This study tested whether taking a specific mix of probiotic supplements for 8 weeks could help relieve the painful symptoms of irritable bowel syndrome (IBS) in adults who also have obesity. Researchers enrolled 80 participants to see if the probiotics provided 'adequate relief'…

This small, completed pilot study explored whether it's practical and acceptable for people with depression to reduce how much ultra-processed food they eat. The study involved 20 adults with major depressive disorder who typically ate a lot of these foods. Researchers wanted to …

This study tested whether a month of spinal traction therapy could reduce pain and improve function for adults with obesity and chronic low back pain. Researchers compared 40 participants with obesity to 20 with normal weight, measuring pain levels, spine mobility, and blood mark…

This study tested whether taking a daily vitamin D supplement for 12 weeks could help older adults with obesity improve their muscle strength and physical function. Researchers gave 29 participants in southern Mexico a high daily dose of vitamin D and measured their grip strength…

This study aimed to understand how different types of trans fats—from natural dairy sources versus industrial processing—affect insulin resistance in obese women. Sixty-six women with higher body weight and waist measurements consumed enriched butter, dairy products, and biscuits…

This study aimed to understand how the brain responds to tasty food, like milkshakes, to learn more about what might make some people more vulnerable to obesity. Researchers used MRI brain scans on 187 young adults while they looked at pictures of milkshakes and then took sips. T…

This study follows 3,439 people for up to 10 years after they completed a weight-loss medication trial. Participants fill out health questionnaires every 6 months to track long-term outcomes like weight changes, heart health, diabetes risk, and quality of life. No medication or t…

This study aimed to understand why obesity develops and persists by comparing how the body processes food in obese and lean individuals. Researchers used MRI scans and blood tests on 20 men to measure how quickly food left the stomach, blood flow to the gut, and levels of hormone…

This early-stage study tested a single dose of an experimental weight management medicine called NNC0662-0419. Researchers enrolled 100 Japanese, Chinese, and non-Asian adults with overweight or obesity to measure how much medicine appeared in their blood and check for side effec…

This study created a registry to track the long-term heart health of children and young adults who are overweight or obese and have high blood pressure. Researchers collected health information from about 200 participants over time through their regular clinic visits. The goal wa…

This study aimed to understand if a person's genes influence how well weight-loss (bariatric) surgery works. Researchers collected blood samples and health information from 2,500 people who had already undergone surgery. They compared genetic data across different ethnic groups t…

This study looked at whether spreading protein intake evenly throughout the day changes how the body uses food for energy. Researchers tested if eating a high-protein breakfast reduces cravings for unhealthy snack foods compared to a low-protein breakfast. The study involved 53 a…

This study aimed to understand how the asthma medication dupilumab works at a cellular level in adults who have both asthma and obesity. Researchers collected nasal cell samples from 28 participants to analyze how the drug changes gene and protein activity. The goal was to learn …

This research study aimed to understand how weight-loss surgery affects liver fat and metabolism in obese teenagers. Researchers followed 20 adolescents aged 13-20 before and one year after their surgery, measuring liver fat, insulin sensitivity, and metabolic markers. The study …

This study looked at existing medical records to understand how common and costly health problems linked to obesity are in Gulf countries. Researchers analyzed data from over 1,300 adults with obesity to see how many had conditions like diabetes, high blood pressure, and heart di…

This study observed 42 people with spinal cord injuries for one year after they left the hospital. Researchers tracked their nutrition, home environment, mood, and activity levels to understand why weight gain is common after such injuries. The goal was to gather information to h…

This study aimed to understand how obesity changes the way the body processes immunoglobulin G (IgG), a medication used to treat immune deficiencies. Researchers measured IgG levels in 40 adults who were already receiving this treatment to determine if current dosing methods base…

This study looked at whether people should temporarily stop taking certain diabetes and weight loss medications before an upper endoscopy. Researchers wanted to see if pausing these drugs reduces leftover food and liquid in the stomach, which can increase the risk of breathing pr…

This study aimed to find the best measurements for predicting metabolic syndrome in people with obesity. Researchers analyzed data from 332 adults, comparing standard body measurements with newer calculations based on waist size and blood tests. The goal was to identify which ind…

This study aimed to understand why weight loss surgery is so effective for obesity by looking at changes in the brain. Researchers measured chemicals in the spinal fluid of 51 adults with obesity before and after surgery, comparing them to people who lost weight through a strict …

This study aimed to understand why some people experience confusion and memory problems after surgery, a condition known as post-operative cognitive dysfunction (POCD). Researchers followed 115 patients having hip or heart surgery to see if inflammation from body fat, especially …

This study aimed to understand how the human body burns calories at different room temperatures, focusing on a special type of fat called brown fat. Researchers enrolled 104 healthy adults to stay in a specialized room where temperatures were carefully controlled, from cool to wa…

This study aimed to understand if taking fish oil supplements could boost the benefits of exercise for reducing harmful inflammation linked to obesity. Researchers enrolled 129 overweight adults with prediabetes and high triglycerides. They tested whether combining fish oil with …

This study aimed to understand exactly how strength training improves the body's ability to use insulin and builds muscle in older adults with insulin resistance, a condition that often leads to type 2 diabetes. Researchers compared 58 adults, some who did supervised strength tra…

This study aimed to understand how common weight-related health problems are among people of different weights in India, Pakistan, the Philippines, and Vietnam. It involved over 1,100 adults who already had at least one weight-related health issue. The research only collected hea…

This study aimed to understand how regular exercise changes where the body sends different types of dietary fat—toward muscle to be burned or toward fat tissue for storage—in inactive men with obesity. Researchers studied 12 participants before and after two months of exercise tr…

This study aimed to understand if obesity makes recovery more difficult for older adults after a traumatic injury. Researchers looked back at the medical records of 100 patients aged 60 and older who were hospitalized for injuries. They compared hospital stays, complications, and…

This study aimed to better understand how type 2 diabetes develops and progresses in children, teenagers, and young adults. Researchers compared 82 young people with diabetes to healthy peers, measuring how their bodies process sugar, store fat, and handle exercise. The goal was …

This early-stage study tested the safety and how the body processes a single dose of an experimental obesity medication called monlunabant. It involved 73 healthy, normal-weight Japanese and Caucasian men to see if the drug was well-tolerated and to measure its levels in the bloo…

This small Mayo Clinic study aimed to understand how specific immune cells called eosinophils interact with body fat in people with obesity and insulin resistance. Researchers enrolled 4 participants who were undergoing a weight-loss procedure to collect fat tissue and blood samp…

This study looked at whether regularly getting 1.5 hours less sleep increases the risk of heart disease, weight gain, and diabetes in women. For 6 weeks at a time, 54 healthy women either slept their normal amount or had their sleep shortened. Researchers measured blood pressure,…

This small, early-stage study aimed to understand how lowering insulin levels affects blood sugar in people at risk for fatty liver disease and type 2 diabetes. Eighteen participants with obesity and insulin resistance underwent two specialized medical procedures where their natu…

This study looked at how changes in taste and smell after weight loss surgery might affect food cravings and diet quality. Researchers surveyed 101 adults who had undergone bariatric surgery at least three months earlier. They collected information on sensory changes, cravings, e…

This study aimed to understand why people have trouble sticking to diet and exercise plans during weight loss programs. Researchers used smartphone surveys and fitness trackers to monitor 119 adults with obesity in real-time as they tried to lose weight. The goal was to identify …

This study aimed to understand why some people regain weight after sleeve gastrectomy surgery. Researchers measured the leftover stomach size in 90 patients two years after their surgery using CT scans. They wanted to see if a larger remaining stomach volume was linked to poorer …

This study aimed to find the safest and fastest way to give extra oxygen to obese patients before they go under anesthesia for surgery. Researchers tested three different breathing techniques on 75 patients to see which one filled the lungs with oxygen quickest while also checkin…

This study aimed to understand how the body absorbs, breaks down, and eliminates a single dose of an experimental drug called GZR18. It involved 6 Chinese men who were overweight or obese. Researchers tracked the drug's path by measuring it in blood, urine, and feces over several…

This study aimed to understand the connections between sleep quality, when people eat during the day, gut bacteria, and body weight. Researchers enrolled 133 adults with different body weights and sleep patterns to gather this information. They also developed and tested a simple …

This study looked at how being overweight or obese affects heart disease rates and risk factors in Chinese adults. Researchers analyzed existing health survey and death records from over 550,000 people to understand the link between weight and heart health. The goal was to measur…

This study aimed to understand how a single hour of walking or jogging affects the body's natural appetite signals and brain activity. Researchers measured hormone levels, food intake, and brain scans in 40 people of different body weights after exercise and at rest. The goal was…

This research project followed 2500 Black adults in five countries to understand if the amount of energy people burn through daily activity is linked to weight gain and diabetes risk. Participants wore activity monitors, and some had special water tests, to accurately measure the…

This study aimed to understand how people's diets change when they start taking GLP-1 agonist medications like Ozempic for weight loss or diabetes. Researchers followed 37 adults in Australia for 3 months, asking them to complete online food diaries and surveys. The main goal was…

This study aimed to understand how a specific healthy diet pattern, a person's natural sleep/wake timing (chronotype), and mental well-being are connected in adults with obesity. Researchers gathered data from 97 volunteers, including their body measurements, blood tests, diet re…

This study looked at how weight-loss surgery might affect fertility in obese men. Researchers followed 46 men before and after surgery, checking their sperm quality, blood markers, and lifestyle factors. The goal was to understand if surgery improves fertility by measuring change…

This study aimed to understand if losing more body fat, rather than just losing weight, leads to better improvements in metabolic health for people with excess weight. It followed 74 inactive adults aged 30-55 as they followed a 12-week diet. The researchers measured changes in b…

This study aimed to understand if a new injectable drug for weight management (BI 456906/Survodutide) changes how the body processes three common substances: caffeine, a sleep aid (midazolam), and an antidepressant (bupropion). It involved 34 otherwise healthy adults with overwei…

This study aimed to understand if experiencing weight stigma (negative attitudes about obesity) causes people to have less healthy daily habits. Researchers from UCLA randomly assigned 330 adults with a higher body weight to either experience a weight stigma situation or a neutra…

This study aimed to understand how the stress and changes from the COVID-19 pandemic affected people's eating habits and weight. Over 5,000 English-speaking adults participated by completing online surveys about their stress, mental health, and eating behaviors over time. The goa…

This study aimed to understand how a person's regular diet affects inflammation, metabolism, and overall health. Researchers observed 393 healthy and obese adults, measuring their body's response to a test meal and collecting extensive health data. The goal was to map the connect…

This study aimed to understand if adding carob flour to a meal could help people feel fuller and better regulate blood sugar and appetite hormones after eating. It involved 20 healthy men of normal weight who ate a test breakfast. Researchers measured their hunger, fullness, and …

This study aimed to understand why keeping weight off is so hard. After losing weight, 234 adults followed one of three diets with different amounts of carbs and fat, but the same protein. Researchers carefully measured how many calories their bodies burned and other health marke…

This study aimed to see if drinking orange juice daily could improve how the body uses insulin, a key hormone for blood sugar control. It involved 36 otherwise healthy but overweight women who drank either orange juice or a control drink for three months. Researchers measured ins…

This study aimed to understand how well obese adults with sleep-related breathing problems stick to using their CPAP therapy machines. It followed 300 patients for one year, tracking how many nights they used the machine for at least 4 hours. The goal was to gather real-world dat…

This study looked at how a person's eating habits in the year after weight loss surgery affect their results. Researchers followed 290 people who had a sleeve gastrectomy procedure to see if their daily diet explained why some people lose a lot of weight and others do not. The go…

This study aimed to understand why weight loss surgery improves the body's ability to manage blood sugar so quickly, often before significant weight loss occurs. Researchers studied 28 women, comparing fat cells from those with and without obesity before and after surgery. They l…

This study aimed to understand if the size of the body area treated during large-volume liposuction affects patient safety more than the total amount of fat removed. Researchers monitored 20 female patients undergoing the procedure, checking their blood counts, clotting ability, …

This study aimed to understand the connection between physical activity, metabolism, and feelings of hunger in adolescents. Researchers tested if regular, structured exercise could improve how the body processes energy and regulates appetite, independent of a teen's weight. They …

This study looked back at medical records to see if using a lower flow of anesthesia gas during weight-loss surgery affects the body's stress and inflammation response. Researchers compared 155 patients who had either a low-flow or standard-flow method. They checked blood markers…

This study investigated whether the time of day people eat salt affects their blood pressure and body clock. Researchers tested 53 adults with obesity to see if avoiding high-salt foods before sleep could improve nighttime blood pressure and the body's natural daily rhythms. The …

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and environmental factors. Researchers enrolled 1,759 adults to measure their body composition, insulin function, and glucose tolerance, and collected tissue and DNA samples. The goal was…

This study aimed to understand why some people with obesity develop obstructive sleep apnea (OSA) while others do not. Researchers studied 106 adults with obesity before and six months after weight-loss surgery, measuring their airway function and structure. The goal was to learn…

This study explored whether a single session of exercise could improve how the brain responds to insulin in middle-aged and older adults. Researchers enrolled 16 participants aged 40-80 who were overweight and not regularly active. They measured brain blood flow and cognitive fun…

This study aimed to understand how women's bodies absorb and use vitamin E, an important antioxidant. Researchers enrolled 50 women, including some who were obese or had diabetes, to measure how different amounts of dietary fat and vitamin C affect vitamin E levels in the blood a…

This study aimed to understand why people with obesity have different types of muscle fibers compared to lean individuals. Researchers compared 48 participants with and without obesity, using exercise and amino acid infusions to see how muscle proteins are made. The goal was to u…

This study aimed to understand why common screening tests for diabetes and heart disease often fail women of African descent. Researchers compared risk factors like blood sugar, body fat, and triglycerides in 146 healthy African, African-American, and white women who were federal…

This French research study aimed to understand the role of gut bacteria in obesity and type 2 diabetes. Researchers collected and analyzed bacteria samples from the small intestine and colon of 90 participants, including people with obesity, obesity plus diabetes, and a control g…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how healthy volunteers' bodies burned calories during 6-week periods of controlled overeating or reduced eating. The goal was to see if these measurements could help p…

This study aimed to understand why some people are more resistant to weight gain when they overeat. Researchers measured how the body burns calories when 203 healthy participants fasted or ate double their usual calories on different diets (like high-protein or high-fat). The goa…

This study aimed to understand if community-led programs could help people in Appalachian Kentucky eat more fruits and vegetables and have more reliable access to food. Researchers worked with a local advisory board to design and test nutrition programs, focusing on lower-income …

This study aimed to understand if the way people perceive sounds they make themselves differs in women with obesity compared to healthy-weight women. Researchers tested whether self-made sounds seem quieter than identical sounds made by someone else, and if working cooperatively …

This study aimed to understand if lean and obese people feel thirst and handle water deprivation differently. Researchers compared 75 healthy lean and obese men during a 13-day hospital stay, which included a 24-hour period without water. The goal was to gather basic knowledge ab…

This study aims to understand if a person's 'metabolic flexibility'—how well their body switches between burning sugars and fats for energy—predicts their future health. Researchers are bringing back 18 people from a study done 16 years ago to check their current health markers. …

This study aimed to see if a blood test taken before weight loss surgery could predict how well a patient would do afterward. Researchers followed 23 patients who had gastric bypass surgery, checking their blood for a marker called PTX3 beforehand. They then tracked the patients'…

This study looked at whether higher vitamin D levels are linked to a lower risk of metabolic syndrome (a cluster of conditions like high blood pressure and insulin resistance) in older adults who do not have a vitamin D deficiency. Researchers surveyed nearly 2,000 community-dwel…

This study aimed to understand how different workout intensities affect a hormone called ghrelin, which controls hunger and metabolism. Researchers compared high and low-intensity exercise in 40 lean and obese adults, some with prediabetes, to see how it changed hormone levels, a…

This study tested a special 3D camera system to create detailed images of people's torsos. Researchers wanted to see if this safe, radiation-free method could accurately measure body shape in people with conditions like scoliosis or obesity, and in healthy volunteers. The goal wa…

This study aimed to understand why people lose different amounts of weight after bariatric surgery. Researchers compared seven people with severe obesity to healthy-weight individuals, measuring how their bodies processed food before and after surgery. The goal was to gather info…

This study is checking back with mothers and children 12 years after a pregnancy program that tested a healthy diet and exercise plan. Researchers want to see if the program had any lasting effects on weight, health, and metabolism for both the moms and their now-preteen kids. Th…

This study aimed to understand how eating behaviors and food preferences, particularly for high-fat foods, might contribute to obesity. Researchers compared 669 healthy adults from Pima Indian and Caucasian backgrounds using questionnaires and measurements of food intake. The goa…

This study aims to understand if a common HIV medication called dolutegravir causes excess weight gain during pregnancy and affects the long-term metabolic health of both mothers and their children. Researchers will follow about 1,900 pregnant women, some with HIV and some withou…

This study aimed to determine if bone density scan results should be interpreted differently for people with obesity. Researchers measured bone density twice in 120 participants with obesity, grouping them by body mass index. The goal was to see if the standard measurement thresh…

This study aimed to understand if a breathing disorder linked to obesity makes things worse for people's fitness and daily life. Researchers compared 64 people with obesity, some with and some without the specific breathing condition. They measured how far people could walk, thei…

This study aimed to understand how the COVID-19 lockdowns affected people's health behaviors. Researchers tracked nearly 5,000 adults in France who were already part of a weight-loss program. They measured changes in weight, sleep, stress, and activity levels before, during, and …

This study aimed to understand why people eat less fatty and sugary foods after weight-loss surgery. Researchers examined 50 obese patients before and six months after surgery to see if the operation changed their taste buds and how they perceive fat. They collected tiny samples …

This study aimed to understand the role of a brain chemical called 26RFa, which is linked to hunger, in obesity and type 2 diabetes. Researchers measured levels of this hormone in 62 obese women (some with diabetes, some without) before and after weight-loss surgery, and compared…

This study aimed to understand how a low-fat meal and taking a drug in the evening affect how the body absorbs and processes a new drug called KAI-7535. It involved 18 healthy adults who were living with obesity or overweight. The main goal was to gather basic safety and drug-lev…

This small pilot study tested whether a standard MRI scan could accurately detect brown fat in healthy adults. Researchers compared MRI results against PET scans, which are considered the best current method. The goal was to find a simpler, safer way to measure brown fat for futu…

This study aimed to understand how a 12-month lifestyle program affects body fat and specific gene activity in adults with metabolic syndrome. Researchers followed 50 participants, tracking their weight, body composition, and blood markers at the start, 6 months, and 12 months. P…

This study aimed to find out how often obese patients having weight-loss surgery experience difficulty when doctors need to place a breathing tube for anesthesia. Researchers observed 1,290 patients to measure how common this problem is and what factors make it more likely. The g…

The main purpose of this study is to evaluate the efficacy and safety of tirzepatide for the maintenance of body weight reduction.