OBESITY

This early-stage trial tested a new vaccine against Group B Streptococcus (GBS) in 90 healthy adults aged 55 to 75. Participants received three doses of the vaccine or a placebo, and researchers monitored safety and immune response for six months. The goal is to see if the vaccin…

This study investigates whether cryolipolysis, a non-invasive fat freezing technique, can lower inflammatory markers in obese postmenopausal women. Participants are women aged 50-60 with a BMI of 30-40. The treatment is applied to the lower belly for 30 minutes, and researchers m…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study investigates whether adding whole-body electrical muscle stimulation (WB-EMS) to a calorie-restricted diet improves body composition and metabolic health in women with obesity. Participants follow an 8-week diet plan, with half also receiving twice-weekly 20-minute WB-…

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. One group received weekly group sessions on diet and activity, while the other got extra health information and classes. Researchers tracked weight ga…

This study tested a new injectable drug called ASC30 in 115 adults with obesity. The goal was to check its safety, how the body processes it, and its effect on weight. Participants received either the drug or a placebo, and researchers monitored side effects and weight changes ov…

This study tested a new medicine called survodutide (BI 456906) to see if it helps people with overweight or obesity and type 2 diabetes lose weight. Over 750 adults received either the drug or a placebo injection once a week for about 76 weeks, along with diet and exercise advic…

This phase 2 study tested a new drug called eloralintide (LY3841136) for weight management in 263 adults with obesity or overweight. Participants received either the drug or a placebo for about 64 weeks. The main goal was to see how much weight they lost after 48 weeks. Results w…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This trial investigates whether adding hypnosis sessions to standard dietary monitoring can help people lose weight after bariatric surgery has not worked. About 25% of patients do not achieve lasting weight loss from surgery alone. The study enrolls 60 adults aged 18-65 with obe…

This completed Phase 1 trial tested how the experimental drug maridebart cafraglutide (AMG 133) is absorbed when given as two different injections. 348 adults with overweight or obesity received a single dose. The main goal was to measure drug levels in the blood, not weight loss…

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis treatment (ixekizumab) helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 250 adults will receive either ixekizumab alone or both drugs together for…

This study tests a new, non-surgical weight loss method called endoscopic Gastric Mucosal Ablation (GMA). It uses a thin tube and heat to treat the stomach lining, aiming to help people with obesity lose weight. The study involves 15 participants and will follow them for up to 12…

This study looks at whether using a continuous glucose monitor (CGM) alongside standard nutrition and activity advice can improve metabolic health in young people aged 11 and older who have prediabetes and are overweight. Participants wear the CGM intermittently to see how daily …

This study tested a new, non-surgical weight loss technique called Gastric Mucosal Ablation (GMA) in 13 people with class III obesity. The procedure uses a device to carefully burn the stomach lining, aiming to mimic the hormonal effects of weight-loss surgery. The main goal was …

This small pilot study tested the safety of a swallowable intra-gastric balloon (IGBalloon) for weight loss in 5 people with obesity. Participants swallowed up to 5 balloons over 8 weeks, with regular check-ups including blood tests and endoscopies. The study also looked at weigh…

This pilot study tested whether a combination of phentermine and topiramate, two drugs used for weight loss, could help shrink uric acid kidney stones in obese people with type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to receive the drug combo or c…

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to…

This study looked at whether giving protein supplements after sleeve gastrectomy surgery helps patients keep their muscle mass while losing weight. 90 obese adults who had the surgery took part. Researchers measured changes in lean body mass and other health markers over 5 weeks.

This study tested a new once-weekly injection called MET097 in 133 adults with obesity or overweight and type 2 diabetes. The goal was to see if it helps with weight loss and blood sugar control compared to a placebo. Participants received either the drug or a placebo for 28 week…

This completed study tested a remote, self-guided lifestyle program for 696 veterans with obesity and obstructive sleep apnea. Participants watched videos, completed handouts, and tracked their eating and activity, with optional coaching. The goal was to see if this low-cost appr…

This study tested whether a school-based gardening, nutrition, and cooking program could help low-income Hispanic children eat more vegetables and maintain a healthy weight. Over 3,000 students in 16 Texas elementary schools took part, with some schools getting the program and ot…

This Phase 3 study tested a new drug called IBI362 (mazdutide) against the well-known semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. Participants received weekly injections for 32 weeks, with some continuing for an extra 24 weeks. The main goal was to s…

This study tested whether a diet focused on low-energy-density foods (like fruits, vegetables, and broth-based soups) helps people maintain weight loss better than simply counting calories. 345 adults with obesity were followed for 22 months. Researchers measured changes in weigh…

This study tested a new medicine called HS-20094 to help overweight and obese adults lose weight. About 600 people took either the drug or a placebo for up to 48 weeks. The main goals were to see how much weight they lost and how many lost at least 5% of their starting weight.

This phase 3 trial tests whether a daily oral drug called orforglipron can help people with obesity or overweight maintain weight loss they achieved with injectable tirzepatide or semaglutide. About 376 participants who completed a prior weight-loss study will receive orforglipro…

This study tested whether a telemedicine program for children with obesity works better than standard in-person care. 100 children aged 10-18 were split into two groups: one received most of their care through video calls, and the other had monthly in-person visits. The main goal…

This early study tested a single injection of a new drug called ENT-03S in 49 people who were either obese but otherwise healthy, or had both obesity and type 2 diabetes. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigne…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested whether two experimental drugs, AZD9550 and AZD6234, given together as weekly shots, help people with obesity or overweight lose more weight than a placebo or either drug alone. 377 adults aged 18-75 with a BMI of 27 or higher and at least one weight-related hea…

This study tested a new drug called MET097, given as a weekly injection, to help adults with obesity or overweight lose weight. 239 participants received either MET097 or a placebo for 28 weeks. The main goal was to see how much weight people lost compared to those on placebo. Re…

This study tested three different diet plans in 108 overweight adults with type 2 diabetes to see which best improves blood sugar control. Participants followed either standard nutrition advice, a structured meal plan with special diabetes drinks, or that same structured plan plu…

This Phase 2 study tested a once-daily pill called RGT001-075 in 267 adults who are obese or overweight with weight-related health problems like high blood pressure or sleep apnea. The goal was to see if the drug helps with weight loss and is safe. Participants took either the dr…

This completed Phase 2 study tested different doses of CX11 tablets against a placebo in 250 overweight or obese adults. Participants took the pill once daily with meals for 36 weeks, followed by a 2-week safety check. The main goal was to see how much weight people lost and whet…

This study tested whether a combination of two weight-loss drugs, phentermine and topiramate, could help 100 teens with severe obesity keep weight off after losing it through a meal replacement program. The goal was to see if the medication could counteract the body's natural ten…

This study tested a lifestyle program to help pregnant women with obesity maintain their weight and lose body fat during pregnancy. About 100 women in early pregnancy took part, receiving either the program or standard care. The goal was to see if the program could improve mother…

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in …

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This study tested a new magnetic device (MagDI System) that creates a connection between two parts of the small intestine without staples or stitches. The goal was to help adults with obesity and type 2 diabetes lose weight and control blood sugar. Twenty-seven participants recei…

This study tested if limiting when you eat (time-restricted eating) helps families lose weight. 36 pairs of one parent and one child (ages 3-9) with obesity were assigned to either eat only within a 10-12 hour window each day or to follow standard diet advice. The program lasted …

This study tested a 6-month peer-led weight loss program called TOPS (Take Off Pounds Sensibly) in 116 older African American women with obesity. Participants attended dietitian-facilitated classes, while a waitlist group received the program later. The goal was to see if this co…

This early-phase trial tested a new drug called XW003 in 48 Chinese teenagers with obesity. The main goal was to check safety and how the body processes the drug, while also tracking weight changes. Participants received either the drug or a placebo injection. Results will help d…

This study tested whether giving small weekly cash incentives (up to $300 total) for tracking what you eat and losing weight helps adults with obesity shed pounds. Over 700 participants were followed for 18 months. The goal was to see if these rewards lead to at least 5% weight l…

This study tested a mental strategy called WOOP (Wish, Outcome, Obstacle, Plan) to help veterans with obesity lose weight. Over 400 veterans were split into two groups: one got the VA's standard weight program (MOVE!) plus WOOP, the other got MOVE! alone. The goal was to see if a…

This study tested a new surgical technique called FundoRing, where the surgeon wraps the unused part of the stomach around the new stomach pouch during gastric bypass. The goal is to improve weight loss and reduce bile reflux compared to the standard bypass. One thousand adults w…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This pilot study tested a 4-month program that combines weight loss strategies with stress management techniques for Black breast cancer survivors who have obesity and high stress. The program is based on the Diabetes Prevention Program and includes 16 sessions. Researchers measu…

This study tested four simple 'nudge' strategies to see if they could get college students to pick sugar-free drinks over sugary ones. Over 1,600 students were shown drink menus with different nudges, like showing sugar content or health warnings. The goal was to see if these gen…

This study tested the Bright Bodies program, a family-based lifestyle intervention for children ages 7-13 with obesity. The program includes nutrition education, behavior modification, and exercise sessions. Researchers measured changes in BMI and other health outcomes across thr…

This study tested a once-daily medication called LY3549492 to help adults with obesity or overweight lose weight. About 288 participants took either the drug or a placebo for around one year. The main goal was to see how much weight they lost and how safe the treatment was.

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if th…

This study tested whether adding a weekly semaglutide injection to a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar in people with type 2 diabetes who are overweight. About 573 adults took part for roughly 11 months. The goal was…

This study tested whether training older high school students as peer mentors could help younger teens become more physically active. Over 500 students from Appalachian high schools took part, comparing a peer-mentored program to a teacher-led one. The goal was to see if the ment…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study tested a daily oral semaglutide tablet (50 mg) for weight loss in 667 adults with overweight or obesity. Participants took the pill or a placebo for 68 weeks, along with diet and exercise advice. The main goals were to measure percentage weight loss and how many people…

This study tested whether taking a probiotic called Hafnia alvei HA4597 can help people lose more weight and control blood sugar better after gastric bypass surgery. 49 adults with obesity and type 2 diabetes took either the probiotic or a placebo twice a day for 90 days, startin…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at whether adding a second drug (mibavademab) to the weight-loss medication tirzepatide helps adults with obesity lose more weight than tirzepatide alone. About 392 participants with a BMI between 30 and 40 took part. The goal was to measure changes in body weig…

This study looked at whether a low-carb, high-fat ketogenic diet with fewer calories can reduce inflammation and improve blood sugar control in prediabetic obese adults aged 18 to 40. Ninety participants were split into three groups: a keto diet, a normal diet with fewer calories…

This study tested whether giving Hispanic teenagers a Fitbit and sending them text messages could help them be more active and sleep better. The goal was to reduce their risk of type 2 diabetes. 43 teens aged 14-16 with obesity took part. The study measured how many teens joined,…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with overweight or obesity lose weight. About 300 adults took part, receiving either CagriSema or a dummy shot once a week for around 1½ years. The main goal…

This study tested a new medicine called survodutide for weight loss in 274 Japanese adults with obesity and related health problems like diabetes or high blood pressure. Participants received weekly injections of survodutide or a placebo for about 1.5 years, along with diet and e…

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much weight people lost and if at least 5% of body …

This study tests a medicine called survodutide in adults with overweight or obesity and a liver condition called NASH. Participants receive weekly injections of survodutide or a placebo for about a year, along with diet and exercise advice. The goal is to see if the drug reduces …

This study tested a new drug called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. About 85 adults took either the drug or a placebo for 44 weeks, along with diet and exercise. The main goal was to check safety and side effects, while also measuri…

This completed Phase 3 trial tested a high 7.2 mg weekly dose of semaglutide (a drug already used for diabetes and weight loss) in 512 adults with obesity and type 2 diabetes. Participants received either the high dose, a lower dose, or a placebo, along with lifestyle counseling.…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose more weight and improve their metabolism. A total of 110 people aged 25-35 with a BMI of 24 or higher took part. The results will help guide better dieta…

This study tested a new drug called Mazdutide to help adults with obesity or overweight lose weight. 179 participants took either the drug or a placebo for about 62 weeks. The main goal was to see how much weight they lost after 32 weeks, with a focus on safety and effectiveness.

This completed Phase 3 trial tested a high dose (7.2 mg weekly) of semaglutide, a drug already used for weight loss, in 1407 adults with obesity. Participants received the drug or a placebo, plus lifestyle advice. The main goal was to measure weight loss from start to 72 weeks. R…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested two versions of a low-calorie Mediterranean diet, each with different carb and fat levels, combined with moderate aerobic exercise in 36 adults with obesity and fatty liver disease (NAFLD). The goal was to see if one diet plan worked better than the other at red…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested a new drug called enicepatide (CT-388) given as a weekly injection for 48 weeks. It involved 469 adults with obesity or overweight who also had at least one weight-related health problem like high blood pressure or prediabetes. The goal was to see how much weigh…

This study tested a new medicine called NNC0519-0130, given as a weekly injection, to see if it helps people with excess body weight lose weight. About 354 adults with overweight or obesity received different doses of the drug, a placebo, or an existing weight-loss drug for up to…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-12) manage their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly group coaching. The main goa…

This completed study looked at 226 adults who had lost at least 15% of their body weight while taking GLP-1 medications like Wegovy or Ozempic. Participants stopped their GLP-1 drug and were given either bupropion-naltrexone or bupropion-naltrexone-metformin, plus behavioral supp…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps overweight adults lose weight and improve their gut bacteria. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, cholesterol, and …

This study tested a new weekly injection (HD1916) similar to semaglutide for weight loss in 462 obese adults without diabetes. Participants received the drug for 44 weeks, and researchers measured how much weight they lost and any side effects. The goal was to see if this treatme…

This study compared two behavioral weight-loss programs in 321 adults with obesity and elevated blood pressure. One program taught maintenance skills before weight loss, while the other focused on losing weight first. Participants were followed for three years to see who could lo…

This study tested a device that uses self-forming magnets to create new connections in the gut. It was done in 28 adults with severe obesity who had already had weight-loss surgery but did not lose enough weight. The goal was to see if the device is safe and works as intended. Th…

This completed Phase 2 study tested an experimental pill called HRS9531 in 166 adults with obesity. Participants took either the drug or a placebo daily for 26 weeks. The main goal was to see how much weight they lost compared to those on placebo.

This completed Phase 1 trial tested a new drug called NNC0519-0130 in 134 overweight or obese adults. The goal was to see if different ways of increasing the dose could reduce side effects. Participants received weekly or twice-weekly injections for about 24 weeks. The study focu…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This completed study tested whether a high-intensity medical weight loss program, supported by a digital platform and continuous glucose monitors, could help people with type 2 diabetes lose weight and achieve remission. 64 participants were enrolled and compared to a group recei…

This study tested whether a probiotic called Lactobacillus gasseri could help overweight women manage their weight and balance sex hormones. Over 12 weeks, 110 women took either the probiotic or a placebo. Researchers measured changes in estrogen levels and body fat. The goal was…

This study tested a weight management program for young adult cancer survivors (ages 18-39) who have obesity and are within 5 years of finishing cancer treatment. The program combined healthy eating, physical activity, and symptom management to help reduce cardiovascular disease …

This early-stage study tested a new medicine, NNC0519-0130, in 20 overweight or obese Chinese men. The goal was to see how the drug moves through the body and if it is safe. Participants received either the drug or a placebo for about 28 weeks. This is not a cure, but aims to hel…

This study tested whether a new medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of the two drugs alone, or a pl…

This study tested whether personalized health planning delivered in shared medical appointments could help adults with obesity lose weight. Eleven motivated patients aged 30 to 60 with a BMI between 35 and 50 took part. The approach combined individual health plans with group sup…

This study tested whether the drug tirzepatide, given once weekly, can help people with obesity or overweight maintain weight loss they achieved during a prior diet period. About 441 participants took either tirzepatide or a placebo for 60 weeks. The goal was to see if the drug c…

This study looked at a procedure called endoscopic sleeve gastroplasty, which reduces stomach size using a flexible tube through the mouth. 75 adults with obesity who had trouble losing weight with diet and exercise alone took part. The goal was to see how much weight they lost a…

This study tested a new weekly injection called petrelintide to help people with obesity or overweight (plus related health issues) lose weight. About 493 participants received either the drug or a placebo, along with diet and exercise advice, for 28 weeks. The main goal was to s…

This study compared two types of gastric bypass surgery for obesity to see which one leads to fewer problems like acid reflux and stomach ulcers. Two hundred adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method is safer and more effective …

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This study tested a 100-day weight management program in 140 overweight adults. The program included meal replacements, protein and fiber supplements, probiotics, diet plans, exercise, and counseling. Researchers measured weight loss and health changes to see if the program is sa…

This study tested whether adding a diabetes drug (polyethylene glycol loxenatide) to a hormone-releasing IUD (LNG-IUS) helps women with a precancerous uterine condition called endometrial atypical hyperplasia. The 30 participants were all obese and wanted to preserve their fertil…

This study tested a workplace weight loss program for employees of a hospital who were obese (BMI 27 or higher). Over 500 participants used the So99 app to track healthy eating and exercise as part of a team competition. The goal was to see if the app helped people lose weight an…

This study tested a new medicine called survodutide (BI 456906) to help people with obesity or overweight lose weight. Over 700 adults without type 2 diabetes received either the drug or a placebo injection once a week for about a year and a half, along with diet and exercise adv…

This study checks whether survodutide, a new weight-loss injection, affects heart rhythm in 110 overweight or obese adults. Participants receive survodutide or placebo for about 30 weeks, with heart tests before and after. The goal is to see if the drug is safe for the heart, not…

This study looked at whether taking spirulina supplements along with cutting calories can help obese men lose weight, lower cholesterol, and improve how their body uses insulin. Thirty-five men took either spirulina or a placebo for 30 days while following a reduced-calorie diet.…

This study compared time-restricted eating (eating only during a 6-8 hour window each day) to daily calorie restriction for weight loss and blood sugar control in 32 adults with type 1 diabetes and obesity. Participants followed their assigned diet while continuing insulin and gl…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This completed phase 4 trial tested whether a rapid weight loss program using semaglutide (Ozempic/Wegovy) plus a very low calorie diet can help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the skull causes headaches and vision proble…

This early-stage study tested an oral drug called orforglipron in 120 adults with obesity or overweight (but without diabetes). The goal was to see how it changes body fat compared to a placebo over about 8 months. Researchers measured fat around organs, appetite, and weight. Thi…

This study tested a two-part approach to help employees lose belly fat and improve insulin sensitivity: a workplace ban on sugary drinks and a single counseling session. Over 600 full-time employees who drank at least three sugary beverages a week took part. Researchers measured …

This study looked at whether tiny plastic particles (microplastics) we encounter daily might contribute to obesity and gut problems. Researchers gave 96 overweight or obese adults either a probiotic supplement or a placebo to see if the probiotic could reduce the harmful effects …

This study tested a daily 25 mg semaglutide pill in 307 adults with overweight or obesity over 64 weeks. Participants taking the drug lost more weight than those on placebo, with many achieving at least 5% body weight reduction. The pill offers a convenient alternative to injecti…

This study compared two types of weight loss surgery in 80 adults with severe obesity. The goal was to see which surgery leads to better weight loss, improves health problems like diabetes and high blood pressure, and has fewer complications. Participants were followed after surg…

This study tested whether sending specific motivational messages at just the right moment helps young adults with overweight or obesity meet their daily weight loss goals. Over 200 participants used a smartphone app with a weight loss program, and some received extra messages tar…

This study tested a new medicine called NNC0487-0111 for weight control in 36 Chinese adults with overweight or obesity. Participants received either the drug or a placebo injection. The main goal was to check safety and how the drug moves through the body. The trial lasted up to…

This study tested whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than the traditional approach of cutting calories every day. Over one year, 165 adults followed either an intermittent fasting plan or a daily calorie goal…

This study tested whether Garcinia cambogia rind powder, a dietary supplement, can improve weight, blood sugar, and cholesterol in 90 pre-diabetic obese adults aged 30-60. Participants took the powder daily for 12 weeks. The goal was to see if it helps control metabolic problems …

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested a GLP-1 drug (a type of medication that affects appetite) against a placebo in 96 adults with obesity. The goal was to see if the drug could reduce cravings, hunger, stress, and food intake. Results suggest the drug may help control eating behaviors and support …

This study tested a new experimental drug called CagriSema (a combination of cagrilintide and semaglutide) against the existing drug tirzepatide for weight loss in 809 adults with obesity. Participants received weekly injections for about a year and a half. The goal was to see if…

This study tested a new daily pill called PF-07976016 in 263 adults with obesity. Participants received either the active drug or a placebo for several weeks. Researchers measured weight changes and tracked any side effects to see if the drug is safe and helps with weight loss.

This study tested a new daily injection called CT-868 in 103 overweight or obese adults with type 2 diabetes. Participants received either the drug or a placebo for 26 weeks. The main goal was to see if CT-868 could lower blood sugar levels (HbA1c) and help with weight loss.

This completed phase 2 trial tested different doses of the drug GV101 against a placebo for weight loss in 131 healthy adults with obesity. The main goal was to see how much weight participants lost after 16 weeks. Researchers compared the average weight change in each dose group…

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This early-stage study tests a new drug called eloralintide, alone or combined with tirzepatide, in 188 adults with overweight or obesity. The main goals are to check safety, side effects, and how the drugs move through the body. Participants receive weekly injections under the s…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection, for weight loss in 1200 adults who are overweight or obese and have type 2 diabetes. Participants received either CagriSema or a placebo for about 1…

This study tested a probiotic supplement made from pasteurized Akkermansia bacteria in 61 overweight or obese adults. Participants took either the probiotic or a placebo for 12 weeks while following a low-carb diet. The goal was to see if the supplement helped with weight loss, b…

This study tested a weekly injection of semaglutide (2.4 mg) in 207 adults with obesity and prediabetes. Participants received either the drug or a placebo for 12 months, plus lifestyle advice. The goal was to see how much weight they lost and whether their blood sugar returned t…

This study looked at whether liraglutide, a drug used for diabetes and weight loss, can help people who are still obese 6 months after metabolic surgery lose more weight. 100 participants received liraglutide injections for 24 weeks along with diet and exercise guidance. The goal…

This completed trial tested whether a heat-killed probiotic called Akkermansia muciniphila Akk11 could help overweight or obese adults lose weight and improve their metabolism. 61 participants took either the probiotic or a placebo capsule daily for 12 weeks, while following a lo…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This study tested a culturally-tailored program called HARMONY for African American women at risk for heart disease, stroke, and diabetes. Over 8 sessions plus monthly boosters, participants learned stress management, exercise, and healthy eating. The goal was to see if the progr…

This study looked at whether a once-weekly medicine called semaglutide (used for weight loss and diabetes) can lower the risk of heart attacks, strokes, and death in people with overweight or obesity. Researchers analyzed medical records of over 285,000 people in the US. The goal…

This study tested whether limiting food intake to an 8-hour daily window (time-restricted eating) works as well as reducing daily calories by 15% for weight loss. 115 obese adults with insulin resistance participated for 12 weeks. Researchers measured changes in weight, body fat,…

This study tested a new medicine called CagriSema (a mix of two drugs) in 331 East Asian adults with obesity or overweight. Participants received a weekly injection for about 1.5 years. The main goal was to see how much weight they lost compared to another drug. The study is comp…

This study tested a behavioral weight loss program designed for college students ages 18-25 with overweight or obesity. The program used a 'small change' approach to help students lose weight and keep it off. 42 students took part, and the study focused on whether students liked …

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This study looked at whether losing weight through a controlled diet, along with a regular exercise program, can improve fitness in obese older adults. 180 sedentary people aged 60 and older with a BMI between 30 and 35 took part. The goal was to see if more fat loss leads to gre…

This phase 2 study tested three different doses of a new injectable drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults who were overweight or obese, some with type 2 diabetes. The main goal was to see how much weight participants lost over 52 weeks. The…

This study looked at whether eating only between certain hours (a 10-hour window each day) and choosing foods that are less calorie-dense (fewer calories per bite) can help older adults with obesity and insulin resistance. Forty participants followed this eating pattern, and rese…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested a special stapler during a combined weight-loss and anti-reflux surgery called Nissen Sleeve. It involved 167 people with obesity and GERD. The goal was to see if the surgery reduces acid reflux and if the stapler works safely.

This study tested a mobile app that helps small corner stores in low-income Baltimore neighborhoods order and sell more healthy foods like fruits and vegetables. About 310 stores and customers took part. The goal was to see if the app could make healthier options more available a…

This study tested how well semaglutide (Wegovy) helps people with obesity lose weight compared to four other approved weight loss medications. About 500 employees from three US companies took part. The goal was to see which drug works best for weight loss and improves quality of …

This study tested a new powered stapler (ECHELON 3000) in 244 people having either stomach reduction surgery or lung surgery. The goal was to see if the stapler is safe and works well. Researchers tracked serious problems like infection, bleeding, or air leaks after surgery.

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested a new weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help Chinese adults with obesity or overweight lose weight. About 300 participants received either CagriSema, semaglutide alone, or a placebo for around one year…

This study tested whether a combination of naltrexone and bupropion can reduce binge-eating episodes and promote weight loss in people with binge-eating disorder and obesity. Participants took either the drug combo or a placebo for 12 weeks. The trial was very small, with only 3 …

This phase 2 trial tested whether adding an experimental drug (NNC0165-1875) to the weight-loss medication semaglutide helps people with obesity lose more weight. 120 adults with a BMI between 30 and 45 took part. Participants received either the drug combo or semaglutide plus a …

This early-phase study tested a single injection of a new drug called AMG 133 (Maridebart Cafraglutide) in 20 overweight or obese Chinese adults. The main goal was to see how the drug moves through the body and to check for any safety issues. This is a first step to see if the dr…

This study tested whether adding peer support and online education helps college students manage their weight and improve their mood. Researchers enrolled 216 full-time students aged 18-25 with a BMI of 24 or higher and randomly assigned them to one of three groups: standard heal…

This completed study looked at the safety and effectiveness of the weight-loss drug Saxenda (liraglutide) in 300 obese adults and teenagers in Taiwan. Participants took the drug as part of their normal care for about 26 weeks. The main goal was to track any side effects and see h…

This study looked at whether giving people personalized lifestyle advice based on their genetic test results (SNP testing) helps them lose more weight than standard advice. Overweight or obese Korean adults were followed for about 17 months. The goal was to see if tailoring diet …

This study tested whether a special fiber supplement, combined with a healthy Mediterranean diet and lifestyle changes, could improve gut bacteria and metabolic health in children with obesity. 36 children aged 8-14 took part for 8 months. The goal was to see if this approach cou…

This completed phase 3 trial tested whether a lifestyle program (diet and exercise) plus the drug metformin could reverse frailty and sarcopenic obesity in 114 older veterans aged 65-85. Participants followed a weight-loss diet and exercised three times a week, while taking metfo…

This study tested whether adding green tea extract to standard metformin treatment can improve insulin resistance in obese children aged 10-18 with prediabetes. 90 participants were split into two groups: one received metformin alone, the other added green tea extract three times…

This study tested a 3-month remote program for people who regained at least 10% of their weight after sleeve gastrectomy. The program included a team of experts and supportive text messages to boost happiness and well-being. 100 participants were split into two groups: one receiv…

This early-stage study tested a new medicine, NNC0519-0130, given as a weekly injection to help people with obesity or type 2 diabetes. The main goals were to check for side effects and measure how the drug moves through the body. 82 participants were randomly assigned to get eit…

This study tested whether a weekly injection of semaglutide (2.4 mg) helps Asian adults with obesity (BMI 25 or higher) lose weight. About 150 participants received either the drug or a placebo for 44 weeks, along with diet and exercise advice. The main goal was to see how much w…

This early study tested a new medicine, NNC0519-0130, in 161 people to see if it is safe and how it works in the body. The medicine aims to lower blood sugar and reduce appetite, which could help people with type 2 diabetes and overweight. Participants received either the medicin…

This study tested a new magnetic system (MagDI) that creates a shortcut in the small intestine to help with weight loss and blood sugar control in adults with obesity and type 2 diabetes. Ten participants received the procedure to see if it is safe and works as intended. The goal…

This study tested a new magnetic system that creates a shortcut in the small intestine to help people with obesity and type 2 diabetes. Fifteen adults aged 18-65 with a BMI of 30-35 and diabetes took part. The goal was to see if the device could safely create a lasting connection…

This study looked at whether a gut bacterium called Akkermansia muciniphila and a natural compound called berberine can help manage prediabetes in obese adults. 110 overweight or obese people with prediabetes were given either the bacterium, berberine, or a placebo for 12 weeks. …

This study tested a new magnetic device that creates a connection between two parts of the small intestine, bypassing some of the digestive tract. The goal was to see if this procedure is safe and feasible for adults with obesity and type 2 diabetes. Only 9 people took part, and …

This study tested whether the drug RDX-002 can lower high blood fat levels in people who recently stopped taking weight-loss medications like semaglutide or tirzepatide. Sixty-eight adults who had lost at least 10% of their body weight on those drugs took either RDX-002 or a plac…

This study compared two types of weight-loss surgery in 256 adults with severe obesity. The goal was to see if a newer, simpler surgery (Omega Loop bypass) works as well as the standard Roux-en-Y gastric bypass, with fewer side effects. Participants were followed for two years to…

This study tested whether a Fitbit activity tracker combined with virtual health coaching could help people on weight loss medications (GLP-1/GIP) become more active. Fifteen participants wore a Fitbit and had up to six coaching sessions over 12 weeks. The main goal was to see if…

This Phase 1 trial tested a new drug called ASC47, given as a shot under the skin, combined with the weight-loss drug semaglutide in 28 adults with obesity. The study was double-blind and placebo-controlled, meaning some participants got a dummy shot. The main goal was to check s…

This study tested a 24-week program that combines WeightWatchers behavioral coaching with prescription GLP-1 medications like Wegovy, Mounjaro, or Zepbound. 180 adults with obesity or weight-related conditions participated. Researchers measured weight loss and related outcomes at…

This study tested a new daily pill called AZD5004 for weight loss in 310 adults with obesity or overweight who also had a weight-related health problem like high blood pressure. Participants took either the drug or a placebo for 36 weeks. The main goal was to see if the drug help…

This study tested a new medicine called AZD6234, given as a weekly shot, to help people with obesity or overweight lose weight. About 262 adults took part for 36 weeks. The goal was to see if the drug leads to greater weight loss compared to a placebo, especially for those with w…

This study tested whether the drug lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapse. 61 participants who initially responded to treatment were randomly assigned to receive LDX or a placebo for 12 weeks. The main goal was to see if LDX re…

This study looked at whether having a peer coach (a trained person like you) helps people with obesity lose more weight than trying on their own. 375 adults aged 21-75 with a BMI between 30 and 50 took part. The main idea was to see if coach support leads to greater weight loss t…

This study tested whether adding food vouchers or home-delivered groceries to a standard weight-loss program helps adults with obesity and food insecurity lose more weight. 105 participants were split into three groups: standard program alone, program plus grocery gift cards, or …

This study tested two weight loss programs in 223 overweight or obese adults aged 21-75. One group followed a fixed calorie reduction plan, while the other varied their calorie intake. The goal was to see which approach leads to more weight loss over time.

This completed Phase IIa study tested a daily pill called ASC30 in 125 adults with obesity or overweight who also had weight-related health problems. The goal was to see if the drug helps with weight loss and is safe. Participants received either ASC30 or a placebo for up to 13 w…

This study tested a 12-month healthy lifestyle program for 112 youth aged 8-18 with serious emotional disturbance who were overweight or obese. Participants worked with a health coach to improve diet and physical activity, with parents involved. The goal was to see if this approa…

This study tested whether giving extra support—like cooking classes, motivational talks, and financial help for physical activity—to overweight teens from less advantaged backgrounds helps them manage their weight as well as standard care helps teens from more advantaged backgrou…

This study tested an online personalized program for pregnant women with obesity to help them gain the right amount of weight and reduce the need for delivery interventions like C-sections or forceps. Over 800 women participated, using a secure website to communicate with dietiti…

This study tested whether a weekly injection of semaglutide (2.4 mg) helps teenagers with overweight or obesity lose weight. 201 teens aged 12 to 18 took part, receiving either semaglutide or a placebo for about 15 months, along with lifestyle counseling. The main goal was to see…

This early-stage trial tested a new drug called maridebart cafraglutide (AMG 133) in 110 adults with obesity. The main goal was to see if the drug is safe and tolerable when given as a single dose or multiple doses. Researchers also measured how the drug moves through the body. T…

This early-stage trial tested an experimental drug called BI 3006337 in 64 adults who are overweight or obese and have fatty liver disease. Participants received weekly injections of either the drug or a placebo for about 4 months. The main goal was to check safety and tolerabili…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study tested whether taking a daily probiotic called Bifidobacterium longum for one month could improve skin barrier damage in people with obesity. 140 participants took either the active probiotic or an inactive placebo. The researchers measured skin water loss and checked …

This study tested whether a healthy eating (Mediterranean diet) and exercise program started before pregnancy could help obese women lose 5-7% of their weight and improve health for both mother and baby. Researchers enrolled 99 women who had a previous baby and were planning anot…

This completed phase 3 trial tested two injectable weight loss drugs, tirzepatide and semaglutide, in 751 adults with obesity or overweight who also had weight-related health problems like high blood pressure. The study lasted about 74 weeks and measured how much weight participa…

This completed study compared two popular diets for weight loss in 120 obese adults. One group followed intermittent fasting (eating only between 1 PM and 9 PM), while the other followed a traditional Mediterranean diet. Both diets cut about 500 calories per day. The goal was to …

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a modestly reduced-calorie diet, helps overweight or obese adults (with or without type 2 diabetes) lose more weight and improve blood sugar and fat levels compared to a placebo. 46 participants wer…

This study tested whether a drug called bromocriptine, which boosts dopamine in the brain, can help people with obesity lose weight. The key twist: the drug's effect may depend on a person's genetic makeup, specifically a gene called FTO. 120 obese adults were given either bromoc…

This completed study tested whether the diabetes drug semaglutide (Rybelsus) could help 60 adolescent girls with PCOS and obesity reduce liver fat and improve insulin sensitivity, compared to a weight loss diet. Participants took a daily oral tablet for 4 months or followed a pre…

This completed study looked at how three different diet plans—Mediterranean diet, time-restricted feeding (a form of intermittent fasting), and a standard diet—affect eating behavior and weight management in 75 overweight or obese adults aged 20-49. Researchers measured body comp…

This study looked at whether teaching women about the Mediterranean diet and sustainable nutrition could help them lose weight and improve body measurements like BMI and body fat. Sixty-two women with overweight or obesity took part. The goal was to see if this education leads to…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug is designed to increase growth hormone levels, which may help reduce liver fat and inflammation. Researchers measured changes in liver fat using special scans an…

This study tested whether using technology for remote check-ins helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part. The main goal was to see if their body mass index (BMI) improved after 15 months.

This study tested whether a virtual coach delivered through MyChart helps obese patients lose weight before ventral hernia surgery. Researchers compared the virtual coach to standard weight loss tools in 32 patients. The goal was to see if the coach leads to more weight loss and …

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce fat in the liver and improve heart health in adults with obesity. 187 people took part. The goal was to see if the combination works better …

This study looked at whether having a live-in support partner helps Veterans lose more weight. 300 Veterans with obesity joined a 72-week weight management program, either with a partner or alone. The goal was to see if teamwork leads to better weight loss and maintenance.

This study tested a surgery that combines two procedures to help people with obesity and type 2 diabetes lose weight and control their blood sugar. 18 adults aged 19-65 with a BMI between 35 and 50 took part. Researchers measured weight loss and metabolic changes over time.

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check safety and side effects, and to measure how the drug moves through the body. Participants were randomly assigne…

This study looked at the long-term safety and effectiveness of the drug HRS-7535 for weight management in 81 adults with obesity who had already completed a 36-week treatment course. Participants took the drug for an additional 32 weeks to see how well it helped maintain weight l…

This study tested a new drug called PB-119, given as a weekly injection, in 32 Chinese adults with obesity. The main goal was to check safety and how the body processes the drug, but researchers also looked at weight loss. Participants were randomly assigned to receive either PB-…

This study tested whether a special nerve block (erector spinae plane block) could reduce the chance of lung collapse after weight-loss surgery. 138 patients having laparoscopic bariatric surgery were randomly assigned to receive either the nerve block or standard pain medicine. …

This study looked at whether giving vitamin D supplements to obese teenagers, along with a healthy diet and exercise program, could improve how well their blood vessels work. 49 teens took either vitamin D or a placebo for 90 days. The main goal was to see changes in blood vessel…

This study tested a smartphone app called ANíMATE designed to help people with obesity better manage their weight and health. 36 adults with obesity used the app for 16 weeks alongside standard care, while a control group received standard care alone. The goal was to see if the a…

This study tested whether an 8-week circuit exercise program could improve markers of inflammation in overweight young women. Twenty-two women aged 20-30 were randomly assigned to either the exercise program or their usual routine. The exercise group showed increases in a benefic…

This study tested a new drug called NNC0487-0111, given as an injection under the skin, to see if it is safe and how it works in the body. It included 125 adults aged 18-55 who were overweight or obese. The goal was to help manage weight, but ongoing treatment may be needed.

This study tested a program called HALO for mothers who had weight-loss surgery and have school-aged children (ages 6-12) at risk for obesity. The program gave mothers education and parenting tips to encourage healthy eating and physical activity in their kids. Researchers measur…

This study tested a lifestyle program called HEALTH, which teaches healthy eating and active living through home visits, to help overweight mothers prevent weight gain and lose weight. Over 600 participants took part in this Phase 3 trial. The program was delivered by trained par…

This study tested an experimental drug called VTX3232, given alone or with the weight-loss drug semaglutide, in 176 adults with obesity. The main goal was to check safety and side effects over 12 weeks. Researchers also measured changes in inflammation levels. The trial is comple…

This study tested two phone-based programs to help people maintain weight loss after an initial diet. 255 adults with obesity first lost at least 5% of their body weight, then were randomly assigned to either a standard monthly check-in or an adaptive program that called more oft…

This study tested whether an online family skills training program is practical and well-liked for Black adults trying to lose weight. 21 participants joined with a family member. The program focused on healthy eating and activity habits.

This study tested a new weight loss program called Med-South, which adapts the Mediterranean diet for Southern tastes, against the popular WW (Weight Watchers) program. Over 360 adults with obesity participated for 2 years, with researchers tracking weight loss, blood markers, an…

This study looked at whether deep brain stimulation (DBS) in a brain area called the lateral hypothalamus could help control severe obesity. Three people who already had DBS electrodes implanted took part. Researchers measured changes in their metabolic rate to find the best stim…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight. The app tracked diet and activity as part of a behavioral weight loss program. The goal was to see if this approach was practical and well-liked by participants. The study involved 6…

This early-stage trial tested the safety of a new drug called AMG 786 in 65 healthy adults and people with obesity. Participants received either the drug or a placebo tablet, and researchers monitored for side effects and how the drug moves through the body. The goal was to see i…

This study tested a 3-month lifestyle program, delivered by Pasifika community health workers, to help Native Hawaiians and Pacific Islanders with conditions like diabetes, high blood pressure, and obesity. The program included healthy eating and activity tips plus support for so…

This study tested whether lifestyle coaching delivered through a patient portal helps adults maintain weight loss. 269 participants who had already lost at least 5% of their body weight were randomly assigned to receive either coaching plus tracking tools or tracking tools alone …

This study tested a weight loss program for African American adults in Petersburg, VA, using informal house chats instead of a clinic setting. The goal was to see if this approach could help people eat better, move more, and lose weight. Twenty-two participants took part, and the…

This study tested whether combining two endoscopic procedures—Hybrid Argon Plasma Coagulation (HAPC) and Endoscopic Sleeve Gastroplasty (ESG)—is safer and more effective than ESG alone for weight loss. The trial included 45 adults with obesity (BMI 30–40) who had not succeeded wi…

This early-stage trial tested a new drug called CT-388 in 129 overweight or obese adults, including some with type 2 diabetes. The study aimed to check the drug's safety and how the body processes it, while also measuring weight loss and blood sugar changes. Participants received…

This study tested whether a probiotic called Bifidobacterium breve can help healthy overweight adults lose fat when combined with exercise. About 95 participants took either the probiotic or a placebo for 12 weeks. Researchers measured changes in body fat using X-ray scans to see…

This early-stage study tested whether adding a new drug (LY3841136) to an existing weight-loss medication (tirzepatide) is safe and tolerable. 96 healthy overweight or obese adults took part over about 42 weeks. The main goal was to check for side effects, not to prove weight los…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The strategies included portion-controlled meals, enhanced self-monitoring with technology, and a tailored lifestyle program called GLB-SCI. The goal was to…

This completed Phase 1 trial tested an experimental drug called AMG 133 in 120 adults with overweight or obesity. Participants received multiple doses of the drug or a placebo to see how the body processes it and to check for safety issues. The study did not aim to measure weight…

This study tested an experimental daily pill, VK2735, to help adults with obesity or overweight (plus a weight-related health issue) lose weight. About 280 participants took either the pill or a placebo for 13 weeks. The main goal was to see how much weight they lost and if the p…

This study tested whether intermittent fasting (eating only within a 4-hour window each day) can improve how well the pancreas makes insulin in people with early type 2 diabetes. 51 adults with type 2 diabetes and obesity took part. The goal was to see if this eating pattern coul…

This study tested whether eating only during an 8-hour window each day (time-restricted eating) helps young adult survivors of childhood cancer manage their weight. Thirteen survivors participated to see if this approach is safe, doable, and acceptable. The goal is to reduce obes…

This completed trial tested a personalized program of physical activity, nutrition guidance, and education for 128 adults with Prader-Willi syndrome. Participants followed the program during a 5-week hospital stay, with the goal of stabilizing or reducing their body mass index (B…

This study compares a newer weight-loss surgery called SADI-S to an older, more complex one called BPD-DS in 62 adults with severe obesity. The goal is to see if SADI-S is safer and just as effective for long-term weight loss and managing related health problems like diabetes. Re…

This study tested a new, non-surgical technique called Gastric Mucosal Ablation (GMA) to help people with obesity lose weight. The procedure uses a tool called HybridAPC to remove a thin layer of stomach tissue, which may affect hormones that control weight. Fifteen participants …

This study looked at whether sharing digital self-monitoring data—like weight, steps, and calories—with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. About 320 participants used a wireless scale and Fitbit to track their progre…

This study tested an experimental injection called GZR18 in 340 Chinese adults who are obese or overweight. The goal was to see if it helps with weight loss over 30 weeks compared to a placebo. Participants also followed a stable diet and exercise plan. The results will show how …

This study tested if a 1-year text messaging program, with or without monthly calls from a community health worker, could help 316 public housing residents in Boston lose weight. Participants were split into three groups: text messages only, texts plus phone coaching, or a contro…

This study tested whether alternate day fasting (eating only 600 calories on fast days) combined with regular aerobic exercise can reduce liver fat in people with non-alcoholic fatty liver disease (NAFLD). Eighty obese adults aged 18–65 with NAFLD participated. The goal was to se…

This study tested whether giving tranexamic acid (TXA) during weight-loss surgery reduces bleeding. 132 adults having sleeve gastrectomy received either TXA or a placebo right after anesthesia. The results showed that TXA lowered blood loss during and after surgery, without incre…

This early-stage study tested a new drug called LY3437943 in 85 people with obesity. Participants received either the drug or a placebo, and researchers measured how many calories they ate and how their bodies used energy. The goal was to see if the drug could help control appeti…

This study tested a new medicine called NNC0662-0419 in 100 adults who are overweight or obese. The main goal was to check if the drug is safe and how the body handles it. Participants received either the drug or a placebo as a weekly injection under the skin. This is the first t…

This study followed 1,581 adults with metabolic syndrome who had bariatric surgery (gastric bypass or sleeve gastrectomy). Researchers tracked weight, blood pressure, blood sugar, and cholesterol for up to 10 years to see if surgery provides lasting health benefits. The goal is t…

This study looked at whether a three-month diet and exercise program before IVF could improve live birth rates in overweight and obese women. 197 women were randomly assigned to either the weight loss group or a control group. The goal was to see if losing weight beforehand leads…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This completed Phase 2 trial tested whether enobosarm, an experimental oral drug, can prevent muscle loss in older adults (aged 60+) who are taking GLP-1 receptor agonists like Wegovy for chronic weight management. The study enrolled 168 participants and measured changes in lean …

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This study tested the safety and tolerability of a new drug called IBI362 in 36 Chinese adolescents aged 12 to 17 with obesity. Participants had not lost much weight through diet and exercise alone. The trial was randomized, double-blind, and placebo-controlled, meaning some got …

This early-phase study tested an oral tablet called ecnoglutide in 87 healthy adults. The drug is a GLP-1 analogue, similar to existing injectable treatments for type 2 diabetes and obesity, but designed to be taken by mouth. The main goal was to check safety and how the body pro…

This study looked at how a weekly injection of semaglutide (2.4 mg) affects appetite, eating behavior, and mood in 120 adults with obesity. All participants also received lifestyle counseling on diet and exercise. The goal was to see if semaglutide reduces calorie intake and impr…

This study tested whether a daily psychobiotic supplement (a mix of friendly bacteria) plus a weight-loss diet could improve mental health, quality of life, and body measurements in 28 obese women over 4 weeks. Participants were randomly assigned to receive either the supplement …

This completed Phase 2 trial tested whether colchicine, an anti-inflammatory drug, can improve insulin resistance in 152 adults and adolescents with obesity. Participants took either colchicine or a placebo daily for 12 weeks. The study measured changes in insulin resistance and …

This study tested whether a diet rich in boron (found in nuts, dried fruits, and legumes) could improve health in 40 obese adults, compared to a standard Mediterranean diet. Over four weeks, researchers measured changes in body mass index, gut bacteria, appetite hormones, and cho…

This pilot study tested whether pea protein can help people with obesity preserve muscle mass while losing weight, compared to whey protein. Sixty adults aged 30 to 50 followed a weight loss regimen and took either pea protein, whey protein, or a non-protein control. Researchers …

This study tested a weekly injection of semaglutide (a drug used for type 2 diabetes and weight loss) in 115 adults with type 1 diabetes and obesity who already use an automated insulin pump. The goal was to see if adding semaglutide helps improve blood sugar levels, reduce hypog…

This completed study tested whether a probiotic called Akkermansia muciniphila Akk11 can help people with obesity lose weight. Over 12 weeks, 106 participants took either the probiotic or a placebo. Researchers measured changes in body mass index (BMI) and also looked at inflamma…

This study looked at whether drinking a strawberry beverage every day for four weeks could improve cholesterol, blood sugar, and other heart health markers in overweight or obese adults. Forty-eight participants with borderline-high cholesterol and normal to slightly elevated blo…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver disease and its severe form, NASH, without needing a liver biopsy. Researchers enrolled 158 people at high risk for metabolic syndrome. The LLIFT test combines patient information lik…

This study tested whether MRI can detect brown adipose tissue (brown fat) as accurately as PET scans, which use a radioactive tracer. Eight healthy adults had both scans under mild cold conditions. The goal is to see if MRI, which avoids radiation, could replace PET for brown fat…

This study tested whether encouraging water instead of sugary drinks in childcare centers helps prevent obesity in young children. Over 1,000 preschool-age children and their families took part. The program included better access to healthy drinks at daycare, plus education and c…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study looked at whether a Mediterranean diet, weight loss, or both could lower colorectal cancer risk in 180 obese African Americans aged 45-75. Participants followed one of four plans for six months, and researchers measured changes in bile acids, gut bacteria, and cell act…

This study tested whether offering free summer day camps with physical activity, enrichment, and meals could reduce unhealthy weight gain in 651 first- to third-graders from low-income households. The camps removed cost barriers that often lead to sedentary time and poor diet dur…

This study tested a 1-year online program designed to help adults aged 40-70 who are at risk for heart disease become more physically active. Participants either received a fitness tracker plus online coaching and goal-setting sessions, or just a fitness tracker with standard act…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus providing bottled water at home, can lower obesity risk in Hispanic mothers and their infants. Over 200 mother-infant pairs were randomly assigned to one of three groups: …

This study tested a group prenatal care program called TLC for obese women at high risk for gestational diabetes. Over 300 women joined small groups led by a healthcare provider and learned about nutrition, exercise, and healthy habits. The goal was to see if this approach could …

This study tested whether taking a daily supplement of lactoferrin (a protein found in milk) can help prevent iron deficiency anemia in pregnant women with obesity. 23 women at risk for anemia took part from mid-pregnancy through labor. The main goal was to see if the approach wa…

This pilot study tested a 12-week telehealth lifestyle program for Black adolescent girls with obesity who are at risk for type 2 diabetes, along with their female caregivers. The program included weekly group wellness sessions (mindfulness, nutrition, dance) and home cooking exp…

This study tested a 12-week wellness program for 98 overweight university employees. The program included brisk walking, nutrition education, and a mobile app for self-monitoring. Researchers measured changes in body fat, muscle mass, waist size, and fitness. The goal was to see …

This study tested a program to help pregnant women with overweight or obesity avoid gaining too much weight. The program included setting goals, tracking weight, learning skills, and getting support from WIC counselors. 416 women from Philadelphia WIC took part, and researchers m…

This completed study tested a health program to prevent obesity in 500 healthy children aged 6 to 12 living in Gharbia, Egypt. The program included dietary and lifestyle guidance, and researchers tracked changes in weight, height, BMI, and blood tests. The goal was to see if a sc…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower their blood sugar as effectively as a program led by a human coach. About 368 adults with prediabetes and overweight took part. The goal was to see which approach …

This study tested a 6-month home-based program for 300 children ages 2–6 who were overweight or obese. Community health workers visited families to encourage healthy eating, physical activity, and parenting skills. The goal was to see if the program could improve children's weigh…

This study tested whether a mindfulness-based training program could help adults who had lost weight keep it off. 48 participants, including those who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The goal was to see if focusing on eating …

This study looked at whether an educational program for pregnant women who are overweight or obese could help prevent their babies from gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits. The goal was to reduce th…

This study tested whether adding a special 'pre-session'—which includes education about diabetes risks, motivational interviewing, and help solving barriers—could encourage more people to attend a national diabetes prevention program. The trial involved 483 adults at risk for dia…

This study is testing a mobile app that gives weekly suggestions to help people with binge eating and obesity. The goal is to see which suggestions work best and in what order. About 300 adults who binge eat regularly and have a BMI of 30 or higher are taking part. The app tracks…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study tested whether a special lung-opening maneuver during anesthesia can reduce breathing problems and oxygen needs after weight-loss surgery. Researchers studied 230 obese patients undergoing bariatric surgery. Half received the extra lung-opening procedure, while the oth…

This study tested whether a 12-week home-based circuit training program could improve blood vessel function and metabolism in adults with obesity. Twenty-nine participants were randomly assigned to either the exercise group or a control group that continued their usual activities…

This study tested a self-help tool called EMBER to see if it helps veterans with obesity engage in VA weight management programs. 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers tracked whether participants used weight management servi…

This study tested whether using a lower amount of fresh gas during anesthesia (low-flow) could reduce lung collapse (atelectasis) after laparoscopic weight-loss surgery. Sixty adults were randomly assigned to receive either low-flow or normal-flow anesthesia. The researchers meas…

This study tested two methods to strengthen the staple line during weight-loss sleeve surgery: using medical glue (cyanoacrylate) or a piece of the patient's own belly tissue (omentum). Seventy adults aged 18-65 with obesity took part. The goal was to see which method better prev…

This study looked at whether taking soluble dietary fiber supplements can improve sperm quality in men with obesity. 74 men took either fiber or a placebo for a period. The goal was to see if fiber could help with sperm movement, shape, and count, which are often poor in men with…

This study tested a dietary supplement called WM Formula in 20 adults with high body fat. The supplement aims to increase GLP-1, a hormone that helps control blood sugar and appetite. Participants took the supplement or a placebo and had blood tests over several hours. The study …

This study tested whether adding a patient coach helps older adults with obesity follow their weight and health plan. 19 participants worked with a coach to address barriers to diet and physical therapy goals. The study measured how many attended appointments, achieved goals, and…

This study tested whether the herb Salacia chinensis, known to slow sugar absorption, can help control appetite and blood sugar in overweight or obese adults. Fifty-one participants took either a low or high dose of the herb or a placebo with a meal. Researchers measured appetite…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women were split into an exercise group and a control group. The exercises focused on core strength and abdominal endurance. Researchers measured lung functio…

This study looked at 290 people having laparoscopic sleeve gastrectomy (a weight-loss surgery) to see which method of reinforcing the staple line works better to prevent leaks. One method uses titanium clips, the other uses suturing and omentopexy (tacking the omentum over the st…

This study tested a new video laryngeal mask airway (SaCoVLM™) in 57 morbidly obese patients undergoing bariatric surgery. The device helped doctors place a breathing tube on the first try in most cases. The goal was to see if it is safe and effective for this group of patients.…

This study tested whether following a very low calorie diet before bariatric surgery helps patients lose more weight and feel more satisfied. 85 adults who were eligible for surgery took part. Researchers compared the very low calorie diet to standard dietary advice.

This study tested two types of balance training—whole body vibration therapy and balance board exercises—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which approach worked better. The goal was …

This study tested a weight management program called MOVE!+UP, designed specifically for veterans with PTSD who are overweight or obese. The program adds extra support to standard PTSD care to help overcome barriers like stress and unhealthy habits. Researchers compared it to the…

This study tested a 6-week group program combining nutrition education with psychological sessions based on Well-Being Therapy in 50 adults with obesity. The goal was to see if improving mental health could lead to healthier, more sustainable eating and weight loss. Participants …

This study compared two ways to find the right spot for spinal anesthesia in 100 obese women having C-sections. One group used ultrasound to guide the needle, the other used traditional touch-based landmarks. The goal was to see which method leads to a successful first attempt, r…

This study tested whether using a nerve block at one or two spots on the back (erector spinae plane block) provides better pain relief after laparoscopic weight-loss surgery. Sixty obese adults were randomly assigned to receive either a one-level or two-level block along with gen…

This completed study tested whether semaglutide, a drug used for type 2 diabetes and weight loss, could improve sleep apnea in 15 people with diabetes or obesity. Researchers measured breathing pauses during sleep (AHI) after 1 and 4 weeks of treatment. The goal was to see if the…

This study compared two types of pain blocks—MTP and ESPB—for people having laparoscopic sleeve gastrectomy (weight loss surgery). 52 adults with a BMI of 35 or higher took part. The goal was to see which block better reduces pain after surgery using a standard pain scale.

This study tested whether a short educational video watched before bariatric surgery could lower patients' fear and improve their recovery. Fifty-one adults having weight-loss surgery were randomly assigned to either watch the video or receive standard care. Researchers measured …

This study looked at whether adding special breathing training to aerobic exercise helps people with obesity. 45 adults aged 25-60 with a BMI between 30-40 took part. The goal was to see if this combination improves body composition, heart health, breathing, and exercise ability.

This pilot study tested whether a remote digital exercise program (Vitala app) is feasible and helpful for adults with obesity and poorly controlled asthma. Twenty participants received a tailored exercise prescription and were encouraged to complete 150 minutes of activity per w…

This study tested if it's safe for people with obesity to go home the same day after a specific type of gastric bypass surgery (FundoRing method) instead of staying overnight. 200 adults were randomly assigned to either same-day or one-day discharge. Researchers tracked complicat…

This study tested whether adults who have bariatric sleeve gastrectomy (a type of weight-loss surgery) can safely recover at home instead of in the hospital. Twenty-eight participants received acute care at home, including nurse and doctor visits, lab tests, and 24/7 urgent suppo…

This study tested if using warm saline (body temperature) to rinse the stomach staple line during laparoscopic sleeve gastrectomy could reduce early bleeding after surgery. 200 adults having weight-loss surgery were randomly assigned to receive either warm or room-temperature sal…

This study looked at whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers tested three specific skills: awareness, acceptance, and values clarity, to see …

This study tested a wearable ear device that sends gentle electrical pulses to a nerve to help control appetite. 60 healthy adult women each had two visits: one with the device on and one with it off. Researchers measured how much they ate, their hunger levels, and food cravings.…

This study tested whether adding magnesium sulphate to the standard painkiller bupivacaine improves pain control after laparoscopic sleeve gastrectomy. Sixty-eight adults undergoing the surgery received either the combination or bupivacaine alone. The goal was to see if the mixtu…

This study tested an 8-week psychoeducation program combining cognitive behavioral therapy and motivational interviewing in 81 adults with obesity. The goal was to reduce emotional eating and increase psychological resilience. Participants were assessed before, right after, and 3…

This study looked at whether a nerve block called an erector spinae plane block can reduce pain and stress after sleeve gastrectomy surgery. Sixty patients were randomly assigned to receive the block or not, and their pain scores, painkiller use, and stress markers were compared.…

This completed pilot trial tested whether adding a low-carb, high-protein diet (like Atkins) helps people lose more weight while taking the injectable drug semaglutide. 60 overweight or obese adults were randomly assigned to follow either a low-carb or low-fat diet for 3 months. …

This study looked at whether limiting eating to a 6- or 10-hour window each day helps adults who recently lost weight keep it off. 29 participants were randomly assigned to one of two time-restricted eating plans for 12 weeks. The goal was to see if this approach is practical and…

This study looked at whether walking downstairs is a good exercise for obese women who don't exercise much. Twenty-four women did stair walking twice a week for 8 weeks. The researchers measured changes in cholesterol, blood sugar, and body fat to see if this simple activity coul…

This study followed 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and overall quality of life, including bette…

This study looked at whether dry needling, a treatment where thin needles are inserted into muscles, can improve insulin resistance in obese women who have gone through menopause. 52 women took part. The main goal was to see if the treatment lowered a key measure of insulin resis…

This early-stage study tested a new drug called LY3532226 in 132 people with obesity to see if it is safe and how the body processes it. Participants received weekly or monthly doses, and researchers monitored side effects and drug levels in the blood. The goal was to gather safe…

This phase 3 study tested a weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it reduces knee pain and helps with weight loss. Participants received either the drug or a placebo for about…

This study tested the safety of a new drug called LY3841136, given alone or with another drug (tirzepatide), in 128 Japanese adults who are obese or overweight. Researchers monitored side effects and how the body processes the drugs over several months. The goal was to see if the…

This study looked at whether brain gym exercises can lower the risk of falling and improve balance and quality of life in obese adults. 32 participants aged 18-50 with a BMI of 30 or higher took part. The exercises focused on mental and physical coordination to help with stabilit…

This study compared two ultrasound-guided nerve block techniques—erector spinae plane block and modified thoracoabdominal nerve block—for pain control in 40 obese patients undergoing laparoscopic sleeve gastrectomy. The goal was to see which method delays the need for rescue pain…

This completed phase 1 trial tested whether CagriSema, a combination of two drugs (cagrilintide and semaglutide), can reduce how much people with overweight or obesity eat, curb their appetite, and slow stomach emptying. 62 participants received either CagriSema or a placebo for …

This completed Phase 1 study tested how CagriSema (a combination of cagrilintide and semaglutide) affects appetite and brain activity in 164 adults with overweight or obesity. Participants received either the drug, a placebo, or no medicine, and researchers measured appetite scor…

This study tested whether a 12-month weight loss program delivered by smartphone, using behavioral economics tricks, could help economically disadvantaged adults lose weight. 195 participants with obesity and low income were split into two groups: one got the standard mobile prog…

This study tested two types of nerve blocks—erector spinae plane block and thoracic paravertebral block—to see which one provides better pain relief after laparoscopic sleeve gastrectomy. Thirty adults having weight-loss surgery received one of the two blocks, and researchers mea…

This study tested if a cream with live good bacteria (Lactobacillus crispatus) could improve skin barrier damage in people with obesity. 98 adults aged 18-40 with a BMI of 25 or higher applied the cream or a placebo to their forearms daily for 4 weeks. The main goal was to see if…

This study tested whether a short therapy program before weight-loss surgery helps patients develop healthier eating habits. About 94 adults preparing for bariatric surgery took part. The goal was to see if the program could improve long-term results by addressing emotional eatin…

This study looked at whether GLP-1 analogues (like Ozempic or Wegovy) combined with lifestyle changes can improve sexual desire in overweight or obese men and women. 85 participants were followed to measure changes in sexual thoughts, activity, and overall sexual health. The goal…

This study looked at whether a simple hand massage can lower anxiety and boost comfort in people who had bariatric (weight-loss) surgery. Ninety adults took part, and researchers measured their anxiety and comfort levels after the massage. The goal was to see if this gentle touch…

This study tested a 20-week program for teens ages 13-17 who struggle with weight stigma and negative feelings about their weight. The goal was to see if the program was acceptable and helpful when added to a standard weight management program. 17 teens took part, and researchers…

This early-stage study tested a new drug called AZD5004 in 45 Chinese adults who were overweight or had obesity, with or without type 2 diabetes. The main goal was to check if the drug is safe and how the body processes it, compared to a placebo. Participants took the drug or a d…

This study looked at the safety of giving lidocaine through a vein during weight-loss surgery. Fifty adults having laparoscopic bariatric surgery received lidocaine, and their blood levels were measured at several points. The goal was to confirm that using a dose based on adjuste…

This study tested whether using virtual reality glasses for discharge education helps patients better care for themselves after bariatric surgery. Sixty adults who had laparoscopic weight-loss surgery were split into two groups: one received standard care, the other watched a 15-…

This study looked at whether a six-week home program combining music with progressive muscle relaxation could improve sleep, fatigue, emotional symptoms, and quality of life in 20 sedentary obese women. Participants did the exercises on their own using phone apps. The goal was to…

This completed Phase 1 trial tested whether MitoQ, a drug that targets cell energy centers, can improve airway reactivity in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo daily for 12 weeks. The study aimed to see if MitoQ could help control …

This study tested whether taking a high dose of vitamin D3 daily for 12 weeks could improve muscle strength and mass in older adults with obesity. Researchers enrolled 29 participants aged 60 and older in southern Mexico. They measured handgrip strength, muscle mass, and physical…

This study looked at whether a weekly injection of semaglutide (a medicine also used for weight loss) can improve heart failure symptoms and daily function in people with obesity-related heart failure. 529 adults with a BMI of 30 or higher took part. Participants received either …

This study tested whether whole-body vibration (standing on a vibrating platform) can help overweight and obese university students lose weight and improve body composition. Thirty-two students aged 18-25 with a BMI of 25 or higher took part. Half stood on a real vibrating device…

This study tested whether Emotional Freedom Technique (EFT), a therapy that involves tapping on specific body points, could reduce kinesiophobia (fear of movement) and pressure sore risk in 148 adults who had obesity surgery. Participants received EFT sessions, and researchers me…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This completed trial tested whether a nerve block called erector spinae plane block (ESPB) can reduce pain and opioid use in super obese patients (BMI over 50) after laparoscopic bariatric surgery. Sixty participants received either the ESPB or standard local anesthetic at the in…

This study tested whether an 8-week ketogenic or Mediterranean diet could reduce inflammation in 26 adults with obesity, psoriasis, and psoriatic arthritis. Participants followed one of the two diets, and researchers measured skin severity (PASI score) and joint activity (DAPSA s…

This study looked at whether a regular stretching routine could improve heart health in pregnant women with obesity. 224 women were assigned to either a stretching program or usual care (moderate exercise). The researchers measured blood pressure and other heart-related markers f…

This study tested whether a daily probiotic powder could relieve irritable bowel syndrome (IBS) symptoms in 80 obese adults. Participants took either the probiotic or a placebo for 8 weeks. Researchers tracked symptom relief and changes in gut bacteria.

This completed Phase 3 trial tested whether a weekly injection of semaglutide (2.4 mg) could help people with obesity and knee osteoarthritis lose weight and reduce knee pain. 407 participants received either semaglutide or a placebo, along with diet and exercise advice, over 68 …

This study tested whether tradipitant, an oral capsule, can reduce nausea and vomiting in healthy overweight or obese volunteers who also received a GLP-1 receptor agonist (a class of weight-loss drugs). 124 participants were randomly assigned to tradipitant or a placebo. The mai…

This study tested a home-based lifestyle program for people with severe obstructive sleep apnea and severe obesity. The program used a tablet and sensors to track sleep, diet, and exercise, along with regular calls from a health coach. The goal was to see if people could use the …

This study tested two video-guided devices (CMAC D-Blade and CMAC Video Stylet) in 150 obese adults undergoing bariatric surgery. The goal was to see which device allows doctors to place a breathing tube more easily and safely on the first try. Participants had a higher risk of d…

This study tested whether showing people a 3D virtual model of their body changes could help them stick to a Mediterranean diet. 133 adults with overweight or obesity followed a diet for 6 months. Some also saw their body's progress in virtual reality. The goal was to see if this…

This study tested whether receiving daily text messages with weight loss advice helps people lose weight. 120 adults with obesity were split into two groups: one got standard group support, the other got daily texts. The goal was to see if the text group could lose as much weight…

This study tested whether the 4-7-8 breathing technique (breathe in for 4 seconds, hold for 7, out for 8) can help with pain, nausea, and vomiting after bariatric surgery. Sixty patients were split into two groups: one practiced the breathing technique hourly, the other received …

This study tested whether delivering healthy meals to the homes of low-income women with obesity could help them manage weight after giving birth. Eleven women received 10 meals per week plus remote support. The goal was to see if the program was practical and acceptable, not to …

This study looked at whether lumbar traction therapy (a device that gently pulls on the spine) can reduce pain and improve function in people with obesity and chronic low back pain. 49 participants received 30 minutes of traction daily for 4 weeks. Researchers measured pain, disa…

This pilot study tested whether laparoscopic sleeve gastrectomy, a common obesity surgery, can be safely performed as a day-case procedure without an overnight hospital stay. Thirty adults with obesity were enrolled, and researchers measured how many patients needed unexpected ad…

This pilot study tested whether a weight loss program before total knee replacement helps improve recovery. 24 adults with obesity (BMI 35-40) were assigned to either a very low-calorie diet with health coaching or standard care. The goal was to see if the program was feasible an…

This pilot study tested whether shared medical visits (group doctor appointments) plus cooking classes help people manage their weight. 43 adults with obesity from a weight management center were randomly assigned to either group visits with cooking classes or online modules abou…

This study tested a 4-hour acceptance and commitment therapy (ACT) workshop in 52 women with obesity. The workshop taught skills like clarifying values and taking committed action to support healthy eating and physical activity. Researchers measured changes in psychological flexi…

This study tested whether an 8-week mindful eating group could help people who had bariatric surgery eat better and feel better. Forty-five participants attended group sessions and filled out questionnaires about their eating, mood, and anxiety. The goal was to see if this approa…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 participated. The goal was to understand why some people are more resistant to gai…

This study looked at how being in different temperatures (from about 61°F to 88°F) affects how many calories healthy adults burn. Researchers also checked for brown fat activity, a type of fat that burns energy to keep you warm. 104 healthy men and women stayed in a hospital unit…

This completed study looked at how lean and obese individuals respond to thirst and water deprivation. Researchers gave 75 healthy men a high-salt infusion and a 24-hour water fast, measuring their thirst, hormone levels, and water intake. The goal was to understand if body fat a…

This Phase 1 study in 40 overweight or obese adults examined how a new drug called HRS-7535 interacts with four common medications: acetaminophen (pain reliever), digoxin (heart medication), rosuvastatin (cholesterol drug), and omeprazole (acid reflux treatment). Participants too…

This study used ultrasound to measure the optic nerve sheath (the lining around the eye nerve) in 56 adults having laparoscopic bariatric surgery. The goal was to see how brain pressure changes during surgery due to gas inflation and body positioning. No drug or treatment was tes…

This study looked at whether a time-restricted eating plan (fasting for 16 hours, 2-3 days a week) is feasible and acceptable for older adults aged 65-80 who have mild cognitive impairment and obesity. 33 participants completed the 12-week program, working with a psychologist to …

This study analyzed health records of over 118,000 adults with obesity, type 2 diabetes, and related heart, kidney, and liver conditions. Researchers compared people who added a second type of diabetes drug (GLP-1 or SGLT2) early to those who did not. The goal was to see if early…

This study examined how being obese (BMI over 30) affects hospital outcomes after coronary artery bypass grafting (CABG) in 500 patients with chronic ischemic heart disease. Researchers tracked death rates, neurological injury, kidney injury, breathing machine time, and need for …

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This study tested whether taking tadalafil (Cialis) daily for 12 weeks can change how fat tissue works in obese adults. Researchers used MRI scans and fat samples to measure fat metabolism and gene activity. The goal was to understand if the drug could make fat behave more like c…

This study looks at whether gastric bypass surgery can protect the kidneys of people who are severely obese and have chronic kidney disease. Researchers measured kidney function before and one year after surgery in 14 patients. The goal is to see if the surgery improves the balan…

This study tested whether a pre-filled syringe and a pre-filled pen deliver the same amount of survodutide into the body. Fifty-six healthy or overweight adults received a single dose of each version in random order. Researchers measured drug levels in the blood to see if the two…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study looked at 255 people with severe obesity who had weight-loss surgery. Researchers wanted to see if losing weight could improve liver scarring (fibrosis) by measuring certain blood tests before and one year after surgery. The goal was to understand how weight loss affec…

This study looked at 60 obese adults scheduled for weight-loss surgery. Doctors used an ultrasound before surgery to measure how much food or liquid was still in the stomach, even after fasting. The goal was to see if a higher body mass index (BMI) or longer fasting time was link…

This study tested whether taking salt with breakfast versus dinner changes blood pressure patterns and nighttime salt excretion in 53 obese adults. Participants took salt tablets at different times of day. The goal was to see if timing affects blood pressure rhythms and related h…

This study looked at how Enneagram personality types are connected to body weight, eating behaviors, emotional eating, and overall well-being in 210 adults. Participants completed questionnaires about their personality, eating habits, and mental health. The goal was to better und…

This study looked at how the upper part of the gut (foregut) senses nutrients and controls metabolism in 27 lean and obese adults. Researchers measured hormone and sugar levels after feeding through a tube to understand if faulty gut signals contribute to obesity. The goal was to…

This study tested a special belt that uses electrical currents to measure lung function in 30 obese patients during laparoscopic surgery. The goal was to see if the belt could set the breathing machine pressure better than standard methods. The results may help improve breathing …

This study collects and stores medical data from adults who had robotic bariatric surgery between 2018 and 2019. The goal is to build a database that helps doctors understand how well this type of surgery works for weight loss and related health issues. By analyzing real-world ou…

This study looked at 90 adults who had bariatric surgery to see if changing the variety of foods they ate affected their food cravings, calorie intake, and weight loss over 12 months. Researchers tracked participants' diets to understand patterns that might help improve long-term…

This study looked at how often people eat and whether it affects weight loss. Researchers followed 30 overweight adults aged 18 to 65. They tracked eating habits, calories, and weight to better understand the link between meal timing and losing weight.

This study looked at whether eating foods with fewer calories per bite (low energy density) helps people lose weight. Sixty adults with overweight or obesity followed a 12-week lifestyle program. Researchers tracked what they ate, how full they felt, and weight changes to find th…

This completed study investigated how eating behaviors and food preferences, especially for high-fat foods, contribute to obesity. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake mea…

This study looked at how three different types of dietary advice affect what families eat and their overall health. It involved 45 families with an overweight parent and a child aged 6-12 who was at a healthy weight. Researchers measured changes in diet, body measurements, and pa…

This study looked at whether a single dose of apple cider vinegar, taken with a meal, changes levels of a substance linked to oxidative stress in the blood of adults with obesity. 46 healthy obese adults were randomly assigned to either receive apple cider vinegar with a standard…

This study looked at 53 obese patients having laparoscopic sleeve gastrectomy (weight-loss surgery) to compare two ways of helping them breathe during the operation. One group received standard ventilation support, while the other got a stronger support with higher pressure and e…

This study looked at how diet affects gum health in 200 adults with obesity but no other health conditions. Researchers calculated each person's dietary inflammation score and measured gum health and inflammation markers in blood and gum fluid. The goal was to see if a pro-inflam…

This study looked at how certain gut hormones change after eating a standard meal in 80 adults aged 40-60 with different body weights. Researchers measured hormones like GLP-1 and GIP, which help control appetite and blood sugar. The goal was to understand how these hormone respo…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This study looked at how levels of ghrelin, a hormone that controls hunger, change after eating a standardized meal in 80 adults aged 40-60 with different body weights. Participants drank a nutritional supplement, and their blood was tested over several hours. The goal was to und…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

This study looks at how type 2 diabetes affects young people aged 12 to 25. Researchers want to see if giving the pancreas a 2-week rest with insulin shots can improve its ability to make insulin. Participants take metformin, follow a diet, and some also get insulin. The study al…

This study looked at whether obesity increases the body's production of oxalate, a substance that can lead to kidney stones. 58 adults without a history of kidney stones ate a special low-oxalate diet for 4 days and provided urine samples. Researchers measured oxalate levels to s…

This study used MRI to examine how the brain and gut communicate after eating different types of drinks in people with obesity and healthy weight. Researchers gave participants a high-fat drink or a carbohydrate drink and scanned their brains and stomachs. The goal was to develop…

This completed study followed 687 people who had bariatric surgery (gastric bypass or sleeve gastrectomy) in Norwegian public hospitals between 2010 and 2015. Researchers aimed to see how long weight loss lasts and whether related health problems like diabetes, high blood pressur…

This completed study from Purdue University looked at whether GLP-1 receptor agonists (like Ozempic or Wegovy) change how people taste, smell, and crave food. Researchers compared 90 adults with obesity who were either not taking the drug, or had been taking it for about 1 month …

This study tested whether tirzepatide, a weight-loss drug, could change certain markers in the blood, breast tissue, and mammograms that are linked to breast cancer risk. It included 25 women with obesity and other breast cancer risk factors. The goal was to see if the drug might…

This study looked at whether saliva can be used to measure endocannabinoids—natural chemicals linked to appetite and weight—instead of taking blood. Researchers compared 12 obese and 12 normal-weight adults after fasting. The goal was to see if saliva levels differ between the gr…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at 216 women aged 18-45 to see if weight affects bladder symptoms, hygiene habits, and body awareness. Researchers compared normal-weight women to those who are overweight or obese using questionnaires. The goal was to understand how these factors relate and to …

This study measured levels of a hormone called pregnenolone and related compounds in the blood of 25 men—some with obesity and some at a healthy weight. Researchers wanted to see if a breakdown in the body's natural feedback loop might lead to overactivity of the endocannabinoid …

This study looked at how the body's natural endocannabinoids (similar to cannabis compounds) interact with the stress hormone cortisol in people with Cushing's syndrome, a condition of high cortisol. Researchers measured blood levels of these compounds in 40 participants, includi…

This study tested whether using a special breath test (indirect calorimetry) can help doctors give the right amount of nutrition to critically ill patients with obesity who are on breathing machines. The study involved 60 adults from intensive care units in Australia and New Zeal…

This completed Phase 1 study in 34 adults with overweight or obesity examined whether CagriSema (a combination of cagrilintide and semaglutide) changes how the body processes atorvastatin (a cholesterol drug) and warfarin (a blood thinner). Participants took single doses of atorv…

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at how eating a high-fat diet for 5 days affects inflammation in older adults (ages 50-79) with normal weight or obesity. Researchers measured blood markers and gut bacteria to see if a high-fat diet causes more inflammation than a low-fat diet. The goal was to …

This study looked at whether cycling in a cool room versus a warm room changes how much fat overweight women lose. Thirty women rode a stationary bike three times a week for three months. Researchers measured body fat, waist size, and blood markers to see if temperature makes a d…

This pilot study tested three simple ways to encourage blood sugar screening in 102 overweight or obese adults without known diabetes: a text message, a patient portal message, or a mailed letter. The goal was to see which method was most acceptable and effective at getting peopl…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Vietnam. The program included monthly lessons, videos, and support to improve eating habits and physical activity. Researchers compared these children to a control group to see i…

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find factors that might predict bleeding during or within 30 days after surgery. By identifying these risk factors, doctors hope to create a score that can help pre…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people with obesity and gum disease (stage II or III). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link betw…

This completed trial compared two types of opioid-free anesthesia—total intravenous (TIVA) versus inhaled gas—in 280 adults undergoing laparoscopic bariatric surgery. The main goal was to see which method reduces postoperative nausea and vomiting in the first 24 hours. Researcher…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty to help them lose weight. The goal was to find out why some people lose more weight than others after the procedure. Researchers checked blood samples and medi…

This study looked at whether a ketone supplement drink can change appetite-related hormones in adults with and without obesity. Twenty-six people took part, each receiving the ketone drink on one visit and a placebo on another. Researchers measured hunger and fullness hormones be…

This study looked at whether body contouring surgery (like tummy tucks) after weight loss surgery helps people keep the weight off and affects metabolism. Researchers measured weight and certain blood markers in 60 adults before and after body contouring. The goal was to see if r…

This completed online trial tested whether adding Nutri-Score labels (A to E, like a nutrition grade) to delivery app menus helps people choose healthier meals. 870 adults who regularly use food delivery apps made hypothetical meal choices in a simulated app. The study compared t…

This completed observational study from Karolinska Institutet looked at 312 children and teens with obesity who used a digital treatment tool called Evira at home. Researchers checked their medical records to see if any developed signs of disordered eating or were diagnosed with …

This study looked at whether 3 weeks of alternate-day fasting (eating normally one day, fasting the next) changes how the heart uses fuel compared to a typical Western diet. Sixteen overweight adults aged 55-70 with insulin resistance underwent PET scans and lab tests after each …

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats in people with obesity, type 2 diabetes, and fatty liver disease. Researchers wanted to understand if the body becomes resistant to glucagon in these conditions. A total of 2…

This study looked at 720 Indian teenagers aged 14-16 to understand how their weight (normal, overweight, or underweight) relates to their mental strength, eating habits, physical activity, and overall quality of life. Researchers surveyed students and their parents in Kolkata sch…

This study tested whether sodium phenylbutyrate can lower levels of branched chain amino acids (BCAAs) in the blood of obese and prediabetic men. High BCAAs are linked to insulin resistance and type 2 diabetes. Researchers also looked at how the drug affects blood sugar, insulin …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutritional counseling and physical activity. The program included three diet workshops and weekly exercise sessions. Researchers an…

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at 89 obese pregnant women to find out how common sleep apnea is and whether it is linked to high blood pressure, preeclampsia, or poor fetal outcomes. Participants had a sleep test (polysomnography) to detect apnea. The goal was to understand the connection and…

This study looked at how physical activity relates to quality of life and mental health in 38 adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track sitting, standing, and movement. The goal was to see if simply monitoring activity coul…

This study looked at how salt affects blood pressure in Black adults. Researchers wanted to see if changes in blood pressure from eating more or less salt were linked to signs seen on medical scans. 19 people took part, and the goal was to learn more, not to test a new treatment.

This study looked at how weight loss from a calorie-restricted diet affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet. The goal was…

This completed study collected neck tissue, blood, and urine from 34 adults having neck surgery. The samples are stored in a central bank for researchers to study obesity and diabetes. The goal is to help scientists learn more about these conditions and find new ways to predict, …

This study examined 160 children aged 8 to 10 who were overweight or obese and had signs of smartphone addiction. Researchers measured their sleep habits and body mass index to see if these factors were connected. The goal was to understand the relationship, not to test a treatme…

This study aims to understand why some people gain or lose weight more easily than others. Researchers will measure how the body's energy use changes during overeating and dieting in 83 healthy adults. Participants will stay in the hospital for 10 weeks, undergoing tests like met…

This study looked at whether a special weight-based dose of the antiviral drug acyclovir works properly in people with obesity. Researchers enrolled 13 hospitalized patients (10 obese and 3 non-obese) who were already receiving acyclovir as part of their care. They took blood sam…

This completed study looked at how well doctors can detect serious and non-serious side effects of the weight-loss drug Saxenda (liraglutide) in 27 Mexican patients with obesity. The main goal was to track cases of pancreatitis and other possible drug reactions. Patients took Sax…

This study looked at 76 children aged 8-10 from rural areas to understand why some stay at a healthy weight despite being surrounded by obesity risks. Researchers measured brain activity, eating habits, and body fat to see how kids learn from food cues. The goal is to find factor…

This study tested new paper and electronic checklists that help people describe the foods in their home. The goal was to see if these tools are accurate and easy to use for English and Spanish speakers. 439 adults who do most of the grocery shopping for their home took part. The …

This study looked at how a 20% calorie-restricted diet changes metabolism in obese men of two age groups: 30-40 and 60-70 years old. Researchers measured fat breakdown at rest and during exercise, along with genetic markers in muscle and fat tissue. The goal was to understand if …

This study looked at how common weight-related health problems are in people of different weights in India, Pakistan, Philippines, and Vietnam. Researchers tracked 1,170 adults for about 2 years without giving any treatment. The goal was to understand which weight groups have mor…

This study looked at 44 adults with obesity to see if symptoms of hyperventilation (like rapid breathing and shortness of breath) are linked to physical performance. Participants completed walking, balance, and strength tests, and reported their breathing symptoms. The goal is to…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the link between p…

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This completed study looked at 128 adults with obesity to understand how blood sugar levels, gut bacteria, and brain iron deposits are connected to thinking skills. Some participants followed a diet or had bariatric surgery, but the goal was to observe changes over one year, not …

This study looked at what happens to the body when people with obesity stop following restrictive diets like calorie cutting or intermittent fasting. Researchers measured changes in mitochondria (the cell's energy factories) and gut bacteria in 84 adults over 24 weeks. The goal i…

This completed study looked at whether eating only during a specific daily window (time-restricted eating) can slow the aging process in 176 adults who are overweight or have early fatty liver disease. Participants followed a Mediterranean diet with or without calorie restriction…

This study tested whether a medical body composition scale (mBCA 555) could pick up early changes in body fat, muscle, and water balance in 41 overweight adults using L112 lipid-binding products. The goal was to find signs of progress that appear before the scale shows weight los…

This study used smartphone surveys and Fitbit trackers to figure out what causes people to slip up on their diet and exercise goals during a weight loss program. About 119 adults with overweight or obesity participated in a remote behavioral weight loss program. The goal is to us…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This completed study examined how diet influences inflammation and metabolism in 393 healthy and obese adults. Researchers measured immune cells, hormones, and other markers after participants ate a high-fat meal. The goal was to better understand the complex interactions between…

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured change…

This study looked at why obese people with asthma often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis to examine airway changes in 49 obese adults with asthma. The goal was to better understand the…

This study looked at the genes of 2,500 people who had weight loss surgery (bariatric surgery). The goal was to find out if certain genes are linked to how well the surgery works and if those genes are more common in some ethnic groups. No new treatment was tested; instead, resea…

This study looked at whether giving an antibiotic (piperacillin-tazobactam) as a longer infusion helps people with obesity reach the right drug levels in their blood. It included 45 hospitalized adults with a BMI of 30 or higher. The main goal was to see if a larger study is poss…

This study compared two types of gastric bypass surgery in 40 adults with obesity and type 2 diabetes. Researchers measured changes in gut hormones like GLP-1 to see which surgery better improves insulin resistance and diabetes. The goal was to understand how each surgery affects…

This completed Phase 1 trial looked at whether multiple doses of Survodutide, a weight-loss drug, change how the body absorbs and processes three common drugs: bupropion (an antidepressant), caffeine, and midazolam (a sedative). Thirty-four otherwise healthy adults with overweigh…

This completed study looked at 115 obese patients undergoing hip or heart surgery to see if inflammation in their fat tissue is linked to confusion or memory problems after the operation. Researchers collected blood and fat tissue samples during surgery and tracked patients' thin…

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This study looked at whether a 12-month lifestyle program could lower body fat and change certain gene markers in 26 adults with metabolic syndrome. Participants tracked their food and activity using a mobile app, and had blood tests and body scans at the start and end. The goal …

This study looked at 1500 people with obesity (BMI 25 or higher) to find out what helps diabetes go away and other health issues improve after weight-loss surgery. Researchers collected health data before and after surgery, including weight, blood sugar, and quality of life. The …

This completed study looked at how people change their eating habits after starting GLP-1 drugs like Ozempic or Mounjaro for weight or diabetes. Researchers tracked 37 adults using dietary records and questionnaires to see if it's feasible to study diet changes this way. The goal…

This study looked at 106 people with obesity who were scheduled for weight-loss surgery. Researchers measured how their upper airways behaved during sleep and used MRI scans to see if changes after surgery could explain why some develop obstructive sleep apnea and others do not. …

This study looked at how losing weight through diet changes body fat and metabolic health in 74 adults with excess weight. Participants followed a 12-week low-calorie diet. The goal was to see if losing more fat for the same amount of weight loss leads to better health improvemen…

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study followed about 1,900 pregnant women and their babies for two years to see how HIV and the medication dolutegravir affect weight gain and overall metabolic health. Researchers compared women with HIV to those without, and also looked at differences between women who sta…

This study tested a special stitch device (STRATAFIX Spiral PDS Plus) used in robot-assisted surgeries for weight loss (sleeve gastrectomy) and hysterectomy. 161 adults took part. The main goal was to see how well it controlled bleeding after stitching. Doctors also rated how eas…

This study looked at whether community programs—like cooking classes and building raised-bed gardens—can improve fruit and vegetable intake and food security in Appalachian Kentucky. About 281 adults from Laurel or Pike counties took part. Researchers measured diet quality, food …

This study investigates how obesity affects the way the body processes intravenous immune globulin (IVIG), a treatment for immune deficiencies. Researchers measured body composition and blood levels of IVIG in 40 obese and normal-weight patients to find the best dosing strategy. …

This study looked at how daily rhythms—like sleep and meal timing—affect fat cell genes and insulin response in 28 women with obesity scheduled for bariatric surgery. Researchers used timed lights and meals to align or disrupt the body's internal clock, then measured changes in f…

This study tested whether using a breathing training device (PrO2 Fit) four times a week for 8 weeks could improve cardiovascular health and mood in postmenopausal women aged 50-75. Researchers measured how quickly the women's oxygen use responded during exercise and how far they…

This study follows people who were in the SELECT trial to see how their health changes over the next 10 years. No new medicine is given—participants just fill out a health questionnaire every 6 months. The goal is to learn about long-term effects like heart attacks, cancer, weigh…

This study looked at whether adding a nutrition program to an existing exercise program is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment joined a 12-week program combining diet advice with exercise. The goal …

This study looked at how regular aerobic exercise changes appetite and metabolism in sedentary overweight teenagers. Researchers measured hunger levels and blood markers after a meal, comparing teens who exercised with those who didn't. The goal is to understand if exercise alone…

This study looked at how tasting fatty acids (like linoleic acid) changes levels of gut hormones in healthy people, those with type 2 diabetes, and obese individuals without diabetes. Researchers measured hormone levels in blood after oral stimulation and compared taste sensitivi…

This study looked at 80 obese adults having spine surgery to see if adjusting the breathing machine based on lung stiffness works better than using a fixed setting. The goal was to improve oxygen levels during surgery and reduce lung complications afterward. Researchers measured …

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study tested three different breathing techniques before anesthesia in 75 obese patients to see which one raises oxygen levels fastest and safest. The researchers measured how quickly oxygen reached a safe level in the lungs and checked if the techniques caused stomach bloat…

This study tested whether adding carob to a Western-style breakfast can help regulate hunger hormones and appetite. Twenty healthy, normal-weight men ate a carob-enriched meal, and researchers measured changes in ghrelin (a hunger hormone) and self-reported fullness. The goal was…

This study looked at how safe and effective the easyEndo™ powered stapler is when used in weight-loss surgery. Researchers checked if the stapler worked correctly during and after surgery in 60 patients. The goal was to see if the device is reliable for cutting and sealing tissue…

This study looked at how certain immune cells (eosinophils) interact with fat tissue in people with obesity and insulin resistance. Four participants had fat biopsies and blood tests to measure immune cells and markers of inflammation. The goal was to better understand these inte…

This study examined the relationship between metabolic syndrome and vitamin D levels in 549 older adults (65+). Researchers collected health questionnaires and blood samples to understand how these factors are connected. The goal was to gather knowledge, not to test a treatment.

This early-phase study looked at how a low-fat meal and taking the drug in the evening affect levels of KAI-7535 in the blood. Eighteen healthy adults with overweight or obesity took the drug under different conditions. The goal was to understand the best way to take it, not to t…

This study looked at how weight-loss surgery affects brain chemicals that control appetite. Researchers measured spinal fluid from 51 people before and after gastric bypass or sleeve gastrectomy, and compared them to people who lost weight through dieting. The goal is to understa…

This study looked at how the drug dupilumab changes gene and protein activity in airway cells from adults with asthma and obesity. Researchers compared allergic and non-allergic participants to understand different treatment responses. The goal was to gather knowledge, not to tes…

This study looked at whether a person's genetic risk for obesity affects how much weight they lose on a diet. Researchers recruited 223 overweight adults with either very high or very low genetic risk scores for high body mass index (BMI). Half received diet coaching for 6 months…

This completed study looked at how consistently 300 obese adults (BMI over 30) used positive airway pressure therapy for sleep-disordered breathing. Researchers tracked whether patients used the device at least 4 hours per night for 70% of nights within the first 90 days and agai…

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease. Researchers used national survey information to find out how common heart problems are in this group and how they change over time. No treatments were giv…

This study looked at whether the smallest meaningful change in bone density measurements is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy when using bone scan…

This study created a registry of 200 overweight children and young adults with high blood pressure to track their heart health over time. Researchers collected medical information from clinic visits to understand how weight affects the heart. No treatments or interventions were g…

This study looked at how experiencing weight stigma (being treated negatively because of body size) changes what people eat, how much they move, and how well they sleep. 330 adults with a BMI of 28 or higher from Los Angeles took part. Some were exposed to a person who expressed …

This completed study tracked 1290 obese adults (BMI 30 or higher) undergoing weight-loss surgery to see how often doctors have trouble placing a breathing tube. The goal was to estimate the rate of difficult airway events and identify patient factors that raise the risk. The find…

This study tested whether motivational interviewing—a therapy that helps people find their own reasons to change—can shift brain activity and food choices in people with food addiction. 56 participants, including those with and without obesity, underwent brain scans while making …

This study used brain scans (fMRI) to see how young adults' brains react to the anticipation and taste of a milkshake compared to a tasteless solution. Researchers focused on reward-related brain regions to identify patterns that might predict obesity risk. The study involved 187…

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenan…

This completed study looked at 3602 people who lost weight through surgery or medication to understand why some regain weight. Researchers used questionnaires about diet, exercise, quality of life, and mental health to identify risk factors. The goal is to build a model that pred…

This study looked at how two types of exercise—high-intensity interval training (HIIT) and combined aerobic and strength training—affect health markers in obese women after menopause. Forty-five women were split into three groups: HIIT, combined training, or no exercise. Over 12 …

This study gathered information from 1,061 adults in Saudi Arabia about their weight, blood sugar, heart health, and lifestyle. The goal was to understand how common heart disease is in people with obesity. Participants filled out a questionnaire during a routine doctor visit, an…

This study tested whether adding a smartphone app to standard dietitian visits helps people prepare for bariatric surgery. 40 adults who qualified for surgery were split into two groups: one got the app plus usual care, the other only usual care. Researchers measured changes in n…

This study tested whether taking an anti-nausea drug (ondansetron) along with AMG 133 changes how the body processes AMG 133. Fifty-nine adults with overweight or obesity participated. The goal was to measure drug levels and check for side effects, not to treat the condition.

This study looked at how sleep quality, when people eat, and gut bacteria are linked to obesity. Researchers tested a mobile app to help people make healthier lifestyle changes. The study included 133 adults with different body weights, including some with sleep apnea. The goal w…

This study looked at how COVID-19 lockdowns changed weight, sleep, and behavior in nearly 4,800 adults already in a weight-loss program in France. Researchers wanted to see if stress, less exercise, and changes in eating habits during confinement slowed weight loss. The study is …

This early-stage study tested a single dose of the experimental medicine NNC0662-0419 in 100 adults with overweight or obesity. Participants were Japanese, Chinese, or non-Asian to see how the drug behaves in different ethnic groups. The main goals were to measure drug levels in …

This study looked at brain activity in 108 women to see if overeating shares features with addiction. Researchers measured brain waves (P300) while women listened to sounds, and also asked about eating habits and mood. The goal was to compare obese women with eating disorders to …

This completed study looked at 60 obese patients who had bariatric surgery (like gastric bypass or sleeve gastrectomy). Researchers checked their gut bacteria and hormone levels before and 6-12 months after surgery. The goal was to see how the microbiome changes and if those chan…

This study looked at 101 adults who had weight-loss surgery at least three months earlier. Researchers asked about changes in taste and smell, and how those changes relate to hunger and diet quality. The goal is to understand whether sensory shifts make it harder to eat well afte…

This study looked at how a two-month exercise program changes the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 who were overweight but not extremely obese took part. Researchers measured fat oxidation and gene expression in …

This study looked at whether sleeping longer can improve how the body processes sugar in people with obesity. About 30 participants who slept less than 7 hours a night were split into two groups: one tried to sleep more, the other kept their usual habits. Researchers measured cha…

This completed study tracked 290 people who had sleeve gastrectomy surgery to see how their eating habits in the first year after surgery affected weight loss. Participants recorded their diet before surgery and at 2, 6, and 12 months after. The main goal was to measure changes i…

This completed Phase 4 trial at the Cleveland Clinic enrolled 69 adults with type 2 diabetes or obesity who take GLP-1 medications. Participants were randomly assigned to either continue or pause their GLP-1 drug before an upper endoscopy. The goal was to see if holding the medic…

This study used MRI scans to compare how quickly food leaves the stomach and how the gut responds to eating in 12 people with obesity and 12 healthy-weight individuals. Researchers also measured gut hormones and blood flow to learn more about why some people remain obese. The goa…

This study looked at whether eating protein at different times of day changes how the body uses energy and affects cravings for snacks. 53 adults with obesity participated. Researchers compared a high-protein breakfast to a low-protein breakfast to see if it reduced the desire fo…

This completed study looked at 332 adults with obesity to see if simple body measurements and blood tests could predict metabolic syndrome, a cluster of conditions that raise heart disease and diabetes risk. Participants were grouped by obesity severity, and researchers calculate…

This study looks at whether drinking orange juice every day can help overweight women become more sensitive to insulin, a hormone that controls blood sugar. Thirty-six women will drink either orange juice or a sugary orange drink for three months. Researchers will measure insulin…

This study measured amino acid levels in the blood of 50 people before and after bariatric surgery, comparing them to 50 healthy individuals. The goal was to see how surgery affects metabolism over three months. It is an observational study, not testing a new treatment.

This study looked at how different types of trans fats—one from dairy products and one from processed foods—affect insulin resistance in obese women. Sixty-six participants were given special diets to compare the effects. The goal was to understand if natural trans fats are less …

This study from the Mayo Clinic looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. 58 participants aged 50-75 completed a 3-month exercise program. Researchers measured changes in m…

This completed Phase 1 study tested two different versions of the experimental drug NNC0519-0130 in 46 adults with overweight or obesity. The main goal was to measure how much of the drug gets into the blood and compare the two formulations. Participants received both versions by…

This pilot study tested whether giving financial rewards for walking and healthy food could help low-income adults with obesity or diabetes. Eight participants were split into two groups: one received incentives, the other did not. The goal was to see if this approach could reduc…

This study looked at whether a blood marker called PTX3 can predict how well people do after gastric bypass surgery. Researchers followed 23 patients for 6 months after surgery, measuring weight loss, insulin resistance, and inflammation. The goal was to see if PTX3 levels before…

This study checks on mothers and their children 12 years after a pregnancy lifestyle program. Researchers want to see if healthy eating and activity during pregnancy affect the child's body composition and long-term health. About 497 families from the original TOP study are invit…

This study looked at whether eating the same number of calories at different times of day affects weight, body fat, and metabolism in people with obesity. Thirty-eight adults were given all their meals and snacks to eat either during the daytime or later in the day. The goal was …

This study looks at how one session of moderate-to-hard walking or jogging changes the brain's response to insulin in adults aged 40 to 80 who are overweight or obese. Researchers will use MRI scans to measure brain insulin sensitivity and also test memory, thinking, and heart he…

This study looked at 140 women to compare metabolic risk markers—like insulin resistance and cholesterol ratios—between those with lipedema and those with obesity. Researchers used existing blood test results to calculate these markers without any new treatments or interventions.…

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This small pilot study looked at whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized plan to reduce these foods. The goal was to see if it was possible and acceptable, not to measure mood changes. …

This study looked at 155 adults who had weight-loss surgery to see if using a low-flow or standard-flow anesthesia gas changed inflammation levels in the body. Researchers measured blood markers like CRP before and after surgery. The goal was to learn more about how anesthesia af…

This study tested whether an 8-week individualized training program could improve heart and blood vessel function in men with obesity or type 2 diabetes. Researchers compared four groups: trained and untrained healthy volunteers, obese subjects, and diabetic patients. The goal wa…

This completed Phase 1 trial tested a single oral dose of monlunabant in 73 healthy Japanese and Caucasian men of normal weight. The main goal was to check safety and how the drug moves through the body. Participants received either monlunabant, placebo, or both, and were monitor…

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. 15 adults with overweight or obesity took part. Researchers measured weight, waist size, and heart health over time to understand what helps…

This study looked at how exercise and amino acid infusions change muscle protein production in people with obesity. Researchers measured how fast different muscle proteins were made in 48 volunteers. The goal was to understand why obesity alters muscle fiber types, which may lead…

This study looked at whether community organizations can successfully run a healthy lifestyle program called Deaf Weight Wise (DWW) for Deaf adults who use American Sign Language. The program involved 16 weekly group sessions led by a trained Deaf counselor via Zoom. Researchers …

This pilot study tested whether older adults with extra weight could stick to either eating fewer calories or eating only within an 8-hour window for 9 months. About 90 people took part, with some getting in-person coaching and others doing it remotely. The goal was to see if the…

This study tested whether training local community members as wellness coaches could help African American adults in economically disadvantaged areas manage their weight. Researchers recruited and trained coaches to lead a 12-week group lifestyle program. The goal was to see if t…

This study looked at whether having a higher body mass index (BMI) and using simple sleep apnea screening questionnaires can predict breathing or sedation-related problems during endoscopy. Researchers enrolled 350 adults with a BMI of 25 or higher who were scheduled for an upper…

This study examined how often adults with obesity in the Gulf region have related health issues like diabetes, high blood pressure, and heart disease. Researchers also looked at the medical costs and healthcare use tied to these conditions. The goal was to better understand the r…

This study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss raises blood pressure, blood sugar, and belly fat. The goal was to understand if sleep is more important for…

This study looked at 20 teens aged 13-20 with severe obesity who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolis…

This study looked at how gut bacteria might influence metabolism in 38 teenagers, some with obesity and some lean. Participants ate special diets while researchers measured short-chain fatty acids and fat production in the liver. The goal was to understand if gut bacteria play a …

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This completed study looked at 20 women who had large-volume liposuction (5–8 liters) to see how removing fat from different body surface areas affects hemoglobin, clotting, and electrolyte levels. The goal was to understand safety risks better. The study did not test a new treat…

This completed study from Istanbul University looked at 64 obese adults to see if obesity hypoventilation syndrome (OHS) causes extra problems beyond obesity alone. Researchers measured exercise capacity, muscle strength, sleep quality, and quality of life. The goal was to unders…

This completed study looked at how the body digests and uses food during weight loss from bariatric surgery. Researchers used advanced 'omics' techniques to track nutrients in 7 participants. The goal was to understand why weight loss varies between people and to generate ideas f…

This completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…

This completed study observed 563 patients who had weight-loss (bariatric) surgery and received extra oxygen during their first night in the hospital. Researchers tracked how often oxygen levels fell below 90% and what actions nurses took, like adjusting the oxygen flow or reposi…

This study looked at 90 people who had sleeve gastrectomy surgery for obesity two years earlier. Researchers wanted to see if the amount of stomach left after surgery (residual gastric volume) was linked to whether the surgery failed to help them lose enough weight. The goal was …

This study looked at how different exercise intensities affect ghrelin, a hormone that controls hunger, in 40 adults with obesity or prediabetes. Participants cycled on a stationary bike while researchers measured ghrelin levels, appetite, and blood vessel function. The goal was …

This completed study looked at whether the amount of energy people burn through daily activity is linked to body weight and diabetes risk. Researchers measured activity levels in 2500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US. They tracked weight chan…

This study looked at how a short, intense running test changes blood sugar, fats, inflammation, and other health markers in normal-weight and overweight/obese teenage girls. 35 girls aged 14-18 completed the Spartacus test, and blood was drawn before, right after, and 30 minutes …

This study looked at how one session of brisk walking or jogging changes appetite-related hormones and brain responses to food pictures in 40 adults with different body weights. Participants exercised for 60 minutes while wearing a mask to measure oxygen use. Researchers measured…

This study tested whether a very low energy diet (800 calories a day using meal replacements) before pregnancy could improve the health of obese women and their babies. 147 women participated, including those with obesity and healthy-weight women for comparison. Researchers measu…

This completed study examined 97 adults with obesity to see if following the EAT-Lancet (Planetary Health) diet is related to their natural sleep-wake patterns (chronotype) and psychological well-being. Participants filled out questionnaires about their diet, sleep preferences, a…

This study looked at 46 obese men aged 18 to 50 who were scheduled for weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy). Researchers measured changes in sperm quality and other fertility-related factors before and after surgery. The goal was to understand if l…

This study looked at how women with obesity perceive sounds they make themselves compared to sounds made by others. Researchers tested 37 women to see if the 'sensory attenuation' effect—where self-made sounds seem quieter—is different in obesity. The goal is to better understand…

This study used MRI brain scans in twins to investigate whether brain inflammation (gliosis) plays a role in obesity and weight regain. Researchers compared people undergoing behavioral weight loss, bariatric surgery, and healthy-weight controls. The goal was to understand why we…

This study looks at whether the body's ability to switch between burning fat and sugar (called metabolic flexibility) is linked to changes in metabolic health over 16 years. Researchers will re-examine 18 people who had their metabolic flexibility measured in 2008-2009. They will…

This study followed 1100 adults with severe obesity who took WEGOVY (semaglutide) for 12 months. Researchers collected data on weight, eating habits, and blood markers to see how the drug worked in different groups. The goal is to use this information, along with artificial intel…