OBESITY

This study tested a once-daily pill called orforglipron to see if it helps people with obesity or overweight maintain weight loss they achieved in a previous study. 376 adults who completed the earlier weight-loss program took either the pill or a placebo. The goal was to measure…

This study tested whether taking capsules of pasteurized Akkermansia bacteria (Akk11) could help overweight or obese adults lose weight and improve their metabolism. 61 participants took either the bacteria or a placebo while following a low-carb diet. The goal was to see changes…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose weight and improve metabolic health. A total of 110 people aged 25 to 35 with a BMI of 24 or higher took part. The results will help guide better dietary…

This study tested three doses of a new drug called maridebart cafraglutide (AMG 133) against a placebo in 592 adults with overweight or obesity, some of whom also had type 2 diabetes. The main goal was to see how much weight participants lost after 52 weeks. The drug aims to help…

This study looked at whether a ketogenic, low-calorie diet can reduce harmful gut-related toxins in the blood and improve insulin resistance in prediabetic obese adults aged 18-40. Ninety participants were split into three groups: a keto low-calorie diet, a normal low-calorie die…

This study tested a new way to help people with obesity lose weight: group doctor visits where each person gets a personal health plan. 11 adults aged 30-60 with a BMI of 35-50 took part. Researchers tracked weight, blood pressure, waist size, and mood to see if this approach wor…

This study tested a drug called enobosarm in 168 adults aged 60 and older who were already taking GLP-1 medications (like Wegovy or Ozempic) for weight management. The goal was to see if enobosarm could prevent muscle loss that often happens with weight loss. Participants receive…

This study tested a smartphone app designed to help people with obesity better manage their weight and health. 36 adults with a BMI between 30 and 40 used the app for 16 weeks to track their weight and follow self-care tips. The goal was to see if the app could improve weight los…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study looked at whether a GLP-1 drug (a type of medication that helps control appetite) can reduce cravings, hunger, stress, and weight in people with obesity. 96 adults with a BMI between 30 and 49.9 took part. The drug was compared to a placebo to see if it helped them eat…

This study tested if weight-loss surgery (vertical sleeve gastrectomy) could improve pancreas, kidney, and heart health in teens aged 12-21 with type 2 diabetes and severe obesity. Researchers measured kidney function, blood flow, and insulin production before and after surgery. …

This study tested a new magnetic system (MagDI) in 10 adults with obesity and type 2 diabetes. The device creates a new connection in the small bowel to help with weight loss and blood sugar control. The main goals were to see if the procedure is safe and works as intended, witho…

This study tested a 3-month remote program for people who regained at least 10% of their weight after sleeve gastrectomy. The program included support from a team of experts and motivational text messages. 100 participants were split into two groups: one received the remote progr…

This study tested a remote, video-based weight loss program with coaching for 696 veterans who have both obesity and obstructive sleep apnea. The goal was to see if the program could improve sleep-related quality of life and help participants lose weight. The program focused on g…

This early-stage study tested a new drug called AMG 786 in 65 healthy and obese adults to see if it is safe and how the body processes it. Participants received either the drug or a placebo, and researchers monitored for side effects. The goal is to gather initial safety data, no…

This study tested a new medicine called survodutide (BI 456906) in 726 adults with overweight or obesity who had not been able to lose weight through diet alone. Participants received weekly injections of either survodutide or a placebo for about 76 weeks, along with diet and exe…

This study tested a once-weekly medicine called semaglutide in 115 adults with type 1 diabetes and obesity who were already using an automated insulin pump system. The goal was to see if adding semaglutide could help them spend more time in a healthy blood sugar range, reduce low…

This study tested an investigational drug called LY3437943 against a placebo in 85 adults with obesity. The goal was to see how the drug affects calorie intake, energy metabolism, and appetite over up to 6 months. Participants followed a calorie-restricted diet and had up to 20 v…

This study tested whether a weight-loss drug (semaglutide) combined with a very low-calorie diet could help people with idiopathic intracranial hypertension (IIH), a condition where high pressure in the brain causes headaches and vision problems. 38 adults with newly diagnosed II…

This study tested whether a once-weekly injection of semaglutide (a diabetes drug) plus a lower dose of insulin works as well as a higher dose of insulin alone for controlling blood sugar. About 573 adults with type 2 diabetes and overweight took part. The goal was to see if the …

This study tested whether a probiotic called Bifidobacterium breve, taken alongside exercise, helps healthy but overweight adults lose more body fat. About 95 people with a BMI between 25 and 30 took either the probiotic or a placebo for 12 weeks. Researchers measured changes in …

This study tested a high dose (7.2 mg) of semaglutide, a once-weekly injection, in 512 adults with obesity and type 2 diabetes. The goal was to see how much weight participants lost and how well their blood sugar was controlled over 72 weeks, compared to a lower dose or a placebo…

This study tested whether a weight loss program delivered through informal house chats could help African American adults in Petersburg, VA, improve their health. Twenty-two participants took part in the program, which focused on increasing physical activity, eating better, and l…

This study compared two types of gastric bypass surgery for people with obesity (BMI 30-50). The goal was to see which method causes fewer problems like acid reflux, bile reflux, and stomach ulcers. 200 adults took part, and researchers tracked their weight loss and complications…

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study looked at whether a once-weekly medicine called semaglutide can lower the risk of heart problems and other obesity-related health issues in people with overweight or obesity. Researchers analyzed medical records from over 285,000 people in the U.S. to see how semagluti…

This study tested a new once-weekly injection called CT-388 (also known as enicepatide) to help people with obesity or overweight who also have related health problems like high blood pressure or prediabetes. About 469 adults took part, receiving either a low, middle, or high dos…

This study tested whether adding a new medicine (NNC0165-1875) to the existing weight-loss drug semaglutide helps people with obesity lose more weight. 120 adults with a BMI between 30 and 45 took part. Participants received either the new drug plus semaglutide or a placebo plus …

This study tested a new once-daily medication called LY3549492 to help adults with obesity or overweight lose weight. About 288 people took part for roughly one year. The main goal was to see how much weight they lost compared to those who took a placebo.

This study tested an experimental injection called GZR18 in 340 Chinese adults who were obese or overweight. Participants received either the drug or a placebo, along with diet and exercise advice. The main goal was to see how much weight they lost after 30 weeks. The study is co…

This study looked at a procedure called endoscopic sleeve gastroplasty, which reduces stomach size using a flexible tube through the mouth, to help people with obesity lose weight. 75 adults who had trouble losing weight with diet and exercise alone took part. The main goal was t…

This study looked at the safety and effectiveness of the weight-loss medicine Saxenda in 300 obese adults and teenagers in Taiwan. Participants took the medicine as part of their regular care for about 26 weeks. The main goal was to track any side effects, and the results help co…

This study tested whether a drug called bromocriptine, which boosts dopamine in the brain, can help people with obesity lose weight based on their genetic makeup. 120 adults with a BMI over 30 took either the drug or a placebo for 18 weeks. Researchers looked at how a specific ge…

This study tested a weight loss competition for hospital employees with obesity (BMI 27 or higher). Participants used the So99 app to track healthy eating and exercise as a team. The goal was to see if the app could help people lose weight and create a healthier workplace. The st…

This study tested whether a virtual coach, accessed through a patient portal, could help people with obesity lose weight before ventral hernia surgery. Researchers compared weight loss over six months between those using the coach and those receiving usual care. The goal was to s…

This study looked at whether alternating between fasting days and eating days, combined with exercise, could help people with non-alcoholic fatty liver disease (NAFLD) and obesity. Researchers measured changes in liver fat, weight, and blood markers in 80 participants. The goal w…

This early study tested a new medicine, NNC0519-0130, given as a weekly shot to help with weight loss and blood sugar control. 82 adults with obesity or type 2 diabetes took part. The main goal was to check for side effects and see how the drug works in the body, with a focus on …

This study looked at 36 adults with obesity and non-alcoholic fatty liver disease (NAFLD). Participants followed one of two low-calorie Mediterranean diet plans, with different amounts of carbs and fats, plus a moderate exercise program. After 3 months, researchers checked liver …

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. The drugs work by lowering blood sugar and promoting weight loss. Researchers used MRI scans t…

This study tested whether an 8-week circuit exercise program (combining aerobic and resistance moves) could improve inflammation markers in overweight young women. Twenty-two women aged 20-30 with a BMI of 25-31 either exercised four times a week or continued their normal routine…

This study tested a daily semaglutide tablet (25 mg) in 307 adults with overweight or obesity to see if it helps with weight loss. Participants took either the drug or a placebo for 64 weeks. The main goals were to measure the percentage of weight lost and how many people lost at…

This study tested two medications, tirzepatide and semaglutide, to see which works better for weight loss in adults with obesity or overweight who also have related health problems like high blood pressure. About 751 people took part over 74 weeks. The main goal was to measure ho…

This study involved 100 adults who were still obese 6 months after weight-loss surgery. Researchers compared starting the drug liraglutide early versus later to see which timing leads to greater weight loss and health improvements. The goal is to find the best way to help patient…

This study tested a daily oral tablet of semaglutide (50 mg) to help people with overweight or obesity lose weight. 667 adults took either the active drug or a placebo for 68 weeks, along with lifestyle advice. The main goals were to measure the percentage of weight lost and how …

This study tested a new medicine called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if it could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers measured ch…

This study tested an experimental drug called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. About 85 adults took either the drug or a placebo for 44 weeks, along with diet and exercise. The main goals were to check safety and side effects, and to…

This study looked at whether lifestyle programs can help overweight or obese pregnant women control weight gain during pregnancy and improve health for both mom and baby. 123 women receiving care at the Phoenix Indian Medical Center took part. Some joined a weekly group program f…

This study looked at whether community health workers can help low-income adults better manage chronic diseases like diabetes, high blood pressure, and obesity. About 200 people took part over 10 months. The goal was to see if working with a health worker improved health markers …

This study looked at how eating strawberries affects heart health and metabolism in 48 overweight or obese adults with borderline high cholesterol. Participants ate strawberries and researchers measured changes in blood fats, blood sugar, and insulin. The goal was to see if straw…

This study tested a new medication called Mazdutide to help adults with obesity or overweight manage their weight. About 179 participants took the drug or a placebo for 62 weeks to see how much weight they lost. The goal was to find out if the drug is safe and effective for weigh…

This study tested a new medicine called survodutide for weight loss in 274 Japanese adults with obesity and related health problems like diabetes or high blood pressure. Participants received weekly injections of either survodutide or a placebo for about 76 weeks, along with diet…

This study tested a new medicine called survodutide (BI 456906) in 755 adults with overweight or obesity and type 2 diabetes. Participants received weekly injections of either the drug or a placebo for 76 weeks, along with diet and exercise advice. The main goals were to see how …

This study looked at 105 adults who have both obesity and trouble affording enough food. Everyone got standard weight-loss counseling, but some also got food vouchers or free home-delivered groceries that fit a healthy diet. The goal was to see if adding food help leads to more w…

This study looked at whether taking a natural plant supplement called phytosterol can help people with nonalcoholic fatty liver disease (NAFLD). 27 adults took the supplement for 3 months. Researchers measured changes in liver enzymes, cholesterol, insulin, and inflammation. The …

This study tested whether using technology for remote follow-up (like apps or video calls) helps obese teenagers lose weight better than standard in-person visits. 91 teens aged 11-17 took part over 15 months. The main goal was to see if the tech group had a greater drop in body …

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a reduced-calorie diet, helps overweight or obese adults lose more weight and improve blood sugar and fat levels compared to a placebo. The study included 46 people aged 30-70 with or without type 2…

This early-stage study tested a single dose of the experimental drug AMG 133 in 20 Chinese adults who are overweight or have obesity. The main goal was to see how the drug behaves in the body and to check for any safety issues. This is a first step to see if the drug might help m…

This study tested two approaches—weight-focused (aiming for weight loss) and weight-neutral (focusing on physical activity without weight loss goals)—to improve metabolic health in Black adults with stage 1 obesity and related conditions like high blood pressure or prediabetes. F…

This study tested whether a drug called polyethylene glycol loxenatide, combined with a hormone-releasing IUD (LNG-IUS), can better treat atypical endometrial hyperplasia—a precancerous condition of the uterine lining. The 30 participants were women with obesity who wanted to pre…

This study looked at whether adding vitamin D supplements to a healthy lifestyle program could improve blood vessel function in obese teenagers. 49 teens participated over 3 months. The main goal was to see if vitamin D helped blood vessels relax and work better, which is importa…

This study tested whether adding mindfulness, acceptance, and values-clarity techniques to standard weight loss counseling helps adults with overweight or obesity lose more weight. 276 adults aged 18-70 with a BMI between 27 and 50 took part. Researchers compared different combin…

This study tested whether the weight-loss drug phentermine/topiramate could help control uric acid kidney stones in people with obesity and type 2 diabetes or pre-diabetes. 19 participants were randomly assigned to either the drug or standard care (citrate, allopurinol, diet) for…

This study tested whether taking a probiotic called Hafnia alvei for 90 days after gastric bypass surgery helps people lose more weight and control their blood sugar better. 49 adults with obesity or type 2 diabetes took either the probiotic or a placebo. Researchers tracked weig…

This study tested whether a capsule containing heat-killed Akkermansia bacteria can help overweight or obese adults lose weight and improve their metabolism. 61 participants took either the probiotic or a placebo for a period of time. Researchers measured changes in body weight, …

This study looked at whether adding a weight-loss drug (tirzepatide) to a standard psoriatic arthritis medicine (ixekizumab) helps people with both conditions. 279 adults with active psoriatic arthritis who were overweight or had obesity took part. The goal was to see if the comb…

This study looked at whether a three-month supervised exercise program can improve blood sugar, body composition, and fitness in men with type 2 diabetes, prediabetes, or related conditions like overweight and high cholesterol. Three hundred sedentary men aged 35-65 took part in …

This study tested a weight management program for people living in public housing in Boston. Participants received either text messages about diet and exercise, text messages plus monthly calls from a community health worker, or no extra support. The goal was to see if the combin…

This study tested a mobile app designed to help small corner stores in low-income Baltimore neighborhoods buy and sell more healthy foods like fruits and vegetables. Researchers worked with 38 stores and 310 regular customers to see if the app improved the availability and sales …

This study tested a new medicine called PF-07976016 in 263 adults with obesity to see if it is safe and helps with weight loss. Participants received either the study drug or a placebo (fake pill) for a period of time. The main goal was to measure changes in body weight and any s…

This study tested whether a 16-week lifestyle program delivered through WeChat could help children with autism (ages 8-16) improve their weight. 276 families were split into three groups: usual care, the WeChat program alone, or the program plus weekly coach-led group calls. The …

This study tested a new magnetic system that creates a shortcut in the intestines to help people with obesity and type 2 diabetes lose weight and control blood sugar. Fifteen adults aged 18-65 with a BMI between 30-35 and diabetes took part. The goal was to see if the device coul…

This study tested a new medication, orforglipron, to see how it changes body fat in adults with obesity or overweight who do not have diabetes. About 120 participants took either the drug or a placebo for around 8 months. The main goal was to measure changes in visceral fat (the …

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or have obesity. The program adds extra support to standard PTSD care to help overcome PTSD-related challenges like stress eating or trouble staying active. 174 veterans …

This study tested a drug called tesamorelin, which boosts growth hormone, in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The goal was to see if it could lower liver fat and improve liver inflammation and scarring. Participants received either tesamorelin or a p…

This study tested whether an electronic program could help pregnant women who are overweight or obese gain a healthy amount of weight and reduce the need for delivery procedures like C-sections or forceps. About 857 women participated. The program provided personalized guidance t…

This study tested a lifestyle program for pregnant women with obesity to help them maintain weight and lose fat instead of gaining extra. About 100 women joined, and researchers checked how the program affected mom's weight, fat, and health risks, as well as baby's growth. The go…

This study tested a new medicine called CagriSema, a once-weekly injection, to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults received either CagriSema or a placebo for around 1.5 years. The main goals were to measure weight loss and ho…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps people who are overweight or obese lose weight and improve their health. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, choles…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with overweight or obesity lose weight. About 300 adults took part, receiving either CagriSema or a dummy shot once a week for around 1½ years. The main goal…

This study tested how well semaglutide helps people with obesity lose weight compared to other approved weight loss medications. About 500 adults from three US employers took part. The goal was to see if semaglutide leads to greater weight loss and improvements in quality of life…

This study tested a 5-week hospital program combining physical activity, nutrition advice, and education for 128 adults with Prader-Willi syndrome. The goal was to help patients stabilize or lose weight 6 months after leaving the hospital. The program focuses on changing daily ha…

This study looked at how a weekly injection of semaglutide (2.4 mg) affects appetite, eating behavior, and food preferences in 120 adults with obesity over 72 weeks. All participants received diet and exercise advice, and either the drug or a placebo. The goal was to see if the m…

This study looked at whether sharing digital self-monitoring data (like weight, steps, and calories) with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. About 320 adults used a wireless scale and Fitbit to track their progress. …

This study looked at 180 obese, sedentary older adults to see if losing fat through a controlled diet while exercising improves their heart and lung fitness more than exercise alone. Participants followed a standard exercise program and some also reduced calories to lose weight. …

This study looked at whether receiving daily text messages on your phone can help with weight loss. 120 adults with obesity were split into two groups: one got standard weight-loss classes, and the other got those classes plus daily texts. The goal was to see if the text group lo…

This study looked at whether eating only during a short daily window (prolonged daily fasting) can help obese adults lose weight and improve health, as an alternative to traditional calorie restriction. About 115 participants with obesity and insulin resistance followed either a …

This study tested a once-weekly injection of semaglutide (2.4 mg) in 150 Asian adults with obesity (BMI 25 or higher). Participants received either the drug or a placebo, plus lifestyle advice, for about a year. The main goal was to see how much weight they lost. Results showed t…

This study looked at whether eating only during a specific window each day (time-restricted eating) combined with short, intense exercise (high-intensity interval training) can improve health markers in people with metabolic syndrome. 200 overweight or obese adults with metabolic…

This study tested a weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. 375 adults took part, some receiving the drug and others a placebo, along with lifestyle counseling. The main goal was to see how much weight they lost over 44 week…

This study tested whether combining two non-surgical procedures (HAPC and ESG) helps people with obesity lose more weight than ESG alone. 45 adults with a BMI between 30 and 40 who had trouble losing weight with diet and exercise took part. The main goal was to see if the combine…

This study tested whether a new investigational medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of its componen…

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce liver fat and improve heart health in adults with obesity. 187 participants were assigned to one of four groups: time-restricted eating alon…

This study tested deep brain stimulation (DBS) in a brain area called the lateral hypothalamus to help control severe obesity. Three people who already had DBS electrodes implanted took part. The goal was to find the best stimulation settings to change metabolic rate and promote …

This study tested whether a new drug called VTX3232, taken alone or with semaglutide, is safe for people with obesity. About 176 adults with a BMI between 30 and 42 took part. The study lasted 12 weeks and checked for side effects and changes in inflammation levels.

This study looked at 226 adults who had lost at least 15% of their body weight using GLP-1 medications like Wegovy or Zepbound. Participants stopped their medication and were assigned different step-down treatments to see which helped maintain weight loss over 12 weeks. The main …

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 adolescents aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. The goal was to…

This study tested a culturally-tailored program that combines stress management, healthy eating, and exercise for African American women. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program could help them be more acti…

This study looked at whether using a non-invasive breathing mask (NIV) right after removing a breathing tube can prevent serious breathing problems in obese patients in the intensive care unit (ICU). About 1000 obese adults who needed a breathing tube for at least 6 hours took pa…

This study looked at whether a program that combines WeightWatchers behavioral coaching with prescription weight-loss drugs (Wegovy, Mounjaro, or Zepbound) helps people lose weight. 180 adults with obesity or weight-related health issues took part for 24 weeks. Researchers measur…

This study tested whether using behavioral economics strategies (like small financial incentives or commitment contracts) can help economically disadvantaged adults lose weight. 195 participants aged 18-75 with a BMI between 25-55 were enrolled. The main goal was to see if these …

This study followed 1,581 adults aged 18-65 who had bariatric surgery (gastric bypass or sleeve gastrectomy) to see how their metabolic syndrome—including high blood pressure, obesity, and diabetes—changed over up to 10 years. Researchers measured weight, blood pressure, blood su…

This study looked at whether taking fish oil supplements while exercising can lower inflammation linked to obesity. Overweight adults with high triglycerides and prediabetes took fish oil and followed an exercise program for several weeks. Researchers measured changes in blood ma…

This study tested a surgical procedure that combines a sleeve gastrectomy with an intestinal diversion to help people with obesity and type 2 diabetes lose weight and improve blood sugar control. 18 adults aged 19-65 with a BMI between 35 and 50 and stable diabetes took part. The…

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. …

This study tested whether starting a lifestyle program before pregnancy can improve health in obese women and their babies. Researchers enrolled 99 women who had a previous full-term pregnancy and were planning another within two years. The program focused on diet and exercise to…

This study tested a high-intensity medical weight loss program combined with a digital platform to help people with type 2 diabetes lose weight and achieve remission. 64 participants with recent diabetes diagnosis and obesity were enrolled. The program used a digital tool to tail…

This study compared two types of weight-loss surgery for people with severe obesity: the standard Roux-en-Y gastric bypass and a newer Omega Loop bypass. Researchers wanted to see which surgery is safer and works better for weight loss. The trial involved 256 adults aged 18 to 65…

This early-stage study tested a new medicine (NNC0487-0111) for weight control in 36 Chinese adults with overweight or obesity. The main goal was to check the drug's safety and how it moves through the body. Participants received either the study drug or a placebo by injection, a…

This study tested a simple diet called time-restricted eating (TRE), where people eat only during a 6-8 hour window each day, against the standard daily calorie restriction diet. The goal was to see if TRE helps adults with type 1 diabetes and obesity lose weight and improve bloo…

This early-stage study tested an oral tablet called ecnoglutide in 87 healthy adults to see if it is safe and how the body processes it. The drug is designed to help manage type 2 diabetes and obesity by mimicking a natural hormone that controls blood sugar and appetite. Since pa…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study tested whether a blend of digital tools (video sessions and a health app) plus standard in-person care works as well as in-person care alone for children and teens with obesity. About 100 families in Sweden took part. The goal was to see if the digital-physical approac…

This early-stage study tested a new medicine called NNC0519-0130 in 134 overweight or obese adults. The goal was to see if different ways of slowly increasing the dose could reduce side effects. Participants were assigned by chance to one of four dosing schedules and were followe…

This study looked at whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than a standard daily calorie-restricted diet. Over one year, 165 adults aged 18-60 with a BMI between 27 and 46 followed either an intermittent fasting…

This study tested a newer, simpler weight loss surgery called SADI-S against a standard, more complex one (BPD-DS) in 62 adults with severe obesity. The goal was to see if SADI-S is safer and works as well for weight loss and related health problems like diabetes. Researchers mea…

This study looked at whether whole-body vibration (standing on a vibrating platform) can help overweight and obese university students lose weight and improve body measurements like waist size and body fat. Thirty-two students took part. The goal was to see if this simple method …

This study looked at two weight loss programs for adults with overweight or obesity. One program told people to cut a fixed number of calories each day, while the other varied the calorie target. The goal was to see which approach helped people lose more weight.

This early-stage study tested a new drug called AMG 133 in 110 adults with obesity to see if it is safe and how the body processes it. Participants received either the drug or a placebo as a single dose or multiple doses. The main goal was to check for side effects and changes in…

This small pilot study tested whether offering financial rewards for exercise and healthy food could help people with obesity and diabetes. Eight participants from a low-income community were split into two groups. The goal was to see if incentives could encourage more walking an…

This study tested a once-daily oral medication called orforglipron against a placebo in over 1,600 adults who are overweight or have obesity and also have type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants took t…

This study tested whether a diet rich in boron (a natural mineral) or a Mediterranean-style diet could improve health in 40 obese adults. Over four weeks, researchers measured changes in body mass index, gut bacteria, appetite hormones, and heart risk factors. The goal was to see…

This study tested two 12-month behavioral weight-management programs in 321 adults with obesity and high blood pressure. Participants were followed for 3 years to see if they could lose at least 7% of their starting weight and keep off most of it. The goal was to find better ways…

This early-stage study tested whether adding a new drug (LY3841136) to the existing weight-loss medication tirzepatide is safe and tolerable. It involved 96 healthy overweight or obese adults and lasted up to 42 weeks. The main goal was to check for side effects, not to measure w…

This study tested whether providing medically tailored meals (MTMs) alone or combined with weekly group support sessions helps Black adults with high blood pressure, type 2 diabetes, or obesity. 75 participants received either meals only, meals plus group support, or delayed meal…

This study tested a weekly injection of semaglutide in 201 teenagers aged 12 to 17 with overweight or obesity. Participants received either the drug or a placebo for about 15 months, along with counseling on diet and exercise. The main goal was to see how much their body mass ind…

This study tested three different weight loss strategies in 110 adults with chronic spinal cord injury who were overweight. The goal was to see which approach—prepackaged meals, better self-monitoring, or a combined program—helped people lose weight and improve their health. The …

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with excess body weight lose weight. 242 participants received either the drug or a placebo for about one year. The main goal was to see how much weight they lost and if at least 5% of body weight was red…

This study tested a once-weekly shot called tirzepatide to see if it helps people with obesity or overweight maintain weight loss they already achieved. About 441 adults who had lost weight during a 60-week diet period took either the drug or a placebo. The goal was to see if the…

This study looked at whether taking spirulina supplements along with cutting calories can help men with obesity lose weight and improve their cholesterol and blood sugar control. 35 men took either spirulina or a placebo for 30 days while following a reduced-calorie diet. The goa…

This study looked at whether the medication lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapsing after initial treatment. 61 participants who responded to acute treatment were randomly assigned to continue LDX or switch to a placebo. The g…

This study looked at whether taking aspirin twice a day (morning and evening) works better than once a day to prevent another heart attack, stroke, or need for emergency heart procedures in people with diabetes who have had a recent heart attack or unstable angina. About 2,500 pa…

This study tested a new, non-surgical weight loss method called Gastric Mucosal Ablation (GMA) in 15 adults with obesity. The procedure uses a special tool to remove a thin layer of stomach tissue, which may help with weight loss. Participants were followed for 6 months to see ho…

This study tested whether a program of exercise combined with a daily drink containing leucine and arginine (amino acids) could help obese adults with metabolic syndrome lose body fat. 79 participants followed the program for several weeks. The main goal was to see if total body …

This study tested a once-weekly injection of semaglutide (2.4 mg) in 207 adults with obesity and prediabetes. Participants received either the drug or a placebo for 12 months, plus lifestyle counseling. The goal was to see if the drug could help them lose weight and return their …

This study tested a new weekly injection called petrelintide in 493 adults with obesity or overweight who also had related health issues like high blood pressure or high cholesterol. The goal was to see how well different doses helped people lose weight compared to a placebo, whe…

This study tested a new medicine called NNC0519-0130 in 354 adults with overweight or obesity. Participants received 1-2 injections once a week for about 42 weeks. The main goal was to see how much weight they lost as a percentage of their body weight. The study also looked at ho…

This study tested whether a digital weight management program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program was delivered through the …

This study tested a high dose (7.2 mg) of semaglutide, a once-weekly injection, in 1407 adults with obesity. Participants also received lifestyle advice. The goal was to see how much weight they lost compared to those on a lower dose or placebo. Results showed significant weight …

This study tested two ways to help people maintain weight loss after an initial program. 255 adults with obesity who lost at least 5% of their body weight were randomly assigned to receive either monthly phone coaching or coaching only when a computer algorithm predicted they wer…

This study tested a new magnetic device that creates a shortcut in the small intestine to help people with obesity and type 2 diabetes lose weight and control blood sugar. Nine adults aged 18-65 with a BMI of 30-40 and diabetes took part. The goal was to see if the device could b…

This study looked at whether limiting when you eat each day can help adults who recently lost at least 5% of their body weight keep it off. 29 participants were asked to eat all their meals within either a 6-hour or a 10-hour window. The goal was to see if this approach is practi…

This study looked at whether having a spouse, partner, or other adult living with you can help Veterans lose more weight in a VA weight management program. About 300 Veterans with obesity took part, and their weight was tracked for 72 weeks. The goal was to see if social support …

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much weight they lost and if at least 5% of body we…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the tablet or a placebo for 44 weeks, along with guidance on healthy eating and physical activity. The main goals were to measure t…

This study tested whether having a peer coach (a trained person like you) helps people with obesity lose more weight than trying on their own. 375 adults aged 21-75 with a BMI between 30 and 50 took part. The program focused on support and guidance through regular sessions and ca…

This study looked at whether pea protein can help people with obesity keep their muscle mass while losing weight. About 60 adults aged 30 to 50 took part. Researchers compared the effects of pea protein and whey protein on muscle size and strength.

This study tested a medicine called survodutide in 218 adults with overweight or obesity and a liver condition called NASH (fatty liver with inflammation). Participants received weekly injections of survodutide or a placebo for about a year, along with diet and exercise advice. T…

This study tested whether a probiotic called Lactobacillus gasseri could help overweight women manage their weight and balance certain hormones. 110 women took part. The main goal was to see if the probiotic changed levels of the hormone estradiol. This is a completed early-stage…

This study tested a new medicine called PB-119 in 32 Chinese adults with obesity. The goal was to see if it is safe and helps with weight loss. Participants received either the drug or a placebo, and researchers measured side effects and weight changes over time.

This study tested a once-daily pill called orforglipron against insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had higher heart risk. The goal was to see if the pill is safe and effective at controlling blood sugar and preventing…

This study tested a new experimental medicine called CagriSema (a combination of cagrilintide and semaglutide) against the existing drug tirzepatide for weight loss in adults with obesity. About 800 participants received weekly injections under the skin for up to 1.5 years. The g…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver and NASH without needing a liver biopsy. Researchers studied 158 people at high risk due to obesity, diabetes, or high blood pressure. The goal is to find a simple, non-invasive way t…

This study tested a short pre-session program to help people at risk for type 2 diabetes attend more classes and lose more weight. It involved 483 adults from underserved backgrounds, including Hispanic and Black communities. The goal was to make the National Diabetes Prevention …

This study tested a program where community health workers visited families at home to help manage childhood obesity. It included 300 children aged 2-6 who were overweight. The goal was to see if this approach could lower their BMI over time.

This study tested whether training peer mentors to lead a healthy lifestyle program could increase physical activity in Appalachian high school teens. Over 500 students participated, comparing the peer-mentor approach to a teacher-led program. The goal was to see if teens helping…

This study tested whether a fully automated digital program could help people with prediabetes lose weight and lower blood sugar as effectively as standard programs led by human coaches. About 368 adults with prediabetes and overweight participated. The goal was to find a more ac…

This study tested a year-long online program to help adults aged 40-70 who are at risk for heart disease become more active. Participants received a fitness tracker, online coaching, and educational sessions. The goal was to see if this approach could increase daily steps and hel…

This study tested whether a mindfulness-based training program could help adults who had already lost weight avoid regaining it. 48 participants, including people who had bariatric surgery or lost weight through medical or lifestyle programs, took part. The approach focused on ch…

This study tested a health program to prevent obesity in 500 healthy children aged 6 to 12 living in Gharbia, Egypt. The program included education and lifestyle changes to help kids maintain a healthy weight. Researchers measured changes in weight, height, body mass index, and b…

This study tested whether an educational program for pregnant women who are overweight or obese could reduce the chance of their babies gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits during pregnancy. The goal…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus home delivery of bottled water, can help prevent obesity in Hispanic mothers and their infants. Over 200 mother-infant pairs were split into three groups: standard educati…

This study tested a program called HEALTH, which helps mothers prevent weight gain and lose weight through healthy lifestyle changes. The program was delivered by parent educators during home visits. 620 overweight or obese mothers took part. The goal was to see if this program w…

This study tested whether taking a daily supplement of lactoferrin, a protein found in cow's milk, could help prevent iron deficiency anemia in pregnant women with obesity. 23 women at risk for anemia took part. The main goal was to see if the approach was practical and acceptabl…

This study tested a program to help pregnant women who are overweight or obese avoid gaining too much weight. It included 416 African American and Hispanic women in Philadelphia who were part of the WIC program. The program used text messages and guidance to support healthy eatin…

This study tested a short therapy program before weight-loss surgery to help patients improve their eating habits. 94 adults preparing for bariatric surgery took part. The goal was to see if this approach leads to better long-term weight control.

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check safety and side effects, and to see how the drug moves through the body. Participants were monitored for about …

This study tested whether a combination of two medications, naltrexone and bupropion, can help reduce binge-eating episodes and promote weight loss in adults with binge-eating disorder and obesity. Participants who did not respond to initial treatments were given either the medic…

This study tested a 4-hour acceptance and commitment therapy workshop for women with obesity. The goal was to see if it could help them adopt and maintain healthy eating and exercise habits. Fifty-two women participated, and researchers measured changes in psychological flexibili…

This study tested a new medicine called NNC0662-0419 in 100 adults with overweight or obesity. The goal was to see if the drug is safe and how the body processes it. Participants received either the study drug or a placebo as an injection under the skin. This was the first time t…

This study looked at whether gentle spinal traction (a pulling force on the spine) can reduce pain and improve movement in people with obesity and chronic low back pain. Forty-nine adults aged 35–60 took part, some with obesity and some with normal weight. They received 30 minute…

This early-stage study tested a new medicine called BI 3006337 in 64 adults who are overweight or have obesity and also have fatty liver disease. Participants received weekly injections of either the study drug or a placebo for about 4 months. The main goal was to see what dose i…

This study tested whether tradipitant can reduce nausea and vomiting caused by GLP-1 weight-loss drugs. 124 healthy overweight or obese volunteers took either tradipitant or a placebo. The goal was to see if tradipitant helps people stick with their weight-loss treatment without …

This study looked at whether a special lung-opening maneuver during weight-loss surgery can help patients breathe easier afterward. Researchers studied 230 obese adults having bariatric surgery. They measured if the technique reduced shortness of breath and the need for extra oxy…

This study tested a new drug called NNC0487-0111, given as a shot under the skin, to see if it is safe and how it works in people who are overweight or obese. 125 adults aged 18-55 with a BMI between 27 and 40 took part. The main goal was to check for side effects and measure how…

This study tested whether delivering healthy meals to low-income women after childbirth could help them manage their weight. Eleven women with obesity received weekly meals and reported how much they ate. The goal was to see if this approach was practical and acceptable, not to m…

This study looked at whether a stretching routine could help reduce heart-related health risks in pregnant women with obesity during late pregnancy. 224 women participated from week 27 to week 37 of pregnancy. The stretching group was compared to a group doing moderate to vigorou…

This early-stage study tested a new drug called LY3532226 in 132 people with obesity to see if it is safe and how the body processes it. Participants received weekly or monthly doses, and researchers monitored side effects and drug levels in the blood. The goal was to gather safe…

This study looked at whether antioxidants in orange juice can help the body respond better to insulin. Overweight but otherwise healthy women drank either orange juice or a similar-tasting drink without the antioxidants every day for three months. Researchers measured insulin sen…

This study looked at whether quercetin, a compound found in many foods, can change how the body absorbs sugar. Researchers gave 24 obese adults, some with type 2 diabetes, either quercetin or a placebo during a sugar-drink test. They measured blood sugar levels to see if querceti…

This early-stage study tested the safety and tolerability of a new drug called eloralintide, given alone or with another drug (tirzepatide), in 188 adults with overweight or obesity. Participants received weekly injections under the skin, and researchers monitored side effects an…

This study tested whether a program combining cognitive behavioral therapy (CBT) and motivational interviewing could help people with obesity eat less in response to emotions and feel more resilient. 81 adults with obesity took part; half received the 8-week psychoeducation progr…

This study tested whether people having laparoscopic gastric bypass surgery can safely go home the same day instead of staying overnight. 200 adults with obesity were randomly assigned to same-day or one-day discharge. The main focus was on safety, readmission rates, and whether …

This study checked whether survodutide, a new medicine for weight loss, causes any heart rhythm problems. About 110 adults with overweight or obesity received weekly injections of survodutide or a placebo for 30 weeks, along with occasional heart monitoring. The main goal was to …

This study looked at how a combination medicine called CagriSema affects appetite and brain activity in people who are overweight or have obesity. About 164 participants took part, some receiving the medicine and others a placebo. The goal was to understand how the drug changes f…

This study tested a once-weekly medicine called retatrutide in 445 adults who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if it can reduce knee pain and help with weight loss compared to a placebo. The trial lasted about 77 weeks and meas…

This study looked at whether walking downstairs (instead of upstairs) can improve heart health, body composition, and strength in obese, inactive women. Twenty-four women aged 18-50 with a BMI of 25-40 took part in an 8-week program, walking stairs twice a week. Researchers measu…

This study tested whether a special probiotic mixture can relieve belly pain and discomfort in obese adults with irritable bowel syndrome (IBS). Eighty participants took the probiotic or a placebo for 10 weeks, and researchers tracked their symptoms and gut bacteria. The goal was…

This study tested whether a 12-week remote digital exercise program using a mobile app called Vitala is feasible and helpful for 20 adults with obesity and poorly controlled asthma. Participants received a personalized exercise plan and were encouraged to do 150 minutes of activi…

This study tested a weekly injection of semaglutide (2.4 mg) versus a placebo in 407 adults with obesity and knee osteoarthritis. Participants received diet and exercise advice alongside the injection. The goal was to see if the drug could reduce body weight and ease knee pain ov…

This study tested a wearable ear device that sends gentle electrical pulses to a nerve to help control appetite. Sixty healthy adult women each had two visits: one with the device on and one with it off. Researchers measured how much they ate, their hunger levels, and food cravin…

This study tested the safety and side effects of a new drug called LY3841136, given alone or with another drug (tirzepatide), in 128 Japanese adults with obesity or overweight. Participants were monitored for about 28 to 40 weeks through blood tests and checkups. The goal was to …

This study tested whether using ultrasound to find the right spot for spinal anesthesia works better than the usual method of feeling for landmarks in 100 obese women having C-sections. The goal was to see if ultrasound helps the doctor succeed on the first try. Results could mak…

This study tested whether a weight loss program before total knee replacement helps people with obesity have better outcomes. 24 adults aged 50-75 with a BMI between 35 and 40 followed a very low-calorie diet for 3 months before surgery and a maintenance diet for 3 months after. …

This study tested whether CagriSema, a combination of two medicines, can reduce how much people eat and their appetite. 62 adults with overweight or obesity received either CagriSema or a placebo for about 32 weeks. Researchers measured food intake and stomach emptying to see if …

This study looked at 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and overall quality of life, including less…

This study tested two types of balance exercises—whole-body vibration therapy and balance board training—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which method worked better. The goal was to…

This study looked at whether intermittent fasting (not eating for certain periods) can improve how well the pancreas makes insulin in people with early type 2 diabetes. 51 adults with diabetes and obesity took part. Researchers measured changes in beta-cell function and blood sug…

This study looked at whether taking a daily high-dose vitamin D3 pill (10,000 IU) for 12 weeks could improve muscle strength and muscle mass in 29 older adults (60+) with obesity in southern Mexico. Participants had their grip strength, muscle mass, and physical performance measu…

This study tested whether a common weight-loss surgery, laparoscopic sleeve gastrectomy, could be safely performed as a day-case procedure—meaning patients go home the same day. Thirty adults with obesity were enrolled, and researchers tracked how many needed unexpected overnight…

This study tested a behavioral weight loss program for college students ages 18-25 with a BMI of 25 or higher. The program used a 'small change' approach to help students lose weight. 42 students participated, and the study measured how acceptable the program was and how much wei…

This early-stage study tested a new medicine called NNC0519-0130 in 20 Chinese men who were overweight or had obesity. The goal was to see how the drug moves through the body and if it is safe. Participants received either the drug or a placebo for about 28 weeks, with up to 7 di…

This study looked at whether special breathing exercises (called functional inspiratory muscle training) can improve health in people with obesity. 45 adults with a BMI between 30 and 40 took part. The goal was to see if these exercises could help with body composition, heart hea…

This study tested whether a phone-based cognitive behavioral therapy (tele-CBT) program could reduce food addiction in people with severe or morbid obesity. 154 participants received either 12 tele-CBT sessions over 18 weeks or standard care. The main goal was to see if tele-CBT …

This study tested whether MitoQ, a supplement that targets cell energy centers, can improve airway function in obese adults with poorly controlled asthma. Over 14 weeks, 47 participants received either MitoQ or a placebo. The main goal was to see if MitoQ reduces airway reactivit…

This study tested a psychological program called well-being therapy in 50 adults with obesity. The goal was to see if improving mental health could help them adopt healthier, more sustainable eating habits and lose weight. Participants attended therapy sessions and were followed …

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were trying to get pregnant for the first time with IVF. Some women followed a diet and exercise progra…

This study tested a weekly injection of semaglutide in 529 adults with obesity and a type of heart failure where the heart pumps normally but doesn't fill properly. The goal was to see if the drug improves heart failure symptoms, daily function, and body weight compared to a plac…

This study tested whether a daily probiotic supplement (called a psychobiotic) could improve mental health, quality of life, and weight loss in obese women following a weight-loss diet. 28 women took either the supplement or a placebo for 4 weeks. Researchers measured changes in …

This study tested whether using warm saline (body temperature) to rinse the staple line during laparoscopic sleeve gastrectomy reduces early bleeding compared to room-temperature saline. 200 adults having primary sleeve gastrectomy were randomly assigned to warm or standard irrig…

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease and death rates. Researchers used national survey information from 2013, 2018, and 2023. No treatments were given—the goal was simply to understand the pro…

This study looked at how daily rhythms affect fat cell genes and insulin response in 28 women with severe obesity scheduled for bariatric surgery. Researchers measured changes in fat cell insulin sensitivity before and 12 weeks after surgery. The goal was to understand the body's…

This study looked at how a single session of walking or jogging changes appetite-related hormones and brain activity in 40 adults who were either normal weight or overweight/obese. Researchers measured hormone levels in blood and used brain scans to see how participants responded…

This study looked at whether four simple nudges—like showing sugar content or health warnings—could encourage college students to pick sugar-free drinks instead of sugary ones. Over 1,600 students took part in menu-choice tasks. The goal was to see if these gentle pushes can prom…

This study tested whether sending specific text messages at just the right moments helps young adults with overweight or obesity meet their daily weight, activity, and diet goals. 255 participants used a mobile weight loss program and received either a message or no message at ra…

This study looked at how being treated unfairly because of weight affects health habits. 330 adults with a BMI of 28 or higher were randomly assigned to experience weight stigma or not. Researchers then measured their eating, physical activity, and sleep over several days to see …

This study looked at how regular exercise changes appetite and metabolism in sedentary, overweight teenagers. Researchers randomly assigned 31 teens to either a 3-month exercise program or a control group. They measured hunger levels and metabolic function to see if exercise, reg…

This study used special 3D cameras to take pictures of people's torsos without any radiation. Researchers wanted to learn more about body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participants aged 2 and older had their to…

This study looked at whether stopping certain diabetes medications (incretin-based therapies) before an upper endoscopy lowers the chance of having leftover food or liquid in the stomach that could interfere with the procedure or cause complications. 69 adults with type 2 diabete…

This study looked at how the body digests and uses food in people who are obese and undergoing bariatric surgery, compared to healthy volunteers. Researchers used advanced 'omics' technology to measure changes in protein building and other body processes. The goal was to understa…

This study looked at two easy methods to measure deep belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that uses a mild electrical current (bioelectric impedance). The goal was to see which method better relates to heart di…

This study looked at how different types of fat distribution—too much, too little, or in the wrong places—affect the body's response to insulin and the immune system. Researchers measured various immune markers, especially interleukin-7, in 126 adults who were normal weight, obes…

This study looked at how eating a high-fat diet for 5 days affects inflammation in older adults (ages 50-79) with normal weight or obesity. Researchers measured blood markers and gut bacteria to see differences between the two groups. The goal was to understand how body weight ch…

This study looked at whether eating less salt before bed can improve blood pressure and body rhythms in people with obesity. Researchers measured blood pressure, body temperature, and sleep-related hormone changes in 53 adults. The goal was to learn how salt timing affects health…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Vietnam. The program included lessons, videos, and activities to improve diet and exercise. Researchers compared these children to a control group to see if the program improved …

This study tested whether MRI can accurately detect brown adipose tissue (brown fat) in healthy adults, using PET scans as the gold standard. Eight volunteers underwent both scans under mild cold conditions. The goal was to see how well MRI matches PET, not to treat or cure any c…

This study analyzed genetic data from 2,500 people who had bariatric surgery to see if certain genes are linked to better weight loss outcomes. The goal was to find out if these genetic factors differ among ethnic groups. No new treatment was tested; instead, researchers looked a…

This study looked at how well a healthy lifestyle program called Deaf Weight Wise works when run by community organizations for Deaf adults who use American Sign Language. 85 Deaf adults from New York took part. The goal was to see if local groups could successfully deliver the p…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in lipid and sugar taste thresholds before and 6 months after surgery. The goal was to understand why taste changes occur after weight loss s…

This study tested whether a ketone supplement can alter appetite-related hormones in adults with obesity compared to those without. Twenty-six participants received either a ketone drink or a placebo with a meal, and researchers measured hunger and fullness hormones over several …

This study tested whether a blood protein called PTX3 can predict how much weight people lose and how their metabolism improves after gastric bypass surgery. Researchers followed 23 adults with obesity for 6 months after surgery. The goal was to see if PTX3 levels before surgery …

This study looked at how well a new video-assisted breathing tube device (SaCoVLM™) works in 57 severely obese patients undergoing weight-loss surgery. The main goal was to see how often the breathing tube was placed correctly on the first try. The device combines a regular airwa…

This study followed 1500 people with obesity (BMI 25 or higher) to understand what factors lead to diabetes remission and improvement of other complications after bariatric surgery. Researchers collected health data and lab tests from patients who had surgery and those who did no…

This study looked at how lean and obese people respond to not having water. Researchers wanted to see if body fat affects thirst and water balance. 75 healthy men stayed in the hospital for 13 days and had tests like a 24-hour water fast and salt water infusions. The goal was to …

This study looked at how quickly food leaves the stomach and travels through the gut in 20 men—some with obesity and some at a healthy weight. Researchers used MRI scans and blood tests to measure stomach emptying, gut blood flow, and hunger-related hormones. The goal was to bett…

This study looked at the bacteria living in the small intestine and colon of 90 adults, including lean people, people with obesity, and people with both obesity and type 2 diabetes. Researchers collected samples during routine endoscopy or colonoscopy to compare these gut bacteri…

This study looked at whether it is possible to add a nutrition program called BfedBwell to an existing exercise program for cancer survivors. Twenty adults who had finished cancer treatment and were overweight or obese took part. The goal was to see if the program was easy to fol…

This study looked at how vitamin E is absorbed and used by the body in normal-weight, overweight, and obese women, including those with type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after different meals and vitamin C doses. The goal was to better un…

This study looked at how obesity changes muscle fiber types and protein production. Researchers measured how fast muscles make new proteins in 48 lean and obese adults. They used exercise and amino acid infusions to see how these factors affect muscle health. The goal was to unde…

This study looked at how well doctors can catch serious and non-serious side effects of the weight-loss drug Saxenda in Mexican patients. It involved 27 people with obesity who were already prescribed Saxenda by their doctor. The main goal was to track cases of pancreatitis and o…

This study looked at 64 obese adults to see if having obesity hypoventilation syndrome (OHS) adds extra problems beyond obesity alone. Researchers measured exercise capacity, muscle strength, and quality of life using walking tests and questionnaires. The goal was to understand h…

This study looked at how stress from the COVID-19 pandemic affected eating behaviors and weight in over 5,000 English-speaking adults. Participants completed online surveys about their mental health, eating habits, and weight changes. The goal was to understand the connection bet…

This study looked at how common weight-related health problems are in people of different weights in India, Pakistan, Philippines, and Vietnam. About 1,170 adults with at least one weight-related complication took part. No treatment was given; participants just continued their no…

This study looked at how losing weight through diet changes affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, and other iron markers before and after a 60-day diet plan. The goal was to…

This study looked at the safety of giving lidocaine (a numbing medicine) during weight-loss surgery. 50 adults having laparoscopic bariatric surgery had their blood tested at several points to measure lidocaine levels. The goal was to confirm that dosing based on a modified body …

This completed study looked at 332 adults with obesity to see if simple body measurements and blood tests could predict metabolic syndrome—a cluster of conditions that raise heart disease and diabetes risk. Researchers grouped participants by obesity severity and calculated vario…

This study looked at whether a new weight-loss drug (BI 456906) changes how the body processes three common drugs: bupropion, caffeine, and midazolam. It involved 34 healthy adults with overweight or obesity. Participants took the three drugs alone, then again while receiving wee…

This study looked at how physical activity relates to quality of life and mental health in adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track their movement and sedentary time. The goal was to understand these connections, not to pr…

This study looked at how trans fats from dairy products and from industrial sources affect insulin resistance in 66 obese women. The goal was to see if these different types of trans fats have different effects on the body's ability to use insulin. Participants underwent tests to…

This study looked at 37 obese adults to understand why their brains show less pleasure when tasting food. Researchers think insulin resistance in the brain may be the cause. They used brain scans to measure responses and checked if weight loss could fix the problem. The goal is t…

This completed early-stage study tested two different forms of an experimental medicine called NNC0519-0130 in 46 adults with overweight or obesity. The main goal was to measure how much of the drug gets into the blood and compare the two versions. The study lasted about 24 weeks…

This study tested whether a mobile app-based weight loss program is practical and well-liked by young adults who survived cancer. Researchers enrolled 63 survivors aged 18-39 and used a smartphone app with activity tracking and diet logging. The goal was to see if people would jo…

This study looked at how two different but equally healthy diet plans affect insulin levels and other markers of metabolic health in adults who are overweight or at risk for insulin resistance. Researchers measured changes in blood sugar control, cholesterol, and metabolism over …

This study looked at how closely 97 adults with obesity followed the EAT-Lancet (Planetary Health) diet, and whether that related to their natural sleep-wake patterns (chronotype) and psychological well-being. Researchers measured body size, blood markers, and diet habits, and us…

This study looked at how different insulin levels impact blood sugar in 18 adults with overweight, insulin resistance, and non-alcoholic fatty liver disease (NAFLD). Participants underwent two procedures where insulin was either kept steady or slowly reduced, and researchers meas…

This study looked at 20 obese teenagers aged 13-20 who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how surgery affects liver health and metabolism.

This study collected neck tissue, blood, and urine from 34 adults having neck surgery. The samples are stored in a central bank so researchers can study them to find new ways to predict, identify, and treat obesity and related conditions like diabetes. The goal is to learn more a…

This study explored how diet influences inflammation in 393 healthy and obese adults. Researchers measured immune cells, hormones, and metabolism after a high-fat meal to understand the link between eating habits and chronic disease risk. The goal was to gather knowledge, not to …

This study looked at how being obese affects hospital stays and recovery in trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer hospital stays, more complications, or higher costs. The goal was to clarify conflict…

This study looked at how obesity affects the way the body processes immunoglobulin G (IgG), a drug used to treat immune deficiency. Researchers wanted to find the best dose for obese patients to avoid side effects from too much medication. The study included 40 adults aged 18 to …

This study aims to understand why obesity leads to obstructive sleep apnea in some people but not others. Researchers will measure airway collapse and muscle responses during sleep in 106 adults with obesity, both with and without sleep apnea. Participants will be studied before …

This study follows people who were in the SELECT trial for an anti-obesity medication. It does not provide any new treatment—instead, participants fill out health questionnaires every 6 months for up to 10 years. The goal is to see long-term effects like heart attacks, strokes, c…

This study aimed to uncover the genetic and lifestyle factors that cause pre-diabetes to turn into type 2 diabetes. Over 1,700 healthy adults aged 18 to 55 underwent detailed tests of how their bodies handle sugar and store fat. Researchers hope these findings will lead to better…

This study looked at 44 adults with obesity to see if symptoms of over-breathing (hyperventilation) are tied to how well they can move and perform daily tasks. Participants completed walking, balance, and strength tests, and reported their breathing symptoms. The goal is to help …

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians (who have high obesity rates) and Caucasians, using questionnaires and food intake m…

This study looked at how the calories people burn through physical activity relate to body weight and diabetes risk. Researchers tracked 2,500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US over two years. They used activity monitors and special water test…

This study looked at how healthy adults burn calories when exposed to different temperatures, from cool to warm. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. The goal was to better understand wh…

This study looked at how an experimental drug for obesity (HRS-7535) interacts with four common medicines: acetaminophen (pain relief), digoxin (heart medication), rosuvastatin (cholesterol), and omeprazole (acid reflux). It involved 40 overweight or obese adults and measured dru…

This study followed about 1,900 pregnant women (some with HIV, some without) and their children for two years to see how HIV and the drug dolutegravir affect weight gain and body fat. Researchers measured things like weight, body composition, and blood markers in both mothers and…

This study looked at 115 patients to see if inflammation in belly fat (white adipose tissue) causes confusion or memory problems after surgery. Researchers measured thinking skills and inflammation levels before and after hip or heart surgery. The goal was to understand why obese…

This study tested whether showing Nutri-Score labels (A to E) on a food delivery app helps people pick healthier meals. Over 800 adults who order takeout at least once a month made hypothetical choices in an online simulation. Some saw labels, some saw labels plus extra education…

This study followed 46 obese men who had weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy) to see how it affected their sperm quality. Researchers measured sperm count and other fertility-related factors before and after surgery. The goal was to learn whether b…

This study looked at whether a weight loss program led by trained community members, called "house chats," could work in a low-income area. It involved 71 African American adults in Petersburg, VA. The goal was to see if the program was practical and well-liked, not to measure we…

This study measured brain fluid chemicals in 51 adults with obesity before and after bariatric surgery or diet-induced weight loss. The goal was to understand why surgery leads to better long-term weight control. By comparing brain signals, researchers hope to find new ways to tr…

This study looked at how sleep quality, when people eat, and gut bacteria are connected to obesity. It included 133 adults with different body weights and sleep issues. The goal was to understand these links and test a simple e-health tool to help people make healthier lifestyle …

This study looked at how the drug dupilumab changes gene and protein activity in airway cells from adults with allergic asthma and obesity (BMI 30 or higher). Researchers collected nasal cells from 28 participants to see how dupilumab affects inflammation signals. The goal was to…

This early-stage study looked at how a low-fat meal and taking the drug in the evening change the way KAI-7535 moves through the body. It involved 18 healthy adults who were overweight or obese. The goal was to gather information for future dosing instructions, not to treat or cu…

This study looked at whether eating at different times of day affects weight and body fat in people with obesity. 38 adults followed two meal schedules to see how timing impacts metabolism. The goal was to gather information, not to provide a treatment.

This study looked at 290 people who had sleeve gastrectomy surgery for obesity. Researchers wanted to see how what they ate during the first year after surgery affected their weight loss. The main goal was to measure changes in body mass index (BMI) one year after the operation.

This study looked at brain activity in 187 young adults when they expected and tasted a milkshake. Using MRI scans, researchers measured how certain brain areas involved in reward responded to the tasty drink. The goal was to understand brain patterns that might make some people …

This early-stage study tested a single dose of the experimental drug monlunabant in 73 healthy men of normal weight, half Japanese and half Caucasian. The main goal was to check for side effects and see how the drug moves through the body. Participants were randomly assigned to r…

This study tested whether teaching women about sustainable nutrition and the Mediterranean diet could improve their body measurements like weight, body fat, and waist size. Sixty-two women with overweight or obesity took part. The goal was to see if education alone could lead to …

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and factors like mood and kitchen access to understand why weight gain happens. The goal is to use this information to design better he…

This study looked at how one session of exercise affects the brain's ability to respond to insulin in adults aged 40 to 80 who are overweight or obese. Researchers measured brain blood flow and thinking skills before and after exercise. The goal is to understand how exercise migh…

This study followed 200 children and young adults who are overweight or have obesity and are at risk for high blood pressure. Researchers collected medical information over time to learn how excess weight affects the heart and blood vessels. The goal is to better understand these…

This study looked at how high-intensity interval training (HIIT) and weight-loss surgery affect nerve health in people with obesity. Researchers measured nerve fiber density in the skin and used eye scans to track nerve changes. The goal was to see if these interventions could lo…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 took part, staying in a special room that measured their calorie burn. The goal wa…

This study examined 549 older adults (65+) to see if metabolic syndrome is connected to vitamin D levels, even in those without vitamin D deficiency. Researchers used surveys and blood tests to gather data. The goal was to better understand these relationships, not to test a trea…

This study followed 1,100 adults with severe obesity who were taking the weight-loss drug WEGOVY®. Researchers tracked weight changes over 12 months and looked for patterns in who lost the most weight. They also used artificial intelligence to find clues—like certain health marke…

This study looked at 116 overweight or moderately obese patients who had a stomach-reducing procedure called endoscopic sleeve gastroplasty. The goal was to find out why some people lose more weight than others after the procedure. Researchers analyzed blood samples and clinical …

This study looked at how certain immune cells, called eosinophils, interact with fat tissue in people with obesity and insulin resistance. Four participants provided fat biopsies and blood samples to measure immune cell levels and markers of inflammation. The goal was to better u…

This study examines whether the body's ability to switch between burning sugar and fat (metabolic flexibility) is linked to changes in metabolic health over 16 years. Researchers will re-evaluate 18 healthy participants from a 2008 study to measure weight, blood sugar, cholestero…

This study looked at 195 overweight or obese pregnant women to understand what factors influence their decision to join a 12-week program combining nutrition advice and physical activity. The goal was to identify barriers and motivators so future programs can be more effective. R…

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Researchers gave some participants insulin shots to give their pancreas a rest and checked if that helped insulin production. They also compared diabetic and non-diabetic volunteers to lear…

This study combined data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers compared the long-term effects of bariatric surgery versus standard medical and lifestyle treatments on blood sugar control. The goal was to see …

This study looked at how well obese adults follow their prescribed breathing machine therapy for sleep-disordered breathing. Researchers tracked 300 patients to see if they used the device at least 4 hours a night for 70% of nights within the first 90 days and again after a year.…

This study looked at how long-term lack of sleep affects heart health and weight gain in women. Researchers compared premenopausal and postmenopausal women to see if sleep loss leads to higher blood pressure, worse blood sugar control, and more belly fat. The goal was to understa…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and produce sugar. Researchers studied 21 people with obesity, type 2 diabetes, and fatty liver disease to understand if the liver becomes resistant to glucagon. The goal was to learn…

This study looked at whether training the muscles used for breathing can improve heart function and mood in women who have gone through menopause. Researchers measured how quickly the body adjusts to exercise and how far participants could walk in six minutes. The study involved …

This study looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. Researchers measured changes in muscle strength, insulin response, and body composition in 58 adults aged 50-75. The go…

This study checks in on mothers and their children 12 years after a program that helped obese pregnant women eat healthier and be more active. The goal is to see if those changes affected the children's body composition and health. About 500 families from the original study are i…

This study looked at how different exercise intensities change levels of ghrelin, a hormone that controls hunger, in 40 adults with obesity and prediabetes. Researchers measured ghrelin in the blood and checked appetite, insulin sensitivity, and blood vessel function. The goal wa…

This study followed 37 adults who were about to start a GLP-1 medication (like Ozempic or Mounjaro) for weight or diabetes management. Participants kept food records and answered questionnaires to track dietary changes and side effects. The goal was to see if this type of researc…

This study looked at whether a 12-month lifestyle program could lower body fat and change certain gene markers in adults with metabolic syndrome and obesity. Twenty-six participants tracked their diet and activity using a mobile app, and had blood tests and body scans at the star…

This study looked at levels of a hormone called prolactin in the gum fluid of 26 people who have both obesity and gum disease (stage II or III). Researchers measured prolactin before and after a standard deep-cleaning treatment to see if the hormone levels changed. The goal was t…

This study looked at how a 20% calorie-restricted diet changes metabolism in obese men of two age groups: 30-40 and 60-70 years old. Researchers measured fat breakdown at rest and during exercise, along with other metabolic and genetic markers. The goal was to understand if older…

This study looked at how the experimental drug GZR18 is processed by the body in 6 overweight or obese Chinese men. Participants took a single dose, and researchers measured the drug and its breakdown products in blood, urine, and feces over 78 days. The goal was to understand ho…

This study looked at whether sleeping longer (over 7 hours a night) can improve how the body processes sugar in people with obesity and early signs of insulin resistance. 31 participants were split into two groups: one aimed to sleep more, the other kept their usual sleep habits.…

This study looked at how a personalized 8-week exercise program affects heart and blood vessel function in men with obesity or type 2 diabetes. Researchers compared these groups to healthy volunteers to understand the differences. The goal was to learn more about the benefits of …

This study looked at 75 obese adults to find the best way to increase oxygen levels before anesthesia. Researchers compared deep breathing alone, deep breathing with pressure support, and deep breathing with pressure support plus positive pressure. The goal was to see which metho…

This study looked at how moderate physical activity affects the way the body processes different types of dietary fat in men with obesity. Twelve men aged 18 to 55 with a BMI over 25 and a sedentary lifestyle completed two months of exercise training. Researchers used stable isot…

This study looked at 1,290 adults with obesity (BMI 30 or higher) who had weight-loss surgery and needed a breathing tube. The goal was to find out how often doctors have trouble placing the tube safely. By tracking patient details and any complications, the results will help ane…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if risk factors for diabetes and heart disease differ by race. Participants completed several visits including blood tests, glucose tolerance tests, body fat measurements, and meal t…

This study looked at 155 adults who had weight-loss surgery to see if using a lower flow of anesthesia gas (sevoflurane) affected inflammation levels differently than a standard flow. Researchers checked blood markers of inflammation before and after surgery. The goal was to lear…

This study looked at 128 adults with obesity to understand how blood sugar levels, gut bacteria, and iron buildup in the brain are connected to thinking and memory. Researchers used glucose monitors, brain scans, and sleep trackers to gather data. The goal was to learn more about…

This study looked at 101 adults who had weight-loss surgery to see if changes in taste and smell are linked to 'hedonic hunger'—the desire to eat for pleasure rather than hunger. Participants filled out questionnaires about their senses, eating habits, and diet quality. The goal …

This study looked at how different diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems after losing weight. Over 200 adults took part, and researchers measured their energy use by having them drink special water and trackin…

This study tested whether a personalized lifestyle program could help people with obesity and related conditions like prediabetes or high blood pressure improve their insulin resistance. Forty adults received either nutrition or exercise counseling first, and if they didn't impro…

This study examined 20 women undergoing large-volume liposuction (5-8 liters) to see if the size of the treated body area affects blood counts, clotting, and electrolyte levels. Researchers compared patients who had liposuction on different surface areas. The goal was to better u…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find what factors might increase the risk of bleeding during or within 30 days after surgery. By identifying these predictors, doctors hope to create a scoring syst…

This study looked at how an anti-nausea drug (ondansetron) affects the levels of an experimental weight-loss medication (AMG 133) in the blood. It involved 59 adults who were overweight or obese. The goal was to gather information on drug interactions, not to treat or cure obesit…

This study looked at how salt in the diet affects blood pressure in Black adults. 19 participants ate both high-salt and low-salt diets to see how their bodies handled salt. The goal was to understand the link between salt and blood pressure, not to test a treatment.

This study measured how often sleep apnea occurs in obese pregnant women and whether treatment with a CPAP machine improves outcomes for mother and baby. Researchers followed 89 women with a BMI of 35 or higher in their third trimester. The goal was to understand the link between…

This study tested whether the timing of protein intake changes how the body uses energy and whether a high-protein breakfast reduces cravings for unhealthy snacks. Researchers studied 53 adults with obesity. Results could help design better eating plans for weight management.

This study looked at whether 3 weeks of alternate-day fasting helps the heart use a special fuel called ketones more efficiently compared to a typical Western diet. Sixteen adults aged 55-70 with obesity and insulin resistance underwent PET scans and lab tests after each diet per…

This early-stage study tested a single dose of a new medicine, NNC0662-0419, in 100 adults with overweight or obesity. Researchers wanted to see how the drug behaves in the body and whether it is safe in Japanese, Chinese, and non-Asian participants. The study lasted up to 2 mont…

This study looked at 80 obese adults having spine surgery to see if customizing the breathing machine's pressure settings improves oxygen levels and reduces lung problems after surgery. One group received standard settings, while the other had settings tailored to their lung flex…

This study tested whether adding carob to a Western-style breakfast can help regulate appetite and blood sugar. Twenty healthy, normal-weight men participated. Researchers measured hunger hormones and satiety levels after the meal. The goal was to see if carob's high fiber and po…

This study looked at why people have trouble sticking to a diet and exercise plan during a weight loss program. Researchers used smartphone surveys and Fitbits to track 119 adults with overweight or obesity. The goal was to find out what causes these slip-ups in daily life, so fu…

This study examined how often adults with obesity in the Gulf region have related health issues like diabetes, high blood pressure, and fatty liver disease. Researchers also looked at the medical costs and healthcare use tied to these conditions. Over 1,300 people were included, …

This study looked at how the COVID-19 lockdown affected weight, sleep, and mental health in nearly 4,800 adults who were already in a weight-loss program. Researchers wanted to see if stress, less exercise, and changes in eating habits during confinement slowed down weight loss. …

This study looked at whether limiting eating to a specific time each day (time-restricted feeding) is practical and acceptable for older adults (ages 65-80) who have mild cognitive impairment and are overweight. Over 12 weeks, 33 participants followed this eating pattern, and res…

This study tested a home-based system that uses remote monitoring and health coaching to help people with severe sleep apnea and obesity make healthy changes. 17 adults took part to see if the system was easy to use and helpful. The goal was to improve health and quality of life,…

This study looked at why obese people with asthma often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis to examine lung changes in 49 obese adults with asthma. The goal was to better understand the r…

This study tested whether community programs can help people in Appalachian Kentucky eat more fruits and vegetables and have better access to food. About 281 adults from Laurel and Pike Counties took part. Researchers measured diet quality and food security over time to see if th…

This study looked at 90 adults who had sleeve gastrectomy surgery for obesity but did not lose enough weight. Researchers measured the leftover stomach volume two years after surgery to see if a larger stomach caused the failure. The goal was to learn if stomach size can help gui…

This study tested whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized diet change for a short time. The goal was to see if it was possible and acceptable, not to measure health effects. Results wil…

This study looked at how the body processes the antiviral drug acyclovir in people with obesity compared to those without. Researchers tested a special dosing formula based on adjusted body weight. About 13 hospitalized patients had blood drawn multiple times over 12 hours to mea…

This research study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Fifteen adults with overweight or obesity took part. The goal was to learn more about what helps or hinders weight management in th…

This study looked at whether women with obesity perceive sounds they make themselves as quieter than sounds made by others, compared to healthy-weight women. 37 women completed a listening task where they compared the loudness of tones they triggered versus tones triggered by the…

This study looked at whether the smallest meaningful change in bone density measurements is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy of bone health tests…

This study looked at what happens inside the body when people with obesity stop following restrictive diets. Researchers measured changes in mitochondria (the cell's energy centers) and gut bacteria after participants returned to normal eating. The goal was to understand why diet…

This study looked at how losing weight through diet affects body fat and metabolic health in 74 adults with excess weight. Participants followed a 12-week low-calorie diet. Researchers measured changes in fat mass and blood markers like triglycerides and insulin resistance to see…

This study aimed to create simple, reliable tools (paper and electronic) to assess the foods people have at home, focusing on items that affect health and obesity. Researchers tested these tools with 439 English- or Spanish-speaking adults who do the main grocery shopping or meal…

This study looked at a recently discovered protein called 26RFa, which may be linked to hunger, blood sugar, and obesity. Researchers measured its levels in 62 obese women (some with type 2 diabetes) before and after weight-loss surgery, and compared them to healthy volunteers. T…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…