New pill aims to stop muscle loss during Weight-Loss drug boom

NCT ID NCT06282458

Completed Disease control Sponsor: Veru Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This completed Phase 2 trial tested whether enobosarm, an experimental oral drug, can prevent muscle loss in older adults (aged 60+) who are taking GLP-1 receptor agonists like Wegovy for chronic weight management. The study enrolled 168 participants and measured changes in lean body mass and fat mass over 112 days. The goal is to help people lose fat while keeping or building muscle, improving strength and physical function.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: enobosarm (a selective androgen receptor modulator, SARM)
What this could lead to: If it works, enobosarm could help people on weight-loss drugs like Wegovy preserve muscle while losing fat, improving overall body composition and physical function.
What could go wrong: This is an early Phase 2 study with only 168 participants, so results may not apply to everyone. Enobosarm is still experimental and its long-term safety is unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

muscular atrophy Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MUSCLE LOSS OBESITY

Contacts and locations

Locations

Altus Research

Lake Worth, Florida, 33461, United States
Artemis Institute for Clinical Research

San Diego, California, 92103, United States
Centennial Medical Group (CMG)

Elkridge, Maryland, 21075, United States
Clinical Trials of Texas, LLC DBA Flourish Research

San Antonio, Texas, 78229, United States
Clinvest Headlands LLC

Springfield, Missouri, 65807, United States
Cullman Clinical Trials

Cullman, Alabama, 35055, United States
DelRicht Research - New Orleans

New Orleans, Louisiana, 70115, United States
Lillestol Research LLC

Fargo, North Dakota, 58104, United States
MARC Research Center

Louisville, Kentucky, 40213, United States
Palm Research Center

Las Vegas, Nevada, 89119, United States
Pennington Biomedical

Baton Rouge, Louisiana, 70810, United States
Pinnacle Trials

Anniston, Alabama, 36207, United States
SKY Integrative Medical Center

Ridgeland, Mississippi, 39157, United States
Universal Axom Clinical Research

Doral, Florida, 33122, United States

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