Could a Two-Drug combo supercharge weight loss?

NCT ID NCT06373146

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study looked at whether adding a second drug (mibavademab) to the weight-loss medication tirzepatide helps adults with obesity lose more weight than tirzepatide alone. About 392 participants with a BMI between 30 and 40 took part. The goal was to measure changes in body weight over 74 weeks.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CTI Clinical Research Center

    Cincinnati, Ohio, 45212, United States

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • Hassman Research Institute Marlton Site

    Marlton, New Jersey, 08053, United States

  • Irvine Clinical Research

    Irvine, California, 92614, United States

  • Juno Research

    Houston, Texas, 77040, United States

  • Lillestol Research

    Fargo, North Dakota, 58104, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Solaris Clinical Research

    Meridian, Idaho, 83646, United States

  • South Texas Clinical Research

    Corpus Christi, Texas, 78404, United States

  • Tandem Clinical Research

    Marrero, Louisiana, 70072, United States

  • Velocity Clinical Research - New Orleans

    New Orleans, Louisiana, 70119, United States

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research, Gardena

    Gardena, California, 90247, United States

  • Velocity Clinical Research, Los Angeles

    Los Angeles, California, 90017, United States

  • Velocity Clinical Research, North Hollywood

    North Hollywood, California, 91606, United States

  • Velocity Clinical Research, Panorama City

    Van Nuys, California, 91405, United States

  • Velocity Clinical Research, Santa Ana

    Santa Ana, California, 92704, United States