New drug targets genetic obesity in phase 3 trial
NCT ID NCT05093634
First seen Nov 01, 2025 · Last updated Apr 24, 2026 · Updated 26 times
Summary
This study tests a drug called setmelanotide for people with obesity caused by specific gene variants (POMC, PCSK1, LEPR, SRC1, or SH2B1). About 296 participants aged 6 to 65 will receive either the drug or a placebo to see if it helps reduce body weight. The goal is to control obesity, not cure it, as ongoing medication is needed.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Advent Health
Altamonte Springs, Florida, 32701, United States
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Aintree University Hospital
Liverpool, L9 7AL, United Kingdom
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Biopharma Informatic
Houston, Texas, 77084, United States
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Bristol Royal Hospital for Children
Bristol, BS2 8AE, United Kingdom
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Centre Hospitalier Universitaire (CHU) de Bordeaux
Pessac, 33604, France
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Chaim Sheba MC, Safra Children's Hospital
Ramat Gan, 52621, Israel
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Charite - Universitatsmedizin Berlin
Berlin, 10117, Germany
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Columbia University
New York, New York, 10032, United States
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Endocrine Associates of Dallas and Plano
Plano, Texas, 75093, United States
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Endokrinologikum Frankfurt
Frankfurt, 60596, Germany
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Erasmus Medisch Centrum
Rotterdam, 3015 GD, Netherlands
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GH Est Hopital Femme Mere Enfant
Lyon, 69677, France
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Geisinger Clinic
Danville, Pennsylvania, 17822, United States
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Hasharon Hospital
Petah Tikva, 49372, Israel
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HonorHealth Bariatric Center
Scottsdale, Arizona, 85258, United States
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Hopital Armand Trousseau
Paris, 75771, France
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Hospital Fundación Jimenez Díaz
Madrid, 28040, Spain
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Hospital General de Valencia
Valencia, 46014, Spain
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Hospital Sant Joan de Deu, Barcelona
Barcelona, 08950, Spain
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Hospital Universitario Virgen de la Victoria de Málaga
Málaga, 29010, Spain
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Hu Pitie Salpetriere Aphp
Paris, 75651, France
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Hôpital Félix Guyon Bellepierre
Saint-Denis, 97400, France
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InQuest Medical Research
Suwanee, Georgia, 30024, United States
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London Medical - The London Diabetes Centre
London, NW1 2PG, United Kingdom
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Marshfield Clinic Research Foundation, a Division of Marshfield Clinic, Inc
Marshfield, Wisconsin, 54449, United States
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Mayo Clinic
Rochester, Minnesota, 55902, United States
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Metro Detroit Endocrinology Center
Dearborn, Michigan, 48126-2619, United States
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Metropolitan Hospital Center
New York, New York, 10029, United States
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Mount Sinai Hospital
New York, New York, 10029, United States
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MultiCare Health System Institute for Research and Innovation
Tacoma, Washington, 98405, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Phoenix Children's Hospital
Phoenix, Arizona, 85016, United States
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Rio Grande Valley Endocrine Center
McAllen, Texas, 78503, United States
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St. Luke's Hospital
Chesterfield, Missouri, 63017, United States
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Ten's Medical Center - Pediatric Endocrinology Clinic
Staten Island, New York, 10306, United States
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Texas Children's Hospital
Houston, Texas, 77030, United States
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Texas Tech
Amarillo, Texas, 79106, United States
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UMASS Memorial Medical Center
Worcester, Massachusetts, 01655, United States
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UPMC Montefiore
Pittsburgh, Pennsylvania, 15213, United States
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Universitaetsklinikum Leipzig
Leipzig, 04103, Germany
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Universitaetsklinikum Ulm
Ulm, 89075, Germany
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University College London Hospitals NHS Foundation Trust
London, WC1E6JF, United Kingdom
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University of Alberta - Alberta Diabetes Institute (ADI)
Edmonton, Alberta, T6G 2E1, Canada
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University of Buffalo
Buffalo, New York, 14260, United States
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University of Cambridge
Cambridge, CB2 0QQ, United Kingdom
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University of Michigan
Ann Arbor, Michigan, 48105, United States
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University of Patras School of Medicine
Rio, 26504, Greece
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University of Puerto Rico
San Juan, 00925-253, Puerto Rico
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Vanderbilt University School of Medicine
Nashville, Tennessee, 37232, United States
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Washington University in St. Louis
St Louis, Missouri, 63130, United States
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West Virginia University
Morgantown, West Virginia, 26506, United States
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Yale Center for Clinical Investigation
New Haven, Connecticut, 06519, United States
Conditions
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