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Can a mask prevent breathing failure in obese ICU patients?

NCT ID NCT04014920

Completed Disease control Sponsor: University Hospital, Montpellier Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether using a non-invasive ventilation (NIV) mask right after removing a breathing tube can prevent respiratory failure in obese intensive care patients. About 1000 obese adults were randomly assigned to receive either NIV or oxygen therapy. The goal was to see which approach reduces the need for re-intubation or other breathing support failures.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
non-invasive ventilation (NIV) and oxygen therapy (high-flow nasal oxygen or standard oxygen)
What this could lead to
If NIV proves superior, it could become the standard post-extubation care for obese ICU patients, reducing the need for re-intubation.
What could go wrong
This is a completed trial, but results may not apply to all obese patients or settings. NIV can cause discomfort or skin damage, and some patients may still need re-intubation.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Respiratory Aspiration ventilation pneumonitis acute respiratory failure prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTENSIVE CARE UNIT OBESITY VENTILATION

Contacts and locations

Locations

  • Centre Hospitalier Universitaire Saint Eloi

    Montpellier, Herault, 34000, France

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