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Diet drinks vs. sugary drinks: which helps you lose more weight?

NCT ID NCT04567108

Disease control Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at whether replacing sugary drinks (like soda and sports drinks) with calorie-free alternatives (like diet drinks or water) can help adults with overweight or obesity lose weight. About 460 people who drink at least one sugary drink per day will be assigned to one of four drink groups for six months. The main goal is to see how much weight they lose and whether their waist size and taste preferences change.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

461 people

The number who actually took part.

Started

Apr 2021

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 69 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults aged 20-69 years 2. Consume ≥1 serving/day (12 oz.) of SSBs (SSBs include soda, fruit drinks, energy drinks, sports drinks, and sweetened waters, sweetened with high fructose corn syrup, sucrose, or fruit juices. SSBs do not include 100% fruit juice, sweetened teas, or flavored milk.) 3. BMI 25.0 to 45.0 kg/m2 4. Access to a smartphone and willingness and ability to download study app 5. Willing to consume beverages consistent with any of the 4 possible group assignments for 6 months Exclusion Criteria: 1. Physician diagnosis of T2D or fasting glucose ≥126 mg/dL at in-person screening visit 2. Intention to move away from greater Boston area within 1 year from randomization 3. Major medical illness (known cardiovascular disease, cancer, kidney disease, cirrhosis, etc.) 4. Phenylketonuria (PKU) 5. Medication that may affect weight or other study endpoints 6. Another family or household member participating in the study 7. Pregnant in the past 12 months, currently breastfeeding, or planning to become pregnant during the study period

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Conditions

The condition(s) this trial relates to.

Body Weight obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body weight

Contacts and locations

Locations

  • Brigham and Women's Hospital

    Boston, Massachusetts, 02215, United States

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