OBESITY

This study is testing whether a new medication called aleniglipron (GSBR-1290) can help people with obesity or overweight manage their weight when combined with diet and exercise. Researchers will compare the drug to a placebo in 82 participants over 44 weeks to see if it's safe …

This study is testing whether adding culturally-relevant stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 participants are randomly assigned to receive either the standard program or the enhanced version with…

This study is testing whether a new drug called MET097, given as a monthly injection after initial weekly doses, helps people with obesity or overweight lose weight. About 250 adults will receive either the drug or a placebo (inactive shot) for over a year to see which is more ef…

This study aimed to test the safety and effectiveness of a new combination weight loss pill (sibutramine and topiramate) in overweight or obese adults, some of whom had other health conditions like high blood pressure. It compared the new pill to a dummy pill (placebo) and to one…

This study aims to understand how two weekly injectable medications for obesity—semaglutide and tirzepatide—affect how the stomach works. Researchers will compare these drugs to a placebo in 30 adults with obesity, measuring stomach emptying, feelings of fullness, and body weight…

This study is evaluating the health results of a 12-week intensive program for adults with type 2 diabetes and obesity. The program focuses on helping participants lose weight and better control their diabetes. Researchers are measuring changes in body weight, blood sugar levels,…

This study is testing whether a new pill called VCT220 helps people lose weight and keep it off. About 840 overweight or obese adults will take either a high dose, low dose, or a placebo pill once a day for a full year. Researchers will measure changes in body weight, waist size,…

This study is testing whether a weekly injection called semaglutide can help adolescents with obesity maintain weight loss over the long term. All 500 participants, aged 12 to under 15, will receive the injection for at least three years. The goal is to see if the treatment helps…

This study is testing whether a daily injection called setmelanotide can help people with Prader-Willi Syndrome manage their weight and reduce extreme hunger behaviors. About 20 participants aged 6-65 will receive the medication for up to one year while researchers monitor safety…

This study is testing a web-based decision support tool in primary care clinics. The tool provides personalized information to doctors and patients about the potential benefits and risks of different weight loss treatments, like medication or surgery, for people with type 2 diabe…

This study is testing whether a new drug called LY3841136, alone or combined with an existing drug called tirzepatide, can help with weight management in adults who have type 2 diabetes and are overweight or have obesity. About 350 participants will receive either the active drug…

This study is testing whether adding a new investigational drug called mibavademab to an existing weight loss medication (tirzepatide) helps people lose more weight. About 392 adults with obesity will receive either the combination or tirzepatide alone for about 74 weeks. The mai…

This study is testing a new weekly injection called CagriSema, which combines two medicines, to see if it helps people with obesity or overweight lose weight. About 3,400 participants will receive either CagriSema, one of its components alone, or a placebo injection for about a y…

This study compares two variations of a minimally invasive procedure called TORe, which helps people who have regained weight after gastric bypass surgery. Researchers are testing whether adding a small cut to the stomach lining during the procedure leads to better weight loss re…

This study is testing whether the drug setmelanotide can help people with obesity caused by specific rare genetic changes lose weight. About 300 participants, aged 6 to 65, with one of these genetic variants will receive either the drug or a placebo for comparison. The main goal …

This study aimed to test how well and safely two different drugs, bimagrumab and tirzepatide, worked alone or together to help adults with obesity or overweight and type 2 diabetes lose weight. The trial was designed to last about 13 months but was withdrawn before any participan…

This study is testing whether a daily injection called liraglutide, combined with lifestyle counseling, can help children aged 6 to 12 with obesity manage their weight. For 56 weeks, about 78 children will receive either the real medicine or a placebo (dummy) injection, and neith…

This study is testing whether a one-time, outpatient endoscopic procedure can help people keep weight off after they stop taking a weight-loss medication (tirzepatide). Participants first take the medication to lose at least 15% of their body weight. They are then randomly assign…

This early-stage study is testing a new injectable medicine for people with overweight or obesity. The main goal is to check if the medicine is safe and to see how the body absorbs and processes it. About 63 healthy adults will receive either the real medicine or a placebo inject…

This study is testing a healthy lifestyle program delivered through a patient's online medical record. It aims to see if a video-based program alone, or with remote coaching, helps adults aged 50-74 lose weight and improve their health to lower the risk of chronic diseases like d…

This study is testing whether a new weekly injection called nimacimab helps people lose weight. Researchers are comparing it to a placebo (dummy shot) and to nimacimab given alongside the approved weight-loss medication semaglutide (Wegovy). The goal is to see if nimacimab is saf…

This study is testing if using two drugs together works better than one for adults who have both moderate-to-severe plaque psoriasis and are overweight or have obesity. About 250 participants will receive the psoriasis drug ixekizumab alone or combined with the weight-loss drug t…

This study is testing whether higher doses of the medication tirzepatide can help people with both type 2 diabetes and obesity lose weight and better control their blood sugar. About 414 participants who are already taking metformin will receive either the study drug or a placebo…

This study is testing if a new weekly injection called IBI362 works better than an existing drug, semaglutide, for people with early type 2 diabetes and obesity. About 349 Chinese adults will receive one of the two injections for 32 weeks to see which one helps more people reach …

This study compares two telemedicine approaches to help rural residents with obesity manage their weight over 18 months. One approach uses quarterly doctor visits, while the other adds group lifestyle coaching sessions via Zoom. Researchers want to see which method helps people l…

This study is looking at how two common weight loss surgeries—gastric bypass and sleeve gastrectomy—affect people's social lives and overall sense of well-being. Researchers will follow 113 people with obesity for a year after their surgery to see if and how their enjoyment of so…

This study is observing 555 adults with obesity in Germany who are already prescribed the medication semaglutide (Wegovy) by their doctor. The goal is to collect real-world data over 12 months on how well the drug, combined with lifestyle changes, helps people lose weight and imp…

This study is testing if semaglutide, a medication used for weight loss, can improve heart function and reduce symptoms in people who are obese and have a type of heart failure where the heart pumps normally but doesn't relax properly. About 81 participants will be randomly assig…

This study is testing if using two drugs together works better than one for adults with psoriatic arthritis who are also overweight or have obesity. One drug (ixekizumab) treats the arthritis, and the other (tirzepatide) is a weight-loss medication. The goal is to see if the comb…

This study aims to monitor the safety and effectiveness of the weight-loss medication Wegovy in everyday medical practice in Japan. Over 1000 adults with obesity, who have already been prescribed Wegovy by their doctor, will be followed for two years. Researchers will track side …

This study is testing whether time-restricted eating (limiting all food intake to a 10-hour window each day) helps obese adults lose weight and improve how their body fat responds to natural weight-loss signals. Researchers will compare this approach to standard nutritional couns…

This study is testing the safety and feasibility of a new, non-surgical weight loss technique called Gastric Mucosal Ablation (GMA). It uses a special endoscopic tool to apply energy to the stomach lining, aiming to mimic some effects of weight-loss surgery. The study will enroll…

This study is testing whether a weekly injection called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. It will compare the medicine to a placebo (dummy shot) to see if it improves long-term blood sugar levels and helps with weight loss. The tri…

This study is testing a year-long program that teaches cooking, nutrition, and healthy habits to adults with obesity. The goal is to see if this 'teaching kitchen' approach, combined with health coaching, is practical and helps people improve their diet, exercise, sleep, and weig…

This study is testing a revised version of an internet-based weight management program called 'Step by Step.' It aims to see if getting more support from a therapist through online or in-person meetings leads to better weight loss, improved quality of life, and healthier habits c…

This study is testing a new surgical device that uses magnets to connect two parts of the small intestine. The goal is to see if this procedure is safe and can help adults with obesity, with or without type 2 diabetes, manage their weight and improve their blood sugar levels. The…

This study aims to see if combining time-restricted eating (limiting daily food intake to a specific window) with high-intensity interval training (short bursts of intense exercise) can improve health in people with metabolic syndrome. Researchers will compare these approaches in…

This large, late-stage study is testing whether a new injectable medicine called maridebart cafraglutide helps adults with obesity or overweight lose more weight than a placebo over 72 weeks. It will also check if the drug improves health measures like blood pressure, cholesterol…

This study is testing a new magnetic device designed to make a type of weight-loss surgery safer and simpler. The device creates a connection in the small intestine to help with weight management and improve blood sugar control in adults with obesity, with or without type 2 diabe…

This study is testing whether adding a simple mental exercise called WOOP can help Veterans with obesity lose more weight. WOOP is a 4-step technique that uses positive imagery to build motivation. Researchers are comparing the standard VA telephone weight-loss program (MOVE!) to…

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study aims to find the most effective way to help people maintain weight loss after they stop taking medications like Ozempic, Wegovy, Mounjaro, or Zepbound. It will enroll about 226 adults who have successfully lost weight on these drugs but are now stopping them. Participa…

This study is testing if a new oral drug called NT-0796 can help people with obesity lose more weight when added to the injectable medication semaglutide (like Wegovy/Ozempic). About 80 participants will take either NT-0796 or a placebo pill twice daily for 6 months, while everyo…

This large, late-stage study is checking if a new weekly injectable weight-loss medicine called survodutide is safe for the heart. It involves over 5,500 adults who are overweight or have obesity and also have heart disease, kidney disease, or other weight-related health risks. P…

This study tests whether an intensive two-year weight loss program works better than standard care for adults with obesity. The intensive program includes meal replacements, behavior coaching, and weight-loss medications, while standard care follows local health service guideline…

This study tests whether adding family relationship counseling to a standard weight loss program helps Mexican American mothers and their adult daughters manage their weight better. The goal is to see if improving family communication and teamwork around healthy eating and exerci…

This study is testing whether adding kefir, a fermented milk drink, to the diet can help obese children manage their weight and improve related health issues. It will involve 60 children with a body mass index above the 95th percentile for their age. Researchers aim to see if kef…

This study is testing whether having a health coach, called a patient navigator, helps obese adults enroll in and stick with proven weight management programs. Researchers are comparing two groups: one gets basic program information, while the other gets that information plus reg…

This study is testing whether specific dietary habit interventions can help people lose more weight and keep it off after having sleeve gastrectomy surgery. It involves 44 patients who have already had this type of bariatric surgery. Researchers are measuring changes in hunger, c…

This small pilot study is testing whether a specially designed, low-calorie, high-protein liquid food given through a feeding tube can help obese patients who rely on tube feeding to lose weight. The study will also check if the formula is well-tolerated and if it improves other …

This study is testing if giving people with both obesity and diabetes a monthly grocery subsidy for fruits and vegetables, along with support using an online delivery service, helps them buy and eat healthier foods. About 214 participants are assigned to different groups that rec…

This early-stage study is testing a new injectable medicine called NNC0519-0130 for people with type 2 diabetes and excess weight. It will measure how the drug moves through the body and check for side effects in 20 Chinese men with overweight or obesity. Participants will receiv…

This early-stage study aims to check if an experimental drug called maridebart cafraglutide affects heart rhythm in people with overweight or obesity. It will involve 81 healthy adults to see if the drug is safe for the heart before larger studies can test if it helps with weight…

This study is testing if having a personal guide, called a patient navigator, helps people with overweight or obesity start and continue using proven weight loss methods. The 12-month program provides a counselor who helps participants understand their options and connect with ef…

This study is testing a new smartphone app that uses artificial intelligence to predict and help prevent unhealthy eating lapses. Researchers want to see if using this app, with or without a continuous glucose monitor, helps adults with overweight or obesity eat better and lose w…

This study is testing a new weekly injection called CagriSema to see if it helps people with obesity lose weight and keep it off long-term. About 400 adults will receive either the real medicine or a placebo (dummy medicine) for two years, followed by a one-year extension phase. …

This study is testing a drug called retatrutide to see if it helps people with obesity maintain weight loss after they've already lost weight. About 643 participants will first take the drug for 80 weeks to lose weight, then some will continue the drug or switch to a placebo for …

This study is testing whether a weekly injection of semaglutide, a medication used for weight loss and diabetes, can reduce harmful fat buildup in people living with HIV. The trial involves 108 adults with HIV who have a specific fat redistribution condition. Researchers will mea…

This study is testing whether giving higher doses of vitamin D can help control asthma in teenagers who are obese and have low vitamin D levels. Researchers will compare a high-dose regimen to a standard dose to see if it reduces asthma symptoms and flare-ups over three months. T…

This study is testing whether a new investigational medicine called cagrilintide helps people with overweight or obesity lose weight and improve their health. About 300 adults will receive either cagrilintide or a placebo (dummy treatment) by random chance for about 18 months. Re…

This study tests whether an educational video and follow-up phone sessions can help veterans start proven weight loss treatments. It involves 440 veterans who are overweight or have obesity but aren't currently in a weight management program. The goal is to see if this simple edu…

This study is testing whether adding a specific long-acting insulin (detemir) to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight than dieting alone. Researchers want to see if the insulin works by changing brain activity related to pleasure and r…

This study is testing whether a new weekly injection called MET097 helps people with obesity or overweight lose weight compared to a placebo shot. About 225 adults will receive either the drug or a placebo for 28 weeks to see which group loses more weight and has fewer side effec…

This study aims to understand how the weight-loss medication Wegovy works for people with obesity in real-world settings over two years. It will follow about 1,250 adults who are starting Wegovy as part of their regular doctor's care. Researchers will track changes in weight, hea…

This study is testing a new weekly injection called CagriSema to see how well it helps people with obesity lose weight. About 300 adults will receive either the real injection or a placebo (dummy medicine) for about a year and a half. The main goal is to measure how much body wei…

This study is testing a new magnetic device designed to perform a type of weight-loss surgery. The device connects two parts of the intestine using magnets instead of traditional staples or stitches. Researchers want to see if this method is safe and works for helping adults with…

This is an early-stage study to check the safety of a new weight loss drug called LY3537031. It will involve about 302 overweight, obese, and healthy volunteers, including some Japanese and Chinese participants. Researchers will give participants the drug and closely monitor thei…

This study compares two different types of stomach surgery for people with severe obesity. Researchers want to see which procedure leads to better weight loss and improvement in health problems like diabetes and high blood pressure, while also checking which one causes fewer nutr…

This study is testing whether online group doctor visits help people better manage type 2 diabetes and related heart conditions. Researchers are comparing virtual group visits to regular individual care for 720 patients across Chicago health systems. The goal is to see if this ap…

This study is testing a smartphone app designed to help adults with obesity and frequent binge eating. It aims to figure out which app features and messages work best to reduce binge eating episodes and support weight-related goals. The app sends timely suggestions and support to…

This study compares two types of intestinal bypass surgery performed after a previous stomach reduction surgery for severe obesity. Researchers want to see if a newer, simpler surgical connection causes fewer digestive problems and nutritional deficiencies than the standard metho…

This study aims to see if a new weekly injection called HRS9531 works as well or better than the established drug semaglutide for weight loss in adults with obesity. About 572 participants will receive one of the two injections for 52 weeks while researchers track changes in body…

This study is testing two investigational drugs, bimagrumab and tirzepatide, to see how well and how safely they help with weight loss. It will involve about 240 adults who have obesity or are overweight with a related health condition, but who do not have type 2 diabetes. Partic…

This study is testing a weekly injection called tirzepatide for adults who have type 1 diabetes and are also overweight or have obesity. The main goals are to see if it safely improves long-term blood sugar control and helps with weight loss. About 465 participants will be in the…

This study is testing whether a weekly injectable medicine called survodutide helps adults with type 2 diabetes and overweight or obesity lose weight. About 755 participants will be randomly assigned to receive one of two doses of the drug or a placebo (a dummy injection) for 76 …

This study is investigating whether the medication tirzepatide, which is approved for weight loss and diabetes, can improve kidney health in people who are overweight or obese and have chronic kidney disease. Researchers will use special MRI scans to see if the drug increases oxy…

This large, late-stage study is testing whether a once-daily oral medication called orforglipron can help adults with obesity or overweight lose weight and improve related health conditions like high blood pressure or cholesterol. Over 3,100 participants will take the drug or a p…

This study is testing whether a new daily medication called LY3549492 can help adults with obesity or overweight manage their weight. About 288 participants will take either the drug or a placebo (inactive pill) for roughly one year. Researchers will measure changes in body weigh…

This study is testing a new drug called IBI362 to see if it is safe and how it affects the body in people with moderate to severe obesity. It involves 98 Chinese adults and compares the new drug to a placebo (inactive substance) and another weight-loss medication. The main goals …

This study is checking if the weekly medication tirzepatide, along with diet and activity coaching, helps older adults with obesity lose fat while keeping their muscles strong and bones healthy. Over 9 months, 40 participants will take the medication, track their weight and food,…

This study is testing whether an investigational medicine called cagrilintide helps people with type 2 diabetes and overweight or obesity lose weight and improve their health. About 330 participants will be randomly assigned to receive either the new medicine or a placebo for abo…

This small pilot study is testing whether adding a personal coach helps older adults with obesity stick to their clinic's weight loss plan. The coach helps patients attend appointments like physical therapy and nutrition counseling, and connect to community resources. Researchers…

This study is testing whether adding a new investigational drug called RO7204239 to an existing weight-loss medication (tirzepatide) helps people lose more weight. It will involve about 285 adults who have obesity or are overweight with at least one related health issue, like hig…

This study is testing a weekly injection called CagriSema to see how well it helps people with obesity lose weight and keep it off for the long term. About 600 participants will receive either the active medicine or a placebo (dummy injection) for over 3 years. Researchers will m…

This early study is testing a new, non-surgical procedure for weight loss called Gastric Mucosal Ablation (GMA). Doctors use a special tool during a routine endoscopy to gently treat the inner lining of the stomach, aiming to change hormones linked to hunger and weight. The main …

This study is testing whether a new weekly oral pill called VRB-101 helps people lose weight compared to a placebo. It involves about 206 adults who have obesity or are overweight with other related health conditions. Participants take the pill or a placebo for 20 weeks to see wh…

This study compares two types of weight loss surgery to see which one leads to fewer digestive problems and a better quality of life. Researchers are following 200 adults with severe obesity for six months after their surgery. They want to know if adding a step called 'transit bi…

This pilot study is testing if the medication Tirzepatide can help people who still have significant obesity (BMI over 30) one year after having gastric bypass surgery. It will compare the weight loss and body composition changes in 30 people taking the drug for 24 weeks to those…

This large, late-stage study is testing whether a new once-daily pill called orforglipron is as safe and effective as standard insulin injections for adults with type 2 diabetes who also have obesity or are overweight and are at higher risk for heart problems. It will involve abo…

This study aims to find the best way to help people maintain weight loss over the long term. It tests if switching from an initial, effective injectable medication to a cheaper oral medication works better than switching to another standard pill. The trial also focuses on a compr…

This study is testing a new weekly injection called petrelintide to see if it helps people with obesity and type 2 diabetes lose weight and better control their blood sugar. About 221 participants will receive either the drug or a placebo (dummy injection) for comparison. The mai…

This study is testing whether a minimally invasive stomach-shrinking procedure can treat advanced fatty liver disease (NASH) in people with obesity. Researchers will perform the endoscopic sleeve gastroplasty procedure on 20 participants and measure changes in liver scarring, fat…

This study is testing a smartphone app designed to help people stay on track with their diet during a weight loss program. The app checks in with users several times a day and uses a smart algorithm to predict when someone might be about to eat off-plan. When a risk is detected, …

This study is testing whether adding one or two new experimental drugs to the approved medication Wegovy (semaglutide) can help people with obesity lose more weight and body fat. It involves over 1,000 participants and will first check the safety of the new drugs in healthy volun…

This small, early-stage study is exploring whether taking a daily probiotic supplement for 12 weeks can help improve asthma control and reduce insulin resistance in obese adults who have both conditions. Researchers will measure changes in gut and airway bacteria, body weight, in…

This study compares two dietary approaches over three years to see which works better for long-term weight control and improving heart health factors in adults with severe obesity and metabolic syndrome. One hundred participants aged 55-75 will be randomly assigned to follow eith…

This study is testing whether a diet focused on eating more fiber helps people with obesity lose weight and improve their eating behaviors better than standard weight loss education. Researchers are comparing three groups: one gets the fiber-focused plan, another gets standard ad…

This study is testing if a non-invasive device that gently stimulates a nerve in the ear can help people with obesity lose weight and improve their quality of life. It involves 131 adults with obesity using the device, which sends low-frequency electrical pulses. Researchers will…

This study aimed to see if adding a new drug called ofirnoflast to the existing medication semaglutide (like Ozempic®) was better for blood sugar control and weight loss in adults with type 2 diabetes who were overweight or obese. It was designed as a 12-week trial comparing the …

This study is testing if a game-like program can help Veterans with obesity and high blood pressure become more physically active. Over 700 Veterans will try programs that use teamwork or friendly competition, tracked with wearable devices, to encourage daily steps. The goal is t…

This study is testing whether a weekly injection called semaglutide, combined with counseling on healthy eating and activity, can help children and teenagers (ages 6-17) manage their weight over a long period. About 210 participants will be randomly assigned to receive either the…

This planned study aimed to see if the weight-loss drug Wegovy (semaglutide) could help control obesity in active-duty military members. It would have measured how the drug affects body fat, muscle mass, and physical performance over 24 weeks of treatment, followed by a year of o…

This study is testing if a new weekly injection called AZD6234 can help people with type 2 diabetes and obesity lose more weight. It will be given alongside their current GLP-1 medication (like Ozempic or Wegovy). The main goal is to see if adding AZD6234 leads to greater weight …

This large, late-stage study is testing whether the weight-loss medication tirzepatide can reduce serious health events like heart attacks, strokes, and death in adults with obesity. It involves over 15,000 participants who are either over 40 with existing heart disease or are at…

This study is observing how well the weekly weight-loss injection Wegovy works for Korean adults with obesity in everyday medical practice. About 500 participants will receive the treatment as prescribed by their doctor, and researchers will track their weight, body composition, …

This study is testing if a specific type of strength training, where muscles lengthen under load, is better than traditional training for improving muscle strength and health in inactive, obese women. Researchers will compare the two methods over 8 weeks in 24 participants. The g…

This study aims to see if a new blood test can accurately diagnose and track a serious liver disease called NASH, which is linked to obesity and type 2 diabetes. Researchers will test the blood of 828 people to see if measuring two specific markers (PLIN2 and RAB14) in white bloo…

This VA study aims to improve how 20 VA medical centers provide virtual health programs to women Veterans. It's testing two different support strategies to help these facilities successfully offer proven programs for preventing heart disease, diabetes, and depression. The goal is…

This study is testing whether a mobile phone app for parents can help prevent overweight and obesity in school children. About 740 children in Mexico City will participate, with half of their parents using the app for a year to get guidance on healthy eating and physical activity…

This study is testing whether making national healthy eating guidelines more culturally relevant helps African American adults improve their diets and lower their risk for type 2 diabetes. Researchers are comparing three different healthy eating patterns over one year to see whic…

This study tests if a program that encourages drinking water instead of sugary drinks in childcare centers and at home can help prevent obesity in young children. Researchers are working with 14 childcare centers, mostly serving low-income Latino families, to change the drinks av…

This study is testing how well a family wellness program called Turtle Island Tales can reach American Indian families to help prevent childhood obesity and related cancers. The program uses cultural stories and activities to promote healthy eating, physical activity, and family …

This study tests a personalized program called COACH that teaches Latino families with young children how to overcome daily barriers to healthy eating and activity. It works with both parents and children together to prevent obesity by building skills for the whole family. The pr…

This study is testing whether a personalized nutrition plan can help prevent obesity in people during their first year after a traumatic spinal cord injury. Researchers are comparing this special diet to usual care in 56 participants to see if it reduces unhealthy fat gain and im…

This study tests whether a community-based exercise and healthy eating program during and after pregnancy can help prevent excessive weight gain, obesity, and type 2 diabetes in mothers and their children. It involves 1,000 pregnant women in urban areas who join before 20 weeks o…

This study is testing a workplace program designed to help newly hired bus drivers prevent weight gain and build healthy habits. Over two years, 284 drivers will either join a program with a game-like competition, health coaching, and online tools, or continue with their usual wo…

This large international project aims to test community-based programs designed to prevent childhood obesity. It will involve 36,000 children aged 6-13 in disadvantaged areas of six countries. The programs will promote healthy eating and physical activity, and researchers will me…

This study is testing whether giving Fitbit smartwatches to adults aged 65 and older makes it easier and more appealing for them to follow a doctor-referred exercise program. The main goal is to see if using the technology is practical and acceptable for this age group, with the …

This study aimed to see if helping parents with their nutrition and weight could also help prevent obesity in their young children. Parents would have joined a free online nutrition program and some might have received weight loss medication. Researchers planned to measure change…

This study is testing if a diabetes prevention program, with or without extra training on recognizing hunger, can help people at high risk for breast cancer lose weight. The goal is to see if weight loss from these programs might lower cancer risk. The study enrolled 51 overweigh…

This study is testing a 16-week family lifestyle program designed to prevent type 2 diabetes in Latino families at high risk. It involves 132 families with children aged 10-16 who have obesity. The program focuses on healthy eating, physical activity, and family support, comparin…

This study aimed to find the best air pressure setting to help severely obese patients breathe on their own after being on a ventilator. Researchers tested if a personalized pressure level could make breathing easier and help patients get off the ventilator successfully. The tria…

This study is testing a 6-month group program that aims to improve mental, social, and physical health for people with obesity without focusing on weight loss. The program teaches intuitive eating and body acceptance to help participants feel better and improve their quality of l…

This study aimed to see if adding game-like challenges to a patient's daily step goals could help them be more active while in the hospital. It planned to use wearable devices and text messages with older adults who had heart or metabolic conditions. The goal was to see if more w…

This study is testing whether virtual reality (VR) therapy can help people feel better about their bodies after they have had major weight loss (bariatric) surgery. It compares a special VR program designed to help patients accept their new body shape against the standard follow-…

This study aims to better understand how amino acids (building blocks of protein) affect the release of two key hormones—glucagon and insulin—that control blood sugar. Researchers are comparing how people with type 2 diabetes, people with obesity, and healthy individuals respond …

This study aims to understand how the hormone glucagon works in the liver and how this process might be different in people with obesity, type 2 diabetes, or fatty liver disease. Researchers will measure how the body processes amino acids with and without glucagon in a small grou…

This study aims to understand how two common types of weight-loss surgery affect bone density and strength in teenagers and young adults with severe obesity. Researchers are following 120 participants aged 13-21 for two years, comparing those who have surgery to a similar group w…

This study aims to understand why storing fat around organs like the liver affects some people's health more than others, potentially leading to conditions like diabetes and heart disease. Researchers are comparing lean and obese individuals, some with and some without metabolic …

This research aims to understand how weight loss surgery helps improve diabetes and metabolism by studying tissue samples from patients. Researchers will collect small samples of fat, muscle, liver, and intestine during scheduled medical procedures like endoscopies and surgeries.…

This study aims to discover the natural chemicals released by muscles during exercise that help the body burn fat. Researchers will compare lean, obese, and athletic volunteers by taking muscle and blood samples before and after exercise. The goal is to identify these 'exercise s…

This study aims to find out which type of knee replacement part works better for obese women. Researchers will compare a standard implant to a slightly longer, stemmed version to see which one is less likely to loosen or collapse over five years. The goal is to gather knowledge t…

This study aims to understand the connections between blood sugar control, gut bacteria, and iron buildup in the brain in people with obesity. Researchers will compare 128 people with and without obesity, and follow some after weight loss from diet or surgery. They will use gluco…

This early-stage study aims to understand how a new investigational drug for obesity, called RAY1225, interacts with four common medications (warfarin, atorvastatin, metformin, and digoxin). It will enroll 32 healthy participants to measure the drug levels in the body and check f…

This study aims to understand why some people with obesity develop related health problems like diabetes while others stay healthy. Researchers are comparing three popular weight-loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants with obesity. Th…

This study is testing a special belt that creates a live image of the lungs to help doctors set breathing machines more precisely during surgery. It focuses on obese patients having a specific type of abdominal surgery where positioning makes breathing harder. The goal is to see …

This study aimed to understand if the time of day people eat affects their body's natural hunger signals and metabolism, potentially influencing weight gain. It planned to look at overweight individuals to see if eating more calories later in the day changes hormone rhythms and h…

This study aims to understand why some people experience a significant slowdown in their metabolism after losing weight, which can make it hard to keep the weight off. Researchers will measure hormones and other body signals in 60 adults with obesity before, during, and after a w…

This study aims to understand why people have 'diet lapses'—moments when they eat off-plan—during weight loss programs. Researchers will track 150 adults in an online weight management program using smartphone surveys and wearable sensors over 18 months. The goal is to identify p…

This study aims to understand why obesity makes it harder for women to get pregnant. Researchers are putting healthy-weight women on a temporary high-fat diet to see if it causes changes in hormones linked to fertility, similar to what happens in obese women. The goal is to learn…

This study aimed to learn how the bodies of obese adults and children with arthritis process the drug etanercept. Researchers wanted to measure drug levels in the blood and see how body weight influences the drug's effectiveness, with the goal of finding the right dose. The study…

This study aims to understand how personalized diet and lifestyle advice affects metabolism and weight loss in overweight Chinese adults. Researchers will closely monitor 117 participants on a 12-week calorie-restricted diet, using detailed tests to see how their bodies process f…

This study is checking if weight loss from common prescription drugs also reduces certain types of inflammation in the body and improves blood fat levels. It will follow 24 adults with obesity for 6 months while they take these medications as part of their standard medical care. …

This study is checking in with people three years after they finished an 18-month weight loss program. Researchers want to see how their weight has changed and measure their current daily habits like physical activity, sleep, and eating patterns. The goal is to learn which daily …

This study aims to understand how common and severe acid reflux disease (GERD) is in obese patients after they undergo weight-loss procedures. Researchers are following 250 patients who have either surgical or endoscopic weight-loss treatments to track their reflux symptoms and c…

This study aims to understand why people store body fat in different patterns, often called 'apple' shape (around the belly) versus 'pear' shape (around the hips and thighs). Researchers are collecting small fat tissue samples from 27 healthy men and women to analyze the biologic…

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This study aims to understand how negative emotions like stress or sadness affect the brain's reward system and food choices in people with binge eating disorders and obesity. Researchers will use brain scans (fMRI) to compare brain activity in four groups of adults: those with b…

This study aims to understand how popular weight-loss medications (like semaglutide and tirzepatide) affect people's food cravings and the overall quality of their diet. About 150 adults with overweight or obesity will track their eating and cravings over 24 weeks using questionn…

This study aims to understand if the body's bile acid system responds differently to weight loss from gastric bypass surgery compared to weight loss from a low-calorie diet. Researchers at Mayo Clinic are observing 21 adults with severe obesity, measuring bile acids in stool and …

This study investigates whether animal-based or plant-based protein works better in ketogenic weight loss diets. Researchers will follow 60 adults with obesity for 12 weeks, measuring changes in weight, body fat, metabolism, and inflammation markers. The goal is to understand how…

This study aims to understand how eating cheese compared to a non-dairy cheese substitute affects inflammation in the hours after a meal. It involves 20 adults who have risk factors for metabolic syndrome or obesity. Participants eat one type of cheese on separate test days, and …

This study aims to collect long-term data on 5,000 patients who have had endoscopic or surgical weight loss procedures. Researchers will track weight changes, health improvements, side effects, and costs over 10 years to better understand which treatments work best. The goal is t…

This study aims to understand how nerve signals that tighten blood vessels might contribute to insulin resistance, a condition common in obesity. Researchers will test if temporarily blocking these nerve signals in the arm improves blood flow and the body's ability to use insulin…

This study aimed to learn if exercising in the morning or evening is better for improving the body's blood sugar control in adults with prediabetes and obesity. It planned to have participants complete short periods of morning exercise, evening exercise, and no exercise while clo…

This small, withdrawn pilot study aimed to understand if taking fish oil supplements while doing high-intensity exercise could work together to reduce harmful inflammation linked to obesity. Researchers wanted to see if fish oil improved gut bacteria, which might make exercise mo…

This study aims to understand how specific components in dairy fat might influence inflammation in the body after eating a high-fat meal. It involves 38 adults with obesity or metabolic syndrome who will drink different test shakes on separate days. Researchers will measure marke…

This study is observing over 31,000 middle-aged and older adults to better understand how being overweight or having obesity, combined with high blood pressure, affects the long-term risk of heart attacks, strokes, and other serious heart problems. Researchers are not testing a t…

This study aims to understand why some people lose more weight than others after bariatric surgery. Researchers are comparing the daily eating habits of 44 patients who had good weight loss results with those who had poor results. The goal is to see if differences in hunger, appe…

This study aims to understand how the body's natural daily rhythms (circadian clock) affect heart health, especially in people with obesity. Researchers will compare 16 lean and obese adults by measuring blood pressure and other heart markers at different times of day and in resp…

This early-stage study aims to understand how the body absorbs and processes an experimental drug called maridebart cafraglutide (AMG 133) for weight management. Researchers will compare two different injection forms of the drug in 348 adults living with overweight or obesity. Th…

This study aims to understand how a single session of exercise changes the cells and signals in body fat (adipose tissue). Researchers are studying 56 healthy and obese adults, both young and older, to see how their fat tissue responds during and after cycling. The goal is to lea…

This study aims to collect and store biological samples from 500 people with obesity. The goal is to build a repository of blood, urine, and tissue to help researchers understand why weight loss treatments sometimes work or fail, and why weight is often regained. This is an obser…

This study looks at existing health records to understand if taking the weight-loss medication Wegovy during pregnancy affects the health of mothers and babies. Researchers will compare about 1,100 pregnancies where women took Wegovy to pregnancies where they didn't. The goal is …

This study aims to develop better, non-invasive tests to screen for, diagnose, and monitor fatty liver disease (MASLD) in people undergoing weight-loss surgery. Researchers will also look for markers in the blood that might predict if a patient's type 2 diabetes goes away after s…

This study aims to understand why Black people living with HIV are at higher risk for serious health problems like kidney disease, diabetes, and heart disease. Researchers collected health information and genetic samples from over 3,000 Black participants with HIV across the UK. …

This study aims to understand how the body processes different types of meals in people with obesity, and how that changes after significant weight loss. Researchers will compare the metabolic effects of a low-carbohydrate meal and a standard meal. They will study 30 adults befor…

This is a long-term observational study that began in 1985 to understand how heart disease risk factors develop in young adulthood. It follows over 5,000 Black and White men and women who were 18-30 years old when they joined. The goal is to identify which lifestyle habits and ch…

This study aims to understand how nutritional counseling and combined exercise training affect markers of cellular aging in older women. It will involve 80 women aged 60-75, comparing those with normal weight and obesity. Researchers will measure changes in cell health, inflammat…

This is a survey study to learn about the real-world experiences of people using the injectable weight loss medication semaglutide. It will collect online responses from over 2,500 participants in four countries over 14 months. The goal is to understand their satisfaction, weight…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This was an early, withdrawn study to check the safety and basic effects of an experimental drug called garetosmab in otherwise healthy adults with obesity. It aimed to see how the body processes the drug and how it might affect hormone levels and blood clotting. No participants …

This study is checking if the weight loss medication tirzepatide changes markers in the body that are linked to breast cancer risk. It involves 20 women with obesity who are already planning to take tirzepatide. Researchers will measure things in their blood, breast tissue, and s…

This study is collecting information about pregnancy outcomes for women who take Wegovy (semaglutide) for weight management. Researchers will compare about 728 pregnant women who take Wegovy with similar women who don't take the medication. They'll track birth outcomes, complicat…

This early research study aims to understand how insulin affects blood flow to the brain and nervous system activity in healthy adults. Researchers will measure brain and leg blood flow, as well as nerve signals, in 65 participants aged 18-45. The study is currently suspended and…

This study aims to discover the specific genes and biological pathways that influence a person's risk of developing type 2 diabetes and related health problems like kidney and eye disease. Researchers will collect health information, blood samples, and genetic data from over 2,00…

This early-stage study aims to understand if a natural hormone, angiotensin-(1-7), can help the body burn more calories at rest. Researchers will give the hormone or a placebo (saltwater) through an IV to 30 adults with obesity and measure changes in their energy use and fat tiss…