OBESITY

This Phase 3 trial tests whether cagrilintide, a new injectable drug, helps people with overweight or obesity lose weight. About 300 adults will receive either cagrilintide or a placebo for up to 18 months, along with lifestyle counseling. The study measures weight change and wai…

This study tests whether tirzepatide, a once-weekly injection, helps teenagers with obesity or overweight (with related health issues) lose weight. About 160 teens will receive either tirzepatide or a placebo for 72 weeks, alongside lifestyle advice. The main goal is to see if bo…

This study tests three home-based programs—healthy eating, physical activity, and gardening—designed to prevent obesity in Hispanic children aged 3 to 4 living in rural West Texas. Over 24 months, researchers will measure changes in body mass index, waist-to-height ratio, and bod…

This study tests whether survodutide, a weekly injection for weight loss, is safe for the heart in people who are overweight or obese and have heart or kidney disease. About 5,500 adults will receive either survodutide or a placebo for up to 2 years, along with diet and exercise …

This study tests a new procedure called BEAM (Bariatric Endoscopic Antral Myotomy) to help people with obesity lose weight. The procedure uses a tube down the throat to make small cuts in the stomach muscle, aiming to change how the stomach empties. Twenty adults with a BMI betwe…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study tests whether combining lifestyle counseling with weight-loss medication helps teens aged 12–17 with severe obesity lose weight. About 120 participants will receive counseling and medication for a year. The goal is to find a practical, effective treatment that is easie…

This early-stage study tests an investigational drug called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will receive single or multiple doses …

This two-year study will follow 1,250 people with obesity who are starting Wegovy (semaglutide) as part of their regular medical care. Researchers will track changes in weight, waist size, and quality of life to see how the drug performs outside of clinical trials. The goal is to…

This study looks at whether sewing shut a specific incision site (the epigastric trocar) during sleeve gastrectomy can prevent hernias from forming later. People having their first sleeve gastrectomy for obesity are included, while those with prior stomach banding or repeat sleev…

This study tests whether a once-weekly injection of semaglutide helps children and teenagers (ages 6 to 17) with obesity or overweight lose weight. About 210 participants will receive either the drug or a placebo for up to 2.5 years, along with healthy lifestyle counseling. The m…

This study tests whether a stepped-care program using digital tools like smart scales, activity trackers, and text messages, plus in-person counseling if needed, can help adults with obesity maintain at least 5% weight loss for a year. About 258 participants first lose weight thr…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study compares two digital weight loss programs for people with obesity. One program uses weekly live video meetings, while the other uses a private Facebook group that participants can access anytime. The goal is to see if the flexible, on-demand option works as well as the…

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a …

This study looks at whether taking a synbiotic supplement (a mix of probiotics and prebiotics) and eating more fruits and vegetables can lower the risk of obesity and related health problems in Hong Kong Chinese adults. One hundred overweight or obese participants will follow the…

This study looks at health records of 120,000 people with type 2 diabetes and overweight to compare two injectable drugs: semaglutide and dulaglutide. Researchers want to see which one better reduces the risk of death, heart attack, or stroke. The goal is to understand how these …

This phase 3 trial is testing different ways to increase the dose of retatrutide, a new weight-loss drug, in 600 people with obesity or overweight who do not have type 2 diabetes. The study lasts about 113 weeks and measures weight loss, waist size, and other health markers. The …

This study looks at whether the diabetes drug metformin, combined with a low-calorie diet, helps overweight or obese adults with a large waistline lose weight. About 150 participants will take either metformin or a placebo for 24 weeks. The main goal is to see if at least 5% of b…

This study tests a 3-month lifestyle program called the PILI Pasifika Program for Native Hawaiian and Pacific Islander adults who are overweight or have conditions like high blood pressure or diabetes. The program includes group lessons on healthy eating and physical activity, pl…

This study tests a family-based program called LEADS for overweight African American teens and their parents. The program teaches stress-coping skills, mindfulness, and positive parenting to help teens become more physically active. Researchers will measure changes in daily exerc…

This study compares two popular weight-loss medications, tirzepatide and semaglutide, in 100,000 adults who are overweight or obese and at risk for heart problems but do not have diabetes. Researchers are analyzing real-world data to see which drug better prevents death, heart at…

This pilot trial tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. Thirty participants will either receive the drug or standard care. The study tracks weight changes and any stomach-r…

This study tests whether a weekly injection of semaglutide can help 500 adolescents with obesity lose weight and maintain that loss for at least 3 years. All participants receive the medicine, which is injected into the stomach, thigh, or upper arm. The goal is to see if the drug…

This study tests a program called SANOS that teaches Mexican adults how to eat healthy without spending a lot of money and how to be more active. About 1,785 overweight or obese participants will receive counseling and be followed for up to a year. The goal is to see if this appr…

This study tests a telehealth program for Latino families with children aged 5 to 12 who have overweight or obesity. The program helps caregivers support healthy changes, and is compared to standard health education. The goal is to see if this approach improves children's weight …

This phase 2b trial tests a weekly oral tablet called ecnoglutide (VRB-101) for weight loss in 206 adults with obesity or overweight plus weight-related health problems. Participants receive either the drug or a placebo for several weeks. The main goal is to see how much body wei…

This study tests a new medicine called KAI-9531 (ribupatide) given as a weekly shot to help people with obesity lose weight. It includes 250 adults who have a BMI of 35 or higher and have tried to lose weight before without success. Participants will receive either the drug or a …

This study looks at how well the Joslin Why WAIT? program helps people with type 2 diabetes and obesity lose weight and improve their health. About 110 participants who have a BMI over 35 are included. The main goal is to see if they can lose at least 7% of their body weight and …

This study tests a new drug called MET097, given as a shot, to help people with obesity or overweight lose weight. After 12 weekly doses, participants switch to monthly shots for up to 64 weeks. The trial compares four different dose schedules against a placebo to see which works…

This Phase 3 trial tests a daily pill called orforglipron in 487 adults with high blood pressure who are also overweight or obese. The study measures how well the drug lowers blood pressure and body weight compared to a placebo. It is currently active but not recruiting.

This study tests whether a moderately low-carb diet can reduce liver fat and improve how the body uses insulin in teenagers with non-alcoholic fatty liver disease (NAFLD) and obesity. About 80 teens aged 10-17 will follow either a carb-restricted or a low-fat diet for 6 months, w…

This Phase 3 trial is testing a once-daily pill called orforglipron in nearly 1,000 people with high blood pressure who are also overweight or have obesity. The study compares the drug to a placebo to see if it safely lowers blood pressure. Participants may be untreated or on sta…

This study looks at whether taking a yerba mate extract can help improve health markers in overweight adults. Eighty people aged 40-65 will take either the extract or a placebo for 90 days. Researchers will measure changes in weight, blood sugar, cholesterol, and inflammation to …

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This study looks at a 12-week program called 'GameDay Ready' to help Black men living in rural South Carolina lose weight. About 29 men will take part, and their weight changes will be compared to a group that does walking and general health education. The goal is to see if the n…

This phase 2 study tests two drugs, bimagrumab and tirzepatide, alone or together, to see if they help adults with obesity or overweight lose weight safely. About 252 participants without type 2 diabetes will take the drugs or a placebo for up to 70 weeks. The main goal is to mea…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This study tests whether a daily injection of liraglutide (3.0 mg) can help children aged 6 to 12 with obesity lose weight. Over 56 weeks, 78 children will receive either liraglutide or a placebo, along with counseling on diet and exercise. The main goal is to see how much their …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This early-stage trial is testing a new drug called MD-18 in healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. About 54 participants will receive either MD-18 or a placebo by injection. The study is currently …

This study tests whether limiting food intake to a 10-hour window each day helps obese adults lose weight and improve body composition. Sixty-one participants will either follow this eating pattern plus nutritional counseling, or just receive counseling alone. The goal is to see …

This study tests a special magnet system that creates a new connection between the stomach and intestine without traditional surgery. It is designed for adults with obesity (BMI 30-50) who also have type 2 diabetes or have regained weight after a previous sleeve gastrectomy. The …

This study tests a new magnetic device (MagDI System) that creates a connection between the duodenum and ileum, bypassing part of the small intestine. The goal is to help with weight loss and blood sugar control in 60 adults with obesity and type 2 diabetes. Researchers are check…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This study compares three treatments for severe obesity: two types of bariatric surgery (gastric bypass and sleeve gastrectomy) and two newer weekly injectable medications (semaglutide and tirzepatide). About 125 adults with a BMI of 35 or higher will be followed for one year to …

This study was designed to see if a dietary supplement called WM Formula could help people with obesity lose weight and improve blood sugar and fat levels. It planned to enroll adults with high body fat who were not taking weight-loss or diabetes drugs. However, the study was wit…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps adults with obesity or overweight lose more weight over 48 weeks. About 285 participants without diabetes will receive either the combination or a placebo pl…

This study tested whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. Over 300 women with high stress levels took part. The goal was to see if a culturally-tailored approach could improve weight loss resul…

This study tests whether a new weekly injection called IBI362 works better than the existing drug semaglutide for weight loss and reducing liver fat in overweight or obese Chinese adults with metabolic dysfunction-associated fatty liver disease (MAFLD). About 479 participants wil…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity from primary care clinics will take part. One group gets extra support and motivation to use these tools, while the other group gets basic informatio…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 905 adults with type 1 diabetes who are also overweight or obese. Participants will receive either tirzepatide or a placebo for about 49 weeks. The study measures changes in blood sugar control (HbA1c) and body wei…

This early-phase trial tests the safety of a single dose of HRS-5817 in 40 obese adults aged 18-55. Participants receive either the drug or a placebo by injection. The study monitors side effects and how the drug moves through the body.

This study tests whether survodutide, a new weekly injection, helps people with obesity burn more energy and fat compared to the existing drug semaglutide (Wegovy). 64 adults aged 18-65 with a BMI between 30 and 45 will be randomly assigned to one of the two drugs. Researchers wi…

This study looks at whether combining high-intensity interval training with recovery in low oxygen (hypoxia) and taurine supplements can improve body composition, metabolism, and mitochondrial function in women with obesity. Fifty women aged 25–45 with a BMI of 30–35 will exercis…

This study tests a new medicine called NNC0662-0419, given as a weekly shot, to see if it helps people with overweight or obesity lose weight safely. About 224 adults aged 18-65 with a BMI of 27 or higher will receive either the drug or a placebo. The main goals are to check for …

This Phase 2 trial tests two experimental drugs, trevogrumab and garetosmab, added to the weight-loss drug semaglutide (Wegovy) in about 1,000 people with obesity. The goal is to see if the combination improves weight loss and body composition (more fat loss, less muscle loss) co…

This study tests a new once-daily pill called RO7795081 for weight loss in adults with obesity or overweight who also have weight-related health problems like high blood pressure or sleep apnea. The trial involves 352 participants and lasts 38 weeks, comparing the drug to a place…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults will be enrolled and their outcomes compared to those treated with standard stents or …

This Phase 3 study tests a once-weekly injection called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with overweight or obesity lose weight. About 3,400 adults will receive either CagriSema, one of the drugs alone, or a placebo for 1.5 years,…

This study tests a smartphone-based weight loss program (EVO) against the standard Diabetes Prevention Program (DPP) in 524 adults with obesity. Participants use an app to track diet, activity, and weight, with remote coaching. The goal is to see which approach leads to more weig…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study tracks 30 adults with obesity who are starting anti-obesity medications like Wegovy or Mounjaro. Researchers will measure how these drugs affect 24-hour energy expenditure and body composition (fat vs. muscle) over 6 months using a metabolic chamber and DXA scans. The …

This study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …

This study uses brain scans (fMRI) to see how the weight-loss drug lorcaserin changes activity in brain areas that control appetite and food intake. Forty obese adults will receive either lorcaserin or a placebo pill. Researchers will also measure changes in body composition. The…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite. Researchers will scan the brains of 28 obese adults to see how they respond to food cues after treatment. The goal is to understand the underlying mechanisms that help p…

This study looks at whether replacing sugary drinks (like soda and sports drinks) with calorie-free alternatives (like diet drinks or water) can help adults with overweight or obesity lose weight. About 460 people who drink at least one sugary drink per day will be assigned to on…

This study is testing a new digital weight management program for adults with obesity who are referred to NHS Tier 3 services. The program uses a smartphone app to help people manage their weight. Researchers want to see if it improves health, saves money, and works well for pati…

This study tests whether semaglutide (Wegovy), a weekly injection for weight loss, can help people in secure mental health care who have gained weight from antipsychotic drugs like clozapine or olanzapine. About 20 adults with a BMI of 35 or higher will receive the drug along wit…

This study tests a new daily pill, aleniglipron, in 58 adults with type 2 diabetes who are overweight or obese. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure weight loss and blood sugar changes. The study is not yet …

This study tests whether a 3-month program of dance classes three times a week plus a personalized nutrition plan can improve health in 40 obese breast cancer survivors. Researchers will measure changes in weight, body fat, fitness, gut bacteria, and quality of life. Participants…

This study tests a 10-week program called Healthy Dads, Healthy Kids for Hispanic families in Houston. Dads aim to lose weight, while kids increase physical activity through group sessions and joint exercise. About 187 fathers and their children are taking part to see if the prog…

This study planned to test whether a virtual weight control program (WW, formerly Weight Watchers) could help adults with type 2 diabetes and obesity lower their blood sugar levels. Participants would have used the WW SmartPoints system and attended weekly online workshops. Howev…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy to buy fruits and vegetables online helps them eat healthier. 214 participants will be split into groups, some getting the subsidy and some not, to see if it increases their produce purchases …

This study tests an experimental daily pill called aleniglipron for weight loss in 220 adults with obesity or overweight who also have a weight-related health issue. Participants receive either the drug or a placebo for 36 weeks, with the option to continue on the drug for anothe…

This Phase 3 trial tests a daily pill called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 participants will take either the drug or a placebo for around 18 months. The study focuses on weight reduction and related health measures like w…

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This Phase 3 trial is testing a once-daily pill called orforglipron to see if it helps people with obesity or overweight lose weight, both in those with and without type 2 diabetes. About 1,200 participants will take either the drug or a placebo for a set period. The goal is to f…

This study looks at whether a non-surgical stomach-reducing procedure called endoscopic sleeve gastroplasty (ESG) can help obese people with nonalcoholic fatty liver disease lose weight and improve liver health. Researchers will measure changes in liver fat and stiffness, as well…

This study follows over 1,000 people with obesity in Japan who are taking Wegovy as prescribed by their doctor. Researchers will track side effects and weight changes for about 2 years to see how the drug works in everyday life, not just in a lab. The goal is to better understand…

This study tests a new medicine called cagrilintide to help people who are overweight or have obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and how …

This Phase 3 trial is testing a once-daily pill called orforglipron in 600 adults who are overweight or have obesity and also have type 2 diabetes. The study compares the drug to a placebo to see if it helps lower blood sugar and body weight over about 18 months. Participants mus…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 participants without type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if it is…

This study looks at whether adding a small bypass (gastroenteroanastomosis) to the standard sleeve gastrectomy can prevent or reduce acid reflux in people with obesity. Sixty patients will be split into two groups: one gets the added bypass, the other does not. Researchers will c…

This study tests whether giving people free boxes of fruits and vegetables along with nutrition education can improve health in three Mississippi counties with high rates of diabetes, obesity, and poverty. About 300 adults with high blood sugar or obesity will receive produce and…

This study looks at whether patient navigators (health coaches) can help more obese adults sign up for and attend weight management programs. About 171 participants will be assigned to either get navigator support or standard care. The goal is to see if this approach increases pr…

This phase 3 trial tests whether retatrutide is better than tirzepatide for weight loss in 800 adults with obesity. Participants receive one of the two drugs for about 89 weeks. The study measures changes in body weight, BMI, waist size, and other health markers.

This study tests whether a new drug called XW003 works better than the existing drug semaglutide for weight loss in Chinese adults with obesity. About 163 participants with a BMI of 30 or higher will receive either drug, and researchers will measure changes in body weight, waist …

This early-stage trial tests whether a drug called RO7204239 can improve how the body uses insulin and affects muscle composition in 30 adults with type 2 diabetes who are overweight or obese. Participants will receive either the drug or a placebo, and researchers will measure ch…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits and infections. About 49 adults who had a kidney transplant in the past 2–12 months and have h…

This study is testing whether adding an experimental anti-inflammatory drug called NT-0796 to the weight-loss medication semaglutide can help people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 to 45 will take either the combination or a…

This phase 2 study tests an experimental drug called HM15275 for weight loss in 267 adults who are obese or overweight but do not have diabetes. Participants receive either the drug or a placebo as a weekly injection for 36 weeks. The main goal is to see how much body weight chan…

This early-stage trial tests the safety and tolerability of a new drug called BMF-650 in 80 otherwise healthy adults who are overweight or obese. Participants receive either the drug or a placebo, and researchers monitor for side effects, vital signs, and how the drug moves throu…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, type 2 diabetes, or high blood pressure. Participants use a tablet, scale, and activity tracker at home, and some get extra support from a co…

This phase 3 trial is testing a weekly injection called VK2735 to help people with type 2 diabetes who are overweight or obese lose weight. About 1,100 participants will receive either the drug or a placebo for 78 weeks. The study measures how much weight they lose and whether th…

This study tests a procedure that reroutes part of the small intestine to help control type 2 diabetes and weight. About 15 adults with diabetes and obesity will be followed for a year to see if their blood sugar and weight improve. The goal is to reduce the need for diabetes med…

This study looks at whether game-like features and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their daily steps. The …

This study looks at whether the weight-loss medication Contrave (naltrexone/bupropion) increases the risk of serious heart problems like heart attacks, strokes, or heart-related death. About 8,600 obese or overweight adults with heart risk factors will be randomly assigned to tak…

This study tests whether the weight-loss drug phentermine, currently approved for only 12 weeks, can be safely used for up to 2 years. About 870 adults with obesity will take phentermine and receive online lifestyle coaching. Researchers will track weight loss, blood pressure, an…

This phase 3 trial tests whether VCT220, a daily pill that targets GLP-1 receptors, can help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo for 12 months. The main goals are to see how much weight they lose and ho…

This study tests whether a gamified mobile health program, including a neurotraining video game, can help overweight men lose weight. 228 men will use either a standard mHealth app or a fully gamified version with team competition and digital rewards. The goal is to see if gamifi…

This phase 2 trial tests different doses of tirzepatide in 414 adults with type 2 diabetes and obesity who already take metformin. The goal is to see if the drug helps with weight loss and blood sugar control. Participants receive either tirzepatide or a placebo for about 89 week…

This study tests a new drug called taldefgrobep alfa (BHV-2000) to help adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo as a weekly or monthly injection for 24 weeks. The main goal is to see how much body weight chan…

This trial compares two versions of a procedure called TORe, which is used to help people who have regained weight after gastric bypass surgery. One version is the classic TORe, and the other is a newer version called ESD-TORe. The study will look at which one leads to more weigh…

This study tests whether a Mediterranean diet adapted to use local Indonesian foods can help obese women lose weight and improve health markers like inflammation and gut bacteria. Fifty-four women will follow either this diet or a standard low-calorie diet for 4 weeks. Researcher…

This study looks at whether a very low-calorie diet (800-960 calories per day) can reduce fat and scarring in the liver for people with obesity and non-alcoholic fatty liver disease (NAFLD). Twenty participants will follow either the low-calorie diet or a standard lower-calorie d…

This Phase 2 study tests an experimental drug called AZD6234, given as a weekly injection, for weight loss in adults with overweight or obesity and type 2 diabetes. Participants are already on a stable dose of a GLP-1 medication. The study will compare AZD6234 to a placebo over 2…

This study tests a new oral drug called aleniglipron (GSBR-1290) in 71 adults with obesity (BMI ≥30). Participants take the drug or a placebo daily for 40 weeks. Researchers measure changes in body fat, waist size, and weight using special scans. The goal is to see if the drug sa…

This study tests a procedure called Revita DMR, which uses a thin tube to treat the lining of the upper gut, to help people with obesity keep weight off after they stop taking the weight-loss drug tirzepatide. About 315 participants who lost at least 15% of their body weight on t…

This study tests an investigational drug called retatrutide in 643 adults with obesity. The goal is to see if it helps maintain weight loss over about 2.5 years. Participants first take the drug for 80 weeks, then are randomly assigned to continue the drug or switch to a placebo …

This phase 3 study tests whether a new weekly injection called HRS9531 works better than semaglutide for weight loss in 572 adults with obesity. Participants receive either drug for 52 weeks, and researchers measure changes in body weight, waist size, and BMI. The trial is active…

This study was designed to test whether adding ofirnoflast to semaglutide helps obese people with type 2 diabetes control blood sugar and lose more weight than semaglutide alone. It was a Phase 2 trial planned for about 200 participants, but it was withdrawn before anyone enrolle…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). One is the standard duodenal switch, and the other is a simpler version called SADI. Researchers track weight loss, health improvements like diabetes and high blood pressure, and complicat…

This phase 3 trial tests tirzepatide, a once-weekly injection, in 465 adults with type 1 diabetes who are also overweight or obese. Participants receive either tirzepatide or a placebo for about 20 months. The study measures changes in blood sugar control (HbA1c) and body weight …

This early study tests a brain implant that monitors and stimulates brain activity to reduce loss-of-control eating in people with severe obesity who haven't been helped by other treatments. Only 6 participants will receive the device, and the main goal is to check safety and see…

This phase 2 trial tests setmelanotide (Imcivree), a daily injection, in 18 people aged 6 to 65 with Prader-Willi syndrome who have obesity. The study will check if the drug is safe and helps reduce body weight and hunger over 52 weeks.

This study tests whether adding relationship skills training to a standard weight management program helps Mexican American mothers and adult daughters lose weight and keep it off. The program includes nutrition and physical activity education along with behavior change technique…

This study looks at whether giving tranexamic acid (a drug that helps blood clot) during weight-loss surgery can reduce dangerous bleeding. About 1000 adults having bariatric surgery will be split into two groups: one gets the drug, the other gets standard care. The goal is to se…

This study compares an intensive weight loss program—using meal replacements, behavior coaching, and weight-loss medication—against standard care for 480 adults with obesity. The goal is to see if the intensive approach leads to greater weight loss, better quality of life, and is…

This phase 3 trial is testing a drug called setmelanotide in people with obesity linked to certain gene variants (POMC, PCSK1, LEPR, NCOA1, or SH2B1). About 296 participants, aged 6 to 65, will receive either the drug or a placebo to see if it helps reduce body weight. The study …

This study is testing a smartphone app that uses artificial intelligence and cognitive behavior therapy to help people with obesity lose weight and improve their health. About 100 adults aged 18 to 65 with a BMI of 27 or higher will use the app for 12 months. The app tracks food …

This study tests whether a patient navigator (a weight loss counselor) can help adults with overweight or obesity choose and stick with an evidence-based weight loss program. 68 participants will work with a navigator for 12 months. The goal is to see if this support improves wei…

This pilot study at Mayo Clinic is testing a special low-calorie, high-protein tube feeding formula called Peptamen Intense VHP in 12 obese patients who rely on tube feeding. The goal is to see if it helps them lose weight while maintaining muscle mass, and also improves blood pr…

This study looks at whether adding the drug insulin detemir to a low-calorie diet helps obese adults with type 2 diabetes lose more weight and improve brain function related to food reward. About 240 people will be split into two groups: one on diet only, the other on diet plus d…

This early-stage trial is checking whether maridebart cafraglutide, a new weight-loss drug, affects the heart's electrical activity. About 81 adults with overweight or obesity will receive the drug or a placebo, and their heart rhythms will be closely monitored. The main goal is …

This early-stage study tests a new drug called LY3537031 in overweight, obese, and healthy volunteers. The main goal is to check safety and how the body handles the drug. Researchers will also measure weight changes and blood sugar levels. The study involves about 300 people and …

This study tests whether providing 10 home-delivered meals per week, plus brief weekly support, can improve diet quality and promote healthy weight gain in low-income Black pregnant women with overweight or obesity. Seventeen women from Alabama are taking part. Researchers are ch…

This 16-week study tests whether an avocado-based dietary supplement (Metavo) can help overweight adults manage their weight and blood sugar. Sixty participants will take either the supplement or a placebo daily, and researchers will track changes in body weight, glucose levels, …

This study tests a new medicine called CagriSema (a mix of two drugs) for helping people with obesity lose weight. About 400 adults with a BMI of 35 or higher will receive either CagriSema or a placebo for 2 years, then some will continue or slowly stop the medicine for another y…

This study tests a new injectable drug called nimacimab, given weekly, to see if it helps overweight or obese adults lose weight. Some participants will receive nimacimab alone, others will get it together with semaglutide (a known weight-loss drug), and some will receive a place…

This study tests a peer mentoring program to help rural Appalachian children with overweight or obesity become more active. Over 400 seventh graders will receive virtual mentoring sessions and family support to increase daily physical activity and reduce sugary drinks. The goal i…

This study tests whether three culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in 198 African American adults. Participants attend weekly classes for 6 months, then bi-weekly for another 6 mon…

This study looks at how the source of protein in a high-protein ketogenic diet influences weight loss and inflammation in people with obesity. Sixty adults will follow a 12-week diet with either plant protein (pea/lupine) or animal protein (whey). Researchers will measure weight,…

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This pilot study tests whether taking a daily probiotic supplement for 12 weeks can improve insulin resistance and asthma control in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and asthma symptoms. Only 7 people are enroll…

This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. Th…

This phase 3 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can reduce the risk of heart attacks, strokes, heart failure, and death in over 15,000 adults with obesity. Participants either have established heart disease or are at high risk. The …

This study looks at whether intermittent fasting (eating only two small meals one day per week) can help overweight veterans maintain weight loss after a 12-week diet and exercise program. Researchers will compare this approach to a standard heart-healthy maintenance plan in 175 …

This study tests whether parent and family support programs can help African American families lose weight. Obesity runs in families and raises cancer risk, so researchers are using health coaching, support groups, and educational materials with 81 parent-child pairs. The goal is…

This study looks at two types of programs—one focused on parents alone and another involving the whole family—to see which works better at reducing obesity risk in African American families. About 120 parent-child pairs will take part. The goal is to find ways to lower obesity an…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests a new medication, maridebart cafraglutide, to see if it helps adults with type 2 diabetes who are overweight or obese lose more weight than a placebo. About 1,100 participants will receive either the drug or a placebo for 72 weeks. The main goal is to measure the…

This study at Mayo Clinic compares two FDA-approved weight-loss drugs, semaglutide and tirzepatide, against a placebo to see how they affect stomach emptying and feelings of fullness. Thirty adults with obesity or overweight plus prediabetes will receive weekly injections for 24 …

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

This was a planned phase 3 study to test a new combination of two drugs, sibutramine and topiramate, for weight loss in overweight and obese adults. The study aimed to see if the combination worked better than either drug alone or a placebo. However, the trial was withdrawn befor…

This study aimed to see if the weight-loss drug Wegovy (semaglutide) could help active-duty military personnel lose weight and improve body composition without harming physical performance. It planned to enroll 0 participants and was withdrawn before starting. No results are avai…

This study tests a new drug called IBI362 in 98 Chinese adults with moderate to severe obesity (BMI ≥ 32.5). Participants receive weekly injections of IBI362, tirzepatide, or a placebo for several weeks. The main goals are to check safety, side effects, and how the drug behaves i…

This study will follow 500 Korean adults with obesity who are starting Wegovy (semaglutide) as part of their normal care. Researchers will track how much weight they lose and any side effects over about 52 weeks. The goal is to see how effective and safe the drug is in real-world…

This study tests whether combining anti-obesity medications with a structured lifestyle program can help people with obesity lose weight and keep muscle. 150 participants will first take tirzepatide or semaglutide for 9 months, then switch to another oral medication for 12 months…

This Phase 3 study tests CagriSema, a weekly injection combining two drugs (cagrilintide and semaglutide), for weight loss and long-term weight maintenance in 609 adults with obesity. Participants are randomly assigned to receive either CagriSema or a placebo for over 3 years. Th…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study tests whether a daily kefir peptide supplement can help obese children lose weight and improve related health issues like insulin resistance and fatty liver. Sixty children with a BMI above the 95th percentile will take either kefir or a placebo for 12 weeks. The goal …

This study compares two types of weight-loss surgery for people who have already had a sleeve gastrectomy but still have obesity. One surgery is the standard duodenal switch, and the other is a simpler single-loop version. Researchers want to see if the simpler surgery causes few…

This study will follow 5,000 adults who have had endoscopic procedures for weight loss, such as stomach stapling through a scope or gastric balloons. Researchers will track weight, blood pressure, diabetes, and cholesterol for up to 10 years to see how well these procedures work …

This study looks at whether a non-surgical stomach reduction procedure (endoscopic sleeve gastroplasty) can improve liver health in people with obesity and advanced NASH (a severe form of fatty liver disease). Twenty adults with obesity and biopsy-confirmed NASH with advanced sca…

This study tests an experimental drug called VK2735, given as a weekly injection, to help people with obesity or overweight lose weight. About 4500 adults without diabetes will receive either the drug or a placebo for 78 weeks. The main goal is to see how much weight they lose an…

This phase III trial tests whether telephone-based Acceptance and Commitment Therapy (ACT) helps overweight or obese adults lose more weight than standard behavioral therapy. About 418 participants will receive coaching over the phone and use a Fitbit and scale to track progress.…

This study was designed to treat toddler obesity by improving the food environment at home. Parents would take part in a free online nutrition program and could also take weight-loss medication. The goal was to help both parent and child lose weight. However, the study was withdr…

This study tests a web-based tool called the BMI-CDS (Weight Loss Wizard) in 40 primary care clinics. The tool gives doctors and patients with type 2 diabetes and obesity personalized estimates of the benefits and risks of treatments like weight-loss surgery or medication. Over 1…

This study tests a new daily pill, orforglipron, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea lose weight. About 3,100 participants will take either the pill or a placebo for 72 weeks, with some continui…

This pilot study is testing the drug tirzepatide (Zepbound) in 40 older adults with obesity to see how it affects body composition, bone density, and physical function over nine months. Participants take weekly injections, track their diet and activity, and attend regular check-i…

This study tests a program called TOTAL that uses an educational video and three telemedicine calls to encourage veterans with obesity to start weight loss treatments like the MOVE! program, medications, or surgery. About 440 veterans will take part. The goal is to see if this si…

This study tests a new drug called maridebart cafraglutide to help adults with obesity or overweight lose weight. About 3853 people will take either the drug or a placebo for 72 weeks. The main goal is to see how much weight they lose and if it is safe.

This study tests whether virtual group visits—where patients meet online for diabetes education, support, and goal setting—can improve blood sugar control in people with type 2 diabetes who also have heart-related conditions. About 720 adults from participating clinics will take …

This study looks at whether a very-low-calorie ketogenic diet (VLCKD) helps people with severe obesity and metabolic syndrome lose more weight and improve heart health over three years compared to a standard Mediterranean diet. About 100 adults aged 55-75 will be randomly assigne…

This study tests whether a year-long program that teaches cooking, nutrition, mindfulness, and exercise can help adults with obesity improve their health. 320 participants will attend weekly classes for 16 weeks, then monthly boosters. Researchers will measure changes in eating h…

This study looks at whether a special oil from herring can lower LDL (bad) cholesterol in adults who are overweight or have obesity. Researchers will give 80 participants herring oil concentrate and measure changes in their cholesterol levels. The goal is to find a natural way to…

This study tests whether a diet rich in fiber (30-35 grams per day) helps adults with obesity lose weight and improve health markers like body composition and gut bacteria. Researchers will compare a fiber-focused program to standard weight loss education in 63 participants. The …

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. It was planned for about 13 months but was withdrawn before enrolling any participants. The main goal was to see how m…

This study tests two drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 participants will take the drugs or a placebo for up to 64 weeks. The goal is to see if these treatments are safe and eff…

This study follows 26 severely obese teenagers aged 14-19 who chose to have one of three weight loss surgeries: gastric band, sleeve gastrectomy, or gastric bypass. Researchers track weight, body fat, blood sugar, and vitamin levels over time to see which surgery is safest and mo…

This study was designed to test an experimental drug called garetosmab in otherwise healthy men and postmenopausal women with obesity. The goal was to check the drug's safety and how it affects hormones and blood clotting. However, the study was withdrawn before any participants …

This study tests whether vitamin D3 supplements can improve asthma control in adolescents aged 12-17 who have obesity, non-allergic asthma, and vitamin D deficiency. Participants receive either a high or standard daily dose of vitamin D3 for three months. Researchers will measure…

This study tests whether a small device that sends gentle electrical pulses to a nerve in the ear (the vagus nerve) can help people with obesity lose weight. About 131 adults with mild to moderate obesity will use the device daily for 6 months. Researchers will measure changes in…

This study evaluates a weight-loss program for children aged 2-18 with obesity in Denmark. The program involves diet changes, physical activity, and counseling for the whole family. Researchers will track changes in BMI and motivation to see if the program helps kids achieve a he…

This study follows 300 children aged 9 to 14 with obesity to see if ultrasound and MRI can detect early signs of liver disease. Researchers will compare imaging markers like liver fat and stiffness with standard tests. The goal is to improve diagnosis and monitoring without invas…

This study looks at whether two blood markers, PLIN2 and RAB14, can accurately diagnose NASH (a serious liver disease) and advanced scarring, without needing a liver biopsy. Researchers will test these markers in 828 adults with NASH, type 2 diabetes, or obesity. If successful, t…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study compares time-restricted eating (eating only between 12pm-8pm) to daily calorie restriction for weight loss and colorectal cancer risk reduction in 193 obese adults aged 45-70. Participants follow their assigned diet for 6 months, then a maintenance phase for another 6…

This study is testing a digital health platform called STELA that creates personalized lifestyle plans to reduce risk factors for heart disease, like obesity, high cholesterol, and insulin resistance. About 100 adults without existing heart disease will use the platform for a yea…

This study tests whether a 16-week family-focused lifestyle program can reduce type 2 diabetes risk in Latino children aged 10-16 who have obesity. The program includes nutrition education, behavior change skills, and physical activity. Researchers will measure glucose tolerance …

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize true hunger. T…

This study tests a mobile health program called Fit for Duty-mobile to help 350 active-duty Air Force members aged 18-39 prevent weight gain over 2 years. Participants use a smartphone app, get coaching calls, and wear a Fitbit. The goal is to see if this approach can stop unheal…

This study tests a mobile app called 'Applícate por tu salud' that sends parents tips, recipes, and videos to encourage healthy eating and physical activity for their school-aged children. About 743 children from 4 primary schools in Mexico City will take part, with some schools …

This study looks at how genetics, eating habits, and lifestyle affect obesity risk in adults aged 18 to 70 in Georgia. One hundred participants will be split into two groups: one follows a reduced-portion diet and exercise plan for 8 weeks, while the other serves as a control. Re…

This study looks at whether a community-based program focused on healthy eating and exercise during and after pregnancy can lower the chances of obesity and type 2 diabetes in mothers and their children. About 1,000 pregnant women in urban areas will take part. The goal is to see…

This study tests community-based programs in six countries to help children ages 6-13 eat healthier and be more active. The goal is to prevent obesity and improve quality of life in disadvantaged urban communities. Researchers will track changes in body mass index and health-rela…

This study tests a personalized coaching program for low-income Hispanic families with young children (ages 4-6) to prevent obesity. The program helps families overcome daily barriers to healthy eating and physical activity. 301 parent-child pairs will be followed for several yea…

This study tests a program to help new bus operators avoid gaining weight and succeed at work. About 284 new hires from several transit agencies will take part. Some will get the special program, while others follow usual routines. The goal is to see if the program helps them sta…

This study tests a family program called Turtle Island Tales to help prevent obesity and cancer in American Indian communities. About 200 caregivers with children ages 3 to 8 living in low-income areas will take part. The program focuses on healthy eating, physical activity, less…

This study tests whether training the muscles you use to breathe can improve how long obese breast cancer survivors can exercise. Researchers will compare breathing exercises plus aerobic exercise to aerobic exercise alone in 78 women who finished treatment. The goal is to see if…

This study is testing a mobile app designed to help teenagers who struggle with binge eating and are overweight or at risk for obesity. The app uses strategies from cognitive-behavioral therapy to improve self-regulation and eating habits. Fifty teens will use the app for 16 week…

This study tests whether brief, one-minute exercise breaks—called 'exercise snacks'—can improve fitness and health in adults with obesity. Eighty inactive participants aged 35-64 will use a phone app to do personalized movement breaks throughout the day for 12 weeks. The goal is …

This pilot study is testing whether a mulberry leaf extract supplement (Reducose) can help control blood sugar spikes after meals in obese children and adolescents. Eighty participants will take either the supplement or a placebo twice daily for 12 weeks. Researchers will measure…

This study compares the effects of soy soft pretzels and wheat pretzels on inflammation in 30 men with obesity. Researchers want to see if the natural chemicals in soy can reduce chronic inflammation, which is linked to health problems like cancer. Participants will eat either so…

This study tests a remote program called ReConnect for people who had bariatric surgery about 2 years ago and their romantic partners. The program uses weekly handouts and videos with positive psychology activities to improve mood, resilience, and relationship satisfaction. 82 co…

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether drinking hydrogen-rich water can make a 4-week weight loss retreat more effective for overweight and obese teens. Sixty adolescents will be randomly assigned to get either hydrogen water or plain water, while all follow the same retreat program. Researche…

This early-stage study tests a new drug called LY3549492 in 120 healthy adults who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it over about 8 weeks. Participants receive multiple doses of the drug, and researchers monito…

This study tests a smartphone app that monitors when you might be about to break your diet and sends helpful alerts or tips. About 200 adults with obesity and heart risk factors will use the app alongside a standard online weight loss program. The goal is to see which types of al…

This study looks at how losing weight affects sexual function and sperm quality in men with severe obesity. About 59 men will either have weight-loss surgery or follow a standard diet plan. Researchers will measure changes in sexual health, hormone levels, and sperm quality to se…

This study looks at whether adding online yoga classes to an internet-based weight loss program can help people lose more weight and keep it off. About 210 adults with obesity will take part. Everyone gets a 12-month online weight loss program, and after 3 months, some also get y…

This study looks at whether a low dose of esketamine, given during and after weight-loss surgery, can help reduce depression in patients who were already depressed before surgery. Forty adults with a BMI over 35 and a Hamilton Depression score of 7 or higher are taking part. The …

This study looks at whether exercising once a week or three times a week is better at reducing liver fat in adults who are centrally obese and have non-alcoholic fatty liver disease (NAFLD). Three hundred Chinese adults aged 18-69 will be assigned to either a once-weekly or thric…

This pilot study tests a new group program called Move Healthier, designed to help people with overweight or obesity increase their exercise using cognitive and behavioral skills. The goal is to see if it boosts physical activity without raising the risk of disordered eating. Onl…

This study tests whether an 8-week nutrition education program focused on fiber-rich foods (like fruits, vegetables, and whole grains) is acceptable and helpful for people with diabetes, prediabetes, or obesity. Researchers will track participants' weight and dietary changes over…

This pilot study tests whether an 8-week program combining mindful eating and yoga is practical and well-liked by adults with overweight or obesity. Researchers will check if participants stick with the program and if it leads to better mindfulness, healthier eating, more physica…

This study tests whether adding group weight-loss classes to standard cardiac rehabilitation helps people with atrial fibrillation and obesity lose at least 10% of their body weight. About 120 adults will take part, with half getting the extra classes. The goal is to see if this …

This early-stage study tests a new medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body processes it. About 63 participants will receive either the study drug or a placebo as an injection under the skin. The me…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher and heart failure with preserved ejection fraction will receive either sem…

This study tests whether high-flow oxygen therapy can prevent low oxygen levels (hypoxemia) in patients at higher risk during sedated digestive endoscopy. The trial includes 326 adults with obesity, sleep apnea, or stable lung or heart conditions. Researchers will compare high-fl…

This study planned to test a laparoscopic-guided nerve block (TAP block) to reduce opioid painkiller use after weight-loss or anti-reflux stomach surgeries. It compared two numbing medicines, Bupivacaine HCL and Exparel. However, the trial was withdrawn before enrolling any parti…

This study tests a smartphone app called eTRIP, which uses artificial intelligence to help people with overweight or obesity make healthier food choices and stick to their weight loss goals. Some participants also wear a continuous glucose monitor for 10 days to see how their blo…

This study tests whether a program combining motivational interviewing and mindfulness can help people who regain weight after bariatric surgery. About 52 adults who have regained at least 5% of their lowest weight after surgery will take part. The goal is to see if this approach…

This study tests whether virtual reality sessions with a psychologist can improve body image dissatisfaction in people who had bariatric surgery 18 to 30 months ago. Eleven participants will either receive 10 weekly VR sessions or standard follow-up care. The main goal is to see …

This study aimed to see if making physical activity into a game could help older hospital patients move more. Participants would have received daily text messages, set step goals, earned points, and worn a Fitbit to track their steps. The study was withdrawn before any patients w…

This study tests a 6-month program for adults with a BMI of 30 or higher that aims to improve mental, social, and physical health without targeting weight loss. It uses intuitive eating and therapy techniques to help people eat based on internal cues and manage body image concern…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer cases of dumping syndrome (nausea, diarrhea, dizziness after eating) and better quality of life. Researchers will follow 20…

This study compares two approaches to help rural adults with obesity lose weight. One method involves quarterly one-on-one visits with a primary care doctor. The other adds a group lifestyle program over Zoom plus quarterly team meetings with the doctor and a lifestyle coach. Res…

This study looks at whether eating only during an early or late 8-hour window helps overweight adults lose weight and improve health. Researchers will track changes in weight and blood sugar over time. The goal is to find out which eating schedule works best and is easier to stic…

This study tests an internet-based treatment program for adults with obesity. The program includes 12 modules over six months, focusing on lifestyle changes and weight control. Researchers want to see if it improves quality of life and leads to weight loss. About 100 people are t…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study was designed to look at how tiny energy-producing parts of cells (mitochondria) in the liver might be linked to fatty liver disease in people with obesity who were scheduled for weight-loss surgery. Researchers planned to take small liver samples during surgery to stud…

This study follows 250 obese adults who are having a weight-loss procedure—either surgery or an endoscopic stomach reduction. The goal is to see how often acid reflux (GERD) develops afterward, including silent reflux with no symptoms. By tracking symptoms and using tests, resear…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study was designed to create a registry of medical information from children aged 1 to 18 with obesity. The goal was to collect historical and clinical data from medical charts to help researchers better understand pediatric obesity. However, the study was withdrawn before e…

This observational study will follow 125,000 adults with employer-based insurance to see how GLP-1 and GLP-1/GIP obesity medications (like Wegovy and Zepbound) affect weight, healthcare use, and medical costs. Researchers will compare people who take these drugs to those who don'…

This study looks at how gastric bypass surgery changes the way the small intestine processes sugar and other fuels, which may explain why the surgery improves obesity and type 2 diabetes. Researchers will collect intestinal tissue and blood samples from 32 people before and up to…

This study tests whether a biomarker found in saliva can predict how much weight people with obesity will lose when taking semaglutide. Researchers will compare weight changes in biomarker-positive and biomarker-negative participants over 24 weeks. The goal is to personalize obes…

This observational study looks at whether a computer program can analyze voice recordings to predict weight loss success in Latino adults with obesity. Researchers will record participants answering one question about their weight loss journey and use AI to guess their personalit…

This study examines whether low-calorie (low energy density) and high-calorie (high energy density) foods act as substitutes in a meal. Researchers will serve 62 healthy-weight adults different combinations of foods across four sessions and measure how much they eat. The goal is …

This study was designed to see how well the stomach-acid drug dexlansoprazole is absorbed before and after gastric bypass surgery, and how often ulcers occur afterward. It planned to enroll smokers with obesity who were scheduled for surgery. However, the study was withdrawn befo…

This study tests whether Eatable Alphabet cards—a fun, child-friendly nutrition tool—can help kids ages 2 to 10 with overweight or obesity eat more fruits and vegetables. About 160 children in a weight management program will use the cards, and parents will report changes in thei…

This study looks at health records of about 1,100 women who took Wegovy during pregnancy and compares them to those who did not. The goal is to see if the drug increases risks for birth defects or other problems in babies. Researchers will use insurance claims data to track outco…

This study aims to adapt a sleep-improvement program for African American adults who are overweight and sleep less than 6 hours per night. Researchers will test if the program is practical and satisfying for participants. The goal is to reduce health disparities linked to poor sl…

This study looks at how changing sleep patterns affects eating behavior and self-control in 120 children who are overweight or at risk for obesity. Researchers will monitor sleep, brain activity, and real-world eating to understand the link between sleep and weight gain. The goal…

This study adapts a 'Health at Every Size' program for pregnant people with a BMI over 30. Ten first-time mothers will attend group sessions on nutrition, movement, and self-advocacy. The goal is to see if the program is acceptable and helpful in reducing weight stigma and improv…

This study looks at 54 obese women getting knee replacements to see if a stemmed or non-stemmed tibial implant works better. The goal is to find out which type reduces the risk of the implant collapsing or loosening over time. Researchers will track these outcomes to guide future…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at how aging changes the way older adults respond to exercise. Researchers will have 26 people who previously completed a structured exercise program do a 6-month aerobic workout. They will measure changes in insulin sensitivity and heart fitness to see if age af…

This study looks at how long you need to fast and how stopping the diabetes/weight-loss drug tirzepatide changes the amount of food left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 people with type 2 diabetes or obesity. The goal …

This registry will follow 10,000 people with obesity who are taking or starting standard weight-loss medications. Researchers will collect data on how well the drugs work and any side effects over time. The goal is to understand the real-world benefits and risks of these treatmen…

This study looks at how the body's internal clock (circadian rhythm) affects heart disease risk, especially in people with obesity. Researchers measured blood pressure and other heart markers in 17 lean and overweight adults over 5 days. The goal is to understand if obesity creat…

This early-stage study tests a single dose of the experimental drug PF-08653944 in 54 overweight or obese adults. Researchers want to see how the drug is absorbed when injected into the abdomen, thigh, or upper arm. The study also monitors safety through blood tests and vital sig…

This study looks at how a baby's emotions, attachment to mom, and feeding habits work together to affect weight gain in the first year of life. Researchers will follow 250 mother-infant pairs to understand what leads to healthy growth or future obesity. The goal is to find ways t…

This study tests whether a swallowable camera capsule, controlled by magnets from outside the body, can safely and effectively examine the stomach and esophagus in 30 people preparing for weight loss surgery. Participants swallow the capsule after fasting, and a surgeon guides it…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance, a condition where the body doesn't use insulin well. Researchers will analyze fat samples from 50 people having weight-loss surgery to see if c…

This study looks at whether taking weekly cold water baths (18°C) for at least 12 weeks can boost brown fat activity in people with obesity. Brown fat is a type of body fat that burns energy to generate heat. Researchers will use special scans to measure blood flow and fuel use i…

This study follows 225 pregnant women—some who had gastric bypass or sleeve gastrectomy, and some without surgery—to see how blood sugar changes affect fetal growth. Participants wear a continuous glucose monitor and activity tracker for 10 days each trimester. The goal is to lea…

This study was designed to test whether a fasting-mimicking diet (FMD) can activate beige/brown adipose tissue—a type of fat that burns calories—in people with overweight. Researchers planned to measure changes using PET scans, thermal imaging, and blood tests. However, the study…

This study was designed to see if a new type of airway device can prevent dangerous drops in oxygen levels during anesthesia in patients who are at high risk, such as those with obesity or sleep apnea. Researchers planned to compare the new device with standard ones in adults und…

This study aims to collect information from weight management clinics across the UK to understand who uses these services, what treatments they receive, and how well they do. Researchers will enroll up to 41,000 people who are already attending these clinics. The goal is to impro…

This study looks at how fat tissue takes up sugar in people with obesity, comparing those with normal blood sugar to those with insulin resistance. Researchers will use labeled sugar infusions and PET scans to measure sugar uptake in fat and muscle. The goal is to understand why …

This study looks at how amino acids trigger the liver to release hormones in healthy people and those with non-alcoholic fatty liver disease. Researchers will give amino acid infusions with or without a drug that blocks natural hormone production. By comparing the results, they h…

This Mayo Clinic study looks at how a single session of exercise affects fat tissue in healthy adults of different ages and weights. Researchers will take small fat samples from the belly before, right after, and three hours after a 30-minute bike workout. They want to see how ex…

This study looks at the genetic and molecular factors behind type 2 diabetes, obesity, and related complications like kidney disease. Researchers will collect health information, blood and urine samples, and perform tests like eye exams and ultrasounds from over 2,300 adults, foc…

This study uses PET scans to look at the brain's reward system in 30 people who had bariatric surgery 2-3 years ago. Researchers want to see if differences in dopamine receptors explain why some patients lose more weight than others. Participants will have brain scans before and …

This study aimed to see if adding pramlintide to semaglutide (Wegovy) could change appetite and eating habits in obese people with prediabetes. It also tried to find ways to predict who would respond best to obesity medication. The trial was withdrawn before any participants were…

This study looks at how eating meals with high or low 'reward value' (like tasty vs. bland food) affects brown fat activity and gut-brain signals. Researchers will scan 30 lean and overweight adults to measure changes in brown fat, gut hormones, and brain receptors after each mea…

This study looks at how popular weight-loss drugs like semaglutide and tirzepatide affect food cravings and diet quality in people with obesity. Over 24 weeks, participants fill out surveys and food diaries to track changes. The goal is to understand whether these medications imp…

This study investigates why brown fat, which burns calories to generate heat, stops working when it's warm. Researchers will use cold vests on 8 healthy and obese adults to see how genes and proteins change. The goal is to find new targets for treating obesity and related metabol…

This study looks at whether regular exercise while breastfeeding changes the makeup of breastmilk in mothers who are overweight or have obesity. Researchers will measure specific sugars and other compounds in the milk and see if these changes affect the baby's growth and health. …

This study looks at whether measuring body water with a harmless device can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group, and can be dangerous for both mother and baby. Researchers will enroll 52 wom…

This 12-month study looks at how a lifestyle program—including group sessions and support from a nurse, dietitian, and kinesiologist—may help women aged 35-75 with obesity improve their weight, heart health, and body image. Some participants may also use GLP-1 weight-loss medicat…

This study looks at how iron levels in the brain, gut bacteria, and blood sugar are connected to thinking and memory in people with obesity. Researchers will track 138 adults aged 30-65 using brain scans, glucose monitors, sleep trackers, and cognitive tests. The goal is to under…

This study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in healthy, non-diabetic obese adults. About 30 participants will receive either glucagon or a placebo through an IV. The goal is to understand the body's energy use, not to treat…

This early-phase study tests how well 20 healthy obese adults tolerate increasing doses of glucagon, a hormone that raises blood sugar. Researchers measure nausea levels to find the highest dose people can handle before feeling sick. The goal is simply to understand tolerability,…

This study looks at how exercise changes the signals muscles send to the rest of the body, especially those that help burn fat. Researchers will compare obese, lean, and athletic participants to find proteins or genetic codes released from muscle during exercise. The goal is to b…

This pilot study tests whether liraglutide (Saxenda), a weight-loss drug, can raise levels of a brain-protective protein called BDNF in 30 people with multiple sclerosis, long-COVID, or leukemia who are overweight and have memory or concentration problems. Participants will injec…

This study aims to understand why people on a weight loss program sometimes break their diet rules (called 'lapses'). Researchers will use smartphone surveys and wrist sensors to track behaviors, feelings, and surroundings in 150 adults with obesity. The goal is to identify patte…

This study looks at how genes and fat cells differ in people with apple-shaped (belly fat) versus pear-shaped (hip and thigh fat) bodies. Researchers will use body scans and fat biopsies from 27 healthy adults to compare fat tissue at the molecular level. The goal is to better un…

This study looks at how nutritional counseling and exercise affect telomeres—the protective caps on our chromosomes that shorten as we age—in elderly women. Researchers will compare women with and without obesity, measuring changes in telomere length and other aging markers after…

This study looks at how the body handles different types of meals after losing about 16-18% of body weight through either a low-calorie diet or gastric bypass surgery. Researchers will measure insulin, blood sugar, fats, and other markers in 30 adults with obesity but without dia…

This study investigates how obesity-related factors like high insulin and fat levels may disrupt fertility in women. Researchers will measure hormone changes and metabolic responses in 84 women. The goal is to understand the underlying causes and inform future treatments to impro…

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into …

This study aimed to find the best level of breathing support (PEEP) for severely obese patients on ventilators. Researchers planned to compare two PEEP levels during breathing tests to see which helped patients breathe easier and come off the ventilator sooner. However, the study…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

This study looks at whether improving sleep can help overweight or obese African Americans who don't get enough exercise become more active. About 28 people will try a sleep program either before or after a physical activity program. The goal is to see if this approach is practic…

This study looks at how amino acids (building blocks of protein) affect the release of glucagon and insulin compared to sugar alone. Researchers will test 30 adults who are healthy, have type 2 diabetes, or are obese. The goal is to better understand these hormone responses, not …

This study aims to find biomarkers that identify people at risk of a disproportionate drop in resting metabolic rate during and after weight loss. Sixty participants with obesity will follow a 6-month meal replacement program with lifestyle advice. Their resting metabolic rate an…

This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through a strict low-calorie diet. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand if the s…

This study follows about 3,000 adults in Port-au-Prince, Haiti, to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other heart problems. Researchers will track participants for about…

This study looks at whether an 8-week program of eccentric (lengthening) resistance training can improve muscle strength, nerve function, and health markers like blood sugar and cholesterol in obese, inactive women. 24 women aged 25-45 with a BMI over 23 will be assigned to eithe…

This study looks at how a personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy before and after a 12-week diet plan. The goal is to understand why people respond differently to the same d…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study looks at why some people with obesity develop conditions like type 2 diabetes while others don't. Researchers are comparing three popular diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 participants to see how they affect insulin sensitivity and over…

This early-stage study checks if a new obesity drug, RAY1225, changes how the body processes common medicines like warfarin, atorvastatin, metformin, and digoxin. About 32 healthy adults will take RAY1225 along with these drugs to measure blood levels and watch for side effects. …

This study looks back at 199 adults in Sweden who had their Roux-en-Y gastric bypass reversed between 2007 and 2023. Researchers want to understand why the reversal was needed, whether symptoms got better, and how weight changed. The goal is to gather information to help doctors …

This study looks at how not having reliable access to enough food might make it harder to lose weight. Researchers are giving 12 women who face food insecurity and have obesity and prediabetes a steady supply of healthy, low-calorie meals for a period. They will measure changes i…

This study follows pregnant women who took Wegovy for obesity or overweight to see if it affects the baby's health. Researchers compare these women to similar pregnant women who did not take Wegovy. The goal is to check for birth defects and other health issues in infants during …

This study aimed to understand how the timing of meals changes daily patterns of natural chemicals in the body that influence eating for pleasure and energy use. It planned to enroll healthy adults without sleep or metabolic disorders. However, the study was withdrawn before any …

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study aims to understand how bariatric surgery affects the body's tissues, like fat, muscle, and liver, and how it improves insulin sensitivity. Researchers will collect tissue and blood samples from 500 adults undergoing surgery or other procedures. The goal is to learn the…

This study follows 60 adults who completed a weight loss program 3 years ago. Researchers will measure their weight, body fat, physical activity, sleep, and eating patterns to see how these habits relate to keeping weight off. Participants wear activity trackers and use a phone a…

This study looks at how insulin in the brain changes blood flow and nerve signals in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, as well as nerve activity. The goal is to understand basic body functions, not to treat any disease.

This study looks at how dairy fat, especially a component called milk fat globule membrane, affects inflammation after a high-fat meal. Thirty-eight adults with metabolic syndrome or obesity will consume shakes with different fats, and researchers will measure inflammatory marker…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, changes inflammation levels in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand the shor…

This study looks at whether changing what you eat can help people lose more weight after bariatric surgery. Researchers will track hunger, calorie intake, and energy use in 44 patients who had sleeve gastrectomy. The goal is to find better ways to support long-term weight loss af…

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program can help them become more active. Researchers will track how many people join, attend, and complete the program, and how they feel about using the watch. The g…

This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years …

This study compares the eating habits of 44 people who had sleeve gastrectomy surgery for obesity. Researchers want to understand why some patients lose more weight than others by looking at hunger, appetite, and related hormones. The goal is to find dietary patterns that lead to…

This study looks at whether the standard doses of the antibiotic cefazolin given before bariatric surgery are high enough for obese patients. Researchers will measure drug levels in the blood and tissues of 70 patients to see if they reach the needed concentration to prevent infe…

This study collects information through online surveys from about 2,500 adults in Australia, Germany, UAE, and Spain who have been prescribed injectable semaglutide for weight management. The goal is to understand their characteristics, treatment experiences, and changes in weigh…

This study follows 113 people scheduled for either gastric bypass or sleeve gastrectomy to see how the surgery affects their social experiences and well-being. Participants will fill out daily diaries about their social interactions and mood at 6 weeks and 1 year after surgery. T…

This study looks at why storing fat around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to find better ways to treat diseases like diabetes and heart di…

This study aimed to see if providing medically tailored meals, lactation support, and food for children could help Black women with hypertensive disorders of pregnancy control their weight after childbirth. The trial was withdrawn before any participants were enrolled, so no resu…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study looks at whether keeping the vagus nerve intact during gastric bypass surgery can lower the chance of developing painful ulcers. Researchers will measure a hormone called gastrin in 50 adults before and after surgery. The goal is to understand how nerve preservation af…

This study planned to test whether an 8-week course of a flavored drink containing essential amino acids plus arginine could reduce liver fat and improve metabolism in obese children aged 7-10. The researchers intended to measure changes in liver fat, blood fats, insulin sensitiv…

This study follows over 31,000 middle-aged and older adults to see how being overweight or having high blood pressure affects their risk of heart attacks, strokes, and death. Researchers will track participants until 2026 using routine health checkups. The goal is to better under…

This study looks at the genes of 1000 people with severe early-onset obesity to find rare genetic causes. It focuses on conditions like Bardet-Biedl syndrome. The goal is to better understand these conditions and improve how they are diagnosed. Participants provide a blood or sal…

This study looks at how two types of weight-loss surgery affect bone health in teenagers and young adults aged 13-21. Researchers will measure changes in bone density and strength over two years in 240 participants, comparing those who had surgery with those who did not. The goal…

This study aimed to understand how body weight influences the way etanercept works in obese adults and children with arthritis. Researchers planned to use blood samples and computer models to find the best dose for heavier patients. However, the study was withdrawn before enrolli…

This early-stage study tests whether a hormone called angiotensin-(1-7) can increase how many calories people with obesity burn while resting. Thirty adults with a BMI between 30 and 40 will receive the hormone or a placebo (saline) through an IV. Researchers will measure changes…

This study follows 163 obese patients undergoing bariatric surgery to see if non-invasive tools like ultrasound and blood markers can accurately diagnose fatty liver disease (MASLD) and predict diabetes remission. Researchers will compare these tests to liver biopsy results befor…

This pilot study aimed to see if taking fish oil supplements could improve gut bacteria and make exercise more effective at reducing inflammation in people with obesity. The study was withdrawn before any participants were enrolled, so no results or conclusions are available.

This pilot study looks at how losing weight with medications like semaglutide (Wegovy) or tirzepatide (Mounjaro) changes inflammatory cells and fats in the blood. Researchers will measure weight loss, immune cells called MDSCs, and markers like C-reactive protein in 30 adults wit…

This study followed 64 adults who had laparoscopic sleeve gastrectomy (a common weight-loss surgery) to see how acid reflux symptoms changed. Researchers compared those who had reflux before surgery with those who did not. They used a standard questionnaire to measure heartburn a…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…

This study uses brain scans to see how negative feelings change food choices and reward processing in people with binge eating disorders. Researchers will compare healthy individuals, those with obesity, and people with binge eating disorder or bulimia. The goal is to understand …