OBESITY

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study tests whether giving people with obesity and diabetes a monthly $160 subsidy for fruits and vegetables helps them buy more healthy food. 214 participants will be split into groups, some receiving the subsidy and some not, for 3 months. Researchers will track how much p…

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 adults who do not have type 2 diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if the…

This large Phase 3 study tests a once-daily tablet called orforglipron against a placebo in 1,200 adults with obesity or overweight, some of whom also have type 2 diabetes. The goal is to see if the drug helps with weight loss and is safe. Participants are split into two groups b…

This study tests a new drug called nimacimab to help people who are overweight or obese lose weight. Some participants will get nimacimab alone, some with another weight-loss drug (semaglutide), and some a placebo. The goal is to see if nimacimab is safe and effective for weight …

This study tests an internet-based program called Step by Step for people with obesity. The program includes six group meetings over 6-8 months to teach about obesity, support lifestyle changes, and reduce stigma. About 100 participants will take part to see if the program improv…

This study tests if semaglutide, a drug used for diabetes and weight loss, can reduce dangerous belly fat and improve heart health in people with HIV who have extra fat around the waist. About 108 adults with HIV and a high BMI will receive either the drug or a placebo for 32 wee…

This study compares a new, remotely delivered weight-loss program (EVO) to the standard Diabetes Prevention Program (DPP) in adults with obesity. About 524 participants with a BMI between 30 and 45 will use a smartphone app and attend video calls. The main goal is to see which pr…

This study tests a non-invasive device that sends mild electrical pulses to a nerve in the ear (the vagus nerve) to help people with obesity lose weight and feel better. About 131 adults with mild to moderate obesity will use the device and be followed for 6 months. The goal is t…

This study tests two experimental drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 participants will take the drugs or a placebo for up to 64 weeks. The goal is to see if these treatments are…

This study tests a new device called the Luso-Cor esophageal stent for closing leaks (fistulas) that can happen after weight-loss surgery or cancer surgery on the stomach or esophagus. About 180 adults who develop such leaks will be randomly assigned to get either the new stent, …

This study tests an experimental drug called AZD6234 to see if it helps people with type 2 diabetes and overweight or obesity lose more weight when added to their current stable GLP-1 medication. About 69 adults will receive either AZD6234 or a placebo for 26 weeks. The main goal…

This study tests different doses of the investigational drug tirzepatide in people with type 2 diabetes and obesity who are already taking metformin. The goal is to see if it helps with weight loss and blood sugar control. About 414 participants will be followed for 89 weeks to c…

This early-stage study is testing a new medicine called LY3537031 in people who are overweight or obese, as well as healthy volunteers. The main goal is to check the drug's safety and how the body processes it. Researchers will also measure changes in body weight and blood sugar …

This study tests a new drug called IBI362 in Chinese adults aged 18-55 with moderate to severe obesity (BMI 32.5 or higher). The goal is to see if the drug is safe, what side effects it may cause, and how the body processes it. Participants receive either IBI362, a placebo, or an…

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 465 participants will receive either tirzepatide or a placebo for around 20 months. The main goals are to see if it improves blood sugar…

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study tests a new tablet called VCT220 to help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or placebo pill once daily for 12 months. The main goal is to see how much weight they lose and if it improves health markers…

This study looks at how two common weight-loss medications, semaglutide and tirzepatide, change the way the stomach empties food and how full people feel. Thirty adults with obesity will take one of the drugs or a placebo for 24 weeks, and their stomach function will be measured …

This study was designed to test a new combination of two drugs (sibutramine and topiramate) for helping overweight adults with conditions like high blood pressure or diabetes lose weight. It was a large, carefully controlled trial that planned to compare the new drug against a pl…

This study tests a new, non-surgical weight loss method called endoscopic Gastric Mucosal Ablation (GMA). It uses a thin tube and energy to remove a small layer of stomach tissue, which may help with weight loss. The study involves 15 adults with obesity (BMI 30-45) and follows t…

This study tests a new weekly injection called CagriSema, which combines two medicines (cagrilintide and semaglutide), to help people with obesity or overweight lose weight. About 3,400 adults will receive either CagriSema, one of the two medicines alone, or a placebo for 1.5 yea…

This study looks at whether the FDA-approved weight-loss drug phentermine can be used safely for up to 2 years to help people with obesity lose weight and improve health. About 870 adults with a BMI of 30 or higher (or 27 with weight-related health issues) will take the drug and …

This study tests a once-daily tablet called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 adults who do not have diabetes will take either the drug or a placebo for around 18 months. The main goal is to measure how much weight they lose …

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps people with obesity or overweight lose more weight over 48 weeks. About 285 adults without diabetes will participate. The goal is to see if the combination i…

This study tests whether a new drug called XW003 works better than semaglutide (a known weight-loss medication) for Chinese adults with obesity. About 163 participants with a BMI of 30 or higher will receive either drug, and researchers will measure weight loss, waist size, and s…

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program on Zoom and has team meetings with their doctor and a coach. Researchers will see which met…

This study tests whether the drug retatrutide can help people with obesity maintain weight loss over time. About 643 participants first take the drug for 80 weeks, then are split into groups receiving either the drug or a placebo for 36 more weeks. The goal is to see if retatruti…

This study tests whether giving free boxes of fruits and vegetables along with nutrition tips can help people with diabetes, high blood pressure, or obesity improve their health. About 300 adults in three Mississippi Delta counties will take part. The main goal is to see if blood…

This study tests a weight management program for Mexican American women that adds relationship skills counseling for mothers and adult daughters. The goal is to improve family communication and teamwork around eating and exercise to support long-term weight control. About 236 wom…

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This early-phase study tests a single injection of HRS-5817 in 40 obese adults aged 18-55 with a BMI of 30-40. The main goal is to check safety and side effects, not to cure obesity. Researchers will also measure how the drug moves through the body and how the immune system respo…

This study looks at whether a new medicine called survodutide helps people with obesity burn more energy and fat compared to an existing drug, semaglutide. About 64 adults aged 18 to 65 with a BMI between 30 and 45 will receive weekly injections for several months. Researchers wi…

This study tests a new medicine called MET097, given as a weekly shot for 12 weeks and then monthly, to see if it helps people with obesity or overweight lose weight safely. About 268 adults who do not have type 2 diabetes will take part. The main goal is to measure weight change…

This study tests a new drug called HRS9531 against an existing weight-loss drug, semaglutide, in 572 adults with obesity. Participants receive weekly injections for 52 weeks to see which drug works better for weight loss. The goal is to find a more effective treatment option for …

This study tests whether adding the experimental drugs trevogrumab (with or without garetosmab) to the weight-loss medication semaglutide (Wegovy) helps people with obesity lose more fat while preserving muscle. About 1,005 adults with obesity (BMI 30 or higher) will take part. T…

This study aimed to see if adding a new drug called ofirnoflast to semaglutide helps control blood sugar and promote weight loss better than semaglutide alone in overweight or obese adults with type 2 diabetes. Participants would have taken the drugs for 12 weeks. However, the st…

This pilot study tests whether a low-calorie, high-protein tube feeding formula can help obese patients who rely on tube feeding lose weight. Researchers will also check how well patients tolerate the formula and its effects on muscle mass, blood pressure, blood sugar, and choles…

This study tests whether adding a mental strategy called WOOP (Wish, Outcome, Obstacle, Plan) to a telephone-based weight management program helps Veterans lose more weight. About 405 Veterans with obesity will either get the standard program alone or with WOOP added. The goal is…

This study tests a new medicine called HM15275 to help people with obesity or overweight lose weight. About 267 adults without diabetes will receive either the drug or a placebo for 36 weeks. The main goal is to see how much weight changes from the start to the end of treatment.

This study tests a procedure that reroutes part of the small intestine to help control blood sugar in people with type 2 diabetes and obesity. About 15 participants will be followed for a year to see if their blood sugar and weight improve. The goal is better disease management, …

This study tests a new drug called MET097, given as a weekly shot, to help people with obesity or overweight lose weight. About 225 adults will receive either the drug or a placebo for 28 weeks. The main goal is to see how much weight they lose compared to those on placebo.

This study tests whether a weekly injection of semaglutide can help 500 adolescents with obesity lose weight and keep it off for at least 3 years. Participants receive the medicine for a minimum of 3 years, and researchers track how many maintain a healthy BMI. The goal is to see…

This study compares an intensive weight loss program—including meal replacements, behavioral support, and weight-loss medication—to standard care for adults with obesity. About 480 participants aged 18-60 with a BMI of 30 or higher (or lower for certain ethnic groups) will take p…

This early-stage study tests an experimental drug called XW003 in 48 Chinese adolescents with obesity. The main goal is to check safety and side effects, while also measuring how the drug works in the body and its effect on weight. Participants must have tried diet and exercise f…

This study tests whether a 6-month low-carbohydrate diet can improve blood sugar control, body composition, and gut-brain communication in obese people with or without prediabetes or diabetes. About 40 participants, including healthy lean controls, will follow the diet and be mon…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma symptoms, lower insulin resistance, and reduce inflammation in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, blood markers, and lung function. The …

This study tests whether spermidine, a natural substance found in foods like wheat germ and soy, can improve heart and muscle health in people aged 65 and older with coronary artery disease. About 180 participants will receive either spermidine or a placebo for a period, and rese…

This study tests whether a new drug, retatrutide, works better than the existing drug tirzepatide for weight loss in 800 adults with obesity. Participants will receive one of the two drugs for about 89 weeks, and researchers will measure changes in body weight, BMI, and other hea…

This study tests whether a combination of two drugs, phentermine and topiramate, can help teens aged 12 to 18 with severe obesity maintain weight loss after a meal replacement program. The body often fights weight loss by increasing appetite and slowing metabolism, making it hard…

This study tests a new injectable drug, survodutide, in about 5,500 adults with overweight or obesity who also have heart or kidney disease or related health problems. Participants receive either the drug or a placebo once a week, plus diet and exercise advice, for up to 2 years …

This study tests whether a once-weekly medicine called tirzepatide can help adults with type 1 diabetes who are also overweight or obese. About 905 participants will receive either tirzepatide or a placebo for about 49 weeks. The main goals are to see if it improves blood sugar c…

This study tests whether tirzepatide, a medication for weight management, can reduce the risk of major health events like heart attacks, strokes, and death in over 15,000 adults with obesity or overweight. Participants must have a BMI of 27 or higher and either have existing hear…

This study looks at two different ways to use weight-loss medicines over 21 months in 150 adults with obesity. Everyone first gets a strong injectable drug (tirzepatide or semaglutide) plus lifestyle coaching. Then they switch to a daily pill—either phentermine-topiramate or nalt…

This study tests an investigational medicine called cagrilintide to see how much it helps people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to measure the perc…

This study tests whether a weekly injection of semaglutide helps children aged 6 to 17 with obesity or overweight lose weight. About 210 kids will receive either the drug or a placebo, plus lifestyle advice. The study lasts about 2.5 years and focuses on safety and long-term weig…

This study tests a smartphone app called eTRIP that uses artificial intelligence to predict and prevent unhealthy eating. Some participants also use a continuous glucose monitor to track blood sugar. The goal is to see if these tools help 300 adults with overweight or obesity eat…

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis drug (ixekizumab) helps people with both moderate-to-severe plaque psoriasis and obesity or overweight. About 250 adults will receive either ixekizumab alone or both drugs together for up to …

This study is testing a new magnetic system (MagDI) that creates a connection in the small intestine to help with weight loss and blood sugar control in adults with obesity and type 2 diabetes. The device is placed using a tube through the mouth, avoiding surgery. The study will …

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. Participants would have taken injections for about 13 months to see how much weight and body fat they lost. However, t…

This study tests whether virtual group visits can help people with type 2 diabetes and at least one heart-related condition (like high blood pressure or obesity) improve their blood sugar control. About 720 adults with high A1C levels will take part. The main goal is to see if th…

This study tests a once-weekly injection called CagriSema (a combination of two medicines) for weight loss and long-term weight maintenance in adults with obesity. About 609 participants will receive either CagriSema or a placebo for up to 3 years. The goal is to see how much wei…

This study tests a new medicine, cagrilintide, to help people with obesity or overweight lose weight. About 300 adults will receive either the drug or a placebo for around 18 months. The main goals are to see how much weight they lose and how many achieve at least a 5% weight red…

This study looks at whether adding the medication insulin detemir to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight and improve brain function related to food pleasure. About 240 adults aged 31-60 will be split into two groups: one on diet only,…

This study looks at whether limiting eating to a 10-hour period each day can help people with obesity lose weight and reduce body fat. About 61 adults who typically eat over 14 hours daily will either get standard nutrition advice or combine that advice with a 10-hour eating wind…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity or overweight plus related health issues will take part. Half will get a 52-week program with support, and the other half will receive educational ma…

This study tests a smartphone app that monitors when people with obesity are at risk of breaking their diet and sends helpful alerts or skill-building exercises. About 200 adults with obesity and heart disease risk factors will use the app alongside a standard online weight-loss …

This study compares a diet focused on fiber to standard weight loss advice in 63 adults with obesity. The goal is to see if fiber helps improve eating habits, weight, and health markers like body fat and gut bacteria. Participants will attend education sessions and provide sample…

This study aimed to see if using a smartphone exercise app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and some would also use the exercise …

This study was designed to treat toddler obesity by improving what toddlers eat. Parents would join a free online nutrition program and could also take weight-loss medication. The goal was to help both the parent and toddler lose weight. However, the study was withdrawn before an…

This study was designed to see if a dietary supplement called WM Formula could help adults with obesity lose weight and improve blood sugar and fat levels. It was withdrawn before any participants were enrolled, so no results are available. The study was planned for people with h…

This study compares a newer, simpler weight-loss surgery (SADI) with the standard more complex bypass in people who already had a partial stomach removal. The goal is to see if the simpler method causes fewer digestive and nutritional problems while still helping with weight loss…

This study tests a new weekly injection called IBI362 against the existing drug semaglutide in Chinese adults with early type 2 diabetes and obesity. The goal is to see if IBI362 is better at lowering blood sugar and helping people lose weight. About 349 participants will receive…

This study tests whether fun, game-like challenges and social rewards can help overweight veterans with high blood pressure become more physically active. About 725 veterans will either compete or work together to increase their daily steps over 9 months. The goal is to see if th…

This study aimed to see if a virtual weight control program (WW) could lower blood sugar levels in adults with type 2 diabetes and obesity. It planned to enroll about 0 participants aged 18-74 with high blood sugar and overweight. However, the study was withdrawn before any parti…

This study tests whether adding an experimental drug (NT-0796) to semaglutide (a weight-loss medication), along with diet and exercise, helps people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 or higher will receive either the combinati…

This study tests whether a 12-month teaching kitchen program—including cooking classes, nutrition education, mindfulness, and exercise coaching—can help 320 adults with obesity improve their health behaviors and lab values. Participants are referred from primary care and must hav…

This study looks at how well the Joslin Why WAIT? program works for people with type 2 diabetes and a BMI over 35. The program aims to help participants lose at least 7% of their body weight and improve blood sugar and cholesterol levels. The study followed 110 participants to se…

This study tests a daily injection called setmelanotide in people aged 6 to 65 with Prader-Willi syndrome, a genetic condition causing severe obesity and constant hunger. The goal is to see if the drug is safe and helps reduce body weight and hunger over 52 weeks. Up to 18 partic…

This study compares two versions of a procedure called Transoral Outlet Reduction (TORe) for people who regained weight after Roux-en-Y gastric bypass. About 70 adults will be randomly assigned to one of the two methods. Researchers will track weight loss, safety, and success rat…

This study tests a new device that uses magnets to create a connection between two parts of the small intestine, bypassing a section to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the procedure is sa…

This study follows 1071 people with obesity in Japan who are taking Wegovy as part of their regular care. Researchers will track side effects and weight changes over 2 years to see how the drug works in everyday life. The goal is to understand real-world safety and effectiveness,…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are also overweight or have obesity. The goal is to see if it helps with weight loss and, for a smaller group, improves sleep apnea. Participants will receive either the drug …

This study follows 1250 adults with obesity who are starting Wegovy as part of their regular medical care. Researchers will track changes in weight, waist size, and quality of life over two years. The goal is to see how well the medication works in real-world settings, not just i…

This study tests a new, non-surgical weight loss method called Gastric Mucosal Ablation (GMA) for people with class III obesity (BMI 40 or higher). Instead of surgery, doctors use a thin tube (endoscope) to treat the stomach lining with a special technique. The main goal is to se…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers c…

This study tests a new weekly injection called petrelintide to help people with overweight or obesity and type 2 diabetes lose weight. About 221 adults will receive either the drug or a placebo for several weeks. The main goal is to see how much weight they lose and how their blo…

This study tests whether a game-like mobile app, combined with brain-training games, can help overweight men lose weight and keep it off. About 228 men will use either a standard weight-loss app or a gamified version with team challenges and rewards. The goal is to see if making …

This study tests a new weekly pill, VRB-101, to help people with obesity or overweight who also have weight-related health problems lose weight. About 206 adults will receive either the drug or a placebo for several weeks. The main goal is to see how much weight they lose compare…

This study tests whether a daily injection of liraglutide (3.0 mg) can help children aged 6 to 12 with obesity lose weight. About 78 children will receive either the drug or a placebo for 56 weeks, along with counseling on diet and exercise. The main goal is to see how much their…

This study compares a very-low-calorie ketogenic diet (VLCKD) to a standard Mediterranean diet in 100 adults with severe obesity and metabolic syndrome. Researchers will track weight, blood sugar, cholesterol, blood pressure, and artery health over 36 months to see which diet lea…

This study tests a once-daily oral medication called orforglipron for weight loss in adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will take either the drug or a placebo for 72 weeks, wi…

This study looks at how the weekly medication tirzepatide affects muscle, bone, and physical function in 40 older adults with obesity over nine months. Participants take the drug, attend regular check-ins with a doctor and dietitian, and track their weight, food, and activity. Th…

This study looks at whether adding kefir, a fermented milk drink, to the diet can help obese children lower their body mass index (BMI) and improve related problems like insulin resistance and fatty liver. About 60 children with a BMI above the 95th percentile will take part. The…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can help people who still have obesity one year after gastric bypass surgery. About 30 adults will either take the drug or continue standard care. The goal is to see if the drug leads to more weight l…

This study is testing whether the weight-loss medication Contrave (naltrexone/bupropion) increases the risk of serious heart problems like heart attack, stroke, or heart-related death. About 8,600 obese or overweight adults with heart risk factors are taking either Contrave or a …

This study tests a new medication called aleniglipron in adults with type 2 diabetes who are also overweight or obese. The main goal is to see if the drug is safe and tolerable at different doses. Researchers will also check if it helps with weight loss and blood sugar control. A…

This study aimed to see if the weight-loss drug Wegovy (semaglutide) could help active-duty military personnel with obesity lose weight and improve body composition and physical performance. It planned to follow participants for 24 weeks on the drug and then 52 weeks off it. Howe…

This study is testing a new magnetic system that creates a shortcut in the intestines to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI of 30-35 and type 2 diabetes will receive the device. The goal is to see if …

This study tests whether two drugs, bimagrumab and tirzepatide, can help adults with obesity or overweight lose weight safely. About 240 participants will receive one or both drugs or a placebo for around 70 weeks. The main goal is to see how much body weight changes from the sta…

This study tests an investigational drug called taldefgrobep alfa to see if it helps adults with overweight or obesity lose weight. About 150 participants will receive either the drug or a placebo by injection for 24 weeks, with an option to continue in an open-label extension. T…

This study compares two weight-loss surgeries for people with severe obesity (BMI over 45). It looks at how much weight is lost, how health problems like diabetes and high blood pressure improve, and the risk of side effects like malnutrition. The goal is to find which surgery is…

This study tests whether a non-surgical stomach reduction procedure, called endoscopic sleeve gastroplasty (ESG), can improve liver health in people with obesity and advanced NASH (a severe form of fatty liver disease). Researchers will measure changes in liver function and press…

This study tests a new medication called maridebart cafraglutide to help adults with obesity or overweight lose weight. About 3853 participants will receive either the drug or a placebo for 72 weeks. The main goal is to see how much body weight changes from the start of the study…

This study tests a procedure called Revita DMR (duodenal mucosal resurfacing) to see if it helps people with obesity maintain weight loss after stopping the drug tirzepatide. About 315 adults who lost at least 15% of their body weight on tirzepatide will be randomly assigned to r…

This study explores whether a NICE-approved digital weight management program can help adults with obesity improve their health and reduce healthcare costs. About 580 participants will use the program as part of their NHS care. The goal is to see if digital tools can make weight …

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, diabetes, or high blood pressure. Participants use a tablet and fitness tracker at home, and some get extra support from a coach by video or …

This study follows 500 Korean adults with obesity who are starting Wegovy (semaglutide) as part of their normal care. Researchers will track weight changes and safety over about 52 weeks. The goal is to see how effective the medication is in real-world settings, not a controlled …

This study is testing a new once-weekly medicine called NNC0662-0419 to see if it is safe and helps people with overweight or obesity lose weight. About 224 adults will receive either the study drug or a placebo (a shot with no active medicine). The main goals are to check for si…

This study looks at whether tirzepatide, a drug used for weight loss, can change certain markers in the blood and breast tissue that are linked to breast cancer risk. The study includes 20 women with obesity who also have other breast cancer risk factors. Researchers will measure…

This study tests a new medicine, CagriSema, for weight loss in 400 adults with severe obesity (BMI 35 or higher). Participants receive either CagriSema or a placebo for 2 years, then some switch to CagriSema or reduce their dose for another year. The goal is to see how much weigh…

This study tests whether adding stress management to a standard weight loss program helps Black women with obesity lose more weight. About 341 women with high stress levels will take part. The program includes 26 sessions focused on diet, exercise, and coping with stress.

This study tests whether adding a new drug (mibavademab) to an existing weight-loss medication (tirzepatide) leads to greater weight loss than tirzepatide alone. About 392 adults with obesity (BMI 30-40) will receive weekly injections for up to 74 weeks. The goal is to see if the…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can improve kidney function in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Participants will have MRI scans to measure kidney oxygen levels and fat content ov…

This study looks at how the type of protein in a high-protein ketogenic diet influences weight loss and body inflammation in adults with obesity. Over 12 weeks, 60 participants will follow a controlled diet and have their weight, body fat, and immune markers measured. The goal is…

This study tests a drug called setmelanotide for people with obesity caused by specific gene variants (POMC, PCSK1, LEPR, SRC1, or SH2B1). About 296 participants aged 6 to 65 will receive either the drug or a placebo to see if it helps reduce body weight. The goal is to control o…

This is an early-stage study to check the safety and side effects of a new drug called BMF-650 in people who are overweight or obese. The study will enroll 80 otherwise healthy participants to receive either the drug or a placebo. The main goal is to see how the body processes th…

This study is testing whether two markers in the blood, PLIN2 and RAB14, can accurately diagnose non-alcoholic steatohepatitis (NASH) and advanced liver scarring. Researchers will analyze blood samples from 828 people with NASH, type 2 diabetes, or obesity. If successful, this ap…

This study tests whether a family-focused lifestyle program can lower type 2 diabetes risk and improve quality of life in high-risk Latino families. About 132 Latino children aged 10-16 with obesity take part. The program focuses on healthy eating and physical activity to prevent…

This study tests whether a personalized nutrition plan can help people with traumatic spinal cord injury avoid gaining excess body fat and becoming obese during the first year after injury. The trial involves 56 participants with spinal cord injuries between levels C1 and L2. Res…

This study tests a family program called Turtle Island Tales that helps American Indian families living in poverty prevent obesity and cancer. About 200 caregivers with children ages 3 to 8 will take part. The program focuses on healthy eating, physical activity, less screen time…

This study tests a program designed to help new bus operators avoid weight gain and adjust to their jobs. About 284 new hires from several transit authorities will take part for two years. Some will receive the special program, while others will follow usual work practices. The g…

This study tests a personalized program to prevent childhood obesity in low-income Hispanic families. It involves 301 children aged 4-6 and their parents, focusing on helping families overcome changing barriers to healthy eating and activity. The goal is to see if this approach c…

This study tests a program called 'Healthy Dads, Healthy Kids' adapted for Hispanic families. It aims to help fathers lose weight and increase their children's physical activity. About 187 fathers and their kids (ages 5-11) in the Houston area will take part. The program focuses …

This study tests whether community-based programs that promote healthy eating and physical activity can prevent obesity in children aged 6-13 from disadvantaged urban areas. About 36,000 children in six countries (Australia, Brazil, Canada, Japan, South Africa, and Spain) will ta…

This study tests if a mobile app for parents can help prevent overweight and obesity in school children aged 5-11 in Mexico City. About 743 children from four schools will take part; some parents get the app, others don't. The app gives tips on healthy eating and physical activit…

This study tests whether three different culturally tailored diet patterns (U.S.-style, Mediterranean, and vegetarian) can improve eating habits and reduce type 2 diabetes risk in African American adults. About 198 participants will follow one of the diets for one year. The goal …

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese participants lose weight and potentially lower their breast cancer risk. About 51 people at high risk for breast cancer will take part. The main goal is to see if the pr…

This study is testing a digital health system called STELA that helps adults without heart disease lower their risk factors like obesity, high cholesterol, and insulin resistance. About 100 participants will get a full health check, a personalized prevention plan, and support thr…

This study tests whether encouraging water instead of sugary drinks in childcare centers can help prevent obesity in young children. Researchers will track 882 preschool kids to see if the drink swap leads to healthier weights and lower calorie intake. The goal is to stop unhealt…

This study looks at whether a community-based diet and exercise program for pregnant women can lower the chances of obesity and type 2 diabetes in both mothers and their children. About 1,000 pregnant women in urban areas will take part during and after pregnancy. The goal is to …

This study tests a mobile health program designed to help young U.S. Air Force personnel prevent weight gain over two years. About 350 active-duty members aged 18-39 with a BMI between 21 and 30 will use a smartphone app and a Fitbit tracker. The goal is to see if this approach c…

This study looks at whether a specific type of resistance training (eccentric, or muscle-lengthening exercises) is better than standard training for improving strength and health in obese, inactive women. Twenty-four women aged 25-45 will do 8 weeks of supervised leg exercises. R…

This study tests whether an 8-session nutrition education program is practical and well-liked by patients in a general medicine clinic. The program focuses on eating more fiber-rich foods like fruits, vegetables, and whole grains. It includes 42 adults with prediabetes, diabetes,…

This study tests whether high doses of vitamin D3 can improve asthma control and reduce severe attacks in adolescents aged 12-17 who have obesity, asthma, and low vitamin D levels. Participants receive either a single high dose plus daily supplements or a lower daily dose for thr…

This study looks at whether exercising once a week or three times a week is better for reducing liver fat in adults with non-alcoholic fatty liver disease (NAFLD) and central obesity. 300 participants will follow exercise programs that match World Health Organization guidelines. …

This early-stage study tests a new injectable medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body processes it. About 63 adults will receive either the study drug or a placebo injection. This is not a cure but…

This pilot study tests whether an 8-week program combining mindful eating and yoga is practical and well-liked by adults with overweight or obesity. Researchers will see if the program improves mindfulness, eating habits, physical activity, body composition, and blood sugar and f…

This study looks at whether adding a small bypass (gastroenteroanastomosis, or GEA) to vertical sleeve gastrectomy (VSG) can lower the chance of acid reflux after surgery. About 60 adults with obesity will be split into two groups: one gets VSG with GEA, the other gets VSG alone.…

This study looks at whether using virtual reality therapy can help people feel better about their body image after bariatric surgery. It involves 11 patients who had surgery 18 to 30 months ago and are unhappy with their body image. Participants will use virtual reality or receiv…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite and food intake. Researchers will scan the brains of 28 adults with obesity to see how the drug affects their response to food cues. The goal is to better understand the …

This study looks at whether adding a patient coach helps older adults with obesity stick to their weight and health plan. About 19 people will take part, and researchers will track things like attending appointments and reaching diet and exercise goals. The goal is to see if extr…

This pilot study is testing a new exercise-focused group for adults who are overweight or have obesity. The goal is to see if the group helps people increase their physical activity without also increasing unhealthy eating or exercise behaviors. Twelve participants will wear Fitb…

This study looks at whether aggressive weight loss using semaglutide can improve symptoms in people with a specific type of heart failure linked to obesity. About 81 participants with a BMI of 30 or higher will receive either semaglutide or a placebo. The main goal is to measure …

This study looks at whether adding online group weight loss classes to standard cardiac rehab helps people with atrial fibrillation (AFib) and obesity lose at least 10% of their body weight. Losing this much weight may reduce or even eliminate AFib symptoms. About 120 adults with…

This pilot study is testing whether a food supplement called Reducose, made from white mulberry, can improve blood sugar and insulin levels in 80 obese children and adolescents after 12 weeks. Participants will have blood tests and body measurements taken during routine visits. T…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer digestive problems (dumping syndrome) and better quality of life. About 200 adults with obesity will be followed for 6 mont…

This study aimed to see if using wearable step counters and smartphone games could encourage hospital patients with heart conditions to walk more. It planned to enroll adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any …

This study looks at how changing eating habits can help people lose more weight after bariatric surgery. Researchers will track hunger, calorie intake, and energy use in 44 patients who had sleeve gastrectomy. The goal is to find better ways to support long-term weight loss after…

This study was designed to see if a new type of breathing tube could help prevent dangerously low oxygen levels during anesthesia in people at high risk, such as those with obesity or sleep apnea. It planned to compare the new device with standard tubes in adults having surgery a…

This study looks at how two types of weight-loss surgery affect bone density and strength in teenagers and young adults aged 13-21. Researchers will compare bone changes in those who have surgery to those who do not. The goal is to understand if these surgeries pose risks to grow…

This study was designed to understand how obesity changes the way the body processes etanercept, a biologic drug for arthritis. Researchers planned to measure drug levels in obese adults and children with rheumatoid or juvenile idiopathic arthritis. The study was withdrawn before…

This study tests whether a patient navigator (a personal guide) can help adults with overweight or obesity choose and stick with proven weight loss programs. 68 participants will receive a navigator for 12 months. The goal is to see if this approach improves weight loss and progr…

This study was designed to find the best level of positive pressure (PEEP) on a ventilator for obese patients to help them breathe on their own after a breathing tube is removed. Researchers planned to test different pressure levels in patients with a BMI of 35 or higher. However…

This early-stage study checks how a new experimental drug for obesity, called RAY1225, affects the way the body processes four common medications: warfarin, atorvastatin, metformin, and digoxin. Thirty-two healthy adults will take RAY1225 along with these drugs to see if any dang…

This study looks at how the tightening of blood vessels (called sympathetic vasoconstriction) may reduce the ability of insulin to widen blood vessels and take up sugar. Researchers will test this by temporarily blocking the tightening signal in the forearm of 36 adults with obes…

This study was designed to test whether a special low-calorie diet that mimics fasting can activate brown fat, which burns energy, in people with overweight. The plan was to compare a fasting-mimicking diet group to a control group over three months, using scans and blood tests. …

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…

This study looks at how the weight-loss drug lorcaserin changes brain activity related to appetite and food intake. About 40 adults with obesity will have brain scans and body composition tests. The goal is to understand which brain areas the drug affects, not to test if it works…

This early-stage study tests how the body processes two different injection forms of maridebart cafraglutide, an experimental drug for overweight or obesity. About 348 adults aged 18-60 with a BMI between 25 and 40 will receive a single dose and be monitored for drug levels and s…

This early-stage study tests whether maridebart cafraglutide, a potential weight-loss drug, affects the heart's electrical activity. About 81 adults with overweight or obesity will receive the drug, a placebo, or a positive control to measure changes in heart rhythm. The goal is …

This study looks at 54 obese women getting knee replacements to see if a stemmed implant (with a rod) helps prevent the bone from collapsing or the implant from loosening compared to a non-stemmed one. The goal is to find which design works better for heavier patients. Participan…

This study looks at how the body's internal clock affects heart disease risk, especially in people with obesity. Researchers will compare 16 lean and obese adults to see if heart risk markers change throughout the day. The goal is to understand why obesity may increase heart prob…

This study looks at how immune cells in fat tissue are linked to insulin resistance in people with obesity. Researchers will collect fat samples from 50 adults undergoing bariatric surgery to measure different types of immune cells and fat cell size. The goal is to understand why…

This study looks at 163 obese adults having weight-loss surgery. Researchers want to see if ultrasound and blood tests can replace liver biopsies to check for fatty liver disease. They also hope to find markers that predict if type 2 diabetes will go away after surgery. Participa…

This study looks at how exercise affects fat tissue and whether those changes can improve health as we age or if we have obesity. Researchers will take fat samples from 56 healthy adults, both younger (18-35) and older (65-85), before and after exercise. They will measure immune …

This study looks at whether losing weight through gastric bypass surgery changes bile acids differently than losing weight through diet alone. Researchers will measure bile acid levels in stool samples from 21 people with obesity. The goal is to understand the body's response to …

This study tests whether a special belt (EIT) can help doctors set the right breathing machine pressure for obese patients during abdominal surgery. About 20 adults with a BMI of 40 or higher will take part. The goal is to see if the belt works better than standard methods to avo…

This study aimed to see if adding pramlintide to semaglutide changes appetite and eating habits in people with obesity and prediabetes. It also looked at whether tests before treatment could predict who responds best. The study was withdrawn before enrolling anyone, so no results…

This study looks at how emotions, attachment, and feeding work together in mothers and babies during the first year of life. Researchers want to understand why some babies gain weight quickly, which can lead to obesity later. About 250 mother-infant pairs will be followed to meas…

This study looks at how increasing insulin in the brain changes blood flow and nerve activity in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, and nerve signals to muscles. The goal is to understand basic body processes, not to treat any di…

This study looks at how exercise affects signals from muscles that help burn fat. Researchers will compare obese, lean, and athletic adults aged 18-40. Participants provide muscle and blood samples before and after exercise. The goal is to find proteins or genetic codes linked to…

This study looks at why brown fat, which helps burn calories, becomes inactive in warm conditions. Researchers will compare blood and fat tissue samples from lean people, people with obesity, and people with obesity and type 2 diabetes before and after cold exposure. The goal is …

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to track heart disease risks like high blood pressure, diabetes, and smoking. Researchers will measure how common these risks are and how they lead to heart attacks, strokes, or heart failure. The g…

This study looks at why some people lose more weight than others after bariatric surgery. Researchers will use brain scans (PET) to measure changes in the brain's reward system, specifically dopamine receptors, in 30 adults who had surgery 2-3 years ago. The goal is to understand…

This study collects information from about 2,500 adults in Australia, Germany, UAE, and Spain who have been prescribed injectable semaglutide for weight management. Participants complete online surveys about their health, weight changes, and quality of life. The goal is to better…

This study looks at how two types of weight-loss surgery (gastric bypass and sleeve gastrectomy) affect people's social experiences and feelings of well-being. Researchers will follow 113 adults for one year after surgery, tracking changes in daily social interactions, mood, and …

This study looks at whether measuring body water using a harmless electrical test can help find pregnant women with obesity who are at risk for obstructive sleep apnea (OSA). OSA is a serious but often missed condition that can harm both mother and baby. The goal is to find a sim…

This study aims to understand how well people with obesity tolerate glucagon, a hormone that raises blood sugar. About 20 healthy obese adults will receive increasing doses of glucagon through an IV. Researchers will measure nausea using a questionnaire to find the highest dose t…

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study looks at why some people with obesity develop conditions like type 2 diabetes and heart disease while others do not. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 adults with obesity. The goal is t…

This observational study collects blood, urine, and tissue samples from 500 obese adults to learn more about obesity, weight loss, and why some people regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up to …

This study looks at whether patient navigators (health coaches) can help more people with obesity sign up for and attend weight management programs. About 171 adults with a BMI between 30 and 45 are taking part. The main goal is to see if the navigators increase enrollment and at…

This study looks at how eating habits after bariatric surgery affect weight loss. Researchers will compare people who lost a lot of weight with those who lost less, measuring hunger, appetite, and related hormones. The goal is to understand why some people have better results tha…

This study aims to find biological markers in the blood that can identify people whose metabolism slows down more than expected during weight loss. Researchers will measure resting metabolic rate and hormone levels in 60 adults with obesity over 18 months. The goal is to understa…

This early-phase study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-protective protein called BDNF in people with multiple sclerosis, long-COVID, or acute leukemia (in remission) who also have obesity and memory or thinking problems. …

This study is a review of many smaller studies that looked at what happens when people replace animal proteins (like meat, dairy, and eggs) with plant proteins (like beans, nuts, and seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressu…

This study looks at whether survodutide enters the body the same way when given by a pre-filled syringe versus a pre-filled pen. About 56 healthy or overweight adults aged 18–55 will each receive both versions in a random order. The goal is to compare how much drug gets into the …

This study looks at how eating different types of food affects brown fat—a type of body fat that burns energy—and how the gut and brain talk to each other. Researchers will compare responses in lean people and those with overweight or obesity. The goal is to understand these proc…

This study tests a mobile app that sends personalized tips to help people stop binge eating and lose weight. Researchers want to learn which strategies work best for different people and in what order. About 300 adults with obesity and frequent binge eating will use the app for s…

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…

This study tests a web-based tool that gives doctors and patients personalized information about the benefits and risks of different obesity treatments, such as surgery or medication. The goal is to see if this tool helps more patients with type 2 diabetes and severe obesity get …

This study observes pregnant women who took Wegovy for weight management and compares their health and their babies' health to pregnant women with similar conditions who did not take Wegovy. Researchers will follow infants for one year after birth to check for birth defects or ot…

This study looked at whether exercising in the morning or evening changes how the body handles sugar in adults with prediabetes. Participants completed short periods of no exercise, morning exercise, and evening exercise while their blood sugar, sleep, and activity were tracked. …

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program helps them become more active. Researchers will track how many people join, attend, and finish the program, and whether they find the smartwatch helpful. The g…

This study looks at why some people store fat around their belly (apple shape) while others store it around their hips and thighs (pear shape). Researchers will take small fat samples from 27 healthy adults and study genetic markers to find clues. No treatment is given—the goal i…

This study explores how losing weight with prescription medication changes certain inflammatory cells and fats in the blood that are linked to cancer risk. Researchers will measure weight loss, immune cells, and cholesterol levels in 30 adults with obesity before and after 6 mont…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyles and risk factors affect heart disease later in life. Researchers measure things like blood pressure, cholesterol, and weight to understand what leads to heart attacks, stro…

This study was designed to test the safety of an experimental drug called garetosmab in men and post-menopausal women with obesity who are otherwise healthy. Researchers planned to measure how the drug affects blood clotting, hormone levels, and whether the body makes antibodies …

This study looks at why people on a weight loss program sometimes break their diet rules. Researchers will use smartphone surveys and wrist sensors to track eating, activity, and mood in 150 adults with obesity over 18 months. The goal is to find patterns in diet slip-ups so futu…

This study looks at how negative emotions change the way the brain processes food rewards and choices in people with binge eating disorder or bulimia. Researchers will use brain scans and real-life mood tracking to understand these links. The goal is to find brain patterns that c…

This study looks at how obesity may cause fertility problems by disrupting hormones that control the menstrual cycle. Researchers will measure hormone levels and insulin response in 84 women with regular cycles. The goal is to understand the link between obesity and infertility t…

This study follows over 31,000 middle-aged and older adults to see how being overweight or having high blood pressure impacts their risk of heart attacks, strokes, and death. Researchers will track participants until 2026 using routine health checkups. The goal is to better under…

This study looks at how the body handles different types of meals in African American and white adults with obesity. Researchers compare responses before and after weight loss from a low-calorie diet or gastric bypass surgery. The goal is to understand changes in insulin, blood s…

This study looks at how amino acids (building blocks of protein) affect liver hormones in healthy people and those with non-alcoholic fatty liver disease. Researchers will give amino acid infusions to 30 participants and measure hormone levels. The goal is to understand why liver…

This study looks at how nutritional counseling and physical exercise affect cell aging in elderly women. Researchers will measure telomere length (a marker of cell age) and other aging-related markers in 60 women aged 60-75, some with obesity and some without. The goal is to unde…

This study tests whether taking weekly cold water baths (18°C) for at least 12 weeks can increase brown fat activity in 45 adults with obesity. Brown fat is a type of body fat that burns energy to generate heat. Researchers will use special PET scans to measure blood flow and fue…

This study looks at how the hormone angiotensin-(1-7) affects how many calories people with obesity burn at rest and whether it helps produce heat in fat tissue. Researchers will give the hormone or a saltwater placebo to 30 adults aged 18-60 with a BMI between 30-40. The goal is…

This study looks at how bariatric surgery affects the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. The goal is to learn more about how the intestines signal other organs, whic…

This study looks at how different parts of dairy fat affect inflammation in adults with metabolic syndrome or obesity. Participants eat a high-fat meal and have their blood tested over six hours to measure inflammatory markers. The goal is to understand which dairy components mig…

This study planned to see if taking fish oil before starting an exercise program could boost the anti-inflammatory benefits of exercise in people with obesity. Researchers wanted to measure changes in blood markers of inflammation and gut bacteria over 6 weeks. However, the study…

This study looks at how often acid reflux (GERD) happens in people with obesity after they have a weight-loss procedure, either surgery or an endoscopic treatment. Researchers will track 250 adults to see who develops GERD symptoms or silent reflux, where acid damages the esophag…

This study was designed to see if when you eat changes natural body chemicals that control eating for pleasure and energy use. Researchers planned to track healthy adults' hunger, blood sugar, and insulin over 24 hours. However, the study was withdrawn before enrolling anyone, so…

This study looks at how amino acids change the way the body releases glucagon and insulin when blood sugar is high. Researchers will compare healthy people, those with type 2 diabetes, and people with obesity. The goal is to better understand these hormone responses, not to test …

This study tracks up to 150 adults with overweight or obesity who are taking GLP-1 medications like semaglutide or tirzepatide. Over 24 weeks, researchers measure changes in food cravings, diet quality, and eating habits using questionnaires. The goal is to understand how these d…

This study looks at how a 12-week personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy and burns fat before and after the diet. The goal is to understand why people respond differently to…

This study looks at whether regular exercise while breastfeeding changes the makeup of breastmilk in mothers who are overweight or have obesity. Researchers will compare breastmilk from mothers who exercise to those who don't, and also check how their babies grow and stay healthy…

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol over 10 years. The goal is to learn how well these procedures wor…

This study uses insurance records to compare pregnancy outcomes in women who took Wegovy (semaglutide) during pregnancy versus those who did not. Researchers will look at birth defects, low birth weight, and other health issues in mothers and babies. The goal is to help patients …

This study looks at how eating cheese compared to a non-dairy cheese substitute changes inflammation levels over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand the short-term effects…

This study tests a 6-month program for adults with obesity (BMI 30 or higher) that aims to improve mental, social, and physical health without focusing on weight loss. Participants learn intuitive eating and body acceptance techniques. The goal is to see if this approach is feasi…

This early-phase study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in 30 healthy, non-diabetic obese adults. Participants receive either glucagon or a placebo via IV, and researchers measure changes in energy use and overall well-bein…

This study looks at how iron stored in the brain, gut bacteria, and blood sugar levels are connected to thinking skills in people with and without obesity. Researchers will measure brain iron, blood sugar patterns, physical activity, and gut microbes in 138 adults aged 30-65. No …

This study follows 60 adults who completed an 18-month weight loss program 3 years ago. Researchers will measure changes in weight, body fat, physical activity, sleep, and eating patterns. The goal is to understand how daily behaviors help or hinder keeping weight off long-term.

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, not individual patients. The goal is to see which strategies work best to get women to sign …

This study looks at whether an educational video and motivational coaching sessions can help more veterans start obesity treatments like weight management programs, medications, or surgery. About 440 veterans who are overweight or have obesity will take part. The goal is to see i…