New shot could help diabetics shed pounds on top of existing meds

NCT ID NCT06851858

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 study tests an experimental drug called AZD6234, given as a weekly injection, for weight loss in adults with overweight or obesity and type 2 diabetes. Participants are already on a stable dose of a GLP-1 medication. The study will compare AZD6234 to a placebo over 26 weeks to see if it leads to greater weight loss. About 69 people will take part.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

AZD6234 (weekly injection)

What this could lead to

If it works, this could offer a new option for weight loss in people with type 2 diabetes who are already on a GLP-1 medication.

What could go wrong

This is a small, early Phase 2 trial. It may not show enough benefit or could have side effects. Success in this study does not guarantee approval.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OBESITY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

endocrine system disorder Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Research Site

    Birmingham, Alabama, 35205, United States

  • Research Site

    Mobile, Alabama, 36608, United States

  • Research Site

    Doral, Florida, 33166, United States

  • Research Site

    Jacksonville, Florida, 32216, United States

  • Research Site

    Miami, Florida, 33135, United States

  • Research Site

    Miami, Florida, 33136, United States

  • Research Site

    Winter Park, Florida, 32789, United States

  • Research Site

    Canton, Georgia, 30114, United States

  • Research Site

    Fayetteville, Georgia, 30214, United States

  • Research Site

    Chicago, Illinois, 60640, United States

  • Research Site

    Oak Brook, Illinois, 60523, United States

  • Research Site

    Newton, Kansas, 67114, United States

  • Research Site

    Lexington, Kentucky, 40509, United States

  • Research Site

    Kansas City, Missouri, 64114, United States

  • Research Site

    Las Vegas, Nevada, 89119, United States

  • Research Site

    Norman, Oklahoma, 73069, United States

  • Research Site

    Knoxville, Tennessee, 37909, United States

  • Research Site

    San Antonio, Texas, 78229, United States