Can pills or counseling boost weight loss after surgery?

NCT ID NCT05157698

Ongoing Disease control Sponsor: Yale University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether adding a combination of two drugs (naltrexone and bupropion) or a behavioral weight-loss program can help people who didn't lose enough weight after bariatric surgery. About 84 participants will receive either the drugs, behavioral therapy, both, or a placebo. The goal is to see if these extra treatments can improve weight loss, heart health, and overall well-being.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naltrexone and bupropion combination pills
What this could lead to: If successful, this could provide a proven way to help people who haven't lost enough weight after bariatric surgery achieve better results.
What could go wrong: This is a small, early-stage trial with only 84 participants, so results may not apply to everyone. The medication can cause side effects like nausea or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Yale School of Medicine

New Haven, Connecticut, 06519, United States

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