Mayo clinic tests popular Weight-Loss drugs on stomach function
NCT ID NCT06801015
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study at Mayo Clinic compares two FDA-approved weight-loss drugs, semaglutide and tirzepatide, against a placebo to see how they affect stomach emptying and feelings of fullness. Thirty adults with obesity or overweight plus prediabetes will receive weekly injections for 24 weeks. Researchers will measure stomach function using special imaging and calorie intake tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Semaglutide and tirzepatide (weekly injections)
What this could lead to
If successful, this could help doctors understand how these weight-loss drugs work on the stomach, potentially improving treatment for obesity.
What could go wrong
This is a small, early-phase study with only 30 participants, so results may not apply to everyone. The drugs are already approved, but this trial focuses on stomach function, not weight loss directly.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, 55905, United States