OBESITY

This pilot study tests a temporary, flexible tube called a duodenal-jejunal bypass sleeve. It is placed in the upper intestine using an endoscope and left for 3 months to help with weight loss and improve metabolic syndrome. The study involves 20 adults with obesity or excess wei…

This study tests whether combining two medications, empagliflozin and finerenone, can lower blood pressure in adults with obesity and stage 1 hypertension. Participants take the drugs or a placebo daily for 12 weeks. The trial also measures effects on kidney function, inflammatio…

This study tests a device called OverStitch NXT, which uses sutures to reduce stomach size through an endoscope (a tube down the throat), avoiding traditional surgery. It involves 136 obese Asian adults with a BMI of 27.5 or higher, some with diabetes or other obesity-related con…

This Phase 2 trial tests whether combining the supplement alpha-lipoic acid with the drug mirabegron can improve how the body processes sugar in people with obesity. Sixty adults aged 18 to 65 with a BMI between 30 and 45 will take the combination or a placebo for 4 weeks. The st…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This study tests an experimental drug called BI 3034701 to help people with obesity or overweight lose weight. About 300 adults aged 18-74 will receive either the drug or a placebo injection for 42 weeks, along with diet and exercise advice. Researchers will measure weight change…

This Phase 3 study tests whether a weekly injection called zenagamtide helps Asian adults with overweight or obesity lose weight safely. About 400 participants will receive either the drug or a placebo for several weeks. The main goal is to see how much body weight changes, with …

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This early-stage study tests whether a new drug, eloralintide, can improve how the body responds to insulin and manage weight in 115 adults with overweight or obesity. Participants will receive either the drug or a placebo injection and be monitored for about 35 weeks. The goal i…

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much…

This Phase 2 study will test whether a once-daily cannabis gummy can help people with obesity lose weight. Forty adults aged 18–65 with a BMI of 30 or higher will receive either the cannabis gummy or a placebo for a set period. The main goal is to measure changes in body weight.…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This Phase 2 trial tests whether BGM0504 tablets can help overweight or obese adults without diabetes lose weight. About 200 Chinese participants will take either the drug or a placebo daily for 20 weeks. Researchers will measure changes in body weight, waist size, and blood suga…

This study investigates whether replacing some wheat flour with legume flours (chickpea, pea, or lentil) in Arabic bread can reduce blood sugar spikes after eating. Overweight or obese adults aged 18–65 will consume different breads and have their blood glucose and appetite measu…

This phase 3 trial tests a once-daily oral drug called aleniglipron for chronic weight management in 3600 adults with obesity or overweight who also have a weight-related health condition. Participants take the drug or a placebo for 76 weeks, along with diet and exercise changes.…

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This study tests a new medicine called NNC0662-0419 in 230 adults with obesity (BMI 30 or higher). Researchers want to see if different ways of increasing the dose over time can reduce stomach side effects while still helping people lose at least 25% of their body weight. The stu…

This study tests whether combining two experimental drugs, petrelintide and enicepatide, helps adults with obesity or overweight lose more weight than taking either drug alone or a placebo. About 486 participants will receive different doses or a placebo for several months. The g…

This study tests whether a 28- to 54-week program of weight-loss medication (semaglutide), a hormone-releasing IUD, diet, and exercise is safe and feasible before surgery in women with early endometrial cancer and a BMI of 40 or higher. Eighty participants will be randomly assign…

This study looks at whether adding professional dental cleaning to semaglutide treatment can improve both oral health and heart-related risks in children with severe obesity. About 50 kids will either get dental cleaning plus hygiene advice, or just hygiene advice. The goal is to…

This early-stage study tests whether a new oral drug, VRB-103, is safe and tolerable when taken alone or with another drug (ecnoglutide) in people with obesity or overweight. About 336 participants will receive either the drug or a placebo. The goal is to check for side effects, …

This study will test whether a 24-week home-based resistance exercise program, when added to the weight-loss drug tirzepatide, helps overweight and obese adults maintain muscle mass and strength. About 108 people starting tirzepatide will be randomly assigned to either exercise p…

This study tests whether the diabetes and weight-loss drug tirzepatide (Mounjaro) can reduce the chance of atrial fibrillation coming back after a heart procedure called catheter ablation. About 602 adults with obesity and a type of heart failure (HFpEF) will get either tirzepati…

This study tests a web-based program called Confident Moves designed to help adults with obesity increase their physical activity and improve overall health. About 348 adults aged 18-64 with a BMI of 25 or higher will be enrolled. Participants will use an online platform with sel…

This study tests a new tablet called DA-302168S to help people lose weight. It is for adults aged 18-75 who are overweight or obese. The study will compare the drug to a placebo to see if it is safe and effective. About 840 people will take part in China.

This study tests whether a probiotic called Akkermansia muciniphila (AKK PROBIO) can help obese children and adolescents aged 7 to 18 improve their weight and metabolism. Half of the 100 participants will take the probiotic capsules, and half will take a placebo. The goal is to s…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight. Participants must have already been on weekly injections of semaglutide or tirzepatide for at least 6 months. The goal is to find …

This study will compare three approaches before gastric bypass surgery for severe obesity: taking the medication tirzepatide for 60 days, following a ketogenic diet for 4 weeks, or receiving standard care. The goal is to see which method leads to the most weight loss one year aft…

This early-stage study will compare two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version for several weeks, and researchers will measure how the drug builds up in the body. The goal is to s…

This study looks at whether a 12-week structured diet and exercise plan can help adults aged 50 and older with obesity and insulin resistance lose fat and improve muscle function. Participants will receive all meals and exercise three times a week under supervision. The goal is t…

This study tests whether adding fecal microbiota transplantation (FMT) to a calorie-restricted diet and a diabetes drug (semaglutide) helps people with obesity and type 2 diabetes lose more weight and improve metabolism. Twenty adults aged 18-60 with a BMI of 30-40 and diabetes f…

This study tests whether patients can safely go home within 6 hours of bariatric surgery instead of staying overnight. 200 adults with obesity will be randomly assigned to same-day discharge or overnight stay. The main goal is to see how many need emergency care within a week.

This study will test whether tirzepatide (Mounjaro), a drug used for diabetes and weight loss, can help people with obesity-related heart failure with preserved ejection fraction (HFpEF). Researchers will measure changes in blood volume and body fat in 50 participants over 15 mon…

This early study tests whether adding an experimental drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo …

This study tests whether virtual classes about healthy eating and exercise can help Puerto Rican men lose weight. About 48 men will take part in online sessions for 4 months, with follow-up meetings. The goal is to see if the program is practical and leads to meaningful weight lo…

The ROOT study is testing a personalized nutrition program for pregnant women. Participants receive standard prenatal care plus customized diet and lifestyle plans based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of preterm birth…

This study looks at whether giving people feedback on their metabolic profile (blood test results) halfway through a 3-month low-starch, low-sugar diet helps them lose more weight. 300 overweight adults (BMI over 25) will follow the diet, and half will learn their metabolic impro…

This phase 2 trial tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are overweight. Twenty adults with active arthritis despite standard treatment will take either disulfiram o…

This study looks at how exercise and eating more fruits and vegetables affect the heart and metabolic health of 120 teens aged 13–17 with obesity. Participants will be split into four groups: standard care, exercise only, diet only, or both exercise and diet. Over 12 weeks, resea…

This study looks at whether metabolic surgery (like gastric bypass) can reduce the severity of atrial fibrillation (AF), a common heart rhythm problem, in people with obesity. About 100 adults with AF and a BMI between 35 and 65 will be randomly assigned to either surgery or medi…

This study will test whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau foods can improve metabolic health in 40 obese adults. Participants will follow a diet based on coconut milk dishes for a period, and researchers will measure ch…

This study tests a 'Food as Medicine' program for 250 children aged 8-15 who are at risk for chronic diseases like obesity. Families get help from a community health worker who sets nutrition goals and connects them to healthy food resources. The goal is to see if this improves d…

This study tests a minimally invasive procedure called POSE2.0 for weight loss in 186 adults with obesity. The procedure uses stitches placed in the stomach without any incisions, combined with a diet and exercise program. Researchers will compare weight loss and safety between t…

This study tests whether taking a daily probiotic called Lactobacillus reuteri for one month can improve skin barrier damage in people with obesity. Researchers will measure water loss through the skin and check changes in gut and skin bacteria. The trial involves 140 adults aged…

This study tests whether a probiotic called Akkermansia muciniphila can help overweight and obese adults lose weight and improve their metabolism. Over 12 weeks, 76 participants will take either the probiotic or a placebo, while following a low-carb diet. Researchers will measure…

This phase 2 trial tests the drug setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The participant will receive daily injections of setmelanotide for six months to see if it leads to weight loss a…

This study tests an injection called GZR18 in 140 obese adults with moderate to severe obstructive sleep apnea who cannot or will not use a CPAP machine. The goal is to see if the drug improves breathing during sleep and helps with weight loss over 52 weeks. Participants will rec…

This study will test the safety and effectiveness of tirzepatide, a once-weekly injection, in 300 adults with obesity or overweight plus related health problems. Participants will receive increasing doses over 12 months while doctors track side effects, weight loss, and improveme…

This study will test whether taking liraglutide together with orlistat helps overweight or obese adults lose more weight than liraglutide alone. About 120 participants will be followed for 24 weeks. The goal is to see which approach works better in real-world conditions.

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 participants aged 18-65 who smoke and have obesit…

This study will test whether a natural fiber called oligofructose, found in foods like onions and bananas, can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. A total of 100 people (50 with diabetes and 50 without) will take either th…

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study looks at whether a GLP-1 receptor agonist, a drug already used for diabetes and obesity, can improve fat buildup in the liver and blood in people with MASLD. Researchers will measure changes in fats, proteins, and genes in 30 participants who already take the drug. The…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) for weight loss in 300 adults with obesity. ESG uses a special device to stitch the stomach smaller from the inside, without cutting or removing any tissue. The goal is to see if it helps people lose weight …

The Reset trial, led by Stanford University, aims to find the best combination of four dietary strategies for weight loss in a fully digital program. 208 adults with overweight or obesity will receive a 12-week remote intervention that includes daily self-weighing, weekly lessons…

This study tests whether a 9-month lifestyle coaching program (individual and group sessions with a dietician) helps obese male firefighters lose weight and improve metabolic health. Fifty participants will be randomly assigned to coaching or usual care. The main outcomes are cha…

This study tests a new medicine called CagriSema to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo for around one year. The main goal is to see how much weight they lose and check for any side effects.

This study tests whether Vibegron, a drug already approved for overactive bladder, can improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Forty participants will take the drug or a placebo for 12 weeks. The goal is to …

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in p…

This study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measurin…

This early study tests if injecting a person's own stem cells into the upper gut is safe and feasible for treating type 2 diabetes. The stem cells are taken from belly fat and processed before being injected during a scope procedure. Only 15 people will take part, and the main go…

This early-stage trial will test two similar injectable drugs for obesity, called HUC2-676 and HUC2-676-R, in 40 healthy adults. Each person will receive a single dose of both drugs at different times to compare safety and how the body processes them. The study is not yet recruit…

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with gout and obesity will take either orlistat or a placebo for 24 weeks, along with diet and exercise advice.…

This study compares two popular weight-loss drugs, semaglutide and tirzepatide, alone or combined with exercise, in 48 adults with obesity. The goal is to see which approach better reduces body fat while preserving muscle mass, and improves strength and metabolic health. Particip…

This study tests whether a weekly injection of tirzepatide (a diabetes drug) plus cognitive-behavioral therapy can help adults with alcohol use disorder and overweight or obesity reduce heavy drinking days. 46 participants will receive either the drug or a placebo shot for 8 week…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or obesity. Participants receive weekly injections for three months. The goal is to see if this drug can help manage weight and …

This study is testing a new AI software called Soma that automatically measures muscle and fat from CT scans. Researchers will compare the software's measurements to those made by three expert radiologists using 200 CT scans from public databases. The goal is to see if the AI is …

This study tests whether eating all meals within an 8-hour window (between early morning and early afternoon) combined with morning exercise can prevent sarcopenia—age-related muscle loss—in postmenopausal women with obesity and type 2 diabetes. Forty-five women will follow eithe…

This trial tests whether a nutrition program designed with input from students, parents, teachers, and cafeteria staff can improve the weight and eating habits of adolescents. About 2,600 teens in grades 7-9 across 52 schools in India and Nepal will take part. Researchers will me…

This study tests whether a temporary catheter placed during laparoscopic sleeve gastrectomy can be used to re-dose nerve-blocking medicine (bupivacaine and dexamethasone) if severe pain or nausea break through after surgery. It includes 30 high-risk patients, such as young women …

This study looks at whether giving a low dose of the hormone HCG can improve the chance of having a baby for overweight women who use frozen embryos in a natural cycle. About 750 women will take part. The goal is to see if this extra hormone support helps more women give birth.

This study tests whether a flexible, symptom-guided dosing plan for tirzepatide can reduce nausea and vomiting compared to the standard dosing plan in adults with obesity who do not have diabetes. Participants will be randomly assigned to one of two dosing strategies and followed…

This study tests whether tracking only high-calorie, low-nutrition foods (Red Zone Foods) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if a simpler approa…

This study will test two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or an external oblique intercostal plane block. Researche…

This study tests two different nerve blocks to see which one controls pain better after laparoscopic sleeve gastrectomy. Sixty adults having this weight-loss surgery will receive either an intertransverse process block or a subcostal transversus abdominis plane block. The goal is…

This study looks at whether brief, intense stair-climbing sessions (called 'exercise snacks') can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study will compare two ultrasound-guided nerve blocks—the external oblique intercostal plane block and the subcostal transversus abdominis plane block—for controlling pain after laparoscopic sleeve gastrectomy. Ninety adults aged 18–65 will receive one of the blocks plus sta…

This study tests two different drugs—dexmedetomidine and low-dose ketamine—given during weight-loss surgery to see which one reduces pain and the need for morphine afterward. Ninety adults having bariatric surgery will be randomly assigned to one of the two drugs or a placebo. Th…

This study tests a mobile app designed for obese children aged 8-10 to improve their eating attitudes, awareness, and confidence in making healthy food choices. The app works on smartphones and offline, and includes input from nurses and software experts. Researchers will measure…

This study tests a non-invasive device that stimulates the vagus nerve through the ear in 60 men aged 25-35 with central obesity (waist >94 cm, BMI ≥30). The goal is to see if it lowers inflammation (IL-6 levels) and reduces waist size. Participants must be otherwise healthy, non…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study tests if giving the asthma drug salbutamol during weight-loss surgery can improve breathing in obese patients. Researchers will measure lung function during surgery and check for breathing problems afterward. The goal is to see if this simple addition can reduce compli…

This study tests a 6-session group therapy based on polyvagal theory, designed to help people with obesity become more aware of body signals and better manage emotions. Ten participants from an NHS weight management service will be randomly assigned to start the therapy after 14 …

This study will test whether adding a breathing muscle trainer to aerobic exercise helps adults with obesity and chronic low back pain. Forty-eight participants will be split into two groups: one using the trainer at a low resistance and one at a higher resistance. Researchers wi…

This study will compare two devices that blow gas into the belly during laparoscopic sleeve gastrectomy (a weight-loss surgery). The goal is to see if one device causes less pain after surgery than the other. About 74 adults aged 22 to 65 having planned sleeve gastrectomy will be…

This study compares two devices used during robotic gastric sleeve surgery to see which causes less shoulder, neck, and chest pain afterward. About 74 adults having non-emergency sleeve gastrectomy will be randomly assigned to receive either the AirSeal or DV5 insufflation system…

This study tests if placing stitches only in the lower part of the stomach works as well as placing stitches in both the lower and upper parts for weight loss. Ten adults with obesity will get one of the two stitch patterns using a device called Endomina. Researchers will track h…

This study looks at whether a nerve block (TAP block) given after laparoscopic gastric sleeve surgery can help the gut work normally again sooner. Sixty adults having weight-loss surgery will either get the block or standard pain care. Researchers will track gut symptoms using pa…

This study tests whether listening to a guided imagery recording can reduce pain, anxiety, fear, and stress, and improve sleep quality in people recovering from bariatric surgery. Seventy adults will be randomly assigned to either listen to the recording or receive standard care.…

This study tests whether watching a 20-minute virtual reality video of a calming forest can reduce pain, anxiety, fear, and stress, and improve sleep in people having bariatric surgery. Seventy patients will be randomly assigned to either the VR experience or standard care. Resea…

This study will follow 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or have metabolic issues. Researchers will collect blood, saliva, urine, and stool samples during routine clinic visits, along with questionnaires about diet, sleep, and mood. The goal is …

This study follows 400 children aged 5 to 7 with obesity or normal weight until age 12. Researchers will track puberty signs, hormones, genes, diet, and chemical exposures to see what predicts early puberty. No treatments are given; the goal is to gather information.

This observational study looks at how being overweight or obese, and changes in lifestyle, impact work performance, quality of life, and well-being in medical residents. Researchers will track 600 participants for 12 months, measuring body weight, lifestyle habits, and using ques…

This study looks at how packaging with warning labels and cartoon characters influences what Colombian teens aged 12 to 17 think about buying and eating ultraprocessed foods. About 1,960 teens will view different product images online and answer questions about how likely they ar…

This study follows 40 adults who recently had laparoscopic sleeve gastrectomy for obesity. Over 6 months, researchers will measure changes in blood sugar, cholesterol, gut barrier markers, and digestive symptoms. The goal is to understand how the surgery affects gut health and me…

This study follows 40 people who recently had laparoscopic sleeve gastrectomy to see how their eating behavior, nutrition, and appetite-regulating hormones change over 6 months. Researchers will measure hormones like ghrelin, GLP-1, and PYY, along with dietary intake and eating a…

This study tests whether showing health warnings, tasty-sounding labels, or both can encourage 1,000 Chinese college students to pick sugar-free drinks over sugary ones. Participants will make drink choices on a platform, and researchers will track which options they select. The …

This study looks at how losing fat versus muscle during a low-calorie diet changes your resting metabolic rate. About 150 adults with overweight or obesity will follow a structured diet, and researchers will measure body composition and metabolism before and after. The goal is to…

This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatmen…

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at whether measuring bile acids and pepsin in saliva can help identify people who develop acid reflux or esophageal damage after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults will give saliva samples before surgery and again 1 and 3 years af…

This observational study will look at how body composition (fat and muscle) relates to breathing endurance and exercise capacity in 100 adults with obesity and a restrictive breathing pattern. Participants will undergo tests like spirometry, body fat measurement, and a six-minute…

This study will measure how body roundness index (BRI) relates to breathing and exercise ability in 120 adults with obesity. Participants will have lung function tests, breathing muscle strength tests, and a six-minute walk test. The goal is to see if BRI can help identify people…

This study tests whether special amino acid-enriched drinks can help people on GLP-1 weight-loss drugs maintain muscle and prevent weight regain. Eight adults aged 30-65 who recently started GLP-1 medication will drink different supplement beverages, and researchers will measure …

This study looks at how inhaled nitric oxide affects oxygen levels and lung function in severely obese patients who have severe breathing failure and are on a ventilator. Researchers will compare these patients to those with normal weight to see if obesity changes how the gas wor…

This study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…

This early-stage study is testing a new medicine for overweight and obesity. The main goal is to see how the drug behaves in people with different levels of liver function, from normal to severely reduced. About 35 adults aged 18-80 will take a single dose, and researchers will m…

This study looks at whether taking a calcium butyrate supplement for 4 weeks can improve how immune cells (monocytes) work and change gut bacteria in adults with obesity. Butyrate is a natural substance made by gut bacteria that helps reduce inflammation. The study will compare t…

This large study tests whether using electronic health records and text messages can help more adults with obesity enroll in proven weight-loss programs. Over 5,000 patients from community health centers will be invited to join. The goal is to see if simple clinic prompts and fol…

This study looks at whether rotating the head 45 degrees to the left improves the view of the vocal cords during video laryngoscopy in obese adults. Fifty patients with a BMI of 30 or higher will be observed. If the maneuver works, it could offer a simple way to reduce airway com…

This study looks at how certain natural chemicals (endocannabinoids) influence the development of fat cells from stem cells found in belly fat. Researchers will take small fat samples from 30 people undergoing abdominal surgery, including healthy controls, people with obesity, an…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This observational study will follow 150 adults with obesity who are already scheduled for bariatric surgery. Researchers will use CT scans and echocardiograms before and about 6 months after surgery to measure fat inside the heart muscle and check how well the heart relaxes. The…

This study is testing a new physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is something people like and can stick with. About 20 people will take part to help resear…

This study looks at how fat tissue in the upper body reacts after a meal, comparing people with obesity to those at a healthy weight. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue work…

This study looks at whether certain autoantibodies (proteins that mistakenly attack the body) are more common in people with obesity and if they are linked to related health problems like type 2 diabetes. Researchers will study 160 adults with a BMI over 30. The goal is to better…

This pilot study tests whether patients having laparoscopic gastric bypass can safely go home the same day if they use a remote monitoring device. Forty adults will be randomly assigned to either same-day discharge with remote monitoring or an overnight hospital stay. The study w…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides personalized advice on side effects and dose adjustments. The study is in its early stages, with only 16 participants, and is…

This study looks at whether a bedside lung ultrasound can help doctors see how well the lungs of obese patients are opening during a breathing machine procedure. The goal is to find the best air pressure to keep lungs open and improve oxygen levels. About 45 adults with a BMI of …

This study compares how two weight-loss surgeries—gastric bypass and sleeve gastrectomy—affect acid reflux in 128 obese patients. Participants will be randomly assigned to one surgery, and their reflux will be measured before and after using a 24-hour pH test. The goal is to see …

This study will look back at medical records of critically ill trauma patients with severe obesity who needed a breathing tube in the ICU. It aims to compare how often dangerous airway events happen in patients with morbid obesity versus super obesity, and whether higher BMI make…

This study watches how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and drug levels in 2,100 adults during surgery. The goal is to understand why heavier patients may have more complications, …

This registry study will follow 10,000 Chinese adults with obesity or overweight across 50 hospitals. Researchers will collect data on weight, lab tests, and liver health over 6 and 12 months. The goal is to understand current treatment patterns and outcomes in real-world clinica…

This early-stage study will test an experimental drug called HDM1005 in 42 overweight or obese adults. Researchers want to see how HDM1005 affects stomach emptying and whether it changes how the body processes common medications like metformin, atorvastatin, warfarin, and digoxin…

This study tests whether adjusting ventilator pressure during laparoscopic sleeve gastrectomy can improve lung function and reduce breathing complications. Forty-six obese patients will receive either individualized pressure settings or a fixed setting. The goal is to see if the …

This study will review medical records of 500-800 children aged 2-18 who attended NHS weight management clinics and had genetic tests for obesity. The goal is to see how often these tests find a genetic cause and whether certain traits, like developmental delays or eating behavio…

This pilot study looks at how the diabetes and weight-loss drugs semaglutide and tirzepatide directly affect blood vessels and heart function, beyond their known effects on weight. Researchers will infuse the drugs into the arm or bloodstream of 112 volunteers with different body…

This study will gather medical data and blood samples from up to 25,000 adults with obesity who visit a special clinic. Researchers hope to learn more about why obesity happens, what treatments work best, and how to improve patients' health. No new treatments are being tested; in…

This study looks at how gut bacteria are linked to obesity and type 2 diabetes in New Caledonia, where these conditions are very common. Researchers will collect blood, urine, and stool samples from 270 adults to analyze their gut microbes and related chemicals. The goal is to be…

This study watches how carbon dioxide gas, used to inflate the belly during laparoscopic weight-loss surgery, changes blood bicarbonate levels. Researchers will track 85 adults having sleeve gastrectomy or gastric bypass to see if these changes relate to how long the gas is used …

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. The goal is to understand why some people gain weight more easi…

This study follows 52 adults who are about to stop taking injectable weight loss drugs due to insurance changes. Researchers will measure a brain protein called Agouti-related peptide (AgRP) and track weight changes over 3 months. The goal is to see if this protein can predict wh…

This study looks at how lowering insulin levels changes the way the liver makes sugar and fat. Researchers will give 36 overweight or obese adults with insulin resistance and fatty liver disease two different insulin infusions—one that keeps insulin high and one that lowers it by…

This study tests whether a special breathing exercise, called intermittent inspiratory muscle training, can have an immediate effect on blood sugar, heart rate, and blood vessel stiffness. Researchers will compare this breathing workout to normal breathing in 48 healthy, obese, a…

This study looks at how two different exercise programs affect a protein called Sestrin-2, which is linked to inflammation and metabolism, in women with obesity and high blood pressure. About 42 women aged 30-65 will do either moderate steady exercise or brisk interval exercise f…

This study looks at whether eating 4-5 servings of dairy foods daily (like milk, cheese, and yogurt) can improve brain function and thinking skills in overweight adults aged 40-75. Participants will be randomly assigned to a high-dairy or low-dairy diet for several weeks. Researc…

This study looks at why metabolism often slows down when people with obesity lose weight through diet and exercise. Ten participants will follow an 8-week lifestyle program while researchers measure changes in body composition, core temperature, and energy use. The goal is to und…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study explores whether smartphone addiction is connected to obesity and reduced physical fitness in young adults. Researchers will observe 212 people aged 18-25 who use their phones over 5 hours daily and have a sedentary lifestyle. The goal is to understand these relationsh…

This study will give 40 obese adults semaglutide for 12 weeks to see how it changes their gut bacteria. Researchers will use stool samples and lab tests to understand the effects. The goal is to learn how semaglutide works on gut flora, not to test weight loss directly.

This small study will test whether a stomach ultrasound can work in people who have already had bariatric surgery. Ten adults scheduled for another surgery will have their stomachs scanned before and after the procedure. The goal is to see if ultrasound can measure stomach size a…

This study will check if a simple breathing measurement called the ROX index, taken before bariatric surgery, can predict which patients will have low oxygen levels in the first 12 hours after surgery. Researchers will measure the ROX index along with other risk scores in 80 adul…

This study will compare two devices that measure muscle relaxation during anesthesia in 30 obese patients having weight-loss surgery. One device tracks thumb movement (AMG), the other measures muscle electrical signals (EMG). The goal is to see which is more accurate for guiding …

This study looks at how children's eating behaviors, like eating quickly or eating large portions, are linked to brain activity and body fat. Researchers will follow 420 children aged 7 to 9 for one year, using brain scans and meal observations. The goal is to understand why some…

This study investigates how two molecules—glycerol from fat and lactate from the blood—are converted into glucose by the liver, especially in people with type 2 diabetes. Researchers will compare these processes in 48 adults with and without diabetes or obesity. Participants rece…

This study tests an online platform called Precare that provides educational content and appointment management for people waiting for bariatric surgery. Researchers want to see if it is easy to use, acceptable to patients, and helps them feel more ready for surgery. About 1,050 …

This study will check for stress, anxiety, depression, sleep problems, and bad breath in 110 adults with obesity who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a portable breath tester. The goal is to learn more about these issues…

This study will examine the connection between high uric acid levels (hyperuricemia) and non-alcoholic fatty liver disease (NAFLD) in 111 obese adults. Researchers will use blood tests, ultrasound, and FibroScan to measure uric acid, liver fat, and liver scarring. The goal is to …

This study will give 28 women with obesity either a calorie-restricted DASH diet or a standard American diet for 4 weeks. Researchers will track weight changes and analyze stool samples to see how diet affects gut bacteria and related health markers. The goal is to understand how…

This study will check how common it is for obese people with sleep apnea to still have low breathing at night even when using a CPAP machine. About 139 adults will wear a special skin sensor that measures oxygen and carbon dioxide levels overnight. The goal is to find out how man…