OBESITY

This study tests a once-weekly injection called NNC0487-0111 to help people with overweight or obesity and moderate-to-severe obstructive sleep apnea (OSA) who do not use a breathing machine. About 300 adults will receive either the study drug or a placebo for up to a year. The g…

This study tests a drug called setmelanotide in one person with pseudohypoparathyroidism type 1a (PHP1a), a rare genetic disorder that often causes severe obesity. The goal is to see if the drug can lead to at least 5% weight loss over 6 months. The participant must have a confir…

This study tests the safety and effectiveness of tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or a BMI over 27. The drug is already used for diabetes and weight management, but its effects in kidney failure patients need m…

This study looks at how exercise and a diet rich in fruits and vegetables affect the heart and metabolic health of teenagers with obesity. About 120 teens aged 13-17 will be placed into one of four groups: standard care, exercise only, diet only, or both exercise and diet. Over 1…

This study tests whether two experimental drugs, macupatide and eloralintide, can help people with obesity or overweight lose weight safely. About 400 adults who do not have type 2 diabetes will receive either one or both drugs or a placebo for about 64 weeks. The main goal is to…

This study is testing whether a new drug called CS0159, when combined with the diabetes drug semaglutide, can help people with fatty liver disease, obesity, and type 2 diabetes. About 30 adults will take the combination or a placebo for 12 weeks. The main goals are to see if it h…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through the body.

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study tests a program that gives pregnant women personalized nutrition and lifestyle advice based on their genes and nutrient levels. The goal is to see if this approach can lower the chances of problems like preterm birth, preeclampsia, and gestational diabetes. About 500 p…

This study tests a new weekly injection called NNC0487-0111 for people who are overweight or have obesity and also have obstructive sleep apnea treated with a breathing machine. About 300 adults will receive either the study drug or a placebo for one year. The goal is to see if t…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. About 64 people who smoke and are considering surgery will be enrolled. The goal is to see if this approach is …

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, to help adults with overweight or obesity lose weight. About 872 participants will receive either the drugs or a placebo. The main goal is to see how much weight they lose and if the dr…

This study looks at how well the drug tirzepatide works for weight loss and blood sugar control in everyday medical practice in Paraguay. It will include 160 adults: 80 with obesity but no diabetes, and 80 with type 2 diabetes (with or without obesity). All participants will take…

This study tests whether a gentle electrical stimulation of the vagus nerve (through the ear) can lower inflammation and reduce waist size in men with central obesity. Sixty healthy men aged 25-35 with a BMI of 30 or more will receive the treatment. The goal is to see if this non…

This study looks at how acid reflux changes after two types of weight-loss surgery: sleeve gastrectomy and gastric bypass. Researchers will monitor stomach acid levels before and after surgery in 128 obese adults who already have mild to moderate reflux. The goal is to see which …

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests a new medicine called CagriSema to see how well it helps people with obesity lose weight, compared to an existing drug, semaglutide. About 2500 adults with a BMI of 35 or higher, with or without type 2 diabetes, will take part. The trial lasts 83 weeks and measur…

This study tests a procedure called Endoscopic Sleeve Gastroplasty (ESG) to help people with obesity lose weight. It involves using a flexible tube to stitch the stomach smaller, reducing its size without traditional surgery. The trial will include 300 adults aged 18-75 with a BM…

This study tests a new medicine, NNC0487-0111, given as a weekly injection, in about 5,600 people who have both heart failure and obesity. The goal is to see if it can reduce the risk of death or hospitalization compared to a placebo. Participants will be randomly assigned to rec…

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study tests whether a once-daily oral cannabis pill can help people with obesity lose weight. Researchers will compare weight changes in 40 adults who take either the cannabis pill or a placebo. The goal is to see if this approach is effective and safe for weight management.

This study tests a 4-month virtual program designed for Puerto Rican men over 35 who are overweight. Participants join online classes about healthy eating and physical activity, led by a community health promoter. The goal is to see if the program is practical and helps men lose …

This study looks at whether professional dental cleaning can make semaglutide work better for children with severe obesity. About 50 kids will either get dental cleaning plus oral hygiene tips, or just the tips alone. The goal is to see if cleaning improves both gum health and ov…

This study tests a new drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese and not on blood pressure medication. The goal is to see if the drug can lower blood pressure and help with weight loss. About 336 adults will take eithe…

This study compares a minimally invasive weight loss procedure called POSE2.0, combined with a moderate diet and exercise program, to diet and exercise alone. About 186 adults with obesity who have not succeeded with non-surgical weight loss methods will participate. The procedur…

This study looks at whether brief, intense stair-climbing sessions, called 'exercise snacks,' can improve blood vessel health and body composition in overweight adults. Sixty participants aged 18-35 will be split into four groups, including a no-exercise control group, for 6-8 we…

This study tests a new weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants will receive two weekly shots (one active, one placebo) for about a year. The main goal is to see how much weig…

This study looks at two popular weight-loss drugs, semaglutide and tirzepatide, to see if adding exercise helps people with obesity lose more fat and keep muscle. About 48 adults aged 25-60 with a BMI between 30 and 40 will take one of the drugs and either exercise or not. The go…

This study tests a new weekly pill called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their weight after losing it. About 120 adults who have already been using weekly injections for weight loss will take either the study drug or a place…

This study tests a new device called the Trans-Duodenal Barrier, a temporary implant placed in the upper small intestine for 6 months. It aims to lower blood sugar (HbA1c) and help with weight loss in adults with type 2 diabetes and obesity. Researchers will also check if it impr…

This study tests how well the experimental medicine CagriSema helps people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo injection for roughly one year. The main goal is to measure the percentage of weight lost and check for…

This study looks at a program to help women with severe obesity (BMI 40 or higher) and early-stage endometrial cancer get healthier before surgery. The program includes weight-loss medication, a hormone-releasing IUD, diet changes, and exercise. The goal is to see if this approac…

This study tests whether a capsule containing a pasteurized gut bacteria (Akkermansia muciniphila) can help overweight and obese adults lose weight and improve their metabolism. 76 participants will take either the probiotic or a placebo daily for 12 weeks while following a low-c…

This study tests whether a natural fiber called oligofructose (found in onions, garlic, and bananas) can help improve blood sugar, cholesterol, and inflammation in Saudi adults with type 2 diabetes. 100 adults (50 with diabetes and 50 without) will take either the prebiotic or a …

This study will test whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau coconut-based foods can improve metabolic health in 40 adults with obesity. Researchers will measure changes in weight, waist size, blood pressure, blood sugar, …

This study tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are also overweight or obese. Twenty adults with active arthritis despite standard treatment will receive either dis…

This study looks at how three medicines—CagriSema, semaglutide, and cagrilintide—affect muscle health in 100 adults aged 50-70 with obesity and slightly high blood sugar. Participants will receive one of the drugs or a placebo for up to 15 months. The goal is to see how these tre…

This early study tests if injecting a person's own fat stem cells into the upper gut can safely improve blood sugar control in type 2 diabetes. About 15 adults with poorly controlled diabetes will receive the treatment through an endoscope. The main goal is to check safety, but r…

This study tests whether orlistat, a weight-loss medication, combined with a structured diet and exercise program, can help obese people with gout lower their uric acid levels and reduce gout attacks. 120 participants will receive either orlistat or a placebo for 24 weeks. The go…

This study will check how safe and effective the drug tirzepatide is for 300 adults with obesity or overweight plus related health problems like type 2 diabetes. Participants will take the medicine as part of their regular care and be followed for 12 months. The main goal is to t…

This study tests a program called MiWeigh that helps people with obesity and related health problems (like diabetes or high blood pressure) lose weight. About 500 adults will either get the program or just information about weight loss. Researchers will measure weight change afte…

This study is testing a combined program to help adult survivors of childhood leukemia who are living with obesity. Participants will receive a weekly weight-loss medication (Tirzepatide) and do supervised resistance exercises from home three times a week for 28 weeks. The main g…

This study tests if an experimental drug called BIO101 can help prevent muscle weakness in people taking the weight-loss drug semaglutide. About 164 overweight or obese adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide and a reduced…

This study will test whether a mobile app can help obese children ages 8 to 10 develop healthier eating attitudes, become more aware of what they eat, and feel more confident about making good food choices. About 52 children and their parents will use the app and complete surveys…

This study looks at whether a TAP block—a type of nerve block given during surgery—can help the stomach and intestines work better after laparoscopic sleeve gastrectomy. About 60 adults having weight-loss surgery will either get standard anesthesia or a TAP block. Their gut funct…

This study tests a 6-session group training program for people with obesity. The program helps participants notice and respond to body signals like hunger and emotions, which may reduce emotional eating. Ten adults from an NHS weight management service will take part. The goal is…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This study tests whether adding a simple breathing muscle trainer to regular aerobic exercise can improve lung function, exercise ability, and pain in adults who are obese and have chronic low back pain. About 48 participants will be split into two groups: one using the trainer p…

This study tests whether Vibegron, a drug already approved for overactive bladder, can improve metabolism, heart health, and physical and thinking abilities in middle-aged and older adults with obesity. Forty participants will take the drug or a placebo for 12 weeks. The goal is …

This study compares two ways of placing stitches in the stomach to help people lose weight. The goal is to see if using fewer stitches in a specific area works as well as the standard method. Ten adults with obesity will be followed for a year to measure weight loss and safety.

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which one works better for pain control during and after weight-loss surgery. The goal is to reduce the need for strong opioid painkillers like morphine. 90 adults having bariatric surgery wil…

This study looks at whether adding pork protein to daily meals can help middle-aged women (30-60) who are overweight or obese and taking GLP-1 medications (like Ozempic) maintain muscle, improve body composition, and feel better. Over 12 weeks, 75 women will continue their medica…

This study will compare breathing tube complications in critically ill trauma patients with morbid obesity (BMI 40+) versus super obesity (BMI 50+). Researchers want to know if higher BMI leads to more severe problems like low oxygen or low blood pressure during intubation. The g…

This study looks at whether certain autoantibodies (proteins that attack the body's own cells) are present in people with obesity and if they are linked to how severe the obesity is. Researchers will also check if these antibodies are connected to obesity-related health problems …

This study aims to find better ways to deliver health services to women Veterans, especially those in midlife. Researchers will test two different strategies at 18 VA sites to see which one helps more women get the care they need. The study focuses on improving engagement with pr…

This study looks at how children's eating behaviors, such as eating quickly or eating large portions, are linked to brain activity and body fat. Researchers will follow 420 children aged 7 to 9 for one year, using brain scans, meal observations, and questionnaires. The goal is to…

This study looks at how tirzepatide, a diabetes drug, helps people with obesity and a type of heart failure called HFpEF. Researchers will measure blood volume and body fat in 50 patients over 15 months to understand how the drug works. The goal is to find out if tirzepatide redu…

This study tests three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults from Yomitan Village, Okinawa. Participants will either receive health leaflets, wear functional clothing, or follow a moderate exercise manual for eight weeks. The goal …

This study looks at how two different exercise programs—moderate steady walking versus short bursts of brisk walking—affect a protein called Sestrin-2 and overall heart health in women with obesity and high blood pressure. About 42 women aged 30-65 will follow an 8-week exercise …

This study looks at how the liver makes new sugar from fat and blood molecules in people with and without type 2 diabetes. Researchers will give special tracers and take blood samples to track this process. The goal is to find new ways to lower blood sugar more effectively. About…

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. They will also test how the brain responds to overfeeding and u…

This study aims to find the best ways to help people with obesity enroll in digital weight-loss programs offered at community health centers. Over 5,000 adults with a BMI of 30 or higher will take part. Researchers will test different strategies, like clinic reminders and patient…

This study will use ultrasound to take pictures of the stomach in 10 patients who are having weight-loss surgery. The goal is to learn how the stomach looks before and after the operation. Patients will be asleep during the imaging, so there is little discomfort.

This study looks at obese adults who use a CPAP machine for sleep apnea to see how many still have trouble breathing properly at night. Researchers will use a special monitor to measure carbon dioxide levels through the skin. The goal is to find out how common this hidden breathi…

This study looks at how obesity is linked to oral health problems like gum disease, cavities, and tooth erosion. Researchers will follow 400 adults who are getting weight-loss treatment (either lifestyle changes or surgery) at a hospital in Norway. They will check participants' m…

This pilot study tests whether a mobile app called SWITCH is practical and helpful for adults taking GLP-1 medications for obesity or type 2 diabetes. About 50 participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if people fi…

This study looks at how fat tissue in the upper body reacts after a meal, comparing normal-weight people to those with obesity. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue works, not…

This study looks at how the weight-loss drug semaglutide changes the gut bacteria in 40 adults with obesity. Participants will take semaglutide for 12 weeks, and researchers will analyze their stool samples to see how the bacteria composition shifts. The goal is to understand the…

This early-stage study looks at how a new drug called HDM1005 affects stomach emptying and interacts with four common medications (metformin, atorvastatin, warfarin, and digoxin) in 42 overweight or obese Chinese adults aged 18-45. The goal is to understand how the body processes…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool provides guidance on adjusting doses and handling side effects. The study involves 16 participants and focuses on gathering feedback t…

This study looks at how cartoon characters on food packages and warning labels influence what Colombian children aged 12 to 17 think about ultraprocessed foods. About 1,960 kids will take an online survey to see if characters make warning labels less effective. The goal is to und…

This study tests whether a calorie-controlled DASH diet (heart-healthy eating plan) affects weight and gut bacteria differently than a standard American diet. Twenty-eight black and white women with obesity will follow one of the two diets for 4 weeks. Researchers will collect st…

This observational study looks at 150 adults with obesity who are already planning weight loss surgery. Researchers will use heart CT scans and ultrasounds before and about 6 months after surgery to see if fat inside the heart muscle decreases and if the heart's ability to relax …

This study will create a large database and biobank of information and blood samples from up to 25,000 people with obesity. Researchers will use this information to better understand obesity, identify factors that predict success or failure of treatments, and develop better manag…

This study tests a free online platform called Precare for people waiting for bariatric surgery. The goal is to see if it helps patients feel more ready and informed, and reduces the number who decide not to have surgery. About 1,050 adults on the waiting list at a Quebec hospita…

This early-stage study tests two similar experimental injections for obesity in 40 healthy adults aged 19 to 65. Each person receives both injections at different times to compare safety and how the drug moves through the body. The goal is not to treat obesity but to gather safet…

This study follows 400 children aged 5 to 7—some with obesity, some at normal weight—until they turn 12. Researchers will track genes, hormones, diet, and chemical exposures to see what predicts early puberty. The goal is to understand why obesity can trigger early development, n…

This study will compare two devices that measure muscle relaxation during anesthesia in 30 obese adults having weight-loss surgery. One device uses motion (acceleromyography) and the other uses electrical signals (electromyography). The goal is to see which gives more accurate re…

This study looks at whether smartphone addiction is connected to obesity and lower physical fitness in young adults aged 18 to 25. Researchers will measure walking ability and body shape in 212 participants who use their phones over 5 hours daily. No treatment is given; the goal …

This study looks at the gut bacteria of 270 adults in New Caledonia to understand how they relate to obesity and type 2 diabetes. Researchers will analyze stool samples to find connections between microbes, diet, and health. The goal is to gather knowledge, not to test a treatmen…

This pilot study looks at whether a new program can help people manage their weight after they stop taking anti-obesity medications like Wegovy or Zepbound. Researchers want to see if patients find the program helpful and if the study itself runs smoothly. About 214 participants …

This study aims to collect health information and biological samples from 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic issues. Researchers will follow participants for up to 30 years to learn how diabetes and obesity develop and change over ti…

This study watches how body fat and muscle affect the way anesthesia drugs work in overweight and obese patients. Researchers will measure drug levels and track complications like breathing problems or infections. About 2,100 adults will take part, but no new treatments are being…

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance, prediabetes, and fatty liver disease. Participants will undergo two procedures where insulin is either kept at a high level or lowered by half, and r…

This study looks back at medical records of 500-800 children aged 2-18 with severe obesity that started before age 5. Researchers want to see how often genetic tests find a cause. No new tests or visits are needed. The goal is to help the NHS better identify which children benefi…

This study will check stress, sleep quality, and bad breath in 110 adults who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a small device to measure breath. The goal is to learn more about these issues so doctors can offer better su…

This study looks at how different Enneagram personality types are connected to eating habits, emotional eating, and overall well-being in 250 adults with obesity. Participants will fill out questionnaires about their personality, eating behaviors, and psychological health. The go…

This study tests whether a bedside lung ultrasound can help doctors see how well collapsed lung areas reopen in obese patients on breathing machines. About 45 adults with a BMI of 33 or higher will be scanned before, during, and after a standard lung-opening procedure. The goal i…

This study will compare different ways to measure body changes in 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give more useful information than simple scales and tape measures. The g…