OBESITY

This study aims to find out which of two exercise programs is better for improving heart health and reducing inflammation in women who have both obesity and high blood pressure. Researchers will compare steady, moderate exercise with a faster-paced interval program over 8 weeks. …

This study aims to find out if exercise, improving diet with fruits and vegetables, or doing both together can improve heart and metabolic health in teenagers with obesity. Researchers will compare four groups over 12 weeks: one group gets usual care, one gets exercise coaching, …

This study aims to see if a common type of diabetes drug (GLP-1 RA) can improve the buildup of harmful fats in the liver of people who have fatty liver disease, diabetes, and obesity. Researchers will compare liver and blood samples from 30 people who have been on the drug for a …

This study is testing whether a new weekly injection called NNC0487-0111 is safe and effective for helping people with obesity lose weight. About 600 adults will be randomly assigned to receive either the real injection or a placebo (a dummy injection with no medicine) for a set …

This study aims to see if a new digital weight management program can improve health services and outcomes for people living with obesity. It will enroll 580 adults already referred to a specialist NHS weight management service. Researchers will compare the digital program to sta…

This study is testing whether combining a dietary supplement (alpha-lipoic acid) with an existing medication (mirabegron) can help the body process sugar and burn fat more effectively in people with obesity. Researchers will enroll 60 adults with obesity to take the combination f…

This study aims to find the best way to help adults with obesity lose weight while keeping their muscle. Researchers are testing if adding a high-protein diet to a common weight-loss medication (GLP-1 agonist) can prevent the loss of muscle mass that sometimes happens with these …

This study will test whether gentle electrical stimulation of the vagus nerve through the ear can help reduce belly fat in obese men. Researchers will measure changes in waist size, body shape, inflammation markers, sleep quality, stress levels, and gut symptoms. The study will i…

This study is testing if eating protein-rich pork foods helps women lose more weight and feel better while taking GLP-1 medications like Ozempic or Wegovy. Researchers will compare 75 middle-aged women with obesity who either just take their medication or take it while also eatin…

This study aims to gather real-world evidence on Endoscopic Sleeve Gastroplasty (ESG), a non-surgical procedure that reduces stomach size to help with weight loss. It will follow 300 adults with obesity in France who haven't had success with diet/exercise and are not opting for t…

This is an early-stage study to test the safety and effects of a new injectable drug called brenipatide in healthy adults who are overweight or have obesity. Researchers will give different doses to about 150 participants to see how the body handles the drug and if it helps reduc…

This study is testing whether a virtual group exercise program combined with health education is better than health education alone at reducing the risk of falls and increasing daily activity in older Veterans. It focuses on Veterans aged 55+ who have obesity and signs of muscle …

This study is testing a 9-month support program to help new mothers improve their heart health after a first pregnancy complicated by preeclampsia. The program uses a special smartphone app for tracking blood pressure and weight, along with online coaching and group meetings. Res…

This study is testing if a simpler stitching pattern inside the stomach works as well as a more complex one for weight loss. It will involve 10 adults with obesity who will have a minimally invasive procedure using a special device. Researchers will compare weight loss and health…

This study aims to find the most effective combination of four dietary strategies for weight loss in a fully digital program. Researchers will enroll 208 U.S. adults with overweight or obesity in a 12-week remote program testing different approaches to eating. The goal is to iden…

This early study is testing whether the weight-loss medication tirzepatide can slow the growth of endometrial cancer tumors. Twenty obese women with this type of cancer will take the drug for four weeks before their scheduled surgery. Researchers will compare tumor samples taken …

This study is testing whether weekly injections of an investigational drug called XW003 can help reduce breathing pauses during sleep and lower body weight in obese adults who have obstructive sleep apnea. Participants will receive either XW003 or a placebo injection for up to 48…

This study is testing a new mobile app designed to help children with obesity develop healthier eating habits. It will involve 52 children aged 8 to 10 and their parents. The goal is to see if using the app improves the kids' attitudes toward food, makes them more aware while eat…

This study is testing if adding a weight loss medication (orlistat) to standard gout treatment helps obese patients better control their uric acid levels. 120 participants will be randomly assigned to receive either the weight loss drug plus a personalized diet and exercise plan,…

This study is testing whether a natural dietary fiber called oligofructose, found in foods like onions and bananas, can help people with type 2 diabetes better manage their condition. For 12 weeks, 100 Saudi adults (50 with diabetes and 50 without) will take either the fiber supp…

This study will follow 300 adults with obesity in Paraguay for one year to see how safe and effective the medication tirzepatide is in real-world use. Participants will receive weekly injections to help with weight loss and improve related health measures like blood sugar and cho…

This study aims to see if two different injection devices for the weight loss medication CagriSema work the same way. About 1,400 adults with overweight or obesity will be randomly assigned to receive either the medication or a placebo for about one year. The main goal is to comp…

This study is testing whether a new weekly injection called KAI-9531 can help people with obesity lose weight. About 250 adults without diabetes will receive either the real injection or a placebo (a dummy shot with no medicine) for 48 weeks. The main goal is to see how much body…

This study is testing whether a new support program can help people maintain their weight after they stop taking prescription weight-loss medications like Wegovy or Zepbound. Researchers will enroll 214 adults with obesity who are discontinuing their medication to see if the prog…

This study is testing a new weekly injection called NNC0487-0111 for people who have both excess body weight and knee osteoarthritis. The main goals are to see if the treatment helps participants lose weight and reduces their knee pain and stiffness. About 400 participants will b…

This study aims to see if adding professional dental cleaning to a weight-loss medication (semaglutide) provides extra health benefits for children with severe obesity. It will compare children who receive cleaning plus hygiene instructions to those who only get instructions. The…

This study aims to see if doing muscle-strengthening exercises and/or eating more protein can help people with obesity keep their muscle mass while they lose weight using medications like semaglutide or tirzepatide. Researchers will follow 232 adults for 6 months to measure chang…

This study is testing whether a weekly weight-loss medication (Tirzepatide) combined with a remote, supervised exercise program can help adult survivors of childhood leukemia lose weight and improve their heart and metabolic health. The 28-week program aims to see if participants…

This study is testing if a virtual lifestyle program tailored for Puerto Rican men can help them lose weight. Researchers will compare a program focused on healthy eating and physical activity to one giving only general health information. The goal is to see if the culturally rel…

This study is collecting real-world safety and effectiveness data on the Orbera365 gastric balloon when it's left in place for up to a full year. It will follow 200 adults in Europe with obesity who have already chosen to get the balloon for weight loss. Researchers will track se…

This study aims to see if a new weekly injection called NNC0487-0111 is safe and works better than the approved drug semaglutide for people with both excess weight and type 2 diabetes. About 1,000 adults will be randomly assigned to receive either the new drug or semaglutide, bot…

This study is testing whether the medication tirzepatide is safe and effective for weight loss in people with advanced chronic kidney failure who also have obesity or diabetes. It will involve 15 patients who are not yet on dialysis. Researchers will track changes in weight, kidn…

This study is testing if a drug called vericiguat can improve heart and metabolic health in Black adults with obesity and insulin resistance. Researchers will enroll 200 participants to take either the drug or a placebo pill daily for 12 weeks. The main goals are to see if the dr…

This study aims to find out if taking a daily oral cannabis product can help obese adults lose weight. It will involve 40 participants who do not currently use cannabis. People will be randomly assigned to receive either the cannabis product or a placebo (inactive substance) to c…

This small pilot study is testing a new group program designed to help people with obesity or overweight increase their physical activity in a healthy way. The main goal is to see if the program helps people exercise more without developing unhealthy relationships with food or ex…

This is a very early safety study for a new injection called SHR-2906, which is being developed to help with obesity. The main goal is to see if the drug is safe and how the body processes it. The study will first test single doses in healthy volunteers, then test multiple doses …

This study is testing if a medication called Vibegron can help improve metabolism, heart health, and physical and mental function in middle-aged and older adults with obesity. Over 12 weeks, 40 participants will take either the drug or a placebo pill. Researchers will measure cha…

This study is testing if a new investigational pill, CS060380, works better than a placebo when added to an approved weight-loss injection (semaglutide) for people who have both a serious fatty liver disease (MASH) and obesity. About 120 adults in China will take either the new p…

This study aims to see if a specific low-calorie diet, based on traditional Indonesian foods rich in coconut oil, can improve health markers in people with obesity. It will involve 40 university staff members with obesity over 12 weeks, comparing this special diet to a standard b…

This study is testing whether a structured diet and lifestyle program can put type 2 diabetes into remission, meaning blood sugar returns to normal without medication. Researchers will compare this intensive program to standard medical care in 92 Malaysian adults with recent diab…

This study is testing a new, temporary implant called the Trans-Duodenal Barrier. Doctors place it in the stomach and small intestine using a camera tube (endoscopy) to see if it helps lower blood sugar and promote weight loss in adults with type 2 diabetes and obesity. The impla…

This study is testing a new weight management program called MiWeigh. It will compare people who get guided support through the program to those who just receive basic weight loss information. The goal is to see if the program helps people lose more weight and manage obesity-rela…

This study aims to check how safe and effective the medication tirzepatide is for adults in India who have type 2 diabetes or who are overweight/obese. About 344 participants will receive the medication for 46 weeks. Researchers will monitor side effects, weight changes, and bloo…

This study is testing a free online platform designed to help people prepare for weight-loss (bariatric) surgery while they are on long waiting lists. It aims to see if the platform is easy to use, acceptable to patients, and can improve their readiness for surgery. The research …

This VA program aims to help clinics better provide proven health services for women Veterans in midlife. It will test two different support strategies across at least 18 VA facilities to help them offer trauma-informed care, menopause symptom therapy, and weight management progr…

This study aims to see if adding exercise to new weight-loss medications provides better health results than medication alone. Researchers will compare two popular drugs, semaglutide and tirzepatide, in 48 adults with obesity. The main goal is to find out which approach—drugs alo…

This study is testing whether a new weekly injection called XW003 can help people who have both obesity and obstructive sleep apnea (OSA). It will compare the injection to a placebo (dummy treatment) in 140 adults who do not use a standard breathing machine (PAP therapy) for thei…

This early study is testing whether injecting a patient's own stem cells into the small intestine can help control type 2 diabetes. Researchers will deliver the cells through a standard endoscopy procedure to target the area near the pancreas. The main goal is to check if this ap…

This study is testing a program designed to help people who smoke and are planning weight-loss surgery. The program combines two medications with behavior therapy to help participants quit smoking and lose weight before their operation. Researchers will compare this combined appr…

This is a small pilot study to see if three simple, low-cost approaches are practical and helpful for reducing stress and encouraging healthy behavior. It will involve 45 adults in Okinawa, Japan, who will try one of the following for eight weeks: receiving health information, we…

This study is testing whether a drug called BIO101 can help prevent muscle strength loss in overweight and obese adults who are taking the weight loss medication semaglutide while dieting. Researchers want to see if taking BIO101 pills twice daily for 21 weeks helps maintain leg …

This study is testing if using a special breathing trainer can help adults who have both obesity and chronic low back pain. Participants will do regular exercise, and half will also use the breathing device. Researchers will check if this extra training improves lung function, ex…

This study is testing if a drug called tradipitant can reduce the nausea and vomiting that some people experience when taking GLP-1 weight loss medications. It will involve 280 overweight or obese adults who do not have diabetes. Participants will be randomly assigned to receive …

This study is testing if a specific pain-blocking injection, given during weight loss surgery, can help patients' stomachs recover and work normally again more quickly. Researchers will compare recovery in 60 patients who get the injection to those who do not. They will measure h…

This study is testing a new online group therapy program for people in a weight management service. The program teaches skills to help people better notice their body's internal signals (like hunger or emotions) and manage their feelings, with the goal of reducing behaviors like …

This study aims to understand how diabetes and obesity develop and change over time, especially in younger people. Researchers will collect health information and samples (like blood and saliva) from up to 1,000 participants during their regular doctor visits. The goal is to gath…

This research aims to understand how genetics and diet contribute to obesity by studying brain inflammation. Researchers will compare identical twins who have different eating habits to see if this affects their body fat and brain scans. The study involves MRI scans, blood tests,…

This study aims to understand if there is a connection between smartphone addiction, obesity, and physical fitness in young adults. Researchers will observe 212 participants aged 18-25 who use their phones more than 5 hours daily. They will measure fitness levels, body shape, and…

This study aims to understand why some children are more likely to gain weight than others by observing their eating behaviors, brain responses to food, and family backgrounds. Researchers will follow 420 children aged 7-9 for one year, using brain scans, meal observations, and q…

This study aims to understand how tirzepatide, a medication for weight loss and type 2 diabetes, affects muscle and bone health during weight reduction. Researchers will compare people taking the medication alongside a lifestyle program (diet and exercise) to a control group usin…

This study aims to understand how different calorie-restricted diets affect gut bacteria and weight loss in Black and White women with obesity. Researchers will provide all meals for 4 weeks to 28 participants, comparing a heart-healthy DASH diet to a standard American diet. The …

This study aims to understand how useful genetic testing is for children with severe obesity that started very early in life. Researchers will review the medical records of about 500 children who already had genetic tests through NHS specialist clinics. The goal is to see how oft…

This study aims to find out which of two small monitoring devices works better to track muscle relaxation during weight loss surgery in obese patients. Researchers will attach one device to each hand of 30 participants to compare accuracy and ease of use. The goal is to improve s…

This early-stage study aims to understand if lowering high insulin levels for one week can reduce the liver's production of new fat, a key driver of fatty liver disease. Researchers will compare a drug called diazoxide against a placebo in 25 adults with obesity, insulin resistan…

This study aims to understand why some children with obesity start puberty earlier than others. Researchers will follow 400 children, aged 5 to 7, for about seven years, tracking their health, genes, diet, and chemical exposures. The goal is to identify which factors—like genetic…

This study aims to understand how high insulin levels contribute to fatty liver disease in people who are overweight and insulin resistant. Researchers will temporarily control insulin levels in 36 participants to measure how the liver produces fat and sugar. The goal is to gathe…

This study aims to understand how obesity might increase the risk of stomach cancer. Researchers will examine stomach tissue samples from 100 obese patients undergoing weight-loss surgery, comparing them to normal tissue. They will look for specific immune cells and blood vessel …

This study aims to understand how the medication semaglutide changes the gut bacteria of people with obesity. Researchers will enroll 40 adults and analyze stool samples before and after 12 weeks of treatment. The goal is to learn the specific ways this drug might work through th…

This research study aims to understand how gut bacteria differ between healthy people and those with obesity and type 2 diabetes in New Caledonia. Researchers will collect stool, blood, and urine samples from 270 adults across three groups: obese with diabetes, obese without diab…

This study aims to better understand why blood sugar is high in type 2 diabetes by measuring how the liver makes new sugar from fat and other molecules. Researchers will compare this process in healthy, obese, and diabetic adults using special tracer infusions and blood tests. Th…

This is an early safety study to see how two slightly different versions of an experimental obesity drug are processed by the body. It will involve 40 healthy adult volunteers, who will each receive both drug versions in a specific order. The main goal is to compare the safety an…

This study aims to understand if patients with extreme obesity face more complications when a breathing tube is placed in an emergency, compared to those with severe obesity. Researchers will look back at medical records of 2 critically ill trauma patients to compare risks like s…

This study aims to understand how blood flow and the release of tiny particles from upper body fat tissue differ between people with normal weight and people with obesity after eating a meal. Researchers will measure these changes by taking specific blood samples from the fat tis…

This study aims to learn the best way to use a handheld ultrasound to see the stomach in people who have had weight loss surgery. Researchers will image the stomachs of 10 patients while they are under anesthesia, both before and after their surgical procedure. The goal is to gat…

This study aims to understand how the medication semaglutide affects muscle health in people using it for type 2 diabetes or weight loss. Researchers will use detailed MRI scans and fitness tests to track changes in muscle and fat in the body and heart over one year. The goal is …

This study is creating a large collection of health information and blood samples from people with obesity. The goal is to better understand why obesity happens, how it affects health, and what treatments work best for different people. Researchers will use this data to learn mor…

This study aims to understand if a person's body composition (like weight and fat distribution) is linked to how their airways react during a specific breathing test. Researchers will measure airway function in 100 people who are already scheduled for a standard methacholine chal…

This study aims to find out how many obese people with sleep apnea continue to have breathing problems at night while using their CPAP machines. Researchers will measure nighttime breathing in 139 patients who have been using CPAP for at least 3 months. The goal is to better unde…

This study aims to understand if a person's Enneagram personality type is connected to their eating habits, emotional eating, and overall well-being. It will enroll 250 adults with obesity to complete questionnaires about their personality, eating behaviors, and feelings. The goa…

This study aims to understand how common stress, poor sleep, and bad breath are in people with obesity who are about to have weight-loss surgery. Researchers will survey 110 adults using questionnaires and a portable breath detector. The goal is to gather information that could h…