New gut implant aims to tackle diabetes and obesity without surgery

NCT ID NCT07417683

Not yet recruiting Disease control Sponsor: Trans-Duodenal Concepts GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a temporary device placed in the upper small intestine to help control type 2 diabetes and obesity. The implant stays for 6 months and is then removed. Researchers will check if it lowers blood sugar (HbA1c), helps with weight loss, and improves liver health in people with MASH. About 126 adults will take part, with regular clinic visits and follow-up after removal.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endoscopic implant (gastroduodenal bypass liner)
What this could lead to: If it works, this could offer a non-surgical, reversible option to help control diabetes and obesity, and possibly improve liver health in MASH patients.
What could go wrong: This is an early approval study with only 126 participants, so results may not apply to everyone. The implant requires endoscopic placement and removal, and there may be side effects or complications.

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Conditions

The condition(s) this trial relates to.

metabolic dysfunction-associated steatohepatitis Obesity obesity disorder type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MASH OBESITY OBESITY TYPE 2 DIABETES MELLITUS TYP 2 DIABETES

Contacts and locations

Locations

Charite Universitätmedizin Berlin CVK

Berlin, 13353, Germany
Klinikum St. Georg Leipzig

Leipzig, Saxony, 04129, Germany
Knappschaft Kliniken Universitätsklinikum Bochum GmbH Medizinische Klinik

Bochum, North Rhine-Westphalia, 44892, Germany
Sozialstiftung Bamberg

Bamberg, Bavaria, 96049, Germany
Städtisches Klinikum Dresden

Dresden, Saxony, 01067, Germany
University of Leipzig Medical Center, Department of Oncology, Gastroenterology, Hepatology and Pneumology

Leipzig, Saxony, 04103, Germany
Universitätsklinikum Würzburg

Würzburg, Bavaria, 97080, Germany
Universitätsmedizin Mannheim

Mannheim, Baden-Wurttemberg, 68167, Germany

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