Can exercise make Weight-Loss drugs work better?

NCT ID NCT07319975

Not yet recruiting Disease control Sponsor: Istanbul Galata University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two popular weight-loss drugs, semaglutide and tirzepatide, alone or combined with exercise, in 48 adults with obesity. The goal is to see which approach better reduces body fat while preserving muscle mass, and improves strength and metabolic health. Participants will be followed for changes in body composition, muscle strength, and other health markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: semaglutide and tirzepatide
What this could lead to: If successful, this could show that adding exercise to these weight-loss drugs helps preserve muscle while losing fat, leading to better overall health.
What could go wrong: This is a small, early-stage study with only 48 participants, so results may not apply to everyone. The drugs can cause side effects like nausea and vomiting.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for OBESITY are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Biruni University

Istanbul, Zeytinburnu, Turkey (Türkiye)

Contact

Contact Phone: •••-•••-•••• Email: •••••@•••••

Contact

Contact

Contact

Contact

More trials for these conditions

Other studies related to the condition(s) this trial covers.