Could a heart drug fix metabolism in black obesity?
NCT ID NCT06320951
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether vericiguat, a drug already used for heart failure, can improve how the body uses sugar and burns energy in Black adults with obesity and insulin resistance. Researchers will give 200 participants either vericiguat or a placebo daily for 12 weeks, measuring changes in insulin sensitivity and energy expenditure. The goal is to see if boosting a natural signaling pathway can lower the risk of heart disease and diabetes in this group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Vericiguat (a drug that boosts a natural signaling pathway to improve metabolism)
- What this could lead to
- If it works, this could point toward a new way to reduce heart disease and diabetes risk in Black individuals with obesity.
- What could go wrong
- This is an early phase 2 trial with only 200 people over 12 weeks. It may not show clear benefits, and results may not apply to other groups.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Alabama at Birmingham
Birmingham, Alabama, 35294, United States
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