PCOS may fuel fatty liver in teens even after accounting for obesity — a study investigates

NCT ID NCT07731373

Not yet recruiting Knowledge-focused Sponsor: Kayseri City Hospital Source: ClinicalTrials.gov ↗

First seen Jul 28, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study explores whether polycystic ovary syndrome (PCOS) independently contributes to fatty liver disease in adolescent girls, beyond the effects of obesity. Researchers will compare three groups of girls aged 10–18: those with PCOS and obesity, those with obesity alone, and healthy-weight controls. Each participant undergoes a single evaluation including a blood draw for an expanded panel of biomarkers and a liver stiffness scan. No treatment is given — the goal is to better understand the biological links between PCOS, hormones, and liver health.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If PCOS is shown to independently drive liver fat accumulation, it could point toward targeted screening and prevention strategies for adolescent girls.
What could go wrong: This is a small, single-center pilot study that can only identify associations, not causes. Results may not apply to all populations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome fatty liver disease Hyperandrogenism metabolic dysfunction-associated steatotic liver disease metabolic syndrome X obesity disorder Pediatric Obesity polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERANDROGENISM INSULIN RESISTANCE SYNDROME METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE PEDIATRIC OBESITY POLYCYSTIC OVARY SYNDROME (PCOS)

Contacts and locations

Locations

University of Health Sciences, Kayseri City Hospital

Kayseri, 38080, Turkey (Türkiye)

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