New pill aims to tackle obesity and inflammation at the same time
NCT ID NCT07693868
First seen Jul 09, 2026 · Last updated Sep 02, 2026 · Updated 5 times
Summary
This early-stage trial tests an experimental oral drug, NNC6022-0004, in healthy adults and people with obesity. The study checks how safe the drug is, how the body processes it, and whether food affects its absorption. Participants receive either the drug or a placebo capsule by chance. The goal is to gather initial safety data before larger studies.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- NNC6022-0004 (oral capsule)
- What this could lead to
- If safe and effective, this drug could offer a new oral treatment option for obesity and related inflammation.
- What could go wrong
- This is an early Phase 1 trial focused on safety, not efficacy. The drug may not work or could have side effects. Results may not apply to broader populations.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 128 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2026
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male, or female of non-childbearing potential. * For Parts A, B, C and D: Age 18-55 years (both inclusive) at the time of signing the informed consent. For optional Part E only: Age 18-65 years (both inclusive) at the time of signing the informed consent. -For Parts A, B, C and D: Body mass index (BMI) between 18.5 to 29.9 kilogram per meter square (kg/m\^2) (both inclusive) at screening. For optional Part E only: BMI between greater than or equal to (≥) 30.0 to less than or equal to (≤) 45.0 kg/m\^2 at screening, or if BMI is between 27.0 and \<30.0 kg/m\^2, waist to height ratio should be greater than (\>)0.5. * Body weight: ≥50.0 kilogram (kg) at screening. * Considered to be generally healthy based on the medical history, physical examination, and the results of vital signs, electrocardiogram and clinical laboratory tests performed during the screening visit, as judged by the investigator. * For optional Part E only: hsCRP ≥2.00 and ≤8.00 milligrams per liter (mg/L) during screening period in 2 separate samples taken ≥4 days apart. Exclusion Criteria: * Known or suspected hypersensitivity to study intervention(s) or similar products. * Any disorder, unwillingness or inability which in the investigator's opinion might jeopardise participant's safety or compliance with the protocol. * Any of the below laboratory safety parameters at screening outside normal range, see designated reference range documents for specific values. * Alanine Aminotransferase (ALT) \> Upper limit of normal (ULN). * Alkaline Phosphatase (ALP) \> ULN. * Aspartate aminotransferase (AST) \> ULN. * Total Bilirubin (TBL) \> ULN. * Creatinine \> ULN. * International normalized ratio (INR) \> ULN. * Fibrinogen outside normal range of 1.6 - 4.2 grams per liter (g/L). * hsCRP \> 5.00 mg/L (males) and \> 8.00 mg/L (females)\*. * applicable for Parts A, B, C and D and for optional Part E: hsCRP \>8.00 mg/L. * Use of prescription medicinal products or vaccines within 14 days before screening and/or non prescription medicinal products within 7 days before dosing. Exceptions are: Topical medications not reaching systemic circulation; less than once per week of over-the-counter paracetamol, ibuprofen and/or acetylsalicylic acid at their labelled doses for mild pain; vitamins at their labelled doses.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The study's own enquiry address
This study publishes an address for enquiries. See it below .
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Show contact details
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Study contacts
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Contact
Email: •••••@•••••
Locations
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ICON - location Groningen
RECRUITINGGroningen, 9728 NZ, Netherlands
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