Brown fat may hold key to weight loss drug response
NCT ID NCT07621640
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatment, using a cooling vest to activate brown fat. Researchers will compare brown fat activity with weight loss and metabolic changes to see if it can serve as a personalized treatment guide.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Semaglutide (Wegovy)
What this could lead to
If successful, this could help doctors predict who will benefit most from semaglutide, leading to more personalized obesity treatment.
What could go wrong
This is an observational study, not a treatment trial. It may find no link between brown fat and weight loss, and results may not apply to everyone.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hallym University Dongtan Sacred Heart Hospital
Hwaseong-si, Gyeonggi-do, 18450, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••