Brown fat may hold key to weight loss drug response

NCT ID NCT07621640

Not yet recruiting Knowledge-focused Sponsor: Hallym University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study looks at whether brown adipose tissue (brown fat), which burns energy as heat, can predict how well people with obesity respond to the weight loss drug semaglutide (Wegovy). Eighty adults starting semaglutide will have PET/CT scans before and after 24 weeks of treatment, using a cooling vest to activate brown fat. Researchers will compare brown fat activity with weight loss and metabolic changes to see if it can serve as a personalized treatment guide.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Semaglutide (Wegovy)
What this could lead to: If successful, this could help doctors predict who will benefit most from semaglutide, leading to more personalized obesity treatment.
What could go wrong: This is an observational study, not a treatment trial. It may find no link between brown fat and weight loss, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BROWN ADIPOSE TISSUE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BROWN ADIPOSE TISSUE METABOLIC SYNDROME OBESITY

Contacts and locations

Locations

Hallym University Dongtan Sacred Heart Hospital

Hwaseong-si, Gyeonggi-do, 18450, South Korea
Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

More trials for these conditions

Other studies related to the condition(s) this trial covers.