New stitch procedure could help obese patients shed pounds without surgery

NCT ID NCT07449520

First seen Mar 07, 2026 · Last updated Jun 22, 2026 · Updated 17 times

Summary

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) for weight loss in 300 adults with obesity. ESG uses a special device to stitch the stomach smaller from the inside, without cutting or removing any tissue. The goal is to see if it helps people lose weight safely and effectively over two years.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Email: •••••@•••••

Locations

  • Centre Mutualiste de l'Obésité

    Saint-Etienne, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Clinique Clémentville

    Montpellier, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Clinique les Eaux Claires

    Baie-Mahault, Guadeloupe

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Clnique des Cèdres

    Échirolles, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hospices Civils de Lyon - Hôpital Edourard HERRIOT

    Lyon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital HURIEZ

    Lille, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpital Privé de Provence

    Aix-en-Provence, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil

    Strasbourg, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Polyclinique Sainte Thérèse

    Sète, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Polyclinique de Franche-Comté

    Besançon, France

    Contact Phone: •••-•••-•••• Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

endoscopic sleeve gastroplasty (a procedure that reduces stomach volume using a suture device, without cutting or removing tissue)

What this could lead to

If successful, this could provide a less invasive, effective weight-loss option for people with obesity who cannot or do not want traditional surgery.

What could go wrong

This is an early-stage, non-randomized study in France, so results may not apply everywhere. The procedure carries risks like any medical intervention, and long-term weight loss success is not guaranteed.

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.