New stitch procedure could help obese patients shed pounds without surgery

NCT ID NCT07449520

Not yet recruiting Disease control Sponsor: IHU Strasbourg Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) for weight loss in 300 adults with obesity. ESG uses a special device to stitch the stomach smaller from the inside, without cutting or removing any tissue. The goal is to see if it helps people lose weight safely and effectively over two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: endoscopic sleeve gastroplasty (a procedure that reduces stomach volume using a suture device, without cutting or removing tissue)
What this could lead to: If successful, this could provide a less invasive, effective weight-loss option for people with obesity who cannot or do not want traditional surgery.
What could go wrong: This is an early-stage, non-randomized study in France, so results may not apply everywhere. The procedure carries risks like any medical intervention, and long-term weight loss success is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBESITY

Contacts and locations

Locations

Centre Mutualiste de l'Obésité

Saint-Etienne, France
Clinique Clémentville

Montpellier, France
Clinique les Eaux Claires

Baie-Mahault, Guadeloupe
Clnique des Cèdres

Échirolles, France
Hospices Civils de Lyon - Hôpital Edourard HERRIOT

Lyon, France
Hôpital HURIEZ

Lille, France
Hôpital Privé de Provence

Aix-en-Provence, France
Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil

Strasbourg, France
Polyclinique Sainte Thérèse

Sète, France
Polyclinique de Franche-Comté

Besançon, France

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